Small rna molecules, precursors thereof, means and methods for detecting them, and uses thereof in typing samples

ABSTRACT

The invention is related to small RNA molecules, precursors thereof and methods for detecting such molecules. The invention is in particular concerned with differentially expressed small RNA molecules and precursors thereof. Various collections of small RNA molecules, precursors thereof and collections of probe and primers that can be used to detect small RNA molecules, precursors thereof are provided. Further provided are diagnostic test based on this differential expression. Also provided are therapeutic applications using one or more of the members of the presented collections.

Cancer of the colorectal part of the gastrointestinal tract is a frequently occurring disorder. In a first stage a benign tumour (adenoma) occurs which can turn into a malignant cancer (adenocarcinoma). Not all adenomas progress to carcinomas. In fact this progression into a carcinoma happens in only a small subset of tumours. Initiation of genomic instability is a crucial step and occurs in two ways in colorectal cancer (Lengauer et al. (1998) Nature, 396, 643-649). DNA mismatch repair deficiency leading to microsatellite instability (abbreviated as MSI or MIN), has been most extensively studied (di Pietro et al. (2005) Gastroenterol., 129, 1047-1059), and explains about 15% of adenoma to carcinoma progression. MSI tumours occur due to defects in the DNA mismatch repair genes (MMR), which promote tumour progression due to the accumulation of mutations and epigenetic changes. In the other 85% of cases where colorectal adenomas progress to carcinomas, genomic instability occurs at the chromosomal level (CIN) giving rise to aneuploidy. While for a long time these chromosomal aberrations have been regarded as random noise, secondary to cancer development, it has now been well established that these DNA copy number changes occur in specific patterns and are associated with different clinical behaviour (Hermsen et al. (2002). Gastroenterol. 123, 1109-1119). Chromosomal aberrations frequently reported in colorectal cancers are 7pq, 8q, 13q, 20q gains and 4pq, 5q, 8p, 15q, 17p, 18q losses. It was shown that 8q, 13q and 20q gains and 8p, 15q, 17p and 18q losses, are associated with progression of colorectal adenomas to carcinomas (Hermsen et al. (2002) cited above). In summary, colorectal cancer results from the accumulation of chromosomal aberrations, mutations and epigenetic changes ultimately causing alterations in gene expression at the RNA and protein level. Recent investigations have shown that a novel class of non-coding RNA molecules called microRNAs (miRNAs) also can act as oncogenes and tumour suppressors during cancer development. These non-coding RNAs contribute to tumour progression due to changes in their expression. Microarray based profiling studies have shown in a number of different tumor tissues and tumor cell lines, that miRNAs are differentially expressed. This differential expression, in some cases, was correlated to type of tumor and could be used to distinguish normal versus aberrant (tumor) tissue (Bloomston et al. (2007) JAMA 297:1901-1908), Iorio et al. (2005) Cancer Res. 65:7065-7070. In some cases, the unique small RNA profile correlated with prognosis (Yanaihara et al. (2006) Cancer Cell 9:189-198, Calin et al. (2005) N. Engl. J. Med. 353:1793-1801). Importantly, expression profiling studies in chronic lymphocytic leukemia have shown that miRNAs signatures can classify leukemia samples according to their developmental history and categorize poorly differentiated tumours more accurately than mRNA expression profiles (Calin et al. (2005) N. Engl. J. Med. 353:1793-1801).

Therefore, these experiments reveal that the accumulation of specific combinations of chromosomal aberrations, epigenetic changes and mutations that characterize a tumour, determine its miRNA expression signature and vice versa. Consequently, miRNA expression profiles are a powerful tool for diagnosis, determining prognosis, progression risk and response to therapy of human cancers.

It is an object of the invention to molecularly identify and characterize the above described progression of adenomas into adenocarcinomas in as early a stage as possible, to allow early stage and more specific treatment of (pre-)malignant tumors while avoiding unnecessary surgical intervention. It is a further object of the invention to identify, high-risk pre-malignant colorectal tumors at a stage when the malignant phenotype (i.e. invasion and metastastis) has not yet emerged. At such a stage there usually are no symptoms yet that evoke clinical evaluation resulting in in situ optical analysis or microscopic analysis of biopsy or resection material. Current diagnostic procedures for early detection of colorectal cancer include colonoscopy, sigmoidoscopy and fecal tests such as faecal occult blood test (FOBT) and DNA faeces tests. Colonoscopy and sigmoidoscopy are not only quite uncomfortable for the patient, but specificity is low since many non-progressive adenomas are detected. Secondly, sensitivity is hampered by experience and devotion (retraction time) of the endoscopist and shape of the tumors (flat lesions go undetected more easily than polypoid). In addition, sigmoidoscopy only covers part of the large intestine. Polypectomies, endoscopic resections or biopsies during colonoscopy are performed when colorectal tumors/lesions are identified to confirm the nature of these lesions by histological analysis. Existing commercial fecal based tests have yielded promising results but need further improvement. FOBT (Faecal Occult Blood Test) is the most recognized method of selecting high risk individuals, and has been demonstrated to reduce death from colorectal cancer at the population level when applied in a population based screening program. Unfortunately, with FOBT a considerable percentage of the tumours is missed and the already bleeding tumour is often discovered at a relatively late stage. DNA faeces tests so far have mainly focused on detecting point mutations in only a limited number of genes, i.e. KRas, APC and p53. kRas mutations have proven not to be very informative, and testing for APC and p53 mutations is technically demanding, and thus expensive. In addition, substantial numbers of CRC do not carry these mutations.

More recently, DNA microarray-based tumor gene expression profiles have been used for cancer diagnosis. However, studies have been limited to a few cancer types and have spanned multiple technology platforms complicating comparison among different datasets. Expression analysis performed at the protein level has a number of drawbacks, the first being linked to the origin of the samples, i.e. the need for an invasive colonoscopy.

The present invention shows that small RNAs (miRNAs and other small RNAs) can serve as informative biomarkers for early detection/secondary prevention of colorectal cancer and biological classification of established colorectal cancer in order to facilitate therapeutic decision making. As miRNAs and other small RNAs are produced from longer precursors it is also possible to use the precursor as a biomarker. As these RNA molecules are typically detected in groups, for instance, using (micro)arrays, the present invention also provides collection of probes for the detection of miRNAs, other small RNAs and/or precursors thereof. These collections are not only useful for the detection of said biomarkers in the context of colorectal cancer. They are also useful in other diagnostic tests to type or classify samples of nucleic acid. mRNAs and other small RNAs are oligonucleotides of between 15 and 200 bases, preferably between 15-100 bases. Typically these RNAs are between 18 and 27 bases.

The invention therefore provides a collection of probes or primers for detecting at least 5, preferably at least 10, more preferably at least 20 of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre-miRNA sequences). In a preferred embodiment said collection of probes or primers comprises probes or primers for at least 100, more preferably at least 500 of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre-miRNA sequences). Preferably said collection of probes or primers comprises at least one probe for each of the nucleic acid molecules of table 23 (the miRNA and star sequences) and/or table 24 (the pre-miRNA sequences). In a preferred embodiment said collection of probes or primers comprises probes or primers for detecting nucleic acid molecules of table 23 (the miRNA and star sequences). Collections of these probes or primers more accurately classify samples, presumable because these molecules and not the precursors are functional in a cell.

In a preferred embodiment a collection of probes of the invention comprises the nucleic acid sequences identified in table 21. These collections are particularly suited for diagnostic tests. The expression levels of nucleic acid molecules identified in table 23 or in table 24 can be determined by labelling the small RNA complement of a sample, for example by direct chemical crosslinking of label to the RNA backbone, end-labelling by adapter ligation or RNA extension, and subsequent hybridization to reverse complement DNA probes (for instance as depicted in table 21) under stringent conditions using state-of-the-art techniques. Other, potentially more sensitive methods for small RNA detection have been described, including the use of DNA-modified probes (e.g. locked-nucleic-acid LNA probes) for hybridization and nucleic acid amplification-based methods using primers specific for the nucleic acid molecules identified in table 23 or in table 24. A preferred method of amplification is real-time PCR. Means and methods for amplifying miRNA or other small RNA molecules and precursors thereof are described in Lee et al (2006) Int. J. Cancer Vol 120, pp 1046-1054; Gaur et al (2007) Cancer Res Vol. 67, pp. 2456-2468; Bandres et al (2006) Molecular Cancer Vol 5: 29). Hybridization is preferably performed under stringent conditions. Hybridization stringency regulates the percentage of nucleotides which must match on two unrelated single-stranded nucleic acid molecules before they will base pair with each other to form a duplex, given a certain set of physical and chemical conditions. The hybridization stringency is used to determine when a hybridization probe and a target nucleic acid will come together, and can be set by the researcher by varying the conditions. In general, if the percentage of matching nucleotides is lower than 90 percent, the two single-stranded nucleic acid molecules are considered nonhomologous and any hybridization is considered nonstringent. Conditions which can be used for stringent hybridization of the probes and primers of the invention are known to person skilled in the art. Other conditions can be obtained by a person skilled in the art by comparing hybridization of the probe or primer with a sequence that has more than 10 percent mismatches with the target sequence. In this way conditions can be selected that allow discrimination between the amount of hybridization to the unmodified target sequence and the sequence having 10% mismatches. Typically, though not necessarily, not all of the probes give a signal when analysing nucleic acid samples. However, starting with a collection of probes of the invention one can easily compare levels of nucleic acid of table 23 or table 24, for instance through hybridization of the respective probes and select probes for inclusion in the diagnostic test on the basis of the levels of hybridization. An obtained pattern for the levels of the nucleic acids such as the pattern obtained for the levels of hybridization to the respective probes is indicative for the type of sample tested. Different types of samples give different patterns and can thus be classified on the basis of pattern. To this end the invention provides the use of a collection of probes or primers of the invention for detecting the levels of at least 10 nucleic acid molecules of table 23 or table 24, preferably through detecting hybridization of nucleic acid from a sample to a collection of probes of the invention. The same types of samples often show a limited amount of variation with respect to the patterns they produce. It is possible to select probes or primers that produce more homogeneous patterns by testing a number of samples. To this end in a preferred embodiment the invention provides a method for selecting probes for testing nucleic acid samples said method comprising hybridizing nucleic acid from a representative number of said samples to a collection of probes according to the invention,

-   -   quantifying hybridization of said probes with nucleic acid in         said representative number of samples, and     -   selecting a subset of probes from said collection of probes,         that (characteristically) hybridizes to nucleic acid of said         sample or that (characteristically) not hybridize to said         nucleic acid of said sample. The characteristic pattern can         comprise specifically detected and/or specifically not detected         small RNAs. The selected subset of probes can be used to         determine whether a test sample is likely to be of the type of         sample the probes are selected for. The selected subset of         probes are detectable and thus identify nucleic acid molecules         of table 23 or table 24 that are present in the representative         number of samples. These identified nucleic acid molecules can         subsequently further be detected by a number of other methods as         discussed herein above. One, non-limiting other method is         real-time PCR using primers that are specific for the particular         nucleic acid molecules. The likelihood of a correct typing of         the sample improves when the method of selection involves two         different types of samples and probes or primers are selected         that detect differences in the levels of nucleic acid molecules,         preferably through exhibit differential levels of hybridization         between the two types of samples. Typically one type of sample         is used as a reference whereas the other is of the same type as         the type the test sample is to be tested. To select probes the         invention provides a method for selecting a collection of probes         that discriminates between at least two types of samples         comprising nucleic acid from cells said method comprising     -   hybridizing nucleic acid from a representative number of samples         of said at least two types of samples to a collection of probes         according to the invention,     -   quantifying hybridization of said probes with nucleic acid in         said samples, and     -   selecting a subset of probes from said collection of probes,         that discriminates between said at least two types of samples.         The selected subset of probes identify nucleic acid molecules of         table 23 or table 24 that are differentially present in the at         least two samples. These identified nucleic acid molecules can         subsequently further be detected using a number of other methods         as discussed herein above. One, non-limiting other method is         real-time PCR using primers that are specific for the particular         nucleic acid molecules. Collections of probes or primers of the         invention are particularly suited for typing human cells, thus         preferably said cells are human cells. They are further suited         for inclusion into a test that distinguishes, types and/or         discriminates between different types of samples. Diagnostic         tests are preferred. Such tests are able to identify,         distinguish, type and/or discriminate samples from an         individual. The at least two samples can be derived from         different parts of the body, however, preferably the at least         two samples are from the same tissue but different in for         instance, developmental stage or disease stage. The at least two         samples do not have to be derived from the same body or         individual. In fact, often the test sample and a reference         sample are derived from different individuals. A method of         selecting probes can distinguish 2 samples (when they are         different). In a diagnostic test it will often not be a         comparison of two samples, but merely a comparison of the         expression profile (hybridization levels) of the test sample         with the predefined levels found based upon the training set of         the diagnostic test. These last levels will lead to a         classification rule (algorithm) in a computer program and the         expression levels found in a test sample will be classified         according to that rule. So in practice, the actual test no         longer requires a comparison between a reference and a test         sample, but only the comparison with a reference.

The predictive value of classifiers as described above can be further improved. A first way would be to increase the sample set this reduces noise and leads to the selection of more predictive small RNAs. This can in some cases increase the accuracy of prediction and decrease the error rate. However, in other cases the predictive value of a diagnostic test has already reached its limit and increasing the sample set will not result in a more accurate predictive set. A further way to improve the predictive value of a diagnostic test of the invention is to combine the dataset based on the microarray data with other data sets. For example, a diagnostic test of the invention may combine data based on the small RNA expression levels with array CGH data obtained from the same samples. This can result in a more accurate prediction of disease state. A further option is to use combined diagnostic tests in a step-wise procedure, where the first diagnostic test will have the best predictive value. For some individuals that are difficult to classify with a method of the invention, a further diagnostic test will follow that will ultimately result in a diagnosis of the disease state. Where the second test on its own might not have given a clear answer, in combination with a method of the invention, a defined and reliable diagnosis can be given also for individuals or samples that are difficult to classify with high confidence with a method of the invention.

A sample can comprise cells. In a preferred embodiment the sample comprises colon cells, colon derived tumor cells or nucleic acid derived therefrom. Typically, however, a sample has undergone some type of manipulation prior to analysing the presence or absence therein of a miRNA, a small RNA and/or hairpin RNA according to the invention. Such manipulation, typically, though not necessarily comprises isolation of at least (part of) the nucleic acid of the cells. The nucleic acid in a sample may also have undergone some type of amplification and/or conversion prior to analysis with a method of the invention miRNA or a small RNA or a precursor thereof can be detected directly via complementary probe specific for said miRNA or small RNA or indirectly. Indirect forms include, but are not limited to conversion into DNA or protein and subsequent specific detection of the product of the conversion. Conversion can also involve several conversions. For instance, RNA can be converted into DNA and subsequently into RNA which in turn can be translated into protein. Of course such conversions may involve adding the appropriate signal sequences such as promoters, translation initiation sites and the like. Other non-limiting examples include amplification, with or without conversion of said miRNA or small RNA in said sample for instance by means of PCR or NASBA or other nucleic acid amplification method. All these indirect methods have in common that the converted product retains at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA, for instance in the nucleic acid sequence or in the amino acid sequence or other sequence. Indirect methods can further comprise that nucleotides or amino acids other than occurring in nature are incorporated into the converted and/or amplified product. Such products are of course also within the scope of the invention as long as they comprise at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA. By at least some of the specificity information of the original miRNA, a small RNA and/or hairpin RNA is meant that the converted product (or an essential part thereof) is characteristic for the miRNA, a small RNA and/or hairpin RNA of which the presence or absence is to be determined. A preferred small RNA is a miRNA. A hairpin RNA is herein also referred to as a precursor of a miRNA. The hairpin does not have to contain the entire sequence of the precursor but contains at least the stem loop structure.

A diagnostic test of the invention is particularly suited for distinguishing, typing and/or discriminating between different stages of disease. A diagnostic test of the invention preferably comprises a test that detects illness in an animal, preferably a primate, more preferably a human. A diagnostic test or a set/collection of probes of the invention is particularly suited to discriminate between different types of colon cells. A diagnostic test or a set/collection of probes of the invention are particularly suited to discriminate between samples comprising nucleic acid of normal colon cells, colon adenoma cells and/or colon carcinoma cells. A diagnostic test of the invention is particularly suited for distinguishing, typing and/or discriminating samples of different stages of tumorigenesis. Thus preferably at least one of said at least two types of samples comprises nucleic acid from tumor cells. In a particularly preferred embodiment said tumor cells are colon tumor cells. A tumor or tumour is an abnormal growth or mass of tissue. A tumor can be either malignant or benign. Preferred benign tumors are pre-malignant tumors, preferably adenomas. Nearly all tumors are examples of neoplasia, although certain developmental malformations or inflammatory masses may occasionally be referred to as tumors. This latter meaning is not intended herein. Tumors are typically caused by mutations in DNA of cells, which interfere with a cell's ability to regulate and limit cell division. Some of these mutations involve loss or gain of large parts of chromosomes (typically at least 100 megabases). Such loss or gain mutations often involve chromosome arms. An accumulation of mutations is needed for a tumor to emerge. Mutations that activate oncogenes or repress tumor suppressor genes can eventually lead to tumors. Cells have mechanisms that repair DNA and other mechanisms that cause the cell to destroy itself by apoptosis if DNA damage gets too severe. Mutations that repress the genes for these mechanisms can also eventually lead to cancer. A mutation in one oncogene or one tumor repressor gene is usually not enough for a tumor to occur. A combination of a number of mutations is necessary. As a result of the transformation tumor cells express genes and RNAs at levels that differ from their normal counterpart. The same holds true for different stages of tumorigenesis. Later stages express genes and RNAs at different levels when compared to less progressed stages. In the present invention it was further found that tumor progression can be monitored by determining the level of RNA using a collection of probes of the invention. It was found that differences in the level of RNA in samples of different stages of the same type of tumor (e.g. colorectal epithelial neoplasia) produce different signatures that can be used to predict tumor progression. Thus differences in the level of specific RNAs of a tumor at a certain stage can be used to predict progression thereof, particularly within a specific time span. The prediction is more accurate for progression within two years, particularly within a year, more in particular within 6 months from the moment the sample was taken. A diagnostic test of the invention can thus be used to determine a prognosis for the individual or the future behaviour of the tumor. A diagnostic test of the invention is particularly suited to characterise a tumor. The invention therefore provides the use of a test of the invention, preferably a diagnostic test of the invention, for characterising a tumor. A diagnostic test of the invention can also be used to predict therapy outcome or efficacy of treatment or be used to follow the effect of a therapy. The invention therefore provides the use of a test of the invention, preferably a diagnostic test of the invention for predicting therapy outcome or predicting efficacy of treatment or for following an effect of a therapy. The invention further provides a kit for a diagnostic test of the invention said kit comprising a collection of probes or primers of the invention.

A tumor is preferably a tumor of the anus, bladder, bile duct, bone, brain, breast, cervix, colon/rectum, endometrium, esophagus, eye, gallbladder, head/neck, liver, kidney, larynx, lung, mediastinum (chest), mouth, ovaries, pancreas, penis, prostate, skin, small intestine, stomach, tailbone, testicles or of the thyroid. A tumor is preferably a papilloma/carcinoma, a choriocarcinoma, an endodermal sinus tumor, a teratoma, a adenoma/adenocarcinoma, dysplasia, hyperplasia, intraepithelial neoplasia, squamous cell carcinoma, undifferentiated carcinoma, transitional cell carcinoma, carcinoma not otherwise specified, a soft tissue sarcoma, a melanoma, a fibroma/fibrosarcoma, lipoma/liposarcoma, a leiomyoma/leiomyosarcoma, a rhabdomyoma/rhabdomyosarcoma, a mesothelioma, an angioma/angiosarcoma, an osteoma/osteosarcoma, a chondroma/chondrosarcoma, a glioma or a lymphoma/leukaemia.

The invention further provides a method for selecting probes or primers of the invention for testing nucleic acid samples. Subsets of probes or primers are preferably selected from the collection of probes or primers for the nucleic acids of table 23 and/or table 24. A probe or a primer for a nucleic acid molecule of table 23 or table 24 is specific for said nucleic acid molecule when used under stringent conditions. Probes are preferably selected from the collection of probes of table 21. The selection is preferably done by comparing at least two types of samples with each other. As mentioned herein above, it is preferred that at least one of said types of samples is a particular type of tumor.

Preferably said type of sample is a particular stage of tumor type. Preferred stages are the benign stage of a tumor, the progressed but not yet metastasized stage and the metastasized stage. Thus the progressed (i.e. locally invasive) but not yet metastasized stage and the respective metastasized stages (i.e. locoregional lymph node metastasis and metastasis to distant organs). It is preferred that at least one other type of sample is a reference sample. The reference sample can be any type of sample. It is preferred that when the test type of sample is of a human, the reference sample type is also human. In one preferred embodiment said reference sample comprises normal cells, preferably from the type of cells that the tumor originated from. Normal cells, counterpart ect. are used herein typically to refer to unaffected cells, counterpart etc, such as are preferably obtained from a healthy individual. In another preferred embodiment said normal cells are obtained from an affected individual but from a site that is not affected by the disease. In a preferred embodiment said normal cells are of the same type of cells that the test sample is derived from and that are suspected of containing diseased cells. In another preferred embodiment the reference sample is the same type of tumor but at a different stage of progression. In yet another preferred embodiment the reference sample is of a different tissue, preferably from blood. In a preferred embodiment the sample and the reference (sample) is a blood sample. A preferred type of blood sample is whole blood, preferably peripheral whole blood or a fraction thereof. A preferred fraction is the fraction of peripheral blood mononuclear cells (PBMC). The small RNA or precursors do not have to be present in intact cells in the blood but can also be present in free form or associated with cell debris or in protein bound complexes. Thus in another preferred embodiment said blood sample comprises serum or plasma. Plasma and serum are particularly suited to detect a nucleic acid molecule of table 23 or table 24 that is not normally present in blood cells. A tumor sample can be obtained in a number of ways. A preferred sample is a biopsy sample. Another preferred sample is a fine needle aspirate (FNA), stool or faeces sample. Such samples contain cells and cell derivatives from which RNA can be prepared. These samples are particularly useful when the individual is suffering from or suspected of suffering from a colon tumor. The invention thus further provides method for detecting cells in a faeces sample comprising detecting small RNA or precursors therefore in said sample. The small RNA or precursors therefore do not have to be present in intact cells in faeces but can also be associated with cell debris or in protein bound complexes. The invention thus further provides method for detecting small RNA or precursors thereof in a faeces sample comprising detecting small RNA in said sample. In a preferred embodiment said method comprises detecting the level of nucleic acid molecules identified in table 8, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 23, table 24 and/or table 34. Preferably the level of the nucleic acid molecules identified in table 11a and/or table 11b is detected. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 12a, table 12b, table 12c and/or table 34 is detected.

Many tumors, particularly at the later stages shed cells into the blood stream. These cells can be detected. Using a method for selecting probes of the invention it is possible to select probes that distinguish, type or discriminate samples of blood from healthy individuals from samples of blood from individuals that suffer from a particular type of tumor. Further provided is a method for detecting cells in a sample of blood or a fractionated part thereof, comprising detecting small RNA in said sample. The sample itself does not have to contain cells. Particularly in blood it is possible that cells can be detected that have shed the indicative nucleic acid into the blood stream, for instance upon death of said cell. Detection of this nucleic acid in the blood, plasma or serum is indicative for the cell that has shed nucleic acid in the blood stream. The cells to be detected are preferably tumor cells, more preferably colon tumor cells. In a preferred embodiment the level of nucleic acid molecules identified in table 13, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, or table 18c, table 23, table 24 and/or table 35 is detected. Preferably the level of the nucleic acid molecules identified in table 16a and/or table 16b is detected. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 18a, table 18b, table 18c and/or table 35 is detected.

The selection methods described herein above yield collections of probes or primers that can be used to distinguish, type and/or discriminate samples containing nucleic acid from cells. As a result the invention provides collections of probes or primers that are obtainable by such a method. In a further aspect the invention provides a subset comprising at least ten probes for the nucleic acids of table 23 and/or table 24. The invention further provides a collection of probes comprising the nucleic acid molecules identified in table 21. A subset of probes is preferably a subset of the collection of the probes of table 21. In a preferred embodiment said subset comprises at least 10 of the probes of table 21.

In a particularly preferred embodiment the invention provides a subset of probes of the collection of probes of table 21, comprising and/or consisting of the probes identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c or table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b and/or table 33. In another preferred embodiment said subset of probes from the collection of probes of table 21, comprises and/or consists of the probes identified in table 8 or table 13.

In a particularly preferred embodiment the invention provides a subset of probes or primers for detecting nucleic acid molecules of table 23 or table 24, comprising and/or consisting of probes or primers for the nucleic acid molecules identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. In another preferred embodiment said subset of probes or primers for detecting nucleic acid molecules of table 23 or table 24, comprises and/or consists of the probes or primers for the nucleic acid molecules identified in table 8 or table 13.

The invention further provides a method for determining whether a sample comprises nucleic acid from a particular type of cells said method comprising hybridising nucleic acid from said sample to a collection of probes for the nucleic acid molecules as identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18, table 19c, table 19d, table 20, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said samples, and comparing the result of said quantification with a reference. In a preferred embodiment said cells are tumor cells or suspected of being tumor cells. Preferably said cells are colon cells.

The invention further provides a subset of probes or primers according to the invention, comprising probes or primers for each of the nucleic acids identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 20, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. Further provided is a subset of probes or primers from the collection of probes or primers of the invention, comprising probes or primers for each of the nucleic acids identified in table 8 or table 13. In a preferred embodiment said cells are tumor cells or suspected of being tumor cells. Preferably wherein said cells are colon cells.

A nucleic acid molecule of the invention such as a probe or primer often can contain a nucleotide analogue. Many analogues are presently available that mimic at least some of the base pairing characteristics of the “standard” nucleotides A, C, G, T and U. Alternatively, nucleotide analogues such as inosine can be incorporated into a nucleic acid molecule of the invention. Other types for analogues include LNA, PNA, morpholino and the like. Further methods for the specific detection of nucleic acid include but are not limited to specific nucleic acid amplification methods such as polymerase chain reaction (PCR) and NASBA. Such amplification methods typically use one or more specific primers. A primer or probe preferably comprises between 12-40 nucleotides having at least 90% sequence identity to a sequence as depicted in table 23 or table 24, or the complement thereof. A probe, primer or nucleic acid molecule of the invention is preferably single stranded. However, for shipping, production and or therapeutic purposes a double stranded molecule is sometimes preferred. For example a miRNA or small RNA is processed in the cell in double stranded form. Such analogues are considered to be a functional equivalent of a nucleic acid molecule such as a probe or a primer of the invention, when they exhibit the same hybridization characteristics under stringent conditions in kind, not necessarily in amount.

The invention further provides a method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 1 in said sample, and comparing the result of said quantification with a reference.

Further provided is a method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 2a, table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference. In this embodiment it is preferred that said reference is a quantification of the levels of the same nucleic acid molecules for a sample comprising nucleic acid from adenocarcinoma cells or from normal cells.

The invention further provides a method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference. In this embodiment it is preferred that the level of the nucleic acid molecules identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table 11b, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 is quantified. In a particularly preferred embodiment the level of the nucleic acid molecules identified in table 4c, table 4d, table 7a, table 25a and/or table 26 is quantified. In this embodiment it is preferred that said reference is a quantification of the levels of the same nucleic acid molecules for a sample comprising nucleic acid from adenoma cells or from normal cells. In a preferred embodiment said normal cells are brushed cells from normal colon mucosa.

In one aspect the invention provides a method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 1, quantifying hybridization of said probes with nucleic acid in said samples, and comparing the result of said quantification with a reference. In another aspect the invention provides a method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 2a, table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12 a and c, table 14a, table 14b, table 16a, table 16b, table 18a and c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference. In a preferred embodiment said reference is a quantification of a hybridization of a reference sample with said collection of probes. Preferably said reference sample comprises nucleic acid from adenocarcinoma cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table 11b, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 20, table 21, table 25a, table 26, table 27, table 34 and/or table 35. In another preferred embodiment said reference sample comprises nucleic acid from normal cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified table 2a, table 2b, table 2c, table 2d, table 5a, table 9a, table 9b, table 12a, table 14a, table 14b, table 18a, table 20 and/or table 21.

In another aspect the invention provides a method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b and c, table 15a, table 15b, table 16a, table 16b, table 18b and c, table 19c, table 19d, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference. In a preferred embodiment said reference is a sample comprising nucleic acid from adenoma cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 4a, table 4b, table 4c, table 4d, table 7a, table 11a, table 11b, table 12c, table 16a, table 16b, table 18c, table 19c, table 19d, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. In another preferred embodiment said reference is a sample comprising nucleic acid from normal cells. In this preferred embodiment it is preferred that said collection of probes is a collection of probes as identified in table 3a, table 3b, table 3c, table 3d, table 6a, table 10a, table 10b, table 12b, table 15a, table 15b, table 18b, table 19c, table 19d and/or 21. In a preferred embodiment said normal cells are blood cells or brush cells from normal colon.

It has been found that probes or primers for miRNAs, small RNAs and/or their precursors are particularly suited for detecting cells that have a chromosomal aberration. The invention thus further provides the use of a collection of probes or primers for miRNAs, small RNAs or their precursors, for classifying cells as cells that contain a chromosomal aberration. These aberrations typically involve a significant part of a chromosome. The aberrations can be the direct origin of the miRNA or small RNA that is being tested for. Alternatively, as miRNA and small RNA regulate the expression of other transcription units and are themselves derived from transcription, the aberration can be detected through its action on the levels of particular miRNA, small RNA or the precursor thereof in a cell. This aspect of the invention is particularly suited for detecting tumor cells that have chromosomal aberrations, and consequently are prone to progression from a premalignant to malignant stage, or have already done so. Preferably said tumor cells are colon tumor cells. This aspect can be used to detect aberrations involving segments of DNA in a chromosome that encode one or multiple small RNAs. In principle it is possible to detect even smaller aberrations. A particularly preferred type of aberration is the loss or gain of a part of a chromosome, preferably a gain of 7pq, 8q, 13q or 20q or a loss of 4pq, 5q, 8p 15q, 17p or 18q, particularly preferred is a loss of chromosome 8p or 17p. In a preferred embodiment said loss of a chromosome 8p or 17p is detected using at least one probe or primer for nucleic acid molecules of table 23 or table 24, as identified in table 19c (for loss of 8p) or table 19d (for loss of 17p). Preferably said loss of a chromosome 8p or 17p is detected using at least 5, more preferably at least 10 and most preferred all of the probes or primers for nucleic acid molecules of table 23 or table 24, as identified in table 19c (for loss of 8p) or table 19d (for loss of 17p).

A sample can be any type of sample as long as it contains nucleic acid. It is preferred that said sample contains complex nucleic acid, preferably nucleic acid derived from a cell. A collection of probes of the invention can be used to analyze any type of nucleic acid, be it DNA, RNA or an analogue thereof having the same hybridization characteristics in kind not necessarily in amount. In a preferred embodiment said nucleic acid comprises RNA derived from cells. This aspect of the invention is useful for determining levels of different RNAs in the cells. In a particularly preferred embodiment the sample is enriched for RNA, preferably for RNA that is smaller than 500 nucleotides. In a particularly preferred embodiment said sample is enriched for RNA that is about 200 nucleotides. Thus in a preferred embodiment a collection of probes or primers of the invention, or a method of the invention involving detecting of a nucleic acid molecule of table 23 or table 24, is used to detect RNA in a sample, preferably small RNA.

miRNAs and other small RNAs are found to be relevant for the tumorigenic state of a tumor. The invention provides miRNA precursors thereof that are up or down regulated in a tumor when compared to normal cells, or up or down regulated in a progressed form of said tumor when compared to the less progressed state. It is thus possible to counteract this level by increasing the level when it is down regulated or decreasing the level when it is upregulated. In this way it is possible to intervene with the tumor or the tumor state. Thus the invention further provides a method for the treatment and/or prevention of a disease in an individual comprising administering to said individual at least one nucleic acid molecule of table 23 or table 24, at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, or a functional equivalent of said at least one nucleic acid molecule. Preferably said individual is suffering from colon cancer or is at risk of suffering therefrom. Said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is preferably a nucleic acid molecule of table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d or table 20, table 25a, table 26, table 27, table 34 and/or table 35, or a functional equivalent thereof. For the treatment of disease, it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/or table 35 or a functional equivalent thereof. For treatment it is particularly preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 19c, table 19d, table 20, table 26, table 27 and/or table 33, or a functional equivalent thereof. In a particularly preferred embodiment it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof is a nucleic acid molecule of table 4c, table 4d, table 19c, table 26, table 27 and/or table 33. Using at least one of these nucleic acid molecules for the treatment it is possible to modify cells of a progressed tumor (preferably an adenocarcinoma tumor) such that they become less progressed (preferably resembling a more adenoma phenotype). For the prevention of disease, it is preferred that said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 2a, table 2b, table 2c, table 2d, table 4a, table 4b, table 4c, table 4d, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 34 and/or table 35 or a functional equivalent thereof. For prevention it is preferred that at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, comprises a nucleic acid molecule of table 2a, table 2b, table 2c, table 2d, table 4a, table 5a, table 7a, table 20, table 25a, table 26 and/or table 27 or a functional equivalent thereof. Using at least one nucleic acid molecule for prevention of disease it is possible to modify cells of a benign stage such that the propensity for tumor progression is reduced in these cells.

In case of a nucleic acid molecule that is downregulated it is preferred that said nucleic acid molecule is provided to the cell wherein it is down-regulated. To this end it is preferred that said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2d, table 3d, table 4d, table 19c, table 19d, table 27 or table 33. In a preferred embodiment said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2d, table 3d, table 4d, or table 27 or a functional equivalent thereof. These preferred nucleic acid molecules are highly correlated with the tumor or tumor stage and or thus effective in a larger fraction of the tumors (stage).

In case of a nucleic acid molecule that is up regulated it is preferred that said nucleic acid molecule is reduced in the cell wherein it is up regulated. To this end it is preferred that said at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2c, table 3c, table 4c or table 19c or table 19d. Preferably said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2c, table 3c or table 4c, or a functional equivalent thereof. These preferred nucleic acid molecules are highly correlated with the tumor or tumor stage and or thus effective in a larger fraction of the tumors (stage).

In one embodiment the invention provides a pharmaceutical composition, comprising as an active agent at least one nucleic acid molecule of table 23a or table 24a, or a nucleic acid molecule comprising the reverse complement of at least one nucleic acid molecule of table 23a or table 24a or a functional equivalent of such nucleic acid molecules, and optionally a pharmaceutically acceptable carrier. A pharmaceutical composition according to the invention further optionally comprises another additive. Such another additive can for example be a preservative or a colorant. Alternatively an additive is a known pharmaceutically active compound. A carrier is any suitable pharmaceutical carrier. A preferred carrier is a compound that is capable of increasing the efficacy of a nucleic acid molecule to enter a target-cell. Examples of such compounds are liposomes, particularly cationic liposomes. A composition is for example a tablet, an ointment or a cream. Preferably a composition is an injectable solution or an injectable suspension. In one embodiment the invention provides a pharmaceutical composition according to the invention for diagnostic applications. In another embodiment the invention provides a pharmaceutical composition according to the invention for therapeutic applications. In a preferred embodiment the invention provides a pharmaceutical composition according to the invention, as a modulator for a developmental or pathogenic disorder. In a preferred embodiment said developmental or pathogenic disorder is cancer. A miRNA molecule for example functions as a suppressor gene or as a regulator of translation of a gene. A method for the treatment of an individual to obtain therein a described effect, wherein said individual is provided with a small RNA, precursor thereof, or the reverse complement thereof as described herein, is similarly a use of said small RNA, precursor thereof, or the reverse complement for the preparation of a medicament for obtaining said described effect. A pharmaceutical preferably comprises a pharmaceutically acceptable carrier or excipient.

A functional equivalent of a nucleic acid molecule of table 23a, for the purpose as a pharmaceutical, is preferably a nucleic acid comprising at least 12 and preferably at least 18 consecutive bases of the nucleic acid molecule of table 23a. The functional equivalent nucleic acid may have 1 or 2, preferably only 1 mismatch with the nucleic acid of table 23a. Preferably there are no mismatches in said consecutive stretch.

A functional equivalent of a nucleic acid of table 24a is a nucleic acid having at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to a nucleic acid of table 24a. The sequence of the small RNA therein is preferably a nucleic acid comprising at least 12 and preferably at least 18 consecutive bases of the small RNA nucleic acid molecule of table 23a. The corresponding small RNA part preferably comprises no more than 2 nucleic acid mismatches. In a particularly preferred embodiment the sequence of the small RNA in said functional equivalent is exactly the same as the sequence thereof given in table 23a.

A functional equivalent of a nucleic acid molecule comprising the reverse complement a nucleic acid molecule of table 23a is preferably a nucleic acid comprising the reverse complementary sequence of at least 12 and preferably at least 18 consecutive bases of the nucleic acid molecule of table 23a. The functional equivalent nucleic acid may have 1 or 2, preferably only 1 mismatch with the reverse complement nucleic acid of table 23a. Preferably there are no mismatches in said consecutive complementary stretch.

A functional equivalent of the reverse complement a nucleic acid molecule of table 24 is a nucleic acid of which its reverse complement has at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to a nucleic acid of table 24a.

A nucleic acid molecule for use as a pharmaceutical is preferably a nucleic acid molecule as identified in table 2d, 3d, 4d, 19c, 19d, 28a, table 28b, table 30, table 32a, table 32b, or 33. Preferably said nucleic acid molecule is also identified in table 19c, table 19d, table 20, table 26 and/or table 27.

A nucleic acid molecule that comprises a reverse complement of a nucleic acid of table 23a is preferably a nucleic acid molecule as identified in table 2c, table 3c, table 4c, table 31a or table 31b. Preferably said nucleic acid molecule is also identified in table 20, table 26 and/or table 27.

A nucleic acid molecule for use as a pharmaceutical as described herein can be an RNA molecule, a DNA molecule, a hybrid thereof or other be modified. For instance, many variants of the naturally occurring bases are known and many more will likely be developed. These synthetic bases can share the same hydrogen bonding characteristics with it natural counterpart. These synthetic bases can be incorporated into a nucleic acid of the invention. A nucleic acid molecule of the invention therefore can include one or more of such synthetic bases. A nucleic acid molecule of the invention can be modified to obtain a desired effect. Examples of nucleic acid molecules comprising such modifications are locked nucleic acid modifications (LNA), morpholino modifications and other modifications. Furthermore, the backbone can be modified to provide resistance to RNAseH. A nucleic acid molecule of the invention may comprise modifications to obtain a variety of effects. For instance, the nucleic acid molecule may be modified to enhance stability, hybridization characteristics, cellular uptake, circulation half life, and targeting of the nucleic acid.

A nucleic acid molecule according to the invention is administered by any suitable known method. The mode of administration of a pharmaceutical composition of course depends on its form. In a preferred embodiment a solution is injected in a tissue. A nucleic acid molecule according to the invention is introduced in a target cell by any known method in vitro or in vivo. Said introduction is for example established by a gene transfer technique known to the person skilled in the art, such as electroporation, microinjection, DEAE-dextran, calcium phosphate, cationic liposomes or viral methods.

A nucleic acid of the invention, such as a small RNA, a miRNA, a precursor thereof or the reverse complement of the mentioned molecules can be administered directly to a cell or an individual, or through a gene delivery vehicle. The gene delivery vehicle preferably comprises an expression cassette containing a promoter and other transcription regulatory and signaling sequences to express the small RNA, a miRNA, a precursor thereof or the reverse complement thereof. The gene delivery vehicle is preferably a viral vector or a plasmid.

The invention further provides the use of a nucleic acid molecule of table 23 or table 24, as a drug target. Preferably provided is the use of a nucleic acid molecule of table 3a, table 4a, table 20, table 26, table 27 or table 33, as a drug target. Also provided is the use of a nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, for identifying a molecular process in a cell that is contributing to a disease or a disease state. Preferably provided is the use of a nucleic acid molecule of table 3a, table 4a, table 20, table 26, table 27 or table 33, for identifying a molecular process in a cell that is contributing to a disease or a disease state.

In yet another embodiment the invention provides a collection of nucleic acid molecules comprising the nucleic acid molecules of table 23 or table 24. Also provided is a subset of this collection of nucleic acids comprising at least 10 of the nucleic acids identified in table 23 or table 24. In a preferred embodiment said subset comprises the nucleic acid molecules identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35. In a particularly preferred embodiment said subset comprises the nucleic acid molecules identified in table 2d, table 3d, table 4d, table 26, table 27 and/or table 33. In another preferred embodiment said subset comprises the nucleic acid molecules identified in table 8 or table 13.

A probe or primer of the invention can be longer than the region of complementarity with the sequence of table 23 or table 24. For a probe, the reverse complement of the sequence depicted in table 23 or table 24 is preferably incorporated into another nucleic acid. This separates the probe sequence from a surface to which it is attached. Such a probe typically exhibits improved hybridization characteristics. A probe or primer of the invention contains at least 7 consecutive nucleotides that together are the reverse complement of a sequence of the same length in the nucleic acid molecule of table 23 or table 24. Preferably said probe or primer contains at least 12, more preferably at least 16 of such consecutive nucleotides. In a particularly preferred embodiment said probe comprises the reverse complement of the entire sequence given for the nucleic acid molecule of table 23 or table 24. A probe or primer specific for a nucleic acid molecule of table 23 may have 1 or 2, preferably only 1 mismatch (in the consecutive stretch of complementarity) with the nucleic acid of table 23 it is specific for. Preferably there are no mismatches in said consecutive stretch.

A probe or primer for that is specific for a nucleic acid of table 24 comprises at least 90%, and preferably at least 95%, more preferably at least 99% sequence identity to the reverse complement of the nucleic acid comprising the region of complementarity of the corresponding nucleic acid of table 24. A primer is typically though not necessarily between 10-30 nucleotides long. A primer can contain one or more nucleotides in addition to the region of complementarity. These sequences can, for instance, be used to attach a label.

A collection of probes of the invention is preferably associated or physically linked to a solid surface. The solid surface is preferably a microarray. In another preferred embodiment a collection of probes is associated or physically linked to a collection of beads. Preferably, the individual probe are associated or physically linked to different beads such that each bead contains essentially one probe.

A collection of probes or primers of the invention preferably comprises probes or primers specific for nucleic acid molecules of table 23a or table 24a. A collection of the invention, of course preferably contains different nucleic acid molecules. When herein a collection is said to have at least a certain number of nucleic acid molecules given in the tables, or probes or primers specific therefore, it is preferred that at least said certain number of these nucleic acid molecules, probes or primers is different. In addition to this number of different ones there may be additional identical ones. A collection of probes or primers or a subset thereof of the invention are preferably used for the detection of one or more nucleic acid molecules of table 23 or table 24. However, such collections can also serve other purposes, for instance therapeutic purposes. When herein reference is made to a collection of probes or primers of the invention, this typically also includes subsets of collection of probes and primers. The same holds true for collections of nucleic acid molecules or the reverse complement thereof.

The invention further provides a collection of nucleic acid molecules comprising the reverse complement of the nucleic acid molecules of table 23 or table 24. A non-limiting use of such collection is a collection of probes for the molecules of table 23 or table 24.

A collection of probes or a subset of probes of the invention preferably comprises no more than 15.000 different probes, preferably no more than 12.000 probes, preferably no more than 10.000 and more preferably no more than 7.000 probes, particularly for probes specific for nucleic acid molecules of table 23a or table 24a. Said preferred maximum amounts are increased by 1000 when also the probes specific for nucleic acid molecules of table 23b or table 24b are included. In a particularly preferred embodiment the collection of probes comprises a maximum of 5000 probes, preferably a maximum of 4000 probes, preferably a maximum of 3000 probes, preferably a maximum of 2000 probes, preferably a maximum of 1000 probes, preferably a maximum of 500 probes. A subset of probes or the invention is preferably present in an array. Preferably a micro-array. Preferably a collection of proves of the invention is associated with a solid surface.

In a preferred aspect the invention provides a collection of probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and/or 6a. These collections are particularly suited to discriminate colorectal adenoma cells from normal colon cells (table 5a), colorectal carcinoma cells from normal colon cells (table 6a), and colorectal adenoma cells from colorectal carcinomal cells (table 25a). In a preferred embodiment said collection of probes or primer comprises probes or primers for detecting each of the nucleic acid molecules of table 25a and table 5a. Particularly preferred is a collection of probes or primers, comprising probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and table 6a. Preferably said collections of probes or primers are used for discriminating between normal colorectal tissue, colorectal adenoma and colorectal adenocarcinoma.

In the present invention it was found that the small RNA of table 23 or the precursors thereof of table 24 are particularly suited to map micro alterations in the chromosomal DNA. It was found that colon carcinoma contain various characteristic micro-deletions and micro-gains (amplifications) of chromosomal DNA. Micro in this context means deletions or gains of less than 3 megabases of chromosomal DNA. Several locations were identified in colon carcinoma cells that are subject micro-deletions and/or microgains. The invention thus further provides a method for determining whether a colon cell comprises a deletion of less than 3 megabases in chromosomal region 1p32.2, 1q21.1, 1q22, 6p22.2, 7p15.2, 11p15.5, 16q12.2 or 17p 13.1 comprising determining whether said cell comprises a deletion of DNA coding for a small RNA as identified in table 28a, or a precursor thereof. Said microdeletions can be detected in various ways including PCR and other amplification strategies using primers that are specific for the deletion or the boundaries thereof. Preferably said method comprises the step that nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof. Preferably said small RNA is a small RNA as identified in table 28b. A method of this embodiment is particularly suited for typing a cell as a colon carcinoma cell. Thus a colon cell comprising a deletion as indicated herein above is a colon carcinoma cell. Thus a method of this embodiment preferably further comprises typing said cell as a colon carcinoma cell. Preferably said small RNA is a small RNA as identified in table 30. The micro-deletion characterised by the small RNAs of table 30 are characteristic for microsatellite stable colon carcinoma cells. A method of this embodiment thus preferably further comprises typing said cell as a microsatellite stable colon carcinoma cell.

In another preferred embodiment said small RNA is a small RNA as identified in table 32a or table 32b. Micro-deletions characterised by the absence of these small RNA or the corresponding precursors characterise microsatellite instable colon carcinoma cells. Preferably said small RNA is a small RNA as identified in table 32b. A method of this embodiment thus preferably further comprises typing said (colon) cell as a microsatellite instable colon carcinoma cell.

The invention further provides a method for determining whether a colon cell comprises an additional chromosomal copy of less than 3 megabases of chromosomal region 5q31.3, 8p21.3, 9p21.3, 10p15.1 or 16q13 comprising determining whether said cell comprises an additional copy of DNA coding for a small RNA as identified in table 29a, or a precursor thereof. Said microgains can be detected in various ways including PCR and other amplification strategies using primers that are specific for the amplified regions or the boundaries thereof. Preferably said method comprises a step wherein nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof. In a preferred embodiment said small RNA is a small RNA as identified in table 29b. Colon cells containing such microgains are colon carcinoma cells. Thus a method of the invention preferably further comprises typing said cell as a colon carcinoma cell. In a preferred embodiment said small RNA is a small RNA as identified in table 31a or table 31b. Preferably a small RNA is a small RNA as identified in table 31b. Microgains characterised by gains of these latter small RNA or precursors thereof are characteristic for microsatellite stable colon carcinoma cells. Thus preferably said embodiment further comprises typing said cell as a microsatellite stable colon carcinoma cell.

The invention further provides a method for the treatment of an individual suffering from a colon tumor comprising administering to said individual a nucleic acid comprising a nucleic acid as identified in table 28a, table 28b, table 30, table 32a, table 32b, or 33 or the precursor of said nucleic acid, or the reverse complement of a nucleic acid as identified in table 31b or a functional equivalent of said nucleic acid. By administering this nucleic acid a small RNA that is present in said (micro)deletion (table 28, table 30, table 32 and table 33) is provided to the colon carcinoma cell thereby supplementing the reduced level of said small RNA in said cell and thereby reducing a tumorigenic state thereof. Preferably said nucleic acid is a nucleic acid as identified in table 28b, table 32b or table 33.

By administering the reverse complement of a small RNA that is present in said microgain (table 31), the colon carcinoma cell is provided with a means for reducing the expression of the overexpressed therein. This reduces the tumorogenic state of said colon carcinoma cell. Preferably said nucleic acid comprises the reverse complement of a small RNA of table 31. Preferably the reverse complement of a small RNA of table 31b.

In a preferred embodiment the nucleic acid is provided as a nucleic acid encoding a precursor for the nucleic acid. The nucleic acid may be administered as indicated herein above. In brief, it may be administered as such and/or in the context of a gene delivery vehicle.

EXAMPLES Example 1 Materials and Methods Samples

67 snap frozen human colorectal tumours (36 non-progressed adenomas and 31 adenocarcinomas) and ten samples of human normal colorectal epithelium obtained from histopathologically tumor free resection margins of colorectal cancer resection specimens were collected prospectively at the VU-University Medical Center (VUmc), Amsterdam, The Netherlands (Table 22). In addition, stool and blood samples from two other patients with colorectal cancer were collected. All samples were used in compliance with the institution's ethical regulations.

Total RNA Isolation

RNA isolation was done using TRIzol and following the manufacture's protocol. Briefly, tumours samples were homologized in 2 ml Trizol using a homogenizer. 0.4 ml chloroform was added to each sample and the tube was shaken vigorously. After 3 min of incubation at room temperature, the samples were centrifuged for 10 min at 12,000 rpm at 4° C. The upper aqueous phase was transferred to a new tube and 1 ml of isopropanol was added. Then the samples were incubated at room temperature for 10 min and centrifuged for 10 min at 12,000 rpm at 4° C. The supernatant was removed by decanting and the pellets were washed by adding 1 ml of 70% ethanol and centrifuging for 5 min at 7,500 rpm at 4° C. After the 70% ethanol was removed by decanting, the pellet was briefly spun down to remove the remaining ethanol using a sharp tip. Last, the pellet was dissolved in 100 μl RNAse-free water. Total RNA was cleanup performed using the RNeasy Mini Kit (QIAgen) and according to the manufacture's protocol. Briefly, a lysis buffer (RLT) was added and mixed well. After adding 100% ethanol the samples were transferred to an RNeasy Mini spin column and centrifuging for 15 s at >10,000 rpm. The flow-through was discarded and washing of the spin column was done twice with the RPE Buffer by centrifuging for 15 s (first washing) and 2 min (second washing) at >10,000 rpm. RNA was finally eluted in a new 1.5 ml tube in 2× 30 ul of RNase-free water by centrifuging for 1 min at >10,000 rpm and stored at −80° C. until use. The quantity of the RNA samples was measured using a spectrophotometer and the quality was evaluated in by visual inspection on an agarose gel (1%).

RNA Labeling and Isolation of Fraction of Small RNA (<100 nt)

RNA labeling and small RNA enrichement was done according Kreatech Biotechnologies' protocol (Kreatech, Amsterdam, The Netherlands). Labelled total RNA was prepared using 500 ng of total RNA as starting material, 0.5 μl of Cy3-ULS/Cy5-ULS, 0.33 μl of 10× labeling buffer solution and water to a final volume of 3.3 μl. The mix was incubated 15 min at 85° C. and then placed on ice. Clean-up of the samples was carried out using KREApure columns. Columns were prepared for use by resuspending the column material using a vortex, inserting the column in a 2 ml collection tube and centrifuging 1 min at 20,800 g. Then the flow-through was discarded and the column was rewashed by adding 300 μl of water and centrifuging 1 min at 20,800 g. After cleaning, the column was placed into a new 1.5 ml tube and the ULS-labelled total material was pipetted onto the column and centrifuged 1.5 min at 20.800 g. The flow-through containing the labeled total RNA was placed on ice and 1 μl was taken to determine the degree of labelling by measuring the OD260 and OD550 (for Cy3-ULS) or OD650 (for Cy3-ULS). After labeling, the material was subjected to small RNA isolation by adding RNAses-free water to a 50 μl volume, 250 μl lysis buffer, 1.75 μl 6-mercapto ethanol, 25 μl 2M sodium acetate (pH 4) and 175 μl ethanol (100%). The samples were then loaded into a RNA-binding column placed into a 2 ml collection tube and centrifuged at 16,000 g 30-60 sec. Following centrifugation, the column was discarded and 583 μl of 100% ethanol was added to the flow-through. Then, each sample was loaded into a new RNA-binding column placed into a 2 ml collection tube and centrifuged 30-60 sec at 16,000 g. Two loads of approximately 700 μl each were needed. Next, samples were washed first with 500 μl of low-salt wash buffer and centrifuged at 16.000 g for 30 sec and after discarding the flow-through with 300 μl of low-salt wash buffer were added and centrifuged at 16.000 g for 30 sec. After discarding the flow-through, 500 μl of fresh 80% ethanol was added in the column and centrifuged 30-60 sec followed by an additional 2 min centrifugation to dry the membrane. Last, 20 μl of RNAse-free water pre-heated at 60° C. directly onto the center of the column, incubated at room temperature for 2 min and centrifuged at 16.000 g for 1 min. Last, the column was reloaded with the flow-through onto the center of the column, incubated 2 min at room temperature and centrifuged at 16.000 g for 1 min. The flow-through containing the labeled small RNA fraction was kept on ice until used.

Hybridization Procedures

Each of the small RNA enriched samples labeled with Cy3 was hybridized against a reference pool labeled with Cy5 containing total RNA from the above described tissue samples tumour samples, 61 tumor cell lines (59 tumor cell lines from the NCI-60 panel plus 2 other colorectal tumor cell lines) and placenta tissue. The rationale behind this common pool is to provide a reference signal to which all experiments can be compared. To make sure that a fold-change for every candidate miRNA can be calculated, the reference pool should give a positive signal for every candidate, which is ensured by including every sample in this pool.

The samples were prepared for hybridization by mixing equimolar amounts of Cy3 and Cy5-labelled samples Hybridization took place to a single subgrid of the 8×15K Agilent microarray under standard conditions. Prior hybridization, each sample was heated at 60° C. in the dark for 2 min, centrifuged at 13,000 rpm for 1 min and place on ice until it was loaded on the array. Hybridization took place at 37° C. for 17 hours at 10 rpm. Post hybridization washes were done at room temperature after careful removal of cover into the Wash solution 1 were the slides were kept for 1 min and then transfer to Wash solution 2, and wash for 1 min. Last, the slides were immersed into wash solution 3 for 30 sec and then dried by air. Images of the arrays were acquired by scanning at 5 micron resolution (Agilent DNA Microarray scanner G2505B-Agilent technologies, Palo Alto, USA).

Array Design

Design of the microarray was based on 474 human pre-miRNA sequences From miRBase 9.1 and 3315 human pre-miRNA sequences from PCT/NL2006/0000010. Positions of mature miRNA sequences within pre-miRNA were known from previous public and private cloning data. In cases where only the mature sequence corresponding to one of the arms of the pre-miRNA was known, the corresponding star sequence was predicted by folding the pre-miRNA using RNAfold (Vienna RNA package, Hofacker Ill. (2003) Vienna RNA secondary structure server. Nucleic Acids Res. 31(13):3429-31) and selecting the sequence from the hairpin stem based on Dicer/Drosha cleaving properties (2 nt 3′ overhang) and the position of cloned mature miRNA sequence. The first 22 nt of every cloned and predicted mature miRNAs were used for designing probes complementary to the respective miRNAs. In cases where the mature miRNA was shorter than 22 nt, it was extended with the corresponding sequence from the pre-miRNA. Agilent custom microarrays (Wolber P K, Collins P J, Lucas A B, De Witte A, Shannon K W. (2006). The Agilent in situ-synthesized microarray platform. Methods Enzymol. 2006; 410:28-57) were designed with 60 nt probe sequences. Every probe carries spacers (CGATCTTT) and two copies of miRNA-specific sequence:

5′-22 nt-miR-CGATCTTT-22 nt-miR-CGATCTTT-3′ where 22 nt-miR is the reverse-complemented sequence of mature miRNAs selected as describe above. In addition, 13 non-overlapping 5S and 13 U6 22 nt sequences were included into array as controls. These sequences were manually selected from proprietary small RNA cloning data. In total the array contained (2×474)+(2×3315)+13+13=7604 probe sequences that were put in duplicates on every subgrid of the 8×15k Agilent custom microarrays. A complete list of all probes included in the microarray is given in Table 21

Data Analysis

Array processing and spot-calling was performed automatically using Agilent's FeatureExtraction software (9.5.3). Background subtractions, array normalization and extraction of gene expression values were performed by limma package from Bioconductor (Tables 1, 8 and 13).

Cluster Analyses (FIG. 1-3)

Supervised cluster analysis was done using TIGR multi experiment viewer (TMev), applying complete linkage and using Euclidian distances as metric

Other Statistical Analyses

For comparing miRNA expression levels in colorectal adenomas and colorectal carcinomas, colorectal adenomas and controls, and colorectal carcinomas and controls a Wilcoxon signed-rank sum test was used with a threshold p-value of 0.2.

For comparing miRNA expression levels in colorectal tumors with and without defined chromosomal aberrations (i.e. 8p loss, 13q loss, 15q loss, 17p loss, 18q loss and 20q gain) a Wilcoxon signed-rank sum test was used with a threshold p-value of 0.3.

To correct for multiple comparisons a Benjamini-Hochberg correction was performed in all analyses.

Indicator miRNAs in Blood or Faeces (Tables 9-11 and 14-16)

Differentially expressed miRNAs (Tables 2-4) were compared to miRNAs expressed in faeces (Table 8) or blood (Table 13). Small RNAs that were expressed differentially in a significant manner (BH<0.2) in tissue and detectable in Faeces or blood (signal/background>2) were listed.

Classification Analysis (Tables 5-7)

For multivariate classification of samples based on small RNA expression levels, PAM (prediction analysis for microarrays) software was used. PAM produces a classification rule using multiple variables (i.e. small RNAs) for optimal classification of predefined categories of samples (e.g. adenomas versus adenocarcinomas). PAM (Tibshirani et al. (2002) Proc Natl Acad Sci USA. 99:6567-72.) is a nearest centroid classification-type algorithm The training data is used to compute so-called class centroids. The centroid is a multivariate (since all expressed small RNAs are used) generalization of a median. Basically, a new sample would be classified to the class to which the squared distance is minimal.

Nearest shrunken centroid classification makes one important modification to standard nearest centroid classification. It “shrinks” each of the class centroids toward the overall centroid for all classes by an amount we call the threshold. This shrinkage consists of moving the centroid towards zero by a threshold, setting it equal to zero if it hits zero. After shrinking the centroids, the new sample is classified by the usual nearest centroid rule, but using the shrunken class centroids. This shrinkage does automatic selection of the most relevant small RNAs.

The error rates are computed by 10-fold cross-validation: 10 samples are left out of the training procedure and their class label is predicted as descibed above. The procedure is set up such that each sample is left out exactly once. The confusion table then displays the number of correct and erronous classifications for both classes.

Pairwise comparisons were performed (control vs adenoma, control vs carcinoma and adenoma vs carcinoma) followed by feature selection. Then, cross-validated misclassification errors were computed (see the confusion tables 5b-7b). This shows which miRNAs were vital for a high accuracy of prediction the type of tissue (control vs adenoma vs carcinoma) and the accuracy of the prediction (%). Subsequently, the selected feature miRNAs were eliminated from the data and the classification was redone. The cross-validated misclassification errors were computed again. An increase in error shows that the accuracy of the classification relies on the presence of the featured miRNAs.

Results Small RNA Fraction Detectable in Colorectal Tissue

A large set of novel small RNAs have recently been experimentally identified at the Hubrecht Institute, Utrecht, The Netherlands, and classified as candidate miRNAs using computational analysis (e.g. stable hairpin formation of the precursor) (Berezikov et al. (2005) Cell 120:21-24, Berezikov et al. (2006) Nature Gen. 38: 1375-1377, Berezikov et al. (2006) Genome Res. 16: 1289-1298, PCT/NL2006/0000010). Earlier studies have shown that expression profiling of small RNAs can be used to classify tumors and use it as a diagnostic tool. In colorectal cancer, early diagnosis could make an enormous difference in life expectancy, morbidity and mortality. To determine whether these novel small RNAs, which are suspected to be miRNAs, are differentially expressed in different types of cancer, analysis of the expression of these small RNAs was performed in different colorectal tissues. The signals detected for the miRNAs and small RNAs obtained for the tissue samples were compared to signals obtained using the reference sample. Table 1 shows the result of this comparison. In total, 1296 probes produced signal with difference between maximum and minimum values above 4 in log 2 scale, indicating substantial differential expression of corresponding small RNAs in at least some of the investigated colorectal tissues.

Differentially Expressed Small RNAs in Diseased Colorectal Tissue Versus Healthy Colorectal Tissue

In order to determine which small RNAs might serve as disease markers and may consequently be used for diagnostic purposes, detection signals of the analyzed small RNAs were compared between colorectal adenomas and control samples, colorectal adenocarcinomas and control samples and colorectal adenomas and adenocarcinomas. This comparison resulted in a list of small RNAs that are differentially expressed between the respective categories analysed (Tables 2-4). Moreover, Tables 2b-4b demonstrate which of the differentially expressed small RNAs are upregulated and which are downregulated. In summary, a comparison of colorectal adenomas and control samples showed that 1554 small RNAs are differentially expressed, of which 50 are upregulated (Table 2c) and 1504 are downregulated (Table 2d) in adenomas. The comparison of colorectal adenocarcinomas and control samples demonstrated that 105 small RNAs are differentially expressed (Table 3a), of which 23 are upregulated (Table 3c) and 82 are downregulated (Table 3d) in adenocarcinomas. Lastly, comparing colorectal adenomas and adenocarcinomas resulted in a list of 1080 small RNAs that are differentially expressed (Table 4a), of which 1 is upregulated (Table 4c) and 1079 are downregulated (Table 4d) in adenocarcinomas. When the statistical analysis was performed under more stringent criteria (p<0.1), a list of 384 small RNAs was selected, that are most significantly differentially expressed between adenoma and adenocarcinoma (Table 26). All of these small RNAs were downregulated in adenocarcinomas. The significance of these results is reiterated by the fact that, when cluster analysis (Euclidean) is performed, using all differentially expressed small RNAs, two distinct clusters are formed (Figure I-III). Figure Ia shows cluster analysis based on all differentially expressed small RNAs between control and adenomas. Cluster analysis shows two distinct clusters: one which included mostly adenomas (Cluster II) and one including mostly controls (Cluster I). This demonstrates that on the basis of the differentially expressed small RNAs it is possible to distinguish these two different tissue types. Statistical analysis (FIG. 1 b) demonstrates that the different tissue samples are assigned to the correct cluster in a significant manner. Importantly, the cluster analysis was repeated with a lower number of differentially expressed small RNAs (p<0.1, p<0.05 and p<0.025 or best 23 predictive, differentially expressed small RNAs) as a result of more stringent statistical criteria (p value linked to the differentially expressed small RNAs is decreased). The results of those analyses show that it remains possible to distinguish, in a significant manner, two clusters containing mainly controls in one and mainly adenomas in the other (FIG. 1 c-h), although the clusters do change somewhat when the number of included small RNAs decreases. Figures II and III, clustering adenocarcinoma and control samples and adenoma and adenocarcinoma samples respectively, show similar results as described for Figure I. These data imply that the selected small RNAs that are differentially expressed have great value for diagnostic purposes and will be further developed as such.

In conclusion, these results show differences in small RNA content between the respective categories of samples (normal colorectal epithelium, adenomas and adenocarcinomas) tested. They further show that the selected small RNAs that are differentially expressed have great value for clinical diagnostic purposes and will be further developed as such. Based on the expression of the different small RNAs identified above, it becomes possible to classify an unknown tissue sample into a normal category an adenoma category or an adenocarcinoma category depending on its small RNA type expression profile. Such a comparison may then result in an accurate diagnosis of normal vs adenoma vs adenocarcinoma. In addition, individual or groups of small RNAs may actually drive (the set of upregulated small RNAs, table 2c, table 3c and table 4c) or inhibit (downregulated small RNAs, table 2d, table 3d, table 4d) the transition from adenoma to carcinoma and may therefore function as targets for therapy.

Classification of Diseased Colorectal Tissue

The subpopulations of small RNAs that are differentially expressed as identified above are still relatively large. This might hamper its use as a diagnostic tool in practice. Therefore, we determined which of the differentially expressed small RNAs are actually most predictive in its classification of a tissue sample in the categories normal, adenoma or adenocarcinoma. The selection of the most predictive small RNAs for multivariate classification of samples based on small RNA expression levels, PAM (prediction analysis for microarrays) software was used. PAM produces a classification rule using multiple variables (i.e. small RNAs) for optimal classification of predefined categories of samples (e.g. adenomas versus adenocarcinomas). It is well-known that with these high dimensional data one may obtain competitive classifiers with (almost) no overlapping features (small RNAs in this case). To assess the importance of the selected small RNAs as a set, we deleted these from the data set and repeated the classification procedure. We observe that the error rates drop substantially, which indicates that the initial set of small RNA does contain features which are essential for discriminating the two groups.

The results of these analyses are shown in Tables 5-7. These tables show lists of small RNAs that have a high predictive value. They are ranked, with the first being the small RNA with the highest predictive value. This predictive value is represented by the largest difference between the adenoma score and the adenocarcinoma score as listed in Tables 5a-7a. The predictive value and power of the complete set of small RNAs selected is due to the combination of these particular small RNAs. Table 5a shows that 55 from the selection of 1554 differentially expressed small RNAs in colorectal adenoma vs control are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.212, table 5b). This is exemplified by the fact that the accuracy rate decreases to 65% (overall error rate 0.349) when these 55 small RNAs are not included in the small RNA population used to classify tissue, demonstrating that these 55 contain good classifiers, to accurately predict the type of tissue analyzed. Table 6a shows that 79 from the selection of 105 differentially expressed small RNAs in adenocarcinoma vs control samples are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.198, Table 6b). This is exemplified by the fact that the accuracy rate decreases to 65% (overall error rate 0.365) when these 79 small RNAs are not included in the small RNA population used to classify tissue. Importantly, when these good predictors are excluded, it results in wrongly classifying 8 controls as an adenocarcinoma compared to 2 wrongly classified controls when the good predictors are included: the false positive rate increases significantly from 0.222 to 0.888. These data show that these 79 probably contain good classifiers, to accurately predict the type of tissue analyzed. Table 7a shows that 26 from the selection of 105 differentially expressed small RNAs in colorectal adenomas vs adenocarcinomas are highly predictive and classify the tissue samples accurately in 80% of the cases (overall error rate 0.198, table 7b). This is exemplified by the fact that the accuracy rate decreases to 65% (overall error rate 0.365) when these 26 small RNAs are not included in the small RNA population used to classify tissue. Moreover, exclusion of these small RNAs results in the increase of the false negative rate of 0.258 to 0.483 as indicated by double the adenocarcinomas that are wrongly classified as adenomas when excluding the 26 small RNAs. These results show that these 26 contain good classifiers to accurately predict the type of tissue analyzed. In conclusion, the described small RNAs (Tables 5a-7a) are minimal sets of small RNAs part or all of which are included in a diagnostic test, which could classify an unknown sample into the different categories (normal, colorectal adenoma, adenocarcinoma). The above described PAM analysis resulted in a classification rule that may be used in a diagnostic application. Such an application makes use of the small RNA content and expression profiles of an unknown sample which will be compared to the above identified combination of small RNAs using advanced algorithms. This calculates whether the final value is below or above a certain threshold that determines the consequent diagnosis. The threshold depends on the required specificity and sensitivity of the final diagnostic test.

Detection of Small RNAs in Faeces and Blood

To design a functional and practical diagnostic test it is important to take into account the type of sample that is to be analyzed. Existing commercial tests are based on the analysis of stool samples. They have yielded promising results but need further improvement. Fecal occult blood test is the most recognized method of selecting high risk individuals. Unfortunately, with FOBT a considerable percentage of the tumours is missed and the already bleeding tumour is often discovered at a relatively late stage. A diagnostic test based on the detection of small RNA can be performed using tissue samples (biopsies) as described above. However, it is preferred to use test samples that can be obtained by less invasive measures. Stool samples and blood samples obtained from suspected colorectal patients could qualify. We therefore tested whether small RNAs derived from the tumor tissue are traceable in either blood or faeces. Therefore, we first determined if it was possible to extract small RNAs from blood and faces. The results are shown in tables 8 and 13. It shows the ratio of detection signal of the different small RNAs over background. For this calculation, processed background and signal values produced by FeatureExtraction software (Agilent) were used. We considered all signals with a ratio of 2 over background a significant signal. It demonstrates that 3759 small RNAs can be detected in stool sample and 3644 small RNAs in whole blood obtained from a patient with a colorectal adenocarcinoma. Interestingly, of some hairpin RNAs both arms of the hairpin could be detected, where one arm is higher expressed than the other, clearly resembling endogenous miRNA processing, where the mature strand gives stronger signals than the star sequence (see tables 8b and 13b). Secondly, we analyzed which small RNA, expressed in faeces and blood, are differentially expressed in comparing the three categories (colorectal adenomas and control samples, colorectal adenocarcinomas and control samples and colorectal adenomas and adenocarcinomas). These analyses should indicate which small RNAs are indicative of abnormality and can be detected in faeces or blood. They are based on the combination of Tables 8 and 13, including all small RNAs expressed twice above background, and Tables 2-4, including all differentially expressed small RNAs (p<0.2). A summary of Tables 9-11 for faeces and 14-16 for blood is given below (Table 17). The table shows that it is possible to recover small RNAs in blood and faeces that are also differentially expressed in tissue. In conclusion, both blood and faeces obtained from suspected colorectal patients are suitable samples for use in diagnostic small RNA based microarray tests. This is once again exemplified by the fact that part of the group of small RNAs identified as good classifiers can also be detected in faeces (Table 12) and blood (Table 18). Importantly, a comparison of these subsets presumable derived from colorectal cancer cells and detected in blood and faeces, learns that blood and faeces have 85-90% of these predictive small RNAs in common. This shows that these small RNAs are indeed derived from colorectal adenocarcinoma cells and more importantly, that both blood and faeces are suitable for detecting colorectal carcinoma derived small RNAs.

Correlation of Expression of Small RNAs with Chromosomal Aberrations

The colorectal tissue samples used in this study have further been characterized on other molecular levels. By means of array CGH analysis it had been determined which of the above studied adenomas and adenocarcinomas are characterized by chromosome instability, and which aberrations specifically. It was shown that 8q, 13q and 20q gains and 8p, 15q, 17p and 18q losses, are associated with progression of colorectal adenomas to carcinomas (Hermsen et al. (2002) cited above). Therefore, we determined whether the chromosomal aberrations frequently reported in colorectal cancer are correlated with the expression of small RNAs. Table 19 shows that two typical chromosomal aberrations, loss of X8p and loss of X17p, correspond to significant expression of 219 and 15 small RNAs respectively. One could view the significance of this correlation of small RNA expression with certain chromosomal aberration in two manners; the first would regard small RNAs correlated with certain chromosomal aberrations as indicators for those aberrations and could therefore be used in diagnostic tests based on such chromosomal instabilities. The second way of regarding this correlation is to take into account the biological consequences. The loss of X8p and X17p affected expression of these particular small RNAs. This could either be a direct consequence: these small RNAs are encoded by the part of these chromosomes that is lost. It could also be an indirect effect: the chromosomes that are lost encode for genes that regulate the expression of these small RNAs. Moreover, the fact that loss of these chromosomes affects clinical behaviour of tumors may suggest that the small RNAs, correlated with this loss, have a biological function in the process of tumorigenesis.

Currently, the small RNA expression profiles identified in these 68 colorectal tissue samples have been analyzed to identify good clinical classifier and correlated with small RNAs recovered from faeces and blood obtained from colorectal adenocarcinoma patients, to determine if a diagnostic small RNA based test would be feasible. Moreover, these expression profiles were combined with array CGH data, determining whether chromosomal aberrations can be correlated with certain small RNAs. It is hypothesized that the small RNAs correlated with loss of X8p and X17p (as identified in table 19) will also have a biological function, since loss of these chromosomal aberrations is correlated with clinical prognosis. Therefore, in the future, these small RNAs will be studied in more detail to test that hypothesis. Importantly, the correlation between small RNA expression profiles and already available mRNA expression profiles will be determined shortly. This may give indications on which genes are targeted by the small RNAs that are identified in colorectal adenomas and adenocarcinomas. It is of particular interest to determine the target genes of small RNAs that are differentially expressed between adenomas and adenocarcinomas. These small RNAs may be involved in progression to adenocarcinomas and may form interesting targets for drug discovery. Consequently, the small RNA gene targets may therefore also be of great interest.

Example 2 Materials and Methods

For materials and methods for the PAM analysis, represented in table 25, we refer to the materials and methods as presented under example 1.

Results

To confirm the classifier as listed in table 7a, the PAM analysis was performed again, this time using a double cross validation to assure accurate prediction of the most predictive small RNAs. The small RNAs as listed in table 25a are the result of this analysis. 41 small RNAs were selected from the list of differentially expressed small RNAs. The combination of these 41 small RNAs is able to distinguish adenomas from adenocarcinomas in a highly predictive manner with a 72% accuracy (overall error rate 0.283, Table 25b). This is exemplified by the fact that the accuracy rate decreases to 66% (overall error rate 0.34) when these 41 small RNAs are not included in the small RNA population used to classify tissue, demonstrating that these 41 contain good classifiers, to accurately predict the type of tissue analyzed. The above described PAM analysis resulted in a classification rule that may be used in a diagnostic application. Such an application makes use of the small RNA content and expression profiles of an unknown sample which will be compared to the above identified combination of small RNAs using advanced algorithms. This calculates whether the final value is below or above a certain threshold that determines the consequent diagnosis. The threshold depends on the required specificity and sensitivity of the final diagnostic test.

To improve the predictive value of such classifiers as described above, a number of strategies can be followed. The first strategy could be to increase the sample set to ensure the correct selection of predictive small RNAs. This strategy could in some cases increase the accuracy of prediction and decrease the error rate. However, in other cases the predictive value of a diagnostic test has already reached its limit and increasing the sample set will not result in a more accurate predictive set. Therefore, a second strategy to improve the predictive value of the diagnostic test may be to combine the dataset based on the microarray data with other data sets. For example, a diagnostic test may combine data based on the small RNA expression levels with array CGH data obtained from the same samples. This could result in a more accurate prediction of disease state. A third option may be to use combined diagnostic tests in a step-wise procedure, where the first diagnostic test will have the best predictive value. For patients that fall within a category for which no clarity as to diagnosis can be given, a second diagnostic test will follow that will ultimately result in a diagnosis of the disease state. The second test on its own would not have given a clear answer, but in combination with the first test, this resulted in a defined and reliable diagnosis.

Importantly, of these 41 classifier small RNAs, a portion of them can be detected in faeces (Table 34) or blood (Table 35). As mentioned, both blood and faeces obtained from suspected colorectal patients are suitable samples for use in diagnostic small RNA based microarray tests. The presence of small RNAs identified as good classifiers in faeces and stool suggests that the classifier can be used as a diagnostic test using faeces or blood as a source for small RNAs derived from colorectal adenomas or adenocarcinomas.

Example 3 Materials and Methods

For materials and methods for the cluster analysis, represented in Fig IV, we refer to the materials and methods as presented under example 1.

Results

From the 384 small RNAs that were found to be most significantly differentially expressed between adenomas and adenocarcinomas (Fig IIIc, d and table 26), 91 were selected and believed to be highly predictive for classification of adenoma vs adenocarcinoma (Table 27). This was reiterated by the fact that, when cluster analysis (Euclidian) was performed using the 91 small RNAs, two distinct clusters are formed (Fig IVa). Moreover, statistical tests showed (Chi-square test) that the clustering based on the 91 selected small RNAs is highly significant (P<0.0001) (Fig IVb).

Example 4 Materials and Methods Patient Samples

Fresh colorectal tissue samples from 58 patients with colorectal tumors were collected prospectively at the department of pathology of the VU-University medical center (VUmc), Amsterdam, the Netherlands. In total 27 adenomas and 31 adenocarcinomas, of which 12 adenomas and 12 carcinomas were also analyzed by small RNA based microarray (see example 1). Of all samples, total RNA was isolated using TRIzol (Invitrogen) following the manufacturer's guidelines with some modifications (http://www.vumc/nl/microarrays/index.html). Total RNA quantity was determined with a Nanodrop ND-1000 spectrophotometer (Isogen, Hackensack, N.J., USN and quality was assessed in a 1% agarose gel, stained with ethidium bromide. The study was carried out in accordance with the ethical guidelines of our institution concerning the use of patient material.

TaqMan PCR

Quantification of the left arm of hsa-miR-24-2 (hsa-miR-24-2-1) expression levels was done by real-time RT-PCT using Tagman® microRNA assays (Applied Biosystems, Foster City, Calif., USA) directed to hsa-mir-24 (ABI4 373072) and an endogenous reference, the RNU48 gene (ABI 437338). Reactions were performed following the manufacture's protocol using 10 ng of total RNA as input material. All reactions were carried out in duplo in a 7300 Real-time PCR System (Applied Biosystems, Foster City, Calif., USA).

Statistical Analysis

Expression levels of the hsa-miR-24-2-1 were calculated from the obtained Ct values using the delta Ct method as previously described. Box and scatter plots were used to appreciate the descriptive statistics of the data (SPSS 14.0 for Windows, SPSS Inc. Chicago, Ill., USA). Significance of differences in expression levels between adenomas and carcinomas were computed by the Mann-Whitney U non-parametric test for independent samples (SPSS 14.0 for Windows, SPSS Inc. Chicago, Ill., USA).

Results

To validate the microarray expression data as presented in FIGS. 1-3, the expression levels of mir-24-2-1, for which primers were commercially available, were determined by real-time RT-PCR in 58 colorectal tumors (27 adenomas and 31 adenocarcinomas). Expression levels of hsa-miR-24-2-1 showed 1.4 fold increased expression in the adenomas (mean expression 13.8) compared to the carcinomas (mean expression 12.2) (p=0.4) (FIG. 5A). This observation was in concordance with the results from the microarray expression experiment, where the expression levels of the hsa-mir-24-2-1 were higher in group of adenomas (mean expression 1.4) compared to carcinomas (mean expression 1.0) (p=0.01) (FIG. 5B).

Example 5

Colorectal cancer (CRC) results from the accumulation of DNA copy number gains and losses, promoter methylation changes, mutations and alterations in microRNAs (miRNAs) expression. It is well documented that 85% of the colorectal tumours show genetic instability through specific chromosomal gains and losses of small or large portions or whole chromosomes. These tumours are known as chromosomal instable (CIN) tumours. The biological consequences of the described DNA copy number changes that characterize CRC have not been fully established since the genes or miRNAs with tumour suppressor or oncogenic function, which are located in those regions have not been fully identified. In the last years, small RNA molecules have shown to play an important role in the pathogenesis of human cancers as oncogenes and tumours suppressor genes. Small RNAs contribute to the pathogenesis of human cancers due to their altered expression. The cause of their altered expression has only been partially characterized. It is known that DNA copy number changes, epigenetic changes and transcription factors involved in human carcinogenesis lead to increase or decrease expression of small RNAs during cancer initiation and progression. Therefore, small RNAs located in loss and gain regions characteristic of CRC as well as small RNAs which expression is associated to DNA copy number changes, may play a role as causative oncogenes or tumour suppressor genes in CRC. Identification of the small RNAs that participate as causative oncogenes and tumour suppressor genes in DNA copy number gain and loss regions will lead to a better understanding of the molecular mechanisms underlying CRC pathogenesis and may both serve as highly specific biomarkers for CRC or as possible targets for pharmaceutical intervention with the development of CRC.

Materials and Methods Materials

38 colorectal carcinomas with array CGH data and microsatellite instability status available were collected at the Zaans Hospital, Zaandam, the Netherlands and Leeds University, UK. The study was carried out in accordance with the ethical guidelines of our institution concerning the use of patient material.

DNA Isolation

DNA from healthy mucosa and tumor DNA of each patient was isolated using the QIAmp microkit (Qiagen, Westburg, Leusden, the Netherlands) as previously described. (Weiss M M, Hermsen M A, Meijer G A, et al. Comparative genomic hybridisation. Mol Pathol 1999; 52:243-51. Buffart T E, Carvalho B, Hopmans E, et al. Gastric cancers in young and elderly patients show different genomic profiles. J Pathol 2007; 211:45-51).

Microsatellite Instability Analysis

Microsatellite Instability analysis was determined by using the MSI Analysis System, MSI Multiplex System Version 1.2 (Promega, Madison, Wis., USA) containing five monomorphic markers (BAT-25, BAT-26, NR-21, NR-24, MONO-27). Reactions were performed following the manufacturer's instructions. The obtained PCR products were separated on a ABI 3130 DNA sequencer (Applied Biosystems, Foster City, Calif., USA) and analyzed by GeneScan 3100 (Applied Biosystems, Foster City, Calif., USA). An internal lane size standard was added to the PCR samples for accurate sizing of alleles and to adjust for run-to run variations. Tumours were considered as microsatellite instable (MSI) when two or more markers ((MSI-H) showed length changes (instability). Tumours showing none or only one instable marker (MSI-L) were considered as Microsatellite stable (MSS).

Array Comparative Genomic Hybridization

Array CGH was performed on 30K oligonucleotide arrays as described before (Snijders A M, Nowak N, Segraves R, et al. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet. 2001; 29:263-4. Van den Ijssel P, Tijssen M, Chin S F, et al. Human and mouse oligonucleotide-based array CGH. Nucleic Acids Res 2005; 33:e192). Briefly, 600 ng of tumour and normal DNA were differentially labelled by random priming (Bioprime DNA Labeling System, Invitrogen, Breda, the Netherlands). Unincorporated nucleotides were removed with Sephadex columns (ProbeQuant G-50 Micro Columns, Amersham Biosciences) and 50 μl of tumour and normal DNA were combined with 10 μg Cot-1 DNA and precipitated by adding 2.5 volumes of ice-cold 100% ethanol and 0.1 volume of 3M sodium acetate (pH 5.2). The DNA was collected by centrifugation at 14000 rpm for 30 minutes at 4° C. The pellet was dissolved in 130 μl hybridization solution and incubated at 73° C. for 10 minutes to denature the DNA, followed by 60-120 minute incubation at 37° C. Next, the hybridization mixture was added to the array in a hybridization station (HybArray12™, Perkin Elmer Life Sciences, Zaventum, Belgium) and incubated for 38 hours at 37° C. After hybridization the slides were washed in six washing steps and dried by centrifugation for 3 minutes at 1000 g.

Image Acquisition and Data Analysis

Images of the arrays were acquired by scanning (Agilent DNA Microarray scanner, Agilent Technologies, Palo Alto, USA) and Bluefuse software version 3.4 (BlueGnome, Cambridge, UK) was used for automatic feature extraction. Spots were excluded when the quality flag was below 1 or the confidence value was below 0.1. Log 2 tumour to normal ratio was calculated for each spot and normalized against the mode of the ratios of all autosomes. For determining copy number gains and losses, the R package CGH call was used (van de Wiel M A, Kim K I, Vosse S J, et al. CGHcall: calling aberrations for array CGH tumor profiles. Bioinformatics 2007; 23:892-4).

Statistical Analysis

ACE-it (Array CGH Expression integration tool) was applied to statistically test whether gene dosage affects microRNA expression (van Wieringen et al., 2006). This tool was applied to the whole genome data. We used a cut-off value 0.15 for gains and losses, a default group value of 9 and an FDR for significance of 0.10.

Results Localization of Small RNAs in Microdeletion or Microgain Regions in Colorectal Carcinoma

Eight microdeleted regions, smaller than 3 megabases, were observed in at least two of the 38 colorectal carcinomas. To determine whether the changes in small RNA expression in colorectal carcinomas may be a consequence of their location in the previously mentioned microdeletions or microgains (smaller than 3 Mb), the localization of small RNAs in such regions detected by array CGH was ascertained. A significant amount of small RNAs appear to be located in these eight deleted regions (table 28a). Out of this list of small RNAs, 6 small RNAs were shown to be differentially expressed between adenomas and carcinomas (table 28b). Due to the location of the small RNA in these specific regions, these small RNAs could therefore contribute causally to colorectal carcinogenesis as tumor suppressor genes or oncogenes and form targets for therapeutic intervention or be used as highly specific biomarkers. Reintroduction of such, previously deleted, small RNAs may benefit the patient by affecting tumor progression or response to therapy and therefore clinical outcome. Moreover, they could be used as biomarkers for early diagnosis, therapy response or clinical outcome of colorectal carcinomas. Five micro-gain regions, smaller than 3 megabases, were observed in at least two of the 38 colorectal carcinomas. In these 5 regions, 22 small RNAs are located (Table 29a), one of which has been shown to be differentially expressed between adenomas and carcinomas (Table 29b). Gain of these small RNAs may be causatively involved in the initiation and maintenance of colorectal tumours. As such, inhibition of these small RNAs could result in the opposite effect and provide a novel therapeutic strategy for the treatment of colorectal carcinomas. In addition, these microRNAs could be used as biomarkers for molecular diagnosis or tumor classification regarding therapy response, therapeutical intervention or clinical outcome.

Localization of Small RNAs in Microdeletion or Microgain Regions in Colorectal Microsatellite Stable Carcinomas

Within the population of colorectal carcinomas, two groups can be distinguished. One group that has stable microsatellites, the other group is defined by instable microsatellites. The microsatellite instability is often a result of DNA mismatch repair deficiencies and therefore, the status of stability of the microsatellites determines the sensitivity of these tumors for the accumulation of mutations or epigenetic changes. To determine whether microdeletions or gains can be found specifically in one group or the other, array CGH data was used to determine such changes in these two groups.

In at least two out of 26 microsatellite stable carcinomas, two micro-deletions, smaller than 3 megabases, were observed. Four small RNAs are located in these regions (table 30). Three micro-gain regions, smaller than 3 megabases, were observed in at least two of the 26 microsatellite stable colorectal carcinomas. In these regions, 10 small RNAs are localized (table 31a), of which 1 is differentially expressed in adenomas compared to carcinomas (table 31b). It is known that MSI and MSS have different clinical outcome and respond differently to the current chemotherapy regimens. On this basis, small RNAs located in microdeleted or microgained chromosomal regions that are most frequently present in MSS tumours, might be responsible for the different clinical behaviour seen in the MSS colorectal tumors. Therefore, small RNAs that are located in these gain and loss regions are highly suitable for use as biomarkers to distinguish microsatellite stable from microsatellite instable carcinomas, for early diagnosis of these tumors or tumor classification regarding therapy response, to dispense the most suitable therapeutical regimen for the patients or predict clinical outcome.

Localization of Small RNAs in Microdeletion or Microgain Regions in Colorectal Microsatellite Instable Carcinoma

Eight micro-deletions, smaller than 3 megabases, were observed in at least two of the 12 microsatellite instable colorectal carcinomas. In these deleted regions, 41 small RNAs are localized (table 32a), of which 4 are differentially expressed between adenomas and carcinomas (table 32b). No microgains could be detected in this group of colorectal carcinomas. These 41 small RNAs that are localized in deleted regions, and in particular the 4 that are differentially expressed, may contribute to the maintenance of the tumor phenotype. Therefore, they could be suitable for therapeutic approaches, where reintroduction of these small RNAs may intervene with tumor growth or other tumor specific characteristics. Moreover, these small RNAs may serve as highly specific biomarkers since it is known that MSI and MSS have different clinical outcome and respond differently to the current chuemotherapy regimens. On this basis, small RNAs located in microdeleted chromosomal regions that are most frequently present in MSI tumours, might be responsible for the different clinical behaviour seen in the MSI colorectal tumors. Therefore, small RNAs that are located in these microdeleted regions are highly suitable for use as biomarkers to distinguish microsatellite stable from microsatellite instable carcinomas, for early diagnosis of these tumors or tumor classification regarding therapy response, to dispense the most suitable therapeutical regimen for the patients or predict clinical outcome.

Integration of Small RNAs Expression and Array Comparative Hybridization Data.

BAC array CGH data were related to small RNA expression array data as presented in Example 1, independently of adenoma or carcinoma status. Therefore, a dedicated integration tool called ACE-it was applied (van Wieringen et al., 2006). We obtained a list of five small RNAs for which DNA dosage affected expression levels (FDR<0.1) (Table 33). The expression of these five small RNAs is associated to DNA copy number changes, located on chromosomal regions implicated in colorectal pathogenesis (Beatriz Carvalho, Cindy Postma, Sandra Mongera, Erik Hopmans, Sharon Diskin, Mark A. van de Wiel, Wim van Criekinge, Olivier Thas, Anja Matthai, Miguel A. Cuesta, Jochim S. Terhaar sive Droste, Mikael Edward Craanen, Evelin Schrock, Bauke Ylstra, and Gerrit A. Meijer. Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression (in press)). This indicates that these 5 small RNAs may be involved and causal in colorectal carcinogenesis. Small RNAs which expression is associated to DNA copy number changes may contribute causally to colorectal carcinogenesis as tumor suppressor genes or oncogenes and form targets for therapeutic intervention or be used as highly specific biomarkers. Moreover, they could be used as therapeutical targets or be used as biomarkers for early diagnosis, therapy response or clinical outcome of colorectal carcinomas.

Brief Description of the Tables Brief Description of the Tables Tables

-   -   1. Differentially expressed small RNAs in colorectal samples vs         reference pool.         -   For every probe, samples with minimal and maximal values of             log 2(sample/reference) were selected and amplitude of             differential expression was calculated by subtracting             minimal value from maximal. Probes with the amplitude above             4 were considered as differentially expressed.     -   2. Differentially expressed small RNAs in colorectal adenoma vs         control         -   A. Small RNAs that are differentially expressed between             control (brush sample of resected colorectal margins) and             adenoma. A wilcoxon analysis was performed adjusting the p             values with a Benjamini-Hochberg correction. Small RNAs are             differentially expressed when the adjusted p value is below             0.2         -   B. Up- or downregulated small RNAs adenoma compared to             control         -   C. List of small RNAs upregulated in adenoma compared to             control. A small RNA is considered upregulated when the             ratio is above 1         -   D. List of small RNAs downregulated in adenoma compared to             control. A small RNA is considered downregulated when the             ratio is below 1.     -   3. Differentially expressed small RNAs in colorectal         adenocarcinoma vs control         -   A. Small RNAs that are differentially expressed between             control (brush sample of resected colorectal margins) and             adenocarcinoma. A wilcoxon analysis was performed adjusting             the p values with a Benjamini-Hochberg correction. Small             RNAs are differentially expressed when the adjusted p value             is below 0.2         -   B. Up- or downregulated small RNAs adenocarcinoma compared             to control         -   C. List of small RNAs upregulated in adenocarcinoma compared             to control. A small RNA is considered upregulated when the             ratio is above 1         -   D. List of small RNAs downregulated in adenocarcinoma             compared to control. A small RNA is considered downregulated             when the ratio is below 1     -   4. Differentially expressed small RNAs in adenoma vs         adenocarcinoma         -   A. Small RNAs that are differentially expressed between             adenoma and adenocarcinoma. A wilcoxon analysis was             performed adjusting the p values with a Benjamini-Hochberg             correction. Small RNAs are differentially expressed when the             adjusted p value is below 0.2         -   B. Up- or downregulated small RNAs adenocarcinoma compared             to adenoma         -   C. List of small RNAs upregulated in adenocarcinoma compared             to adenoma. A small RNA is considered upregulated when the             ratio is above 1         -   D. List of small RNAs downregulated in adenocarcinoma             compared to adenoma. A small RNA is considered downregulated             when the ratio is below 1     -   5. Classification on the basis of predictive small RNA subset         for distinction between normal tissue and adenoma         -   A. List of small RNAs that are selected by PAM as good             classifiers to distinguish control from adenoma tissue         -   B. Confusion tables before and after exclusion of the             selected set of small RNAs     -   6. Classification on the basis of predictive small RNA subset         for distinction between normal tissue and adenocarcinoma         -   A. List of small RNAs that are selected by PAM as good             classifiers to distinguish control from adenocarcinoma             tissue         -   B. Confusion tables before and after exclusion of the             selected set of small RNAs     -   7. Classification on the basis of predictive small RNA subset         for distinction between adenoma and adenocarcinoma         -   A. List of small RNAs that are selected by PAM as good             classifiers to distinguish adenoma from adenocarcinoma             tissue         -   B. Confusion tables before and after exclusion of the             selected set of small RNAs     -   8. Recovered small RNAs in faeces. For every probe, ratio of         processed signal above background, as determined by         FeatureExtraction software, was calculated, and probes with the         ratio above 2 were considered as positively detected in the         sample.     -   9. Small RNAs recovered from faeces and differentially expressed         in adenoma vs control tissue         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenoma compared to control and are detectable in faeces             (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   10. Small RNAs recovered from faeces and differentially         expressed in adenocarcinoma vs normal tissue         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenocarcinoma compared to control and are detectable in             faeces (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   11. Small RNAs recovered from faeces and differentially         expressed in adenocarcinoma vs adenoma         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenocarcinoma compared to adenoma and are detectable in             faeces (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   12. Presence of classifiers in faeces         -   This table includes small RNAs that were selected as good             classifiers in tables 5-7 and could be detected in faeces             -   A. Classifiers for adenoma vs control detectable in                 faeces             -   B. Classifiers for adenocarcioma vs control detectable                 in faeces             -   C. Classifiers for adenoma vs adenocarcinoma detectable                 in faeces     -   13. Recovered small RNAs in blood.         -   For every probe, ratio of processed signal above background,             as determined by FeatureExtraction software, was calculated,             and probes with the ratio above 2 were considered as             positively detected in the sample.     -   14. Small RNAs recovered from blood and differentially expressed         in adenoma vs normal tissue         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenoma compared to control and are detectable in blood             (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   15. Small RNAs recovered from blood and differentially expressed         in adenocarcinoma vs normal tissue         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenocarcinoma compared to control and are detectable in             blood (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   16. Small RNAs recovered from blood and differentially expressed         in adenocarcinoma vs adenoma         -   This table includes small RNAs that were expressed             differentially in a significant manner (p value<0.2) in             adenocarcinoma compared to adenoma and are detectable in             blood (signal/background>2) were listed.             -   A. Small RNA hairpin arm that shows highest expression                 with signal/background>2             -   B. Small RNA hairpin arm that shows lowest expression                 with signal/background>2     -   17. Summary of results shown in Tables 8-16     -   18. Presence of classifiers in blood         -   This table includes small RNAs that were selected as good             classifiers in tables 5-7 and could be detected in blood             -   A. Classifiers for adenoma vs control detectable in                 blood             -   B. Classifiers for adenocarcinoma vs control detectable                 in blood             -   C. Classifiers for adenoma vs adenocarcinoma detectable                 in blood     -   19. Correlation of expressed small RNAs with chromosomal         aberrations in adenoma and adenocarcinoma samples         -   A. Small RNAs correlated with a loss of chromosome 8p. No             correlation could be detected between these small RNAs and             loss of chromosome 17p or gain of 13q (see table) or gain of             15q, 18q or 20q (data not shown).         -   B. Small RNAs correlated with a loss of chromosome 17p. No             correlation could be detected between these small RNAs and             loss of chromosome 8p or gain of 13q (see table) or gain of             15q, 18q or 20q (data not shown).         -   C. List of small RNAs correlated with loss of X8p         -   D. List of small RNAs correlated with loss of X17p     -   20. List of 23 best predictive small RNAs in adenoma vs control     -   21. Sequences of microarray probe inserts for small RNA         detection         -   22. Sample IDs of patient material         -   23. Small RNA mature and star strand sequences             -   A. Small RNA sequences derived from PCT/NL2007/000012             -   B. Small RNAs sequences derived from public miRNA                 database miRBase     -   24. Small RNA precursor sequences         -   A. Small RNA precursor sequences derived from             PCT/NL2007/000012         -   B. Small RNAs precursor sequences derived from public miRNA             database miRBase     -   25. Classification on the basis of predictive small RNA subset         for distinction between adenoma and adenocarcinoma         -   A. List of small RNAs that are selected by PAM as good             classifiers to distinguish colorectal adenoma from             adenocarcinoma tissue         -   B. Confusion tables before and after exclusion of the             selected set of small RNAs     -   26 Most significantly differentially expressed small RNAs         between adenomas and adenocarcinomas         -   List of small RNAs (N=384) that are differentially expressed             according to stringent statistical criteria (p<0.1). All of             these small RNAs are downregulated in adenocarcinomas             compared to adenomas (see also Fig. IIIc and IIId).     -   27 Selection of predictive small RNAs for classification of         adenomas vs adenocarcinomas         -   A selection of 91 small RNAs was made that can cluster             adenomas or adenocarcinomas highly predictable (p<0.0001)             (see also Fig IVa and IVb)     -   28 Small RNAs located on micro-deletions present in colorectal         carcinomas         -   Microdeletions of smaller than 3 megabases were determined             in colorectal carcinomas using array CGH data.         -   A, Small RNAs located in the determined deleted regions are             listed.         -   B, Differentially expressed small RNAs (adenoma vs             carcinoma) localized in the deleted regions are listed     -   29 Small RNAs located on micro-gains present in colorectal         carcinomas         -   Microgains of smaller than 3 megabases were determined in             colorectal carcinomas using array CGH data.         -   A, Small RNAs located in the determined microgain regions             are listed.         -   B, Differentially expressed small RNAs (adenoma vs             carcinoma) localized in the gained regions are listed     -   30 Small RNAs located on micro-deletion present in         microsatellite stable colorectal carcinomas         -   Microdeletions of smaller than 3 megabases were determined             in colorectal microsatellite stable carcinomas using array             CGH data. Small RNAs located in the determined deleted             regions are listed.     -   31 Small RNAs located on micro-gains present in microsatellite         stable colorectal carcinomas         -   Microgains of smaller than 3 megabases were determined in             colorectal microsatellite stable carcinomas using array CGH             data. A, Small RNAs located in the determined microgain             regions are listed. B, Differentially expressed small RNAs             (adenoma vs adenocarcinoma) localized in the gained regions             are listed     -   32 Small RNAs located on micro-deletions present in         microsatellite instable colorectal carcinomas         -   Microdeletions of smaller than 3 megabases were determined             in colorectal microsatellite instable carcinomas using array             CGH data.         -   A, Small RNAs located in the determined deleted regions are             listed.         -   B, Differentially expressed small RNAs (adenoma vs             adenocarcinoma) localized in the deleted regions are listed     -   33 Five small RNAs showed associated expression and DIVA copy         number levels in colorectal cancer.     -   The software program ACE-it integrated small RNA based         microarray data with array CGH data, determining whether         differences in expression of small RNAs is a consequence of DNA         copy number changes. Results show that expression of 5 small         RNAs is associated with DNA copy number changes.     -   34 Presence of classifiers distinguishing adenomas from         adenocarcinomas in faeces         -   This table includes small RNAs that were selected as good             classifiers in tables 25 and could be detected in faeces     -   35 Presence of classifiers distinguishing adenomas from         adenocarcinomas in blood         -   This table includes small RNAs that were selected as good             classifiers in tables 25 and could be detected in blood             The sequence of the small RNAs listed by name in the tables             1-35 is given in table 23. The sequence of associated             precursors is given in table 24. The sequence of a             collection of probes for the small RNAs of table 23 is given             in table 21.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1. a. Hierarchical cluster analysis of 36 colorectal adenoma samples and ten normal colorectal epithelium controls. Cluster analysis with expression data of 1554 small RNAs yields one cluster (cluster 1) containing six out of ten controls and a second cluster (cluster 2) containing 27 colorectal adenoma samples. Each column represents a colorectal (adenoma or control) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. Only a fraction of the complete heat chart is shown, indicating the clusters. b. Cross table adenomas and control samples versus cluster membership. Cluster 1 contains six controls and nine adenoma tumours and cluster 2 includes four control samples and 27 colorectal adenoma tumours. c and d. The same hierarchical clustering was performed on the basis of 852 small RNAs, that were differentially expressed with a p value<0.1 including a cross table. e and f. The same hierarchical clustering was performed on the basis of 359 small RNAs, that were differentially expressed with a p value<0.05 including a cross table. g. The same hierarchical clustering was performed on the basis of 230 small RNAs, that were differentially expressed with a p value<0.025. h. The same hierarchical clustering was performed on the basis of the best 23 predictive small RNAs.

FIG. 2. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and ten normal colorectal epithelium controls. Cluster analysis with expression data of 105 small RNAs yields one cluster (cluster 1) containing all ten control samples and a second cluster (cluster 2), including 26 colorectal carcinoma samples. Each column represents a colorectal (carcinoma or control) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. b. Cross table carcinomas and control samples versus cluster membership. Cluster 1 contains all ten control samples and five carcinoma tumours and cluster 2 includes 26 colorectal carcinomas. c and d. The same hierarchical clustering was performed on the basis of 44 small RNAs, that were differentially expressed with a p value<0.1 including a cross table.

FIG. 3. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and 36 colorectal adenomas. Cluster analysis with expression data of 1080 small RNAs yields one cluster (cluster 1) that includes 20 colorectal adenoma tumours and a second cluster (cluster 2), which comprises 24 of the colorectal carcinoma tumours. Each column represents a colorectal (carcinoma or adenoma) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. b. Cross table carcinomas and adenomas tumours samples versus cluster membership. Cluster 1 contains 20 colorectal adenoma tumours and seven colorectal carcinomas and cluster 2 contains 24 colorectal carcinomas and 16 colorectal adenoma samples. c and d. The same hierarchical clustering was performed on the basis of 384 small RNAs, that were differentially expressed with a p value<0.1 including a cross table.

FIG. 4. a. Hierarchical cluster analysis of 31 colorectal carcinomas samples and 36 colorectal adenomas. Cluster analysis with expression data of small RNAs yields one cluster (cluster 1) that includes 23 colorectal adenocarcinoma tumours and a second cluster (cluster 2), which comprises 28 of the colorectal adenoma tumours. Each column represents a colorectal (adenocarcinoma or adenoma) tissue sample and each row represents a different small RNA. In the heat map, green signals represent down-regulation, black signals indicate no differences in expression of small RNAs and red signals represents up-regulation. b. Cross table carcinomas and adenomas tumours samples versus cluster membership. Cluster 1 contains 8 colorectal adenoma tumours and 23 colorectal adenocarcinomas and cluster 2 contains 8 colorectal adenocarcinomas and 28 colorectal adenoma samples. The clustering is highly significant: p<0.0001.

FIG. 5. RT-PCR analysis of hsa-mir-24-2-1. RNA was isolated from 27 colorectal adenomas and 31 adenocarcinomas and Taqman PCR was performed. a, The expression levels of hsa-mir-24-2-1 RNA were detected and compared between the two groups. b, RT-PCR results were compared with expression level results for has-hir-24-2-1 as detected by microarray.

TABLE 1 Differentially expressed small RNAs in colorectal samples vs reference pool MAX log2 Systematic Name (Sample/REF) MIN log2 (Sample/REF) log2 range¹ Hsd_1_l 2.088695405 −1.912512559 4.001207964 HS_from_MM_216_l 3.039107456 −0.964247181 4.003354637 Hsd_95_r 3.436602675 −0.567767452 4.004370127 hsa-mir-519b_r 1.808824422 −2.195595466 4.004419888 HS_from_MQbrain_387_l 3.011798091 −0.99318349 4.004981581 HS_from_MQbrain_1453_l 3.18109327 −0.826023558 4.007116828 HS_146_l 1.925545312 −2.081708119 4.007253431 Hsd_108_r 1.995591703 −2.013406769 4.008998471 Hsd_33_r 2.141519065 −1.86783118 4.009350246 HS_from_MQbrain_1851_r 1.953336363 −2.057525604 4.010861967 HS_from_MQbrain_832_l 3.446216492 −0.566661909 4.012878401 HSbrain_695_l 1.63064494 −2.383156365 4.013801306 HS_from_MQbrain_285_r 1.034414575 −2.980175248 4.014589823 HSbrain_741_r 1.543845894 −2.470976079 4.014821974 HSbrain_421_l 2.072907825 −1.942291385 4.01519921 HSbrain_649_r 3.326270271 −0.688997381 4.015267653 Hsd_64_l 1.408247542 −2.608890571 4.017138113 hsa-mir-526a-2_l 2.708372776 −1.309295741 4.017668517 HS_from_MQbrain_782_l 1.743725561 −2.274212896 4.017938457 HS_155_r 2.837291129 −1.181419902 4.018711031 Hsd_61_l 2.219038295 −1.801406885 4.02044518 HS_70_l 2.52640836 −1.494414894 4.020823253 HSbrain_444_l 1.582704817 −2.438311287 4.021016104 HS_from_MQbrain_1024_r 3.014769503 −1.007329753 4.022099256 HSbrain_194_l 2.348967735 −1.673488376 4.022456112 HS_from_PT_48_r 2.631303094 −1.39222147 4.023524564 Hsd_from_Mmd_468_r 2.454803712 −1.568889086 4.023692798 HSbrain_273_l 1.831392763 −2.192600976 4.023993739 HS_74_l 3.265905838 −0.758224149 4.024129986 HSbrain_524_l 3.180726782 −0.843561389 4.024288171 HS_from_MM_299_r 2.292740527 −1.731689095 4.024429622 HS_from_MQbrain_689_r 2.222938714 −1.802712043 4.025650757 HS_from_MQbrain_1873_r 2.237532145 −1.788151021 4.025683166 Hsd_from_Mmd_383_l 3.448975628 −0.577051179 4.026026807 HS_from_MQbrain_222_l 2.584403955 −1.441772057 4.026176012 Hsd_from_Mmd_237_r 2.204167698 −1.822293249 4.026460947 HS_from_MQbrain_1332_r 1.428609239 −2.598212413 4.026821651 hsa-mir-190_l 0.962332185 −3.064623649 4.026955834 HS_from_MQbrain_345_l 2.472953718 −1.554177129 4.027130847 Hsd_from_Mmd_306_r 3.114214478 −0.913664866 4.027879344 HSbrain_1336_r 1.98318273 −2.044872431 4.028055161 hsa-mir-590_r 1.480590433 −2.547657779 4.028248213 Hsd_60_r 2.714183878 −1.314177354 4.028361232 hsa-mir-527_l 3.274510245 −0.75478888 4.029299126 hsa-mir-125b-1_l 1.669667452 −2.36030098 4.029968432 HS_from_MM_208_l 3.113520569 −0.918925647 4.032446216 Hsd_from_Mmd_42_r 1.788514504 −2.244615379 4.033129883 HS_from_MQbrain_779_r 3.074553118 −0.95948886 4.034041979 Hsd_97_l 3.120215279 −0.91479182 4.035007099 HS_from_MQbrain_717_l 3.336120523 −0.700043063 4.036163585 HS_from_MQbrain_995_l 1.923042913 −2.113284502 4.036327415 HSbrain_379_l 3.395930199 −0.640690918 4.036621116 HSbrain_360_r 1.399949752 −2.63714983 4.037099583 HSbrain_23_r 2.78275896 −1.254450749 4.037209709 HSbrain_46_r 2.613865567 −1.423787971 4.037653539 hsa-mir-450-2_l 0.985889776 −3.051941859 4.037831636 hsa-mir-299_r 2.867791219 −1.171901952 4.039693171 Hsd_from_Mmd_41_l 2.481504187 −1.558977032 4.040481219 HS_from_MQbrain_1734_l 3.746423731 −0.295131716 4.041555446 HS_from_MQbrain_1182_r 3.139834681 −0.902030206 4.041864887 HSbrain_665_r 1.487643319 −2.557027009 4.044670329 HSbrain_563_l 2.360039309 −1.684782813 4.044822122 HS_from_PT_292_l 1.685434947 −2.359996291 4.045431238 HSbrain_182_l 1.794410839 −2.252022992 4.046433831 HS_from_MQbrain_1197_l 3.110590697 −0.936448606 4.047039303 Hsd_from_Mmd_49_r 2.579386826 −1.468504049 4.047890874 hsa-mir-583_l 2.230582983 −1.820568126 4.051151108 HS_298_r 2.975580603 −1.077341264 4.052921867 HS_210_l 3.005408513 −1.049259575 4.054668089 HS_from_MQbrain_1216_l 2.724796118 −1.330579318 4.055375436 HS_from_MQbrain_1108_r 2.862237119 −1.193744151 4.05598127 HSbrain_579_r 1.40925375 −2.647444316 4.056698066 HS_from_MM_6_r 3.124595142 −0.933246204 4.057841346 Hsd_from_Mmd_180_l 1.610394113 −2.447473763 4.057867876 HS_from_MQbrain_1214_l 2.82335625 −1.23529739 4.05865364 HS_from_MQbrain_1757_l 3.146647396 −0.912182423 4.058829818 HS_from_MQbrain_984_r 3.299222196 −0.761264239 4.060486435 Hsd_68_l 3.407872364 −0.652984039 4.060856403 Hsd_from_Mmd_167_l 3.307979739 −0.755409571 4.06338931 HS_from_PT_210_l 1.555223227 −2.508438651 4.063661879 hsa-mir-29c_l 2.251504167 −1.812858532 4.064362698 HS_from_MQbrain_946_l 2.987652722 −1.081392757 4.069045479 Hsd_from_Mmd_336_l 2.685058565 −1.384237172 4.069295737 HSbrain_11_l 1.50304215 −2.566901844 4.069943994 HS_210_r 2.548656471 −1.521791374 4.070447845 HS_from_MQbrain_766_r 1.495004303 −2.575468452 4.070472755 HS_from_MQbrain_1504_l 1.928779508 −2.143286333 4.072065841 HS_from_PT_221_l 3.113947553 −0.958652008 4.072599561 HS_241_r 2.727132873 −1.345845446 4.072978319 hsa-mir-450-1_l 0.967359793 −3.107519985 4.074879778 HSbrain_2_r 1.714101263 −2.364273227 4.07837449 HS_from_MM_112_r 2.766784429 −1.31191063 4.078695059 hsa-mir-429_r 3.270712052 −0.808687162 4.079399213 Hsd_from_Mmd_272_r 2.686690588 −1.39497378 4.081664368 HSbrain_294_r 1.93035153 −2.156250764 4.086602294 hsa-mir-525_r 3.499359361 −0.59153303 4.090892391 hsa-mir-32_r 1.511270971 −2.580050206 4.091321177 hsa-mir-194-2_l 1.877987368 −2.213953242 4.091940609 HSbrain_601_l 1.447126351 −2.645387932 4.092514283 hsa-mir-146b_l 1.231334378 −2.862293453 4.093627831 Hsd_from_Mmd_518_r 2.983229897 −1.110549566 4.093779463 HS_from_MQbrain_744_l 1.996266499 −2.099304092 4.095570591 HS_from_MQbrain_613_r 3.331023916 −0.764672498 4.095696414 HS_from_MQbrain_1663_r 1.446639428 −2.649696845 4.096336273 HSbrain_750_l 2.08655999 −2.011722123 4.098282113 hsa-mir-194-1_l 1.930819662 −2.168480826 4.099300489 HS_from_MQbrain_740_l 2.298572839 −1.801408165 4.099981003 HS_232_r 1.212775317 −2.888763224 4.10153854 Hsd_from_Mmd_413_l 3.254011952 −0.847828032 4.101839983 HS_242_l 3.281061296 −0.821383269 4.102444565 hsa-mir-302d_r 1.134037131 −2.969490448 4.103527579 HS_13_r 3.325827789 −0.778265765 4.104093555 HSbrain_33_r 2.646811644 −1.458438688 4.105250333 Hsd_66_l 2.387342505 −1.717921714 4.10526422 hsa-mir-639_r 3.362748936 −0.742532587 4.105281523 HS_from_MQbrain_1048_r 3.368346417 −0.736954975 4.105301392 hsa-mir-630_l 0.934157367 −3.172776941 4.106934308 HS_from_MQbrain_21_l 1.739970275 −2.367317237 4.107287512 HSbrain_127_r 0.842157726 −3.267834226 4.109991953 Hsd_from_Mmd_69_l 3.35164685 −0.758839345 4.110486195 HS_from_MQbrain_198_l 3.019877358 −1.090753169 4.110630528 HS_from_MQbrain_198_l 2.446960973 −1.66685195 4.113812923 HS_from_MQbrain_663_l 1.257822727 −2.857700652 4.115523379 HSbrain_1387_l 2.551619155 −1.564398693 4.116017848 hsa-mir-486_r 2.253616104 −1.862596947 4.116213052 hsa-mir-424_l 1.874062513 −2.242250797 4.116313311 HSbrain_566_r 3.063293636 −1.053635725 4.116929361 HSbrain_1392_l 2.525149812 −1.591990324 4.117140135 HSbrain_100_r 3.126583282 −0.990797952 4.117381235 HS_from_PT_108_l 3.792884876 −0.325020225 4.117905101 HS_from_MQbrain_261_r 2.72514481 −1.394675248 4.119820057 HS_from_MQbrain_549_r 2.403950881 −1.716060047 4.120010928 HSbrain_668_r 3.09183027 −1.028865429 4.120695699 HSbrain_125_l 1.812802385 −2.308656215 4.1214586 HSbrain_815_l 1.494998806 −2.627703969 4.122702775 HS_from_MQbrain_366_l 1.873826288 −2.249669571 4.123495859 HS_from_MQbrain_1306_l 3.481994339 −0.642164797 4.124159135 HS_from_MQbrain_637_l 3.269301702 −0.855197558 4.12449926 HS_from_MQbrain_1055_l 3.826461999 −0.298321824 4.124783823 hsa-mir-182_l 3.043662609 −1.082124344 4.125786953 HS_from_PT_134_r 1.677604376 −2.448920174 4.12652455 HS_from_MQbrain_283_l 1.511361471 −2.615228726 4.126590197 HSbrain_421_r 2.294092029 −1.833066173 4.127158202 hsa-mir-606_r 1.673921879 −2.454731269 4.128653148 HS_from_MM_123_r 2.41352431 −1.71625623 4.12978054 HSbrain_670_l 2.568284445 −1.56212134 4.130405785 HS_from_MQbrain_1112_l 2.498183737 −1.634144642 4.13232838 Hsd_56_l 2.102749876 −2.030606037 4.133355913 HS_from_MQbrain_1682_r 2.090005371 −2.044755865 4.134761237 HS_from_MQbrain_663_r 2.865084367 −1.269689425 4.134773792 HS_269_r 3.826634218 −0.309441006 4.136075224 HSbrain_341_r 1.858468781 −2.279907256 4.138376036 HS_from_MQbrain_1779_l 2.793138989 −1.346080788 4.139219777 HSbrain_491_l 1.302048165 −2.837651231 4.139699395 hsa-mir-98_l 0.966572026 −3.173625248 4.140197274 HS_from_PT_70_l 1.059894906 −3.082005806 4.141900712 HS_from_MQbrain_1656_r 2.347722084 −1.797177196 4.14489928 HS_from_MQbrain_1410_l 2.1604767 −1.984558858 4.145035557 HS_203_r 1.993454149 −2.15178467 4.14523882 HSbrain_274_r 2.551357842 −1.595269122 4.146626965 HSbrain_848_l 2.826198231 −1.320514298 4.146712528 Hsd_from_Mmd_326_r 2.412744392 −1.735454736 4.148199128 HSbrain_561_r 4.051652073 −0.099717017 4.151369091 HS_from_MQbrain_1235_l 3.416522189 −0.735166181 4.15168837 HSbrain_439_l 1.289303857 −2.862525771 4.151829629 HS_from_MQbrain_1711_l 3.497043706 −0.655263539 4.152307245 hsa-mir-653_r 0.98182448 −3.171621167 4.153445647 HS_from_MM_44_r 2.804739701 −1.349347414 4.154087115 HSbrain_595_l 1.463193402 −2.694308006 4.157501407 HS_from_MQbrain_545_l 3.22663762 −0.931256531 4.15789415 HS_249_r 1.514697456 −2.644437886 4.159135342 HSbrain_64_r 1.971703045 −2.187896901 4.159599947 HS_from_MQbrain_952_l 3.446889258 −0.718850097 4.165739355 HSbrain_486_r 1.897118787 −2.268757685 4.165876473 hsa-mir-675_l 3.115834412 −1.051639823 4.167474235 HS_from_MM_339_l 1.597557716 −2.571789523 4.169347238 HSbrain_344_r 1.467181102 −2.703440434 4.170621536 HS_from_MQbrain_1525_r 2.789776074 −1.381436483 4.171212557 HS_from_MQbrain_1880_l 3.193429908 −0.978119046 4.171548954 HSbrain_259_l 3.182274869 −0.989342132 4.171617001 HS_36_l 2.048680384 −2.124225689 4.172906073 HSbrain_1398_l 2.411483784 −1.761492961 4.172976745 hsa-mir-504_l 3.725684236 −0.449577893 4.175262129 HSbrain_490_r 2.474326459 −1.702004657 4.176331116 hsa-mir-518a-1_l 3.217992148 −0.958678037 4.176670184 hsa-mir-502_r 3.042089261 −1.135977424 4.178066684 HS_from_MQbrain_1760_l 2.670972591 −1.508208772 4.179181363 HS_from_MQbrain_1685_r 2.747861927 −1.433994718 4.181856645 HS_51_r 0.981611798 −3.202059726 4.183671524 HS_from_MQbrain_638_l 1.253620613 −2.931319081 4.184939694 Hsd_68_l 2.193173751 −1.991888607 4.185062359 hsa-mir-34b_r 1.448020386 −2.737588019 4.185608405 hsa-mir-575_l 3.249553651 −0.937042648 4.186596299 HSbrain_645_r 2.889118823 −1.29773156 4.186850383 HS_80_r 3.559275497 −0.627597731 4.186873227 hsa-mir-1-2_r 1.726687457 −2.460219642 4.186907098 HSbrain_240_r 1.808684952 −2.378448037 4.187132989 HS_from_MQbrain_1261_l 0.989075555 −3.198383282 4.187458837 HSbrain_209_r 2.441264501 −1.746557031 4.187821532 Hsd_from_Mmd_54_r 2.481322129 −1.707213145 4.188535274 HS_from_MQbrain_31_l 3.528457094 −0.660289124 4.188746218 HS_248_r 1.565168322 −2.624393107 4.189561428 HSbrain_88_r 2.495129206 −1.695239284 4.19036849 HS_from_MQbrain_297_l 1.937994705 −2.252672464 4.190667169 HSbrain_682_r 1.410233792 −2.780493784 4.190727576 HS_from_MQbrain_1474_r 2.129160072 −2.063207402 4.192367474 Hsd_from_Mmd_184_r 1.692567998 −2.499800673 4.192368671 hsa-mir-148a_r 2.381580191 −1.811256667 4.192836858 HS_from_MQbrain_1325_r 3.40225604 −0.79135648 4.19361252 HSbrain_414_l 1.257763203 −2.937220384 4.194983586 HS_from_MM_236_l 3.202704643 −0.99362294 4.196327582 HS_from_MQbrain_634_l 1.69303102 −2.504197611 4.197228631 HS_from_MQbrain_572_l 1.50074111 −2.701387364 4.202128474 hsa-mir-99a_l 1.502009642 −2.700136694 4.202146337 HS_from_PT_157_l 2.462685253 −1.740216562 4.202901815 HSbrain_1391_l 2.671096297 −1.532233245 4.203329541 HS_from_MQbrain_1778_r 2.934787151 −1.26895031 4.203737461 HS_161_l 1.674576671 −2.530254246 4.204830917 HS_from_MQbrain_1985_l 3.558937263 −0.646414954 4.205352217 HSbrain_354_r 3.215840235 −0.989522007 4.205362242 HSbrain_358_l 3.050110083 −1.156063694 4.206173777 HSbrain_1408_l 1.59049657 −2.616103125 4.206599695 HS_from_MQbrain_135_r 2.52167077 −1.686270916 4.207941686 HS_from_MQbrain_1_l 2.618807889 −1.590013898 4.208821787 HSbrain_280_l 2.400542218 −1.811399359 4.211941577 HSbrain_810_r 1.526197944 −2.687063483 4.213261427 HS_from_MQbrain_1217_l 2.951744954 −1.261942862 4.213687816 HS_from_MM_178_l 2.777706709 −1.437120908 4.214827616 HSbrain_737_r 2.512564121 −1.704063393 4.216627514 HSbrain_552_l 2.860555433 −1.356572784 4.217128217 HS_from_MQbrain_820_r 1.545176254 −2.672133591 4.217309845 Hsd_from_Mmd_81_l 2.472179995 −1.74637033 4.218550325 HS_from_MQbrain_1756_r 1.681853948 −2.536721437 4.218575385 HS_from_MQbrain_1195_r 1.885039255 −2.333704713 4.218743968 HS_from_MM_194_r 3.005858693 −1.213331908 4.219190601 Hsd_from_Mmd_326_l 1.716092716 −2.503314163 4.219406879 HS_from_MQbrain_63_r 1.519160307 −2.702599207 4.221759513 HS_from_MQbrain_1849_l 3.839096883 −0.382995879 4.222092763 HS_from_PT_294_l 2.934016726 −1.289998538 4.224015264 hsa-mir-635_r 0.928797317 −3.296314912 4.225112229 HSbrain_736_r 2.710837276 −1.514896277 4.225733554 Hsd_from_Mmd_266_l 1.401547647 −2.825134496 4.226682143 HSbrain_172_l 3.029809819 −1.196882004 4.226691823 Hsd_from_Mmd_461_r 3.638050804 −0.589232538 4.227283342 HS_from_MQbrain_450_l 1.868517764 −2.35909134 4.227609104 HSbrain_436_r 2.923867369 −1.303801843 4.227669212 Hsd_from_Mmd_464_l 2.308890741 −1.920451642 4.229342384 hsa-mir-205_l 3.176538808 −1.057279883 4.233818691 HS_from_MQbrain_484_l 2.916214688 −1.317725066 4.233939754 Hsd_from_Mmd_225_r 2.907514253 −1.327273348 4.234787601 HSbrain_616_l 3.607147454 −0.628332803 4.235480257 HSbrain_680_r 1.472380281 −2.763715095 4.236095376 Hsd_39_r 3.060942071 −1.175793781 4.236735853 HSbrain_612_r 3.328984449 −0.908882357 4.237866806 HS_from_MM_294_l 2.811442111 −1.426899879 4.238341991 HS_80_l 3.517733101 −0.725042388 4.242775489 HS_from_MM_310_r 2.782446733 −1.460597803 4.243044536 HS_from_PT_176_r 3.245762647 −1.000908258 4.246670905 HS_from_MQbrain_799_l 3.595960369 −0.651540194 4.247500563 HS_86_l 2.379766914 −1.868806993 4.248573906 HS_from_MQbrain_1885_l 1.245427632 −3.005778939 4.251206571 HSbrain_76_r 1.50817019 −2.746517086 4.254687277 HS_from_MQbrain_1396_l 2.443623064 −1.812361766 4.25598483 HS_from_MQbrain_869_r 3.610900505 −0.645668315 4.256568821 hsa-mir-302a_r 1.230869052 −3.027608594 4.258477647 HS_from_MQbrain_1300_l 3.768112955 −0.490898468 4.259011423 HSbrain_537_l 2.13090412 −2.128153839 4.259057958 HS_from_MQbrain_1856_l 3.301347997 −0.958010544 4.25935854 HSbrain_674_l 2.805619786 −1.455808413 4.261428199 Hsd_109_l 2.223976209 −2.039753844 4.263730053 HS_from_MQbrain_1489_l 3.112857587 −1.150941421 4.263799007 HS_from_MQbrain_579_l 3.413818624 −0.850427918 4.264246542 HS_303_l 1.686349724 −2.579990869 4.266340593 HS_from_MQbrain_150_r 1.317629296 −2.949323637 4.266952934 HSbrain_485_l 2.718807568 −1.548574948 4.267382515 HS_from_MQbrain_68_r 2.204805375 −2.063481157 4.268286531 hsa-mir-199a-2_r 1.898521955 −2.371665771 4.270187726 HSbrain_629_r 1.551897427 −2.718549113 4.27044654 Hsd_from_Mmd_263_r 2.9987514 −1.273122535 4.271873935 HS_from_MQbrain_1387_l 2.950511517 −1.323862732 4.274374249 hsa-mir-518a-2_l 3.541635836 −0.737015883 4.278651719 HS_156_r 2.35772661 −1.922889953 4.280616563 HS_from_MQbrain_1322_r 2.965520841 −1.317796304 4.283317145 HSbrain_37_r 1.417208531 −2.868417211 4.285625742 Hsd_78_l 2.638054745 −1.64824861 4.286303355 HS_207_r 3.680232978 −0.60794586 4.288178838 Hsd_from_Mmd_23_r 1.292673035 −2.996174822 4.288847858 HS_from_MQbrain_106_l 1.942789396 −2.34615461 4.288944006 HS_from_MQbrain_1345_l 2.59664488 −1.693143144 4.289788024 HSbrain_684_r 1.465370969 −2.82459941 4.289970379 HS_from_PT_118_r 3.968735645 −0.321653838 4.290389483 HSbrain_120_l 3.00499768 −1.287502149 4.292499829 HSbrain_315_r 1.472305455 −2.821264784 4.293570239 HSbrain_287_r 2.849961269 −1.444781236 4.294742505 hsa-mir-107_r 1.993410686 −2.3019042 4.295314886 Hsd_35_r 3.230763888 −1.065574345 4.296338233 HS_247_r 1.560942652 −2.735473232 4.296415884 HS_from_MQbrain_1746_l 3.111397024 −1.185339352 4.296736376 HS_from_MQbrain_578_l 2.764554074 −1.532398648 4.296952723 HS_from_PT_301_r 2.180273215 −2.1170404 4.297313615 HS_from_MQbrain_836_l 2.785167893 −1.514221257 4.29938915 HSbrain_869_l 1.687597965 −2.61309708 4.300695045 HSbrain_209_l 3.548747368 −0.755661606 4.304408974 HS_from_PT_211_l 2.902527183 −1.403507999 4.306035182 HS_from_MQbrain_451_r 1.019967237 −3.286548425 4.306515662 HSbrain_1331_r 3.579692118 −0.727316755 4.307008873 Hsd_59_l 2.691558346 −1.616238627 4.307796973 HS_from_MQbrain_339_l 3.305410559 −1.003192418 4.308602977 HS_from_MQbrain_1522_l 2.800381489 −1.510695647 4.311077135 HS_from_MQbrain_385_l 3.237637453 −1.073728609 4.311366062 HS_55_l 1.722065182 −2.590618285 4.312683467 HS_from_MQbrain_635_l 1.658237403 −2.656390086 4.314627489 hsa-mir-320_r 2.706082085 −1.609750237 4.315832323 HSbrain_673_r 1.501956895 −2.814291249 4.316248144 HS_from_MQbrain_91_l 2.363727935 −1.952949293 4.316677228 HS_from_MQbrain_80_l 2.864297039 −1.453562797 4.317859836 HS_from_MQbrain_281_r 1.76433421 −2.554908026 4.319242236 HS_from_MQbrain_932_l 1.614404263 −2.704963908 4.319368171 HS_from_MQbrain_778_r 3.243268583 −1.076769934 4.320038517 Hsd_from_Mmd_293_l 1.530646274 −2.789430607 4.320076881 HSbrain_492_r 3.37112138 −0.950022151 4.321143531 HS_from_MQbrain_904_r 3.01547216 −1.306889582 4.322361741 HSbrain_134_l 2.913704299 −1.410680816 4.324385114 HS_from_PT_55_r 1.702808701 −2.621922146 4.324730846 HSbrain_630_r 1.437649162 −2.88773263 4.325381792 Hsd_from_Mmd_382_r 4.061472311 −0.265165071 4.326637382 HS_from_MQbrain_398_l 3.327522246 −0.999576342 4.327098587 hsa-mir-574_l 1.800159605 −2.527710871 4.327870476 HS_from_MM_334_l 2.441453922 −1.886565596 4.328019518 HS_246_r 1.645801886 −2.683296681 4.329098567 Hsd_from_Mmd_515_r 3.418010274 −0.912720525 4.3307308 hsa-mir-145_r 2.776275383 −1.554693859 4.330969242 HS_from_MQbrain_244_l 2.847057079 −1.487503511 4.33456059 HS_from_MQbrain_1327_r 3.716135032 −0.620138116 4.336273147 hsa-mir-146a_l 1.751434667 −2.585843672 4.337278339 HS_from_MQbrain_284_l 3.546036194 −0.793745822 4.339782016 HS_from_MQbrain_1553_l 1.638201508 −2.702270891 4.340472399 HSbrain_620_r 2.145542525 −2.19517459 4.340717115 hsa-mir-30a_l 1.356214192 −2.984587855 4.340802047 hsa-mir-302b_l 2.93276614 −1.411032981 4.343799121 HSbrain_688_r 3.114665698 −1.230112179 4.344777877 HSbrain_363_r 2.121405211 −2.225401911 4.346807122 HSbrain_666_l 2.562979559 −1.784301651 4.34728121 HS_from_MQbrain_922_r 2.658152261 −1.689314118 4.347466378 Hsd_79_r 3.259391947 −1.089850572 4.349242518 HS_from_MQbrain_954_r 1.630346726 −2.723582546 4.353929272 HSbrain_677_r 1.495676583 −2.859143772 4.354820355 HS_from_MQbrain_1670_r 2.754544435 −1.600565308 4.355109743 HSbrain_669_r 1.430328027 −2.925989464 4.356317492 hsa-mir-520d_r 2.847548728 −1.509966377 4.357515105 HSbrain_519_l 3.691255539 −0.666768683 4.358024222 HSbrain_1388_l 2.716374763 −1.643334542 4.359709305 HS_from_PT_95_l 1.73042541 −2.630740693 4.361166103 HS_179_r 1.614599929 −2.748003316 4.362603246 hsa-mir-451_l 2.184012027 −2.178954894 4.362966922 HS_from_MQbrain_741_l 1.394403683 −2.968605749 4.363009431 HS_from_MQbrain_1424_r 1.578189632 −2.786536503 4.364726135 Hsd_111_l 2.177414337 −2.187565567 4.364979904 HSbrain_477_l 3.356586104 −1.00848162 4.365067723 HS_277_r 1.616373868 −2.756902974 4.373276842 HSbrain_198_l 1.514081575 −2.864075011 4.378156586 HS_from_MQbrain_54_r 2.069520645 −2.310045271 4.379565915 HS_from_MM_299_l 1.877993675 −2.503341883 4.381335558 Hsd_from_Mmd_181_l 4.044579996 −0.339367355 4.383947351 HS_from_MQbrain_1721_r 3.267494953 −1.11686394 4.384358893 HS_17_r 2.958938895 −1.431731886 4.390670781 HSbrain_357_r 1.88320241 −2.508549736 4.391752146 HS_from_MQbrain_1815_l 1.863856722 −2.528287591 4.392144313 HS_from_MQbrain_115_l 1.73172028 −2.660450811 4.39217109 HS_from_MM_264_l 3.187804117 −1.204639433 4.39244355 HS_from_PT_99_l 4.187204332 −0.207565199 4.39476953 HS_from_MQbrain_499_r 2.915614281 −1.479420493 4.395034773 HS_from_MQbrain_476_r 3.652782317 −0.743903218 4.396685535 hsa-mir-15b_l 1.171609006 −3.225080876 4.396689881 HSbrain_592_r 3.12628873 −1.27307126 4.39935999 Hsd_56_l 3.329760494 −1.072669427 4.402429922 HS_from_MQbrain_1322_l 2.298050317 −2.105139368 4.403189685 HSbrain_656_l 2.995302493 −1.408744426 4.404046919 Hsd_from_Mmd_435_r 1.965877521 −2.438930551 4.404808071 HS_14_r 2.279108528 −2.127372705 4.406481233 HS_from_MM_70_l 1.470797877 −2.93634624 4.407144117 HS_from_MQbrain_113_l 3.305005418 −1.10233229 4.407337709 HSbrain_65_l 2.857530515 −1.550065162 4.407595677 Hsd_from_Mmd_262_l 3.349068609 −1.059783835 4.408852444 HSbrain_678_l 2.702675258 −1.706371763 4.409047021 hsa-mir-142_r 0.446226699 −3.963478719 4.409705419 HS_from_MQbrain_1286_l 3.236714118 −1.176377798 4.413091916 HS_from_MQbrain_536_l 1.766898397 −2.649369834 4.416268231 HSbrain_61_l 1.751028569 −2.665635932 4.4166645 HSbrain_687_r 1.53020899 −2.886588647 4.416797637 HSbrain_1_l 2.110848824 −2.308051191 4.418900016 HSbrain_308_l 3.658177289 −0.760843683 4.419020972 hsa-mir-139_r 3.346487837 −1.072811228 4.419299065 HSbrain_550_l 1.974672856 −2.447238634 4.42191149 HS_from_PT_305_l 3.254701005 −1.168910361 4.423611366 Hsd_from_Mmd_468_l 3.370104224 −1.053626532 4.423730757 HS_from_MM_172_l 1.169829365 −3.256401768 4.426231133 HS_from_MM_283_r 3.179469573 −1.247560791 4.427030364 hsa-mir-372_l 3.260736336 −1.167100664 4.427837 HS_from_MQbrain_1585_r 1.655543967 −2.776140391 4.431684358 HS_1_l 2.833567324 −1.599596683 4.433164007 hsa-mir-23b_l 3.011159748 −1.422148221 4.433307969 HS_282_l 3.513870872 −0.920969256 4.434840128 HS_from_MQbrain_738_l 2.929959668 −1.505719088 4.435678756 HSbrain_449_r 1.730175496 −2.709151333 4.439326829 HS_from_MQbrain_1279_r 2.440884923 −2.000568538 4.441453461 HS_from_MQbrain_99_l 2.627467917 −1.814476687 4.441944603 HSbrain_325_r 1.930462567 −2.512357187 4.442819754 HSbrain_210_r 1.917791002 −2.529124663 4.446915666 HS_from_MQbrain_112_r 2.944931331 −1.503200661 4.448131992 hsa-mir-769_l 3.23305404 −1.218437305 4.451491345 HSbrain_667_l 2.847266892 −1.604802788 4.45206968 HSbrain_683_l 2.821294245 −1.631661787 4.452956032 HSbrain_45_l 2.101526263 −2.351898115 4.453424377 Hsd_from_Mmd_294_l 2.456098611 −1.998348032 4.454446643 HS_from_MQbrain_2689_r 3.324416377 −1.131968296 4.456384674 HSbrain_427_l 3.816463754 −0.645996005 4.462459759 Hsd_from_Mmd_437_r 2.587319388 −1.875230042 4.462549431 HSbrain_427_r 3.274557686 −1.189431959 4.463989645 hsa-mir-519c_r 1.411687272 −3.055395521 4.467082793 HS_from_MM_292_l 1.330865479 −3.138464895 4.469330374 HS_from_MQbrain_458_r 2.762590489 −1.708300044 4.470890533 HS_from_MQbrain_270_l 2.427057688 −2.044857075 4.471914763 HS_from_MQbrain_1112_r 2.836725338 −1.636028691 4.472754029 HS_from_MQbrain_1546_r 2.026857743 −2.446318376 4.473176119 Hsd_51_r 3.268384618 −1.205432003 4.473816621 HS_from_PT_3_l 2.862514315 −1.611509863 4.474024179 HS_from_PT_155_r 3.146539722 −1.328212909 4.474752632 HS_from_MQbrain_1792_l 3.694645407 −0.780305388 4.474950795 HS_from_MQbrain_366_r 2.699618632 −1.776038681 4.475657313 HS_from_MQbrain_883_l 3.69681464 −0.779545386 4.476360026 HS_from_MM_105_l 1.711052783 −2.767859192 4.478911975 hsa-let-7a-2_l 1.283354756 −3.199923534 4.48327829 HSbrain_356_r 2.144223548 −2.340345355 4.484568903 HS_from_MQbrain_350_r 3.208448604 −1.27992208 4.488370684 HS_266_r 2.936367584 −1.552977041 4.489344625 HS_255_l 3.054441067 −1.436439891 4.490880957 Hsd_52_l 2.877644595 −1.615144472 4.492789067 HS_from_MQbrain_118_r 3.603659469 −0.890473388 4.494132857 HSbrain_580_l 1.496287112 −2.998426375 4.494713487 HS_270_l 3.593561927 −0.906035898 4.499597825 HS_from_MQbrain_1092_l 1.899448204 −2.601928834 4.501377038 Hsd_from_Mmd_226_l 1.31223755 −3.192258052 4.504495602 HSbrain_387_l 2.87116755 −1.633510028 4.504677579 HSbrain_449_l 2.600768007 −1.907137901 4.507905908 HSbrain_137_r 3.092871639 −1.415834041 4.508705681 Hsd_from_Mmd_69_r 1.332468024 −3.17780478 4.510272804 HSbrain_1305_l 3.070453573 −1.439904175 4.510357748 HSbrain_559_r 1.311678919 −3.200744976 4.512423895 hsa-mir-522_r 2.464862857 −2.048022208 4.512885065 HS_from_MQbrain_1782_r 1.639263872 −2.87373984 4.513003712 HS_from_MQbrain_1507_r 3.842852849 −0.670182731 4.51303558 HS_from_MQbrain_1552_l 3.85137131 −0.662960439 4.51433175 HS_215_r 3.47796408 −1.037817097 4.515781178 HS_from_MQbrain_471_l 2.580477757 −1.935713839 4.516191596 HS_from_MQbrain_1558_l 3.698728559 −0.818218931 4.516947491 HSbrain_314_r 3.203836216 −1.314579638 4.518415854 HS_from_MQbrain_1620_r 2.297687402 −2.22075291 4.518440312 HSbrain_248_r 2.625010945 −1.894332557 4.519343501 HS_from_MM_120_l 3.088821529 −1.430865824 4.519687353 hsa-mir-153-2_l 1.040941445 −3.481560724 4.522502169 HS_from_MQbrain_1034_r 3.127449244 −1.396056107 4.523505351 HS_from_PT_26_r 2.941680303 −1.583530072 4.525210374 Hsd_from_Mmd_197_r 2.725489619 −1.800780811 4.52627043 HSbrain_223_r 3.480320951 −1.046593962 4.526914914 HS_from_MQbrain_709_r 1.922231476 −2.605796413 4.528027889 HS_303_l 1.884663028 −2.649317147 4.533980175 HS_from_MQbrain_346_r 2.619417953 −1.916393902 4.535811855 HSbrain_525_r 1.903359782 −2.63259443 4.535954212 HS_from_MQbrain_14_l 3.160424873 −1.379272393 4.539697267 HS_from_MQbrain_72_l 3.8663402 −0.674416791 4.540756991 HS_from_MQbrain_131_l 3.577445645 −0.964918599 4.542364244 HS_293_r 3.726624217 −0.816128471 4.542752689 HSbrain_198_r 3.254203304 −1.28980211 4.544005414 Hsd_69_l 2.893291378 −1.650766011 4.54405739 HS_239_r 3.393133156 −1.152324612 4.545457769 HS_243_l 2.925307082 −1.623932342 4.549239424 HS_from_MM_103_r 2.703439033 −1.845835577 4.549274609 HSbrain_110_l 1.645810531 −2.903885229 4.54969576 HS_from_MQbrain_118_l 3.283241084 −1.266561381 4.549802464 HS_from_MM_283_l 2.767294378 −1.785355658 4.552650036 HSbrain_170_l 3.52711995 −1.025868775 4.552988725 HSbrain_608_r 2.871169843 −1.682701268 4.553871111 HS_from_MQbrain_1612_r 2.042791017 −2.511168193 4.55395921 HS_from_MQbrain_594_l 3.046755258 −1.509472285 4.556227542 HS_from_MQbrain_484_r 2.761435223 −1.799275478 4.560710701 hsa-mir-7-3_l 2.956272869 −1.604442698 4.560715567 HSbrain_806_l 2.576344432 −1.985092208 4.561436641 hsa-mir-644_l 2.139841722 −2.422250025 4.562091746 HS_from_MM_153_r 3.176592499 −1.387208126 4.563800625 HS_from_PT_40_l 2.29564242 −2.271794708 4.567437128 Hsd_from_Mmd_353_r 2.908039613 −1.664269151 4.572308764 HS_from_MQbrain_478_l 3.87424015 −0.698209618 4.572449768 Hsd_from_Mmd_494_l 2.062189458 −2.511111728 4.573301186 HS_from_MQbrain_76_r 3.463870673 −1.109572924 4.573443598 HSbrain_712_r 2.210055746 −2.3651778 4.575233545 hsa-mir-615_r 2.872152528 −1.70512199 4.577274517 HS_from_MQbrain_325_r 2.013062823 −2.564421029 4.577483852 HSbrain_136_l 3.262845735 −1.317027782 4.579873517 HSbrain_1437_r 2.641918297 −1.938728227 4.580646525 HS_from_MQbrain_436_r 1.338217093 −3.243051772 4.581268865 HS_from_MQbrain_465_l 3.494207424 −1.087087336 4.58129476 HS_38_r 1.930212885 −2.657422927 4.587635811 HS_143_l 2.688590054 −1.899072336 4.58766239 HS_269_l 3.59985888 −0.987989834 4.587848713 hsa-mir-16-1_l 1.713130507 −2.877698901 4.590829408 HSbrain_297_r 1.857831981 −2.737274685 4.595106666 HS_from_MQbrain_1723_l 3.16533212 −1.430651344 4.595983464 HSbrain_725_l 2.603417138 −1.993933701 4.597350839 HS_291_r 2.657557971 −1.940041489 4.597599459 HSbrain_27_l 1.1841553 −3.415107586 4.599262886 hsa-mir-15a_l 1.311847976 −3.289656486 4.601504462 HS_from_MQbrain_1325_l 3.274854262 −1.327730524 4.602584786 hsa-mir-559_l 1.74049034 −2.863272859 4.603763199 HS_296_r 3.670682358 −0.934935245 4.605617603 HS_from_MQbrain_1463_r 3.023733191 −1.582584711 4.606317903 hsa-mir-10b_l 2.441199589 −2.165609909 4.606809498 HS_from_MM_40_r 3.816348891 −0.79143766 4.607786551 HS_from_MQbrain_656_l 3.320716895 −1.287500265 4.608217159 HS_from_MQbrain_1584_r 1.583737691 −3.024762003 4.608499694 hsa-mir-221_l 3.188155557 −1.423138768 4.611294325 HS_from_MQbrain_1958_l 3.640767565 −0.97169984 4.612467406 HS_from_MQbrain_343_r 3.352393225 −1.2610524 4.613445626 hsa-mir-184_l 1.923843766 −2.691092784 4.614936551 HS_224_l 3.493750704 −1.123113155 4.61686386 Hsd_49_l 1.631949419 −2.985919283 4.617868703 HS_from_MM_305_r 1.966746456 −2.651920635 4.618667091 Hsd_from_Mmd_412_r 1.409505326 −3.20932782 4.618833146 HSbrain_203_r 3.519377561 −1.099634942 4.619012503 hsa-mir-7-2_l 3.014182935 −1.606124546 4.620307481 HSbrain_116_r 1.382934557 −3.24282889 4.625763448 HS_from_MQbrain_151_l 3.212830892 −1.413130286 4.625961178 hsa-mir-129-1_r 3.465041908 −1.161114235 4.626156143 hsa-mir-127_l 4.034286121 −0.593971364 4.628257485 HS_from_MQbrain_211_l 2.75908417 −1.873385059 4.632469229 HSbrain_170_r 2.472068757 −2.162096701 4.634165457 HSbrain_178_r 3.482942501 −1.151768997 4.634711497 HS_from_MM_155_l 1.38167318 −3.253679639 4.635352819 HSbrain_389_l 3.225268717 −1.41225515 4.637523867 HS_from_MQbrain_1503_r 3.942616983 −0.697998271 4.640615253 Hsd_from_Mmd_461_l 4.389062425 −0.252921143 4.641983569 HSbrain_454_r 3.63277761 −1.010458004 4.643235614 HS_from_MQbrain_1795_r 3.225071288 −1.420381056 4.645452344 HS_from_PT_206_r 1.224782289 −3.420691168 4.645473457 HS_from_MQbrain_1439_l 3.860235729 −0.789688181 4.64992391 HSbrain_284_l 1.934599805 −2.718177339 4.652777144 HS_193_l 2.258310122 −2.394683737 4.652993859 hsa-let-7a-1_l 1.260886496 −3.393741485 4.654627981 HSbrain_505_r 4.222171738 −0.433219031 4.655390769 HS_from_PT_251_l 3.538833617 −1.116582673 4.655416291 HS_from_MM_20_r 2.703859402 −1.951881337 4.655740739 hsa-mir-203_r 3.294573295 −1.361989825 4.65656312 HSbrain_697_l 3.814563494 −0.842836292 4.657399785 HS_from_MQbrain_1323_l 3.526017505 −1.132277159 4.658294664 HS_from_MM_163_l 1.614626536 −3.044691758 4.659318293 HS_from_MQbrain_1378_l 4.142050526 −0.517476259 4.659526785 Hsd_60_l 4.155701156 −0.503883924 4.65958508 hsa-mir-421_r 2.871695273 −1.788332271 4.660027544 HSbrain_892_l 1.838090774 −2.823450887 4.661541661 HS_from_MQbrain_1087_r 3.6055718 −1.057505619 4.663077419 HS_from_MQbrain_825_l 2.849639526 −1.816395137 4.666034664 HSbrain_672_l 2.852249215 −1.814168504 4.666417719 HS_from_MQbrain_1145_r 2.155166385 −2.511643096 4.666809481 HS_295_l 3.611931466 −1.056759345 4.668690811 HS_from_MQbrain_915_r 3.122038749 −1.550797092 4.672835841 hsa-mir-381_r 4.065989059 −0.607318147 4.673307206 HS_from_MM_191_r 1.85244859 −2.821037944 4.673486534 HS_from_PT_218_l 1.615608436 −3.058489618 4.674098054 HS_from_MQbrain_801_r 3.017891127 −1.65979213 4.677683257 HS_from_MQbrain_16_l 4.599967046 −0.078619751 4.678586798 hsa-mir-650_l 2.937629839 −1.745153308 4.682783147 hsa-mir-192_l 2.527501562 −2.15582679 4.683328352 Hsd_from_Mmd_376_l 3.879796479 −0.803578775 4.683375254 Hsd_from_Mmd_328_l 3.472263136 −1.212889518 4.685152653 HS_from_MQbrain_1290_r 3.510149512 −1.176216936 4.686366448 HSbrain_542_r 4.274225607 −0.412195881 4.686421489 HS_from_MQbrain_284_r 3.667030032 −1.02136734 4.688397372 HSbrain_821_l 1.84549341 −2.843343708 4.688837118 HSbrain_219_l 3.232284116 −1.457514192 4.689798308 hsa-mir-210_r 3.775218629 −0.914635749 4.689854378 HSbrain_1286_l 3.83059884 −0.860230199 4.690829039 HSbrain_1386_l 2.98072241 −1.711947185 4.692669595 HS_from_MQbrain_1514_l 3.704802336 −0.989467433 4.694269769 HS_294_l 3.739276109 −0.956345183 4.695621293 HS_from_MQbrain_787_l 3.540784146 −1.1561351 4.696919246 HS_230_l 3.579499332 −1.119718794 4.699218125 HS_from_MQbrain_1180_r 3.461732885 −1.240753943 4.702486828 HS_from_MQbrain_114_l 1.642277041 −3.060349557 4.702626598 HS_245_r 2.530846625 −2.172124697 4.702971322 HSbrain_624_r 1.722472157 −2.980985395 4.703457552 HS_from_MM_187_r 3.765531037 −0.938377757 4.703908794 hsa-mir-196a-1_r 2.744883754 −1.961319163 4.706202917 HS_227_l 3.55500649 −1.152895607 4.707902097 HS_from_MQbrain_787_r 1.558863027 −3.149529499 4.708392526 hsa-mir-181d_r 2.987972963 −1.723753302 4.711726264 HS_94_l 1.969693174 −2.745533312 4.715226487 hsa-mir-302b_r 1.691313911 −3.025743438 4.717057348 HSbrain_393_r 2.74572076 −1.97184178 4.717562541 hsa-mir-552_l 1.641371363 −3.077124298 4.718495662 HS_from_MQbrain_701_l 1.860679784 −2.858977215 4.719656999 HS_from_PT_121_l 3.514910587 −1.205511603 4.72042219 HSbrain_685_r 2.94857295 −1.777872924 4.726445874 hsa-mir-602_r 3.540750869 −1.186860327 4.727611196 HS_from_PT_113_r 3.13333352 −1.595510169 4.728843689 hsa-mir-24-1_r 2.798304346 −1.93259045 4.730894796 Hsd_from_Mmd_40_l 4.029351576 −0.704252338 4.733603914 HS_from_PT_203_r 1.613246274 −3.124432272 4.737678546 HSbrain_279_l 3.384031798 −1.353831919 4.737863717 HS_from_PT_194_l 0.924714762 −3.813857839 4.738572601 HSbrain_304_l 3.070625303 −1.671021556 4.741646859 HSbrain_270_l 3.051575508 −1.69024559 4.741821098 HS_187_r 4.181054383 −0.563707635 4.744762018 HS_from_MQbrain_1734_l 4.25369456 −0.491487493 4.745182053 HS_from_MQbrain_1343_r 2.106607573 −2.641191028 4.747798601 HS_from_MQbrain_353_r 3.224065244 −1.524931275 4.748996519 HS_from_MQbrain_1238_r 3.797414496 −0.95218608 4.749600576 hsa-let-7a-3_l 1.313035955 −3.439225691 4.752261645 HSbrain_121_r 3.274067942 −1.47858121 4.752649152 Hsd_from_Mmd_228_l 1.364401048 −3.391566948 4.755967996 HS_from_MQbrain_1810_l 2.464713896 −2.291639748 4.756353645 hsa-mir-22_r 2.327475186 −2.431711551 4.759186737 HS_from_MQbrain_931_r 3.337852904 −1.42441839 4.762271294 Hsd_36_l 1.792951533 −2.96936417 4.762315703 HSbrain_398_l 2.684490701 −2.078898807 4.763389509 HS_from_MQbrain_1551_l 3.884000425 −0.880841465 4.76484189 HS_from_MQbrain_315_l 3.782987997 −0.985110598 4.768098595 HSbrain_655_r 3.738631397 −1.031243068 4.769874465 Hsd_from_Mmd_276_l 4.297154523 −0.475301178 4.772455702 HS_from_MQbrain_792_l 2.864158787 −1.911891394 4.776050181 Hsd_54_l 3.286974174 −1.491907307 4.778881481 hsa-mir-193b_l 2.727217972 −2.056913463 4.784131435 hsa-mir-614_l 3.463898896 −1.322148739 4.786047634 HS_from_MQbrain_476_l 3.995342346 −0.791737922 4.787080269 hsa-mir-500_r 3.658269534 −1.128950477 4.787220011 HS_57_r 3.895038619 −0.89282786 4.787866479 HSbrain_771_r 1.712937445 −3.075072903 4.788010348 HS_from_MQbrain_1728_r 3.313868672 −1.477206863 4.791075535 HS_from_MQbrain_234_l 4.453471636 −0.338793312 4.792264948 HSbrain_486_l 3.965014616 −0.829489353 4.794503969 hsa-mir-16-2_l 2.037765015 −2.758194516 4.795959531 HS_from_MQbrain_1048_l 4.009645727 −0.787303704 4.79694943 HS_from_MQbrain_637_l 3.498843713 −1.299597114 4.798440828 HS_from_MQbrain_297_r 3.448132327 −1.354086506 4.802218833 HS_from_PT_44_r 3.263050978 −1.539848565 4.802899542 HS_from_MM_13_r 3.263480901 −1.540007607 4.803488508 hsa-mir-768_r 2.589938983 −2.216918992 4.806857975 HS_from_MQbrain_960_l 2.606113508 −2.203471342 4.80958485 HS_31_l 3.22456319 −1.585254746 4.809817936 HS_from_MM_96_l 2.855031474 −1.954884854 4.809916329 HS_from_PT_7_l 3.346007287 −1.464276638 4.810283925 HS_from_PT_258_r 2.241699745 −2.569827569 4.811527314 Hsd_from_Mmd_274_l 3.091015535 −1.722379515 4.81339505 HS_from_MQbrain_751_l 3.347608177 −1.466031951 4.813640127 HS_from_MQbrain_31_r 4.073436603 −0.740794212 4.814230815 HSbrain_333_r 3.313933938 −1.50150797 4.815441908 HSbrain_278_l 3.014590423 −1.802503646 4.817094069 HSbrain_536_l 3.392835933 −1.427196124 4.820032057 HSbrain_342_l 2.719428812 −2.102932954 4.822361766 HSbrain_496_l 3.009231766 −1.818080955 4.82731272 HSbrain_362_r 2.710368961 −2.121158851 4.831527812 HS_234_l 3.673093797 −1.158581679 4.831675476 HS_from_MM_290_l 1.931507501 −2.904133218 4.83564072 hsa-mir-135a-2_l 1.443761332 −3.393789375 4.837550707 HS_from_MQbrain_1246_r 3.167779633 −1.670405213 4.838184845 HS_271_r 3.688454263 −1.150107795 4.838562058 hsa-mir-195_l 1.315266951 −3.526131828 4.841398779 HSbrain_218_l 1.933765045 −2.909864581 4.843629626 HS_from_MQbrain_870_r 3.780725549 −1.065328564 4.846054112 HS_from_MQbrain_1901_l 1.567447504 −3.279664791 4.847112294 Hsd_87_l 2.715380529 −2.133080693 4.848461222 HSbrain_202_r 2.894163056 −1.956817817 4.850980873 HSbrain_288_r 3.627702358 −1.224190854 4.851893213 hsa-mir-221_r 2.243776712 −2.60842676 4.852203472 Hsd_83_r 2.312030239 −2.540245962 4.8522762 HSbrain_638_r 4.263737826 −0.591230463 4.854968289 HSbrain_156_r 3.832628684 −1.025783562 4.858412246 Hsd_from_Mmd_190_l 2.96540259 −1.894736437 4.860139027 hsa-mir-7-1_l 3.254137311 −1.607608592 4.861745902 HSbrain_603_l 3.378028895 −1.484260577 4.862289472 hsa-mir-498_l 2.857356323 −2.006366908 4.863723231 HS_298_l 3.245727352 −1.618515418 4.86424277 HS_from_MQbrain_1082_l 3.038041153 −1.828692848 4.866734001 HS_from_MQbrain_1212_r 1.726440526 −3.140455926 4.866896452 HSbrain_539_r 4.254297153 −0.61404578 4.868342934 HS_from_MQbrain_319_l 1.271264614 −3.599037252 4.870301866 HS_270_r 3.807800171 −1.063485635 4.871285805 HSbrain_83_l 4.757960986 −0.113347793 4.871308779 HS_242_r 2.943246653 −1.929069135 4.872315788 HS_238_l 3.778030931 −1.096875033 4.874905964 HS_from_MQbrain_399_l 2.300484061 −2.575422631 4.875906693 HS_236_l 3.868926399 −1.007140666 4.876067065 hsa-mir-150_r 4.007829804 −0.868328259 4.876158063 HS_from_MM_82_r 4.04313532 −0.83522739 4.878362709 HS_from_MM_359_r 2.887847105 −1.991716996 4.879564102 HSbrain_631_r 2.878955855 −2.001762682 4.880718537 Hsd_from_Mmd_26_r 1.582237121 −3.299428257 4.881665378 hsa-let-7b_r 2.255968183 −2.62716493 4.883133114 HS_from_MQbrain_441_l 3.163026535 −1.72251182 4.885538355 HS_from_MQbrain_2700_r 2.72330886 −2.162562338 4.885871198 Hsd_from_Mmd_80_l 1.626004464 −3.260603521 4.886607985 HSbrain_650_r 4.051139114 −0.837554055 4.888693169 HS_from_MM_192_l 1.500793799 −3.390697473 4.891491271 HS_293_l 3.736043938 −1.156903247 4.892947185 hsa-mir-611_r 4.127661712 −0.765879211 4.893540923 hsa-mir-18b_l 3.366454205 −1.531598877 4.898053082 HS_from_MQbrain_1180_l 2.86662064 −2.031634669 4.898255309 hsa-mir-99b_l 3.220612794 −1.677890004 4.898502798 HSbrain_718_r 1.879461783 −3.019233792 4.898695575 hsa-mir-517a_r 3.323648272 −1.575175801 4.898824073 HS_from_MQbrain_238_r 3.888716774 −1.010966178 4.899682951 HS_from_MQbrain_593_l 4.095851317 −0.80414063 4.899991947 HS_from_MQbrain_694_l 3.545397631 −1.360080526 4.905478156 hsa-mir-503_l 3.294641284 −1.611368203 4.906009487 HSbrain_395_r 3.211007963 −1.697550148 4.90855811 HS_from_MQbrain_215_l 3.06264762 −1.847586802 4.910234422 HS_from_MQbrain_1636_l 3.627089647 −1.283917526 4.911007173 HS_from_MQbrain_478_r 3.361299201 −1.550505901 4.911805101 HS_from_MQbrain_659_l 3.747111102 −1.165383071 4.912494173 HS_from_MQbrain_1672_l 2.154788884 −2.757967795 4.912756679 HSbrain_733_l 2.368226164 −2.544612556 4.912838719 HS_from_MQbrain_954_l 2.257530912 −2.658631141 4.916162054 HS_from_MQbrain_402_r 2.522419295 −2.396131891 4.918551186 HS_from_MQbrain_1334_r 1.60360394 −3.316561509 4.92016545 hsa-mir-100_l 1.936797577 −2.986252743 4.923050321 HSbrain_567_r 4.168866772 −0.755661684 4.924528456 HSbrain_1390_l 2.883536151 −2.04232685 4.925863001 HS_from_MQbrain_1353_l 1.831945649 −3.097732139 4.929677789 HS_297_l 3.658138951 −1.272758506 4.930897457 hsa-mir-451_l 2.860114507 −2.079355672 4.93947018 HS_from_MQbrain_687_l 3.520203571 −1.422585034 4.942788605 HS_from_MQbrain_920_l 3.643544221 −1.300173672 4.943717893 HS_from_MQbrain_864_l 3.495420383 −1.44897999 4.944400374 HS_from_MQbrain_708_r 3.760727675 −1.18697574 4.947703415 HSbrain_1_r 3.779079405 −1.169504771 4.948584176 HS_from_MM_40_l 4.541405432 −0.410590356 4.951995787 HS_from_MQbrain_693_l 3.671566694 −1.28293922 4.954505913 HS_from_MQbrain_295_l 3.542603651 −1.415423739 4.958027391 HS_from_MQbrain_349_r 3.40314322 −1.562680299 4.96582352 hsa-mir-7-2_r 2.308679799 −2.657442201 4.966122 HS_from_MQbrain_1551_r 3.278055161 −1.692740815 4.970795976 HS_44_r 1.672788352 −3.298341886 4.971130238 HS_from_MQbrain_1671_r 3.387447413 −1.583907189 4.971354602 HS_from_PT_303_l 3.609655813 −1.364530153 4.974185966 HS_226_l 3.413696096 −1.560559144 4.97425524 HSbrain_149_l 3.40164818 −1.574699619 4.976347799 HS_192_l 3.463427645 −1.513330625 4.976758269 hsa-mir-10a_l 2.764589881 −2.215232301 4.979822182 HS_from_MQbrain_110_r 4.47883335 −0.520780129 4.999613479 HS_from_MQbrain_1832_r 1.664160694 −3.337085827 5.001246521 HS_from_MQbrain_1209_r 4.121755836 −0.879515257 5.001271093 HS_28_r 2.506035722 −2.497749025 5.003784746 Hsd_from_Mmd_149_l 3.042130919 −1.962241796 5.004372716 HS_147_l 3.847931471 −1.162487129 5.0104186 Hsd_50_r 3.891133142 −1.123087161 5.014220303 HSbrain_321_l 4.222442609 −0.793746716 5.016189325 Hsd_from_Mmd_91_l 1.75725669 −3.25953709 5.016793781 HSbrain_422_r 4.616518979 −0.409413813 5.025932792 HS_from_MQbrain_374_r 3.088425979 −1.945101148 5.033527127 HS_296_l 3.691753934 −1.342843015 5.03459695 Hsd_from_Mmd_343_l 3.153669719 −1.881983743 5.035653463 HSbrain_553_r 3.023799224 −2.014682079 5.038481303 HS_from_MQbrain_240_r 3.559428342 −1.486398141 5.045826483 HS_from_MQbrain_1318_r 3.842538771 −1.203331739 5.04587051 HS_221_l 3.666584393 −1.382013375 5.048597768 HSbrain_57_l 4.384467535 −0.664284292 5.048751827 hsa-mir-565_r 2.606965747 −2.44387871 5.050844458 HSbrain_239_l 3.543168484 −1.514224544 5.057393029 Hsd_from_Mmd_411_l 4.050389674 −1.009209988 5.059599662 HS_174_l 2.798895904 −2.263723875 5.062619779 HS_from_MQbrain_1147_r 2.005031358 −3.057860126 5.062891484 HS_from_MQbrain_575_r 2.969253009 −2.094812156 5.064065166 HS_from_MQbrain_973_r 3.283047874 −1.781131015 5.064178888 HSbrain_426_l 1.956473761 −3.108397502 5.064871263 HS_from_MQbrain_1863_l 0.639055626 −4.426586344 5.06564197 HS_from_MQbrain_1552_r 3.420250449 −1.646229571 5.06648002 HSbrain_429_l 3.774359349 −1.297650721 5.07201007 hsa-mir-135a-1_l 1.499107172 −3.573907366 5.073014539 hsa-mir-181a-1_l 1.793713318 −3.283917125 5.077630443 HS_from_MQbrain_1175_l 4.296965999 −0.782331004 5.079297003 HS_from_MM_145_l 4.10808325 −0.972938521 5.081021771 hsa-mir-181a-2_l 1.588474029 −3.494881079 5.083355108 HS_from_MQbrain_599_r 3.257923847 −1.827189852 5.085113699 HS_from_MQbrain_192_l 3.426958595 −1.65937693 5.086335524 HSbrain_563_r 2.031249955 −3.056601747 5.087851701 HS_from_MQbrain_1560_l 2.467180549 −2.625032361 5.09221291 Hsd_from_Mmd_284_r 2.655380318 −2.437192118 5.092572436 HS_205_l 4.497520544 −0.595149237 5.092669781 HSbrain_789_r 4.560892088 −0.533678481 5.094570569 HS_from_MQbrain_1606_r 3.757884262 −1.338282135 5.096166397 HSbrain_159_r 4.915227951 −0.1863132 5.101541151 HS_from_PT_195_l 4.0936569 −1.008393271 5.102050171 hsa-mir-602_l 4.073233665 −1.034079832 5.107313496 hsa-mir-24-2_r 3.043402392 −2.065397837 5.108800229 HS_93_l 4.032506399 −1.078035098 5.110541497 HS_from_MQbrain_986_r 2.686570455 −2.424099698 5.110670153 hsa-mir-801_l 4.38259069 −0.730479368 5.113070057 HS_from_MQbrain_771_r 2.40206001 −2.711446095 5.113506104 HS_from_MQbrain_1432_l 3.27618405 −1.839114824 5.115298873 hsa-mir-326_l 2.940648196 −2.182634073 5.123282268 HS_65_r 1.996145069 −3.130828915 5.126973984 HS_180_l 2.983951957 −2.144700078 5.128652035 hsa-mir-18b_r 1.979463641 −3.151317755 5.130781396 HS_43_r 3.478491086 −1.652974563 5.131465649 hsa-mir-27b_r 1.106946065 −4.025174898 5.132120964 hsa-mir-373_l 3.400782096 −1.733979786 5.134761882 HS_from_MQbrain_778_l 3.849723243 −1.290768764 5.140492008 HS_from_MQbrain_708_l 4.727897848 −0.412642135 5.140539984 Hsd_from_Mmd_187_r 2.417885525 −2.726246624 5.144132149 HS_from_MQbrain_1601_r 3.518530966 −1.627291134 5.1458221 HSbrain_805_l 2.8792199 −2.268912216 5.148132116 HSbrain_223_l 3.773237758 −1.37527471 5.148512468 HS_from_MQbrain_241_l 4.409019063 −0.740818822 5.149837885 HS_from_MQbrain_516_l 3.731961903 −1.421300713 5.153262616 HS_103_r 3.181156033 −1.974743918 5.155899951 Hsd_from_Mmd_529_r 2.622526108 −2.537313848 5.159839956 hsa-mir-380_l 4.598642438 −0.561416269 5.160058708 HS_from_MM_93_l 3.552677807 −1.610726515 5.163404322 HS_271_l 3.690765734 −1.477208823 5.167974557 HS_from_MQbrain_1010_r 3.808974254 −1.36161643 5.170590685 HS_from_MQbrain_640_r 4.128384546 −1.044972488 5.173357034 HS_from_MQbrain_713_l 3.970101877 −1.205755763 5.17585764 Hsd_from_Mmd_45_l 4.255208484 −0.923202105 5.178410589 HS_from_MQbrain_687_r 4.929705256 −0.250929378 5.180634634 HS_from_MQbrain_272_r 3.991791748 −1.19109437 5.182886118 HSbrain_64_l 3.947334812 −1.238110975 5.185445787 HS_from_MQbrain_557_l 3.54559829 −1.640039969 5.185638259 HS_from_MQbrain_52_l 3.78705098 −1.402264784 5.189315765 HS_from_MM_210_r 2.484073079 −2.707049953 5.191123032 HS_from_MQbrain_497_r 4.104385799 −1.089926272 5.194312071 HS_from_PT_216_r 4.251217878 −0.947559321 5.198777199 HS_228_l 3.733842855 −1.465213159 5.199056015 HSbrain_1404_l 4.666209621 −0.535452732 5.201662353 HS_from_MM_268_l 2.974107426 −2.228999851 5.203107277 HS_from_MQbrain_874_r 2.161736137 −3.043846435 5.205582573 HSbrain_285_l 4.114220627 −1.094451712 5.208672338 HS_from_PT_35_r 4.183001303 −1.026084249 5.209085553 HS_from_MQbrain_827_l 4.109900073 −1.103162754 5.213062827 hsa-mir-615_l 3.74521244 −1.469688886 5.214901325 hsa-mir-519a-1_r 2.816289364 −2.399292953 5.215582317 HS_253_r 4.206055431 −1.011509985 5.217565415 HS_from_MQbrain_535_r 3.322904452 −1.895704159 5.218608611 HS_from_MQbrain_1625_l 3.862343093 −1.357111315 5.219454408 HS_from_MQbrain_827_r 3.304620914 −1.914980744 5.219601658 HS_from_MQbrain_1820_r 4.193120277 −1.031492467 5.224612743 HSbrain_11_r 4.423014918 −0.802072 5.225086918 HS_from_MQbrain_280_l 3.312828284 −1.922504255 5.235332539 HS_from_MQbrain_734_r 4.261730669 −0.977035212 5.238765882 HSbrain_281_r 3.433530801 −1.806335569 5.23986637 HS_from_MQbrain_666_r 3.203599212 −2.040637249 5.244236461 hsa-let-7i_l 1.79628002 −3.448940058 5.245220079 HS_from_MQbrain_1082_l 1.671121361 −3.580483686 5.251605047 HSbrain_1168_l 3.438385288 −1.814179309 5.252564597 HS_203_l 2.853775347 −2.398893509 5.252668856 HS_from_MQbrain_1020_r 4.230939895 −1.023262488 5.254202383 HS_from_MQbrain_298_l 1.991021091 −3.266047475 5.257068566 HS_from_MQbrain_1689_l 3.098496199 −2.16035018 5.258846379 hsa-mir-194-2_l 4.512111515 −0.747268618 5.259380133 HS_from_PT_156_l 3.47565461 −1.7855137 5.261168311 HS_from_MQbrain_797_l 3.86534469 −1.397104049 5.26244874 HSbrain_406_r 4.454702816 −0.81003235 5.264735165 HS_from_MQbrain_238_l 3.087539957 −2.178610623 5.266150579 HS_from_MQbrain_811_r 3.066374781 −2.202835994 5.269210776 HS_250_r 4.062466414 −1.207232039 5.269698453 HS_222_l 3.700771895 −1.571023484 5.271795379 HSbrain_418_l 4.561662378 −0.713760039 5.275422417 HSbrain_186_l 3.995222297 −1.280916841 5.276139138 Hsd_from_Mmd_343_r 3.74915385 −1.528358566 5.277512415 HSbrain_164_l 4.018503935 −1.261726538 5.280230473 HS_from_PT_66_l 3.637998024 −1.64939961 5.287397634 HS_from_MQbrain_816_l 4.848657421 −0.43894031 5.287597731 hsa-mir-542_l 3.341049921 −1.947022915 5.288072837 HS_from_MQbrain_542_l 3.709550896 −1.579371536 5.288922431 HSbrain_445_r 4.35680089 −0.932516703 5.289317593 HS_from_MQbrain_628_l 3.529917584 −1.760032633 5.289950216 HS_from_MM_176_r 2.733425405 −2.557008216 5.290433622 HS_272_l 3.786459783 −1.513513457 5.29997324 HS_from_MQbrain_1493_l 3.831014826 −1.469908707 5.300923533 HSbrain_379_r 3.23587819 −2.071753506 5.307631696 hsa-mir-93_l 1.882604466 −3.426522329 5.309126795 HS_from_MQbrain_645_l 2.498506817 −2.812854101 5.311360919 HS_from_PT_301_l 3.917612364 −1.39468483 5.312297194 HS_from_MQbrain_1381_l 4.379678458 −0.93461924 5.314297697 HSbrain_582_l 1.432690413 −3.886262822 5.318953235 HSbrain_724_l 1.988490494 −3.331175949 5.319666443 HS_from_MQbrain_829_l 4.50954359 −0.819501435 5.329045025 HS_from_MM_304_l 4.325762714 −1.004234861 5.329997575 hsa-mir-574_r 2.85838056 −2.473509603 5.331890163 HS_from_MQbrain_1550_r 4.04701921 −1.286517289 5.333536499 HS_188_r 2.600205622 −2.733838356 5.334043977 HS_from_MQbrain_314_r 4.789345003 −0.549127536 5.338472538 HS_36_r 4.612352422 −0.728545264 5.340897687 hsa-let-7f-1_l 1.588019082 −3.763964322 5.351983404 Hsd_from_Mmd_291_l 4.361840207 −0.992699443 5.35453965 HS_from_MQbrain_1558_r 4.035543346 −1.323253464 5.358796811 HS_91_r 3.819488244 −1.542548961 5.362037205 HS_2_l 3.458196989 −1.903902242 5.362099231 HSbrain_368_r 4.433887145 −0.929879117 5.363766263 HSbrain_616_r 3.002236638 −2.362695746 5.364932384 HSbrain_100_l 3.570227349 −1.79471515 5.3649425 HS_from_MQbrain_1215_r 4.925531911 −0.450970567 5.376502478 HS_from_MQbrain_1879_r 4.228976536 −1.1529606 5.381937136 HS_284_l 2.666555812 −2.71628398 5.382839792 HSbrain_68_l 3.874118734 −1.511493305 5.385612039 HS_from_PT_193_l 4.186127732 −1.204004669 5.390132401 HSbrain_558_r 4.119685364 −1.272218165 5.391903529 HSbrain_81_l 4.673459962 −0.721409572 5.394869535 HS_233_l 3.742243209 −1.656301561 5.39854477 HS_from_MQbrain_296_r 3.304003275 −2.095052299 5.399055573 HSbrain_163_r 4.382358889 −1.022213096 5.404571986 HSbrain_691_l 3.473723841 −1.94134288 5.415066721 HS_from_PT_332_l 3.767926637 −1.650173792 5.41810043 HSbrain_397_r 3.218220646 −2.200206295 5.418426941 hsa-mir-17_r 4.940072682 −0.485631302 5.425703984 hsa-mir-519a-2_r 2.97948479 −2.449215663 5.428700453 HSbrain_222_l 3.403657332 −2.029974787 5.433632119 HS_from_MM_66_r 4.371687398 −1.063556189 5.435243587 HS_from_MM_66_l 4.438051051 −0.998643315 5.436694367 HS_from_MQbrain_1238_l 3.98451293 −1.453005517 5.437518447 HS_from_MQbrain_1638_l 3.418178988 −2.02094608 5.439125068 Hsd_76_l 3.490670938 −1.951881927 5.442552865 HS_from_MQbrain_545_r 3.955126899 −1.490012408 5.445139307 Hsd_from_Mmd_411_r 4.332224304 −1.116578962 5.448803266 hsa-mir-92b_r 2.748668498 −2.702394176 5.451062674 HS_from_MQbrain_564_r 3.294902232 −2.156804516 5.451706748 HSbrain_628_l 3.082499121 −2.376106514 5.458605635 HSbrain_656_r 2.982458237 −2.477502715 5.459960952 Hsd_14_l 3.689163499 −1.771700139 5.460863639 HS_from_MQbrain_1454_r 4.577495936 −0.887402432 5.464898368 HS_from_MQbrain_855_r 3.825345577 −1.640085564 5.465431141 HS_from_MQbrain_599_l 3.412798886 −2.055944156 5.468743042 Hsd_from_Mmd_226_r 1.291227061 −4.183190395 5.474417456 HS_from_MQbrain_123_r 3.479302649 −1.995817976 5.475120624 HS_301_l 4.627077308 −0.850607121 5.47768443 HS_from_PT_139_l 4.073422524 −1.409405185 5.482827709 Hsd_109_l 3.72673689 −1.759885872 5.486622762 hsa-mir-330_r 3.714449537 −1.773773894 5.488223431 Hsd_65_r 3.748646304 −1.742543071 5.491189375 HS_152_l 3.102277233 −2.393380365 5.495657598 HSbrain_660_l 3.466157655 −2.029987544 5.496145198 HS_from_MQbrain_1382_r 3.13793393 −2.363726857 5.501660787 HS_181_r 4.419469122 −1.082251591 5.501720713 HSbrain_805_l 4.074433503 −1.429676402 5.504109905 Hsd_from_Mmd_516_l 3.412475113 −2.095033896 5.507509009 Hsd_from_Mmd_245_l 3.780690306 −1.727121945 5.507812252 HS_from_MQbrain_578_r 4.166135797 −1.350306755 5.516442553 HSbrain_591_r 4.391529413 −1.12924627 5.520775683 HSbrain_648_r 3.194624354 −2.333467448 5.528091801 HS_from_PT_176_l 3.956699706 −1.576116801 5.532816508 Hsd_7_l 3.22704522 −2.306215626 5.533260846 HS_104_l 3.942124617 −1.592915077 5.535039694 HSbrain_190_l 4.758036339 −0.780199851 5.53823619 HS_from_MM_33_l 3.840554748 −1.69933794 5.539892688 hsa-mir-19a_r 1.9628064 −3.57807505 5.540881449 HSbrain_377_l 2.436684747 −3.106433448 5.543118196 Hsd_from_Mmd_372_r 4.246402876 −1.299267958 5.545670834 HS_from_MQbrain_1326_l 3.976713406 −1.572423915 5.549137321 HSbrain_715_r 3.453512886 −2.09921914 5.552732026 hsa-mir-26b_l 1.764835795 −3.788243571 5.553079366 HS_from_MQbrain_594_r 4.355831166 −1.197465154 5.55329632 HSbrain_653_r 3.322388663 −2.234544302 5.556932965 hsa-mir-801_l 4.017543096 −1.544979742 5.562522838 HS_from_MM_172_r 1.397454629 −4.169510735 5.566965364 hsa-mir-124a-3_r 4.617726819 −0.952351832 5.57007865 HSbrain_29_r 4.260687702 −1.309423869 5.570111571 HS_from_MQbrain_1357_r 4.306226408 −1.270483357 5.576709765 HSbrain_20_l 3.751601424 −1.849028269 5.600629694 HS_from_PT_220_r 4.281748809 −1.320114272 5.601863081 hsa-let-7f-2_l 1.76029603 −3.845246655 5.605542685 HS_from_MQbrain_618_l 3.445454811 −2.164340001 5.609794812 HSbrain_1405_l 4.679472115 −0.934087199 5.613559314 Hsd_14_r 5.086071816 −0.528975621 5.615047436 HSbrain_54_r 4.294762627 −1.32100822 5.615770847 HSbrain_610_l 3.599846841 −2.015963198 5.615810039 HS_from_MQbrain_1405_l 3.775686066 −1.842781398 5.618467464 HS_21_l 3.418371497 −2.205431424 5.623802922 HS_from_PT_219_r 4.403612245 −1.228598506 5.632210751 HS_from_MQbrain_354_l 4.735786231 −0.899065708 5.63485194 HS_from_MQbrain_918_r 4.702403782 −0.933235667 5.63563945 HS_from_MQbrain_1061_r 4.062583748 −1.573537454 5.636121203 hsa-mir-23a_r 2.510329712 −3.127381226 5.637710938 Hsd_from_Mmd_266_r 2.805780405 −2.834756512 5.640536917 HSbrain_411_r 2.613717186 −3.042395943 5.656113129 HS_from_MQbrain_1646_l 4.15001229 −1.523739312 5.673751602 HSbrain_317_r 3.162439297 −2.516972317 5.679411615 hsa-mir-31_l 3.922440913 −1.765548382 5.687989296 HS_90_l 4.227924969 −1.461704043 5.689629012 HS_183_l 3.456161799 −2.234645299 5.690807098 HSbrain_99_l 3.920364938 −1.770561757 5.690926695 HS_from_MM_47_r 3.671346828 −2.024788693 5.696135521 hsa-mir-572_r 4.971923816 −0.727695707 5.699619523 Hsd_from_Mmd_115_l 4.853790974 −0.852245434 5.706036407 HS_from_MQbrain_796_r 4.415678039 −1.29112765 5.706805689 HS_from_MQbrain_433_r 4.108677086 −1.600787572 5.709464658 hsa-mir-181c_l 2.138737177 −3.573048009 5.711785186 Hsd_from_Mmd_154_r 3.762836127 −1.949146778 5.711982905 Hsd_33_l 3.343345301 −2.369363954 5.712709255 HSbrain_499_l 3.469097037 −2.246893498 5.715990535 HS_from_MQbrain_1362_r 4.28548566 −1.435541542 5.721027201 HS_from_MM_210_l 4.10523656 −1.617132807 5.722369367 hsa-mir-519e_r 3.116430575 −2.612911942 5.729342517 HS_72_l 4.268290644 −1.463946628 5.732237271 HS_from_PT_125_l 4.702104541 −1.033066802 5.735171343 HSbrain_1389_l 3.024112414 −2.711581946 5.735694359 HS_from_MQbrain_273_r 4.632780656 −1.124780689 5.757561345 hsa-mir-124a-2_r 4.828261068 −0.933932683 5.762193751 HSbrain_327_r 4.660529086 −1.10899521 5.769524296 HSbrain_482_l 4.199508553 −1.575202359 5.774710912 Hsd_from_Mmd_35_r 4.487620932 −1.295421708 5.78304264 HSbrain_40_l 4.019944325 −1.773412253 5.793356578 HSbrain_533_r 4.196700156 −1.619525068 5.816225224 HS_from_MQbrain_1858_r 4.483323757 −1.335052328 5.818376085 hsa-let-7g_l 1.806582222 −4.012710072 5.819292294 HS_from_MM_35_r 4.703256578 −1.11746028 5.820716859 HSbrain_112_l 3.235279252 −2.586285347 5.821564599 Hsd_from_Mmd_246_r 2.780871742 −3.043528889 5.824400631 HSbrain_28_r 5.48605974 −0.346305969 5.832365709 hsa-mir-566_l 3.429280027 −2.403734308 5.833014335 HS_from_MQbrain_924_r 3.811192391 −2.037005336 5.848197727 HS_from_MQbrain_575_l 4.830160754 −1.01981064 5.849971394 Hsd_72_l 3.836626412 −2.014491701 5.851118113 HSbrain_377_r 2.907687708 −2.947146756 5.854834465 HSbrain_657_r 4.303051294 −1.556854409 5.859905704 HSbrain_26_r 4.236057005 −1.63051195 5.866568955 hsa-mir-200c_r 2.576005313 −3.290828708 5.866834021 HS_from_MM_296_l 4.744357804 −1.129429551 5.873787355 HS_267_r 3.354881307 −2.520776419 5.875657726 HS_from_MQbrain_732_l 5.596275896 −0.283871028 5.880146923 HSbrain_418_r 4.272110494 −1.60831359 5.880424085 HS_from_MQbrain_2633_l 3.794994035 −2.096595326 5.891589361 HSbrain_278_r 3.805184267 −2.089225652 5.894409919 HSbrain_558_l 4.291784938 −1.602898464 5.894683402 HS_143_r 3.012115136 −2.894275789 5.906390924 HS_from_MQbrain_792_r 3.643333503 −2.281909887 5.92524339 HS_14_l 4.709045762 −1.218830057 5.927875819 HS_118_l 3.878595746 −2.054769168 5.933364914 HS_from_MQbrain_8_r 3.772568617 −2.162192464 5.934761082 hsa-mir-23b_r 2.780138092 −3.160150843 5.940288935 HS_from_PT_7_r 4.737928104 −1.206096838 5.944024942 Hsd_from_Mmd_260_l 4.790164575 −1.156684188 5.946848763 HSbrain_654_l 4.975188549 −0.97202554 5.947214089 HSbrain_15_l 4.679770369 −1.269776956 5.949547325 HS_from_MM_234_l 4.240768704 −1.717054897 5.957823601 hsa-mir-143_r 4.421696799 −1.538445702 5.960142501 HS_from_MQbrain_760_r 5.809892718 −0.155311287 5.965204005 hsa-mir-542_r 4.473592048 −1.497936368 5.971528416 hsa-mir-124a-1_r 5.075346959 −0.896800495 5.972147454 HS_from_MM_29_l 4.117736752 −1.854487591 5.972224343 HS_192_r 4.989345344 −0.993611356 5.9829567 HS_254_r 4.114536249 −1.868510953 5.983047203 HS_from_MQbrain_843_l 4.352681523 −1.63782679 5.990508313 HS_193_l 4.75212295 −1.239024261 5.99114721 HS_from_PT_130_r 3.148538054 −2.856593123 6.005131177 HSbrain_765_r 4.882015038 −1.128191572 6.01020661 HS_from_MQbrain_1421_r 3.888984872 −2.124894931 6.013879803 HSbrain_436_l 4.30323071 −1.715247803 6.018478513 HS_287_r 4.495264347 −1.534503365 6.029767713 HSbrain_499_r 4.098369288 −1.932646304 6.031015592 hsa-mir-564_r 4.909851444 −1.123461194 6.033312638 HSbrain_208_r 3.212598106 −2.830561144 6.043159249 HS_from_MQbrain_807_l 4.661135153 −1.382077972 6.043213126 Hsd_from_Mmd_222_r 3.32302302 −2.721408253 6.044431273 HSbrain_1360_r 4.547229214 −1.500155717 6.047384931 Hsd_from_Mmd_271_r 3.42090646 −2.633339035 6.054245494 hsa-mir-636_l 4.586138795 −1.480297143 6.066435938 HSbrain_83_r 5.045353177 −1.02436812 6.069721297 HS_from_MQbrain_452_l 3.931878227 −2.142948942 6.07482717 HS_from_MQbrain_661_l 3.309819773 −2.767618454 6.077438227 HSbrain_111_l 4.478063253 −1.601864592 6.079927845 HS_from_MQbrain_1205_r 3.798533287 −2.287026649 6.085559937 HS_from_PT_123_r 4.699877455 −1.393673208 6.093550663 HS_from_MQbrain_1803_l 3.990717912 −2.104101824 6.094819736 hsa-mir-208_l 4.498924031 −1.604037691 6.102961722 HSbrain_238_l 4.522924806 −1.581116125 6.104040931 HS_from_MQbrain_137_l 5.249572176 −0.855933068 6.105505244 HSbrain_1363_r 4.690028685 −1.419093516 6.109122201 HS_from_MM_260_r 3.447152671 −2.667288315 6.114440986 hsa-mir-30e_l 3.0644184 −3.050098809 6.11451721 HSbrain_16_l 4.573890866 −1.550435178 6.124326044 HSbrain_122_r 4.320735556 −1.818946269 6.139681825 hsa-mir-551a_r 4.680313939 −1.465502125 6.145816064 hsa-mir-520f_l 5.79689907 −0.350966934 6.147866004 HSbrain_394_l 4.573621055 −1.590725756 6.164346812 HSbrain_375_l 4.170862628 −1.99497765 6.165840277 HS_from_MQbrain_287_r 4.390750308 −1.775092716 6.165843023 Hsd_26_r 4.528037162 −1.646247286 6.174284449 HSbrain_131_r 4.642917681 −1.531943569 6.17486125 HS_from_MQbrain_1502_l 4.306880119 −1.872571169 6.179451288 HS_117_l 3.914149118 −2.266893911 6.181043029 HS_from_MQbrain_374_l 4.048069346 −2.135713316 6.183782662 HSbrain_366_r 4.695428359 −1.500832349 6.196260708 HS_11_r 4.359066265 −1.840949358 6.200015623 HSbrain_766_r 4.292091907 −1.907936735 6.200028642 Hsd_from_Mmd_433_l 4.189641245 −2.014185933 6.203827179 HS_288_r 4.613651482 −1.601155032 6.214806514 Hsd_92_l 4.453319016 −1.772517608 6.225836624 HS_from_MQbrain_1295_l 4.467230834 −1.769790663 6.237021496 hsa-mir-498_r 4.742805113 −1.497579431 6.240384544 HS_from_MQbrain_1312_l 3.945332299 −2.307158367 6.252490666 HS_from_MQbrain_521_r 4.250672499 −2.008401215 6.259073714 HS_114_l 4.014399822 −2.260096796 6.274496618 HSbrain_383_l 2.848711871 −3.430707313 6.279419184 HSbrain_653_l 3.553247415 −2.727155834 6.280403249 HS_from_MQbrain_1765_l 4.776879998 −1.506865206 6.283745204 hsa-mir-363_l 4.650693847 −1.643106855 6.293800702 HS_from_MQbrain_1065_l 4.432098881 −1.863369953 6.295468834 HSbrain_706_l 4.714094744 −1.583427201 6.297521946 Hsd_from_Mmd_59_r 4.939409317 −1.365011536 6.304420853 HS_205_r 4.953281694 −1.358308462 6.311590155 HS_206_l 3.947577057 −2.36586125 6.313438307 hsa-mir-106b_l 2.230048384 −4.084607376 6.314655761 hsa-mir-375_r 3.404471243 −2.913526702 6.317997945 hsa-mir-612_r 4.153701447 −2.164532199 6.318233646 Hsd_from_Mmd_227_r 4.969514785 −1.350466056 6.319980841 HS_from_MQbrain_525_l 4.325248296 −2.001844685 6.327092981 HS_284_r 4.382098264 −1.948138028 6.330236293 hsa-mir-27a_r 1.963166985 −4.378793384 6.341960369 HSbrain_42_r 3.597747739 −2.746338563 6.344086302 HSbrain_118_l 5.091238684 −1.260477419 6.351716103 HS_from_MQbrain_1110_r 4.905874678 −1.456293927 6.362168605 HS_from_PT_63_l 4.729838898 −1.633775996 6.363614894 HSbrain_484_l 3.495467707 −2.874483359 6.369951066 HS_from_MQbrain_820_l 5.400175183 −0.969934259 6.370109442 HS_from_MQbrain_601_l 4.33308059 −2.041207019 6.374287609 HS_from_MQbrain_1570_r 5.826121312 −0.554136646 6.380257959 HS_212_r 2.969552561 −3.426937067 6.396489629 hsa-mir-551b_r 5.02160857 −1.381305208 6.402913778 hsa-mir-517a_l 4.530169487 −1.873171691 6.403341178 HSbrain_214_l 4.736730898 −1.66726547 6.403996368 HS_302_l 4.597912524 −1.826783726 6.42469625 HS_from_MQbrain_630_l 4.231929713 −2.193260438 6.425190151 HSbrain_20_r 5.062760753 −1.364215928 6.426976681 HS_from_PT_104_r 5.278512668 −1.162086911 6.440599579 hsa-mir-200b_r 2.909157847 −3.54818764 6.457345488 HS_from_MQbrain_967_l 4.266510532 −2.202403708 6.46891424 HS_257_r 5.232858698 −1.254197891 6.48705659 Hsd_from_Mmd_137_r 4.206897564 −2.282544453 6.489442017 HS_82_r 4.799299574 −1.691810282 6.491109856 HSbrain_566_l 4.66772169 −1.83147388 6.499195571 HS_from_MQbrain_1793_l 4.095637227 −2.40403094 6.499668167 HS_273_l 4.833637268 −1.671078137 6.504715405 HS_100_l 3.193876747 −3.31976598 6.513642727 hsa-mir-29a_r 2.028711838 −4.495005517 6.523717354 HS_from_PT_155_l 5.059131261 −1.466536807 6.525668067 HS_from_PT_104_l 4.4602838 −2.066362192 6.526645992 HSbrain_28_l 5.393049923 −1.139202058 6.532251981 HS_from_PT_221_r 4.355040962 −2.180277912 6.535318874 HSbrain_1362_r 4.944687989 −1.59084435 6.535532339 HS_from_MQbrain_1777_r 5.150932182 −1.387694907 6.538627089 hsa-mir-19b-2_r 1.989061638 −4.549799434 6.538861071 HS_from_MQbrain_144_l 4.038471969 −2.503355258 6.541827227 HS_from_MQbrain_1144_l 3.758683069 −2.80260379 6.56128686 hsa-mir-484_r 5.579400105 −0.985905105 6.56530521 HS_from_MQbrain_537_l 4.746677785 −1.819698903 6.566376688 HS_from_PT_180_r 4.902484378 −1.667109583 6.569593961 HS_from_MM_83_l 4.066456218 −2.51897756 6.585433779 HS_289_r 5.108709649 −1.481421146 6.590130794 HS_from_MQbrain_462_l 4.64779877 −1.957301099 6.605099869 hsa-mir-106a_l 2.12180599 −4.487431834 6.609237824 HSbrain_526_l 4.573914512 −2.037321142 6.611235653 hsa-mir-20b_l 2.021731933 −4.59922435 6.620956283 HSbrain_806_r 4.240528032 −2.384542882 6.625070914 HS_from_MM_323_r 5.480266936 −1.14677998 6.627046915 Hsd_11_r 5.249599651 −1.383955949 6.6335556 hsa-mir-141_r 3.847321923 −2.789655843 6.636977766 HS_from_MQbrain_207_r 4.838454137 −1.807132718 6.645586855 HS_from_MQbrain_1175_r 4.195815982 −2.452473053 6.648289034 HS_from_MQbrain_1712_l 4.569203391 −2.079799264 6.649002655 hsa-mir-517c_l 4.491318049 −2.1589711 6.650289149 HS_from_PT_269_l 4.12142642 −2.531640317 6.653066737 HSbrain_638_l 4.928462908 −1.742445994 6.670908902 HS_from_MQbrain_477_l 4.941037179 −1.737334585 6.678371764 HSbrain_644_l 5.690934417 −0.990262022 6.681196439 HS_from_MQbrain_1090_l 4.563380193 −2.118979823 6.682360015 HS_from_MQbrain_1571_r 5.33383266 −1.354822809 6.688655469 hsa-mir-26a-1_l 2.86738772 −3.823840736 6.691228456 HS_from_MQbrain_506_l 4.997959927 −1.694546909 6.692506836 hsa-mir-19b-1_r 2.111928811 −4.594002685 6.705931496 HSbrain_137_l 4.893237752 −1.816706861 6.709944614 hsa-mir-517b_l 4.566645976 −2.145699396 6.712345372 HS_from_MQbrain_140_r 3.986572678 −2.726394722 6.7129674 HS_from_MQbrain_16_r 5.566280457 −1.148896248 6.715176705 HS_from_MQbrain_1539_l 4.876671232 −1.847412856 6.724084088 HS_from_MQbrain_552_r 5.017813786 −1.716953375 6.734767161 HS_290_r 5.182365159 −1.562217353 6.744582512 hsa-mir-20a_l 2.062165027 −4.684878044 6.747043071 hsa-mir-17_l 2.126869394 −4.625109005 6.751978399 HSbrain_750_r 4.066569697 −2.700350055 6.766919752 HS_from_MQbrain_340_r 4.435814155 −2.341736847 6.777551002 hsa-mir-26a-2_l 3.040722248 −3.737428702 6.77815095 HS_from_MQbrain_17_r 4.479251469 −2.303997472 6.783248941 HSbrain_332_l 5.213396221 −1.578722089 6.79211831 Hsd_from_Mmd_483_r 5.315092406 −1.483685329 6.798777735 HS_from_MQbrain_1728_l 4.985635056 −1.822843757 6.808478813 HS_from_MQbrain_340_l 3.895756709 −2.917362468 6.813119177 HS_from_MQbrain_279_l 5.214245442 −1.60627643 6.820521872 HSbrain_438_l 4.738087688 −2.085318354 6.823406042 HS_from_MM_129_l 4.874406145 −1.951318632 6.825724776 HS_from_MQbrain_1201_l 4.276418531 −2.551107134 6.827525665 HS_from_MQbrain_1497_r 4.97080598 −1.859203898 6.830009878 hsa-mir-200a_r 3.963877308 −2.86637397 6.830251278 HS_from_MQbrain_1320_r 5.103524221 −1.729838067 6.833362287 Hsd_55_l 4.531891327 −2.302100667 6.833991994 HSbrain_660_l 5.513419211 −1.330781278 6.844200489 HSbrain_1364_r 5.366606756 −1.485438789 6.852045545 hsa-mir-593_l 4.932339535 −1.925441211 6.857780746 HS_231_l 4.686130131 −2.174007413 6.860137544 hsa-mir-29c_r 2.178692982 −4.681702494 6.860395475 HSbrain_437_l 4.762473053 −2.124418959 6.886892012 HS_250_l 4.137454636 −2.750116172 6.887570808 HS_from_MQbrain_153_l 5.873972902 −1.014588707 6.888561609 hsa-mir-557_l 5.733681079 −1.162104113 6.895785191 HSbrain_758_l 5.103685318 −1.794979992 6.898665311 HS_from_MQbrain_453_l 4.787359609 −2.13175075 6.919110359 HS_from_PT_292_l 4.552921488 −2.386407281 6.93932877 hsa-mir-560_l 4.394413378 −2.551856773 6.946270152 hsa-mir-345_r 4.273594511 −2.678761116 6.952355627 HS_from_MQbrain_279_r 4.939079839 −2.042983141 6.98206298 HS_from_MQbrain_809_l 4.985103282 −2.011053263 6.996156544 HS_from_MM_147_l 3.743097086 −3.261243741 7.004340828 HS_from_MQbrain_1843_l 5.965959445 −1.052555568 7.018515013 HS_from_MQbrain_622_l 4.376171362 −2.645175527 7.021346889 HS_from_MQbrain_606_r 4.756545126 −2.283771606 7.040316732 HSbrain_582_r 3.689488954 −3.354690718 7.044179672 HS_from_MQbrain_1463_l 4.880859335 −2.164240124 7.045099459 HSbrain_136_r 5.079441797 −1.971376246 7.050818042 HS_from_MQbrain_2630_l 4.398935251 −2.674677908 7.073613159 HSbrain_72_r 6.017630146 −1.069678172 7.087308318 HSbrain_587_l 5.1299973 −1.964544846 7.094542146 HS_from_MQbrain_973_l 4.943200444 −2.172290006 7.11549045 HS_from_MQbrain_1168_l 4.97862079 −2.137842327 7.116463118 Hsd_from_Mmd_426_l 3.747335182 −3.370219535 7.117554717 hsa-mir-663_l 5.011240432 −2.159387436 7.170627867 hsa-mir-517c_r 4.480986651 −2.69422913 7.175215781 HSbrain_237_r 4.675472342 −2.51110095 7.186573292 HS_from_MQbrain_1404_l 4.05761419 −3.139556758 7.197170948 Hsd_from_Mmd_74_l 4.339313831 −2.867371228 7.206685059 HS_from_MQbrain_170_l 6.138058127 −1.080821964 7.218880091 HS_from_MM_329_r 5.712011478 −1.521907738 7.233919216 HS_from_MQbrain_1497_l 6.073170949 −1.174094228 7.247265177 HS_from_MQbrain_1810_r 6.122979468 −1.126623894 7.249603362 HS_from_MQbrain_808_l 4.947162374 −2.309157784 7.256320158 Hsd_from_Mmd_286_r 4.226672233 −3.037609517 7.26428175 HS_from_MQbrain_671_l 5.534101291 −1.744414628 7.278515919 HS_from_MQbrain_1195_l 5.519733146 −1.778822251 7.298555397 HS_from_MQbrain_137_r 4.292665749 −3.02271647 7.315382219 HS_from_MQbrain_453_r 5.096022508 −2.234501088 7.330523596 HSbrain_620_l 4.619780262 −2.722968038 7.3427483 HS_from_MQbrain_800_l 4.99053162 −2.358874546 7.349406166 hsa-mir-29b-1_r 2.507736393 −4.843123724 7.350860117 hsa-mir-565_l 4.149892881 −3.206795324 7.356688205 HSbrain_468_l 3.80362517 −3.563185747 7.366810918 hsa-mir-29b-2_r 2.563842324 −4.826456007 7.390298331 HSbrain_534_l 4.500081575 −2.894021126 7.394102701 HS_from_MQbrain_1109_l 4.029606516 −3.382276204 7.41188272 HS_130_l 6.21383474 −1.223177365 7.437012105 HS_213_r 3.448098231 −4.004380141 7.452478372 HS_from_MQbrain_1784_r 5.458060554 −2.008655821 7.466716375 hsa-mir-92-1_r 3.953740575 −3.523815432 7.477556007 HS_from_MQbrain_681_r 4.86756847 −2.655295001 7.522863471 HS_from_MQbrain_1030_r 5.482419864 −2.050160962 7.532580827 HSbrain_1337_r 3.552234375 −3.996126137 7.548360511 HS_from_MQbrain_386_r 4.667495409 −2.88737231 7.554867719 HSbrain_609_r 5.007422508 −2.616095825 7.623518334 hsa-mir-92-2_r 3.874690749 −3.760803493 7.635494241 hsa-mir-663_r 5.467271847 −2.171521464 7.638793311 HS_from_MQbrain_485_l 4.276180188 −3.36267375 7.638853938 HS_from_MQbrain_530_l 4.530899577 −3.136538969 7.667438546 HS_from_MQbrain_1590_r 5.618889763 −2.063583825 7.682473587 HSbrain_412_l 4.076386045 −3.674915919 7.751301964 hsa-mir-9-2_r 4.593661545 −3.177024616 7.770686161 HS_from_MQbrain_666_l 5.485658527 −2.32972148 7.815380007 HS_from_MQbrain_1490_l 5.64200061 −2.257253419 7.899254029 hsa-mir-9-1_r 4.700973627 −3.281093675 7.982067302 hsa-mir-9-3_r 4.729775968 −3.255497845 7.985273812 HS_from_PT_114_l 3.583990998 −4.407945806 7.991936804 HS_from_MQbrain_868_l 4.38199392 −3.612346682 7.994340602 HS_from_MQbrain_750_l 4.24585762 −3.788058659 8.033916279 HSbrain_225_l 5.102922553 −3.13165277 8.234575323 HS_from_PT_114_r 3.967307291 −4.292042281 8.259349572 HS_68_l 4.385354801 −3.937554066 8.322908867 hsa-mir-520g_l 4.943810712 −3.467378187 8.4111889 HS_from_MM_303_r 4.847876578 −3.649650041 8.497526619 HS_306_l 5.653094519 −2.863407345 8.516501864 Hsd_from_Mmd_383_r 4.846843191 −3.732116805 8.578959996 HS_306_l 5.556294478 −3.05973905 8.616033528 hsa-mir-145_l 5.644247849 −3.038892211 8.683140061 Hsd_from_Mmd_94_l 4.90141117 −3.801059753 8.702470924 Hsd_13_l 5.772543113 −2.933788243 8.706331355 HS_from_MQbrain_817_l 5.668999177 −3.046828158 8.715827335 HS_from_PT_206_l 4.727701851 −4.018056539 8.74575839 hsa-mir-520h_l 5.131084114 −3.655170271 8.786254385 hsa-mir-671_l 5.767779447 −3.053619735 8.821399182 hsa-mir-21_l 1.609681489 −7.236732615 8.846414105 HS_from_PT_313_l 5.481942633 −3.408145534 8.890088167 HS_from_MQbrain_722_r 5.410709411 −3.573201166 8.983910577 HSbrain_126_r 5.454802988 −3.86635451 9.321157497 ¹Cut off log2 range > 4

TABLE 2a Small RNAs that are differentially expressed between control and adenoma adenoma vs Systematic Name control adj p¹ HS_from_MM_118_r 0.000489293 HS_from_MM_169_r 0.000489293 HSbrain_106_r 0.000489293 HSbrain_801_r 0.000489293 Hsd_from_Mmd_485_r 0.000489293 Hsd_from_Mmd_452_l 0.000704567 hsa-mir-130a_r 0.001129352 HSbrain_731_r 0.001129352 HS_from_MQbrain_1311_r 0.001446314 hsa-mir-655_l 0.001446314 HS_from_MQbrain_1297_l 0.001647426 HSbrain_458_r 0.001883183 HS_from_MQbrain_1292_r 0.003939952 HS_from_MQbrain_1657_r 0.003939952 HS_from_MQbrain_839_r 0.003939952 HS_from_PT_36_l 0.003939952 HS_79_l 0.004006907 HS_from_MQbrain_100_l 0.004006907 HS_from_MQbrain_1183_l 0.004006907 HS_from_MQbrain_1363_l 0.004006907 HS_from_MQbrain_1628_r 0.004006907 HS_from_MQbrain_1823_r 0.004006907 hsa-mir-633_l 0.004006907 HS_from_MQbrain_288_r 0.004431894 HSbrain_377_l 0.004431894 HS_from_MQbrain_131_r 0.004575487 HS_from_MQbrain_20_r 0.004575487 HS_from_MQbrain_212_r 0.004575487 hsa-mir-125a_r 0.004575487 hsa-mir-196a-2_r 0.004799641 hsa-mir-302d_l 0.004799641 hsa-mir-497_r 0.004799641 HSbrain_629_l 0.004799641 HS_from_MQbrain_1070_r 0.004957702 HS_from_MQbrain_2380_r 0.004957702 hsa-mir-616_r 0.004957702 HSbrain_52_r 0.004957702 Hsd_from_Mmd_480_l 0.004957702 hsa-mir-421_r 0.006601644 HSbrain_224_r 0.006601644 HS_from_MM_339_r 0.00676609 HS_from_MQbrain_566_l 0.00676609 hsa-mir-554_l 0.00676609 hsa-mir-573_l 0.00676609 HSbrain_1076_r 0.00676609 HSbrain_426_r 0.00676609 HSbrain_102_r 0.007781761 HS_from_MQbrain_441_l 0.008573112 HSbrain_231_l 0.008573112 Hsd_49_r 0.008573112 HS_217_l 0.008946182 HS_from_MM_295_l 0.008946182 HS_from_MQbrain_1485_r 0.008946182 HS_from_MQbrain_1522_r 0.008946182 HS_from_PT_101_r 0.008946182 Hsd_from_Mmd_298_r 0.008946182 HS_141_l 0.009734613 HS_71_l 0.009734613 HSbrain_411_r 0.009734613 Hsd_from_Mmd_117_r 0.009734613 HS_291_r 0.01044887 HS_from_MQbrain_1462_l 0.01044887 hsa-mir-325_l 0.01044887 HSbrain_483_l 0.01044887 HSbrain_754_r 0.01044887 HS_215_r 0.010727702 HS_from_MQbrain_1056_l 0.010727702 HS_from_MQbrain_655_l 0.010727702 HS_from_MQbrain_671_r 0.010727702 hsa-let-7a-3_l 0.010727702 hsa-mir-135a-2_r 0.010727702 hsa-mir-516-3_l 0.010727702 hsa-mir-659_l 0.010727702 hsa-mir-768_r 0.010727702 hsa-mir-98_l 0.010727702 HSbrain_253_l 0.010727702 HSbrain_268_r 0.010727702 HSbrain_337_l 0.010727702 HSbrain_398_r 0.010727702 HSbrain_472_l 0.010727702 HSbrain_485_r 0.010727702 HSbrain_583_l 0.010727702 HSbrain_727_l 0.010727702 HSbrain_794_r 0.010727702 HSbrain_811_r 0.010727702 HS_232_l 0.011699489 HS_from_MQbrain_629_l 0.011699489 HSbrain_359_r 0.011699489 HSbrain_709_l 0.011699489 HSbrain_916_l 0.011699489 HS_169_l 0.012506309 HS_from_MQbrain_194_l 0.012506309 HS_from_MQbrain_330_r 0.012506309 HSbrain_1437_r 0.012506309 HSbrain_722_l 0.012506309 Hsd_from_Mmd_155_l 0.012506309 Hsd_from_Mmd_219_r 0.012506309 HS_from_MQbrain_1687_l 0.013034759 HS_from_MQbrain_71_r 0.013034759 HS_from_MQbrain_843_r 0.013034759 hsa-let-7f-1_l 0.013034759 hsa-let-7g_l 0.013034759 hsa-mir-126_r 0.013034759 hsa-mir-516-4_l 0.013034759 HSbrain_399_l 0.013034759 HSbrain_617_l 0.013034759 Hsd_107_l 0.013034759 HS_from_MQbrain_1444_l 0.014035635 HS_from_MQbrain_79_r 0.014035635 HSbrain_2_l 0.014035635 HSbrain_377_r 0.014035635 HSbrain_446_l 0.014035635 HSbrain_75_l 0.014035635 Hsd_70_l 0.014035635 HS_9_r 0.015394932 HS_from_MQbrain_1485_l 0.015394932 HS_from_MQbrain_349_l 0.015394932 HSbrain_1305_l 0.015394932 HSbrain_540_r 0.015394932 HS_21_r 0.015739043 HS_from_MQbrain_1624_l 0.015739043 HS_from_MQbrain_1792_r 0.015739043 HS_from_MQbrain_191_l 0.015739043 HS_from_MQbrain_2700_r 0.015739043 HS_from_MQbrain_375_l 0.015739043 HS_from_MQbrain_619_r 0.015739043 HS_from_MQbrain_940_r 0.015739043 hsa-mir-133a-2_r 0.015739043 hsa-mir-181a-1_l 0.015739043 hsa-mir-591_r 0.015739043 HSbrain_12_l 0.015739043 HSbrain_753_r 0.015739043 Hsd_from_Mmd_473_l 0.015739043 HS_281_r 0.016464393 HS_from_mM_264_l 0.016464393 HS_from_MQbrain_350_l 0.016464393 HS_from_MQbrain_825_r 0.016464393 HS_from_MQbrain_854_r 0.016464393 HS_from_PT_114_r 0.016464393 hsa-let-7a-1_l 0.016464393 hsa-Iet-7a-2_l 0.016464393 HSbrain_1_l 0.016464393 HSbrain_158_l 0.016464393 HSbrain_171_l 0.016464393 HSbrain_420_r 0.016464393 HS_from_MQbrain_1100_l 0.017198956 HS_from_MQbrain_1128_l 0.017198956 HS_from_MQbrain_1393_r 0.017198956 HS_from_MQbrain_1630_l 0.017198956 HS_from_MQbrain_965_l 0.017198956 HS_from_PT_190_r 0.017198956 hsa-mir-181c_l 0.017198956 hsa-mir-296_l 0.017198956 HSbrain_148_r 0.017198956 HSbrain_225_r 0.017198956 HSbrain_713_r 0.017198956 Hsd_18_l 0.017198956 Hsd_from_Mmd_519_l 0.017198956 HS_from_MM_39_l 0.018600058 HS_from_MQbrain_1625_r 0.018600058 hsa-mir-454_r 0.018600058 HSbrain_398_l 0.018600058 HSbrain_636_l 0.018600058 HSbrain_703_r 0.018600058 Hsd_from_Mmd_533_l 0.018600058 Hsd_from_Mmd_92_r 0.018600058 HS_262_l 0.019454312 HS_from_MM_309_r 0.019454312 HS_from_MQbrain_1103_l 0.019454312 HS_from_MQbrain_917_r 0.019454312 HS_from_PT_146_r 0.019454312 HS_from_PT_40_r 0.019454312 hsa-mir-299_l 0.019454312 hsa-mir-568_r 0.019454312 hsa-mir-92-2_r 0.019454312 HSbrain_1377_l 0.019454312 HSbrain_1413_l 0.019454312 HSbrain_321_r 0.019454312 HSbrain_714_l 0.019454312 HSbrain_723_l 0.019454312 HS_291_r 0.021088597 HS_from_MM_63_l 0.021088597 HS_from_MQbrain_1260_r 0.021088597 HS_from_PT_201_r 0.021088597 HS_from_PT_237_r 0.021088597 hsa-mir-125a_l 0.021088597 Hsd_46_l 0.021088597 Hsd_from_Mmd_527_r 0.021088597 HS_from_MM_178_r 0.022745616 HS_from_MM_18_l 0.022745616 HS_from_MQbrain_207_l 0.022745616 HS_from_MQbrain_549_l 0.022745616 hsa-mir-27a_r 0.022745616 hsa-mir-383_r 0.022745616 HSbrain_500_r 0.022745616 HSbrain_597_r 0.022745616 HSbrain_74_r 0.022745616 HS_218_r 0.023736962 HS_from_MM_241_l 0.023736962 HS_from_MM_319_l 0.023736962 HS_from_MQbrain_1317_r 0.023736962 HS_from_MQbrain_1456_l 0.023736962 HS_from_MQbrain_1632_r 0.023736962 HS_from_MQbrain_1884_r 0.023736962 HS_from_PT_114_l 0.023736962 HS_from_PT_257_r 0.023736962 HS_from_PT_26_r 0.023736962 HS_from_PT_32_r 0.023736962 hsa-mir-29a_r 0.023736962 HSbrain_243_l 0.023736962 HSbrain_527_r 0.023736962 HSbrain_8_r 0.023736962 Hsd_26_l 0.023736962 HS_255_l 0.024762366 HSfrom_MM_334_l 0.024762366 HS_from_MQbrain_1043_r 0.024762366 HS_from_MQbrain_1085_l 0.024762366 HS_from_MQbrain_1300_r 0.024762366 HS_from_MQbrain_1761_r 0.024762366 HS_from_MQbrain_1808_r 0.024762366 HS_from_MQbrain_55_l 0.024762366 hsa-mir-197_l 0.024762366 hsa-mir-323_l 0.024762366 hsa-mir-92-1_r 0.024762366 HSbrain_1384_r 0.024762366 HSbrain_362_r 0.024762366 HSbrain_503_r 0.024762366 HSbrain_6_r 0.024762366 HSbrain_778_r 0.024762366 Hsd_from_Mmd_387_l 0.024762366 HS_from_MM_121_l 0.026800941 HS_from_MM_131_l 0.026800941 HS_from_MQbrain_1684_l 0.026800941 HS_from_MQbrain_444_r 0.026800941 HS_from_MQbrain_509_r 0.026800941 HS_from_MQbrain_734_l 0.026800941 hsa-mir-598_l 0.026800941 hsa-mir-647_r 0.026800941 HSbrain_359_l 0.026800941 HS_262_r 0.028655448 HS_from_MQbrain_391_r 0.028655448 HS_from_MQbrain_74_r 0.028655448 HS_from_PT_139_l 0.028655448 hsa-let-7d_l 0.028655448 hsa-mir-373_r 0.028655448 hsa-mir-378_r 0.028655448 hsa-mir-500_l 0.028655448 HSbrain_318_l 0.028655448 HSbrain_50_r 0.028655448 HSbrain_545_r 0.028655448 Hsd_from_Mmd_302_r 0.028655448 HS_106_l 0.02997784 HS_from_MQbrain_1169_l 0.02997784 HS_from_MQbrain_1832_l 0.02997784 HS_from_MQbrain_1985_l 0.02997784 HS_from_MQbrain_918_l 0.02997784 HS_from_PT_299_l 0.02997784 hsa-let-7f-2_l 0.02997784 hsa-mir-134_r 0.02997784 hsa-mir-146a_l 0.02997784 hsa-mir-331_r 0.02997784 hsa-mir-453_l 0.02997784 hsa-mir-95_r 0.02997784 HSbrain_114_r 0.02997784 HSbrain_259_r 0.02997784 HSbrain_296_l 0.02997784 HSbrain_546_r 0.02997784 HSbrain_696_r 0.02997784 HSbrain_713_l 0.02997784 HS_118_l 0.03224042 HS_from_MQbrain_1392_r 0.03224042 HS_from_MQbrain_1443_r 0.03224042 HS_from_MQbrain_1445_l 0.03224042 HS_from_MQbrain_1469_r 0.03224042 HS_from_MQbrain_1863_l 0.03224042 HS_from_PT_103_l 0.03224042 hsa-mir-106b_r 0.03224042 hsa-mir-145_l 0.03224042 Hsd_105_l 0.03224042 Hsd_17_r 0.03224042 HS_231_r 0.03374871 HS_from_MM_359_l 0.03374871 HS_from_MQbrain_1690_l 0.03374871 HS_from_MQbrain_435_l 0.03374871 HS_from_MQbrain_482_l 0.03374871 HS_from_MQbrain_800_r 0.03374871 HS_from_MQbrain_969_l 0.03374871 hsa-mir-133a-1_r 0.03374871 hsa-mir-640_l 0.03374871 hsa-mir-668_r 0.03374871 HSbrain_165_l 0.03374871 HSbrain_316_l 0.03374871 HSbrain_41_l 0.03374871 HSbrain_458_l 0.03374871 HSbrain_500_l 0.03374871 HSbrain_760_l 0.03374871 HSbrain_792_r 0.03374871 Hsd_from_Mmd_487_r 0.03374871 Hsd_from_Mmd_81_l 0.03374871 HS_97_r 0.036099692 HS_from_MQbrain_1340_l 0.036099692 HS_from_MQbrain_1513_r 0.036099692 HS_from_PT_295_r 0.036099692 HS_from_PT_299_r 0.036099692 hsa-mir-26b_l 0.036099692 hsa-mir-30c-1_l 0.036099692 hsa-mir-423_r 0.036099692 HSbrain_272_l 0.036099692 Hsd_102_l 0.036099692 Hsd_from_Mmd_23_l 0.036099692 Hsd_from_Mmd_410_r 0.036099692 Hsd_from_Mmd_97_l 0.036099692 HS_292_l 0.038273758 HS_33_l 0.038273758 HS_from_MM_354_r 0.038273758 HS_from_MQbrain_1087_l 0.038273758 HS_from_MQbrain_1315_l 0.038273758 HS_from_MQbrain_1420_l 0.038273758 HS_from_MQbrain_282_l 0.038273758 HS_from_MQbrain_498_r 0.038273758 HS_from_MQbrain_883_l 0.038273758 hsa-mir-140_l 0.038273758 hsa-mir-550-2_r 0.038273758 HSbrain_261_l 0.038273758 HSbrain_266_r 0.038273758 HSbrain_543_r 0.038273758 HSbrain_580_r 0.038273758 HSbrain_700_r 0.038273758 HS_189_l 0.040151024 HS_191_l 0.040151024 HS_56_r 0.040151024 HS_from_MM_276_l 0.040151024 HS_from_MQbrain_1080_l 0.040151024 HS_from_MQbrain_1379_r 0.040151024 HS_from_MQbrain_1561_r 0.040151024 HS_from_MQbrain_1703_r 0.040151024 HS_from_MQbrain_1747_r 0.040151024 HS_from_MQbrain_470_l 0.040151024 HS_from_MQbrain_951_l 0.040151024 HS_from_PT_43_l 0.040151024 hsa-let-7a-2_r 0.040151024 hsa-let-7c_r 0.040151024 hsa-mir-181a-2_l 0.040151024 hsa-mir-329-2_r 0.040151024 HSbrain_109_l 0.040151024 HSbrain_92_l 0.040151024 Hsd_from_Mmd_436_r 0.040151024 Hsd_from_Mmd_527_l 0.040151024 HS_15_l 0.042549287 HS_177_l 0.042549287 HS_261_r 0.042549287 HS_from_MM_289_l 0.042549287 HS_from_MQbrain_1227_l 0.042549287 HS_from_MQbrain_1246_l 0.042549287 HS_from_MQbrain_1388_l 0.042549287 HS_from_MQbrain_1844_r 0.042549287 HS_from_MQbrain_67_r 0.042549287 HS_from_MQbrain_782_r 0.042549287 HS_from_PT_63_r 0.042549287 HS_from_PT_91_r 0.042549287 hsa-mir-148a_r 0.042549287 HSbrain_1410_l 0.042549287 HSbrain_752_r 0.042549287 Hsd_42_r 0.042549287 Hsd_from_Mmd_261_l 0.042549287 HS_266_r 0.045725655 HS_from_MQbrain_1143_r 0.045725655 HS_from_MQbrain_1717_r 0.045725655 HS_from_MQbrain_951_l 0.045725655 HS_from_PT_21_r 0.045725655 HS_from_PT_70_r 0.045725655 hsa-mir-148a_l 0.045725655 hsa-mir-653_l 0.045725655 HSbrain_284_l 0.045725655 Hsd_63_r 0.045725655 Hsd_from_Mmd_34_r 0.045725655 Hsd_from_Mmd_422_l 0.045725655 HS_114_l 0.048378078 HS_212_l 0.048378078 HS_from_MM_1_r 0.048378078 HS_from_MM_32_r 0.048378078 HS_from_MQbrain_1006_l 0.048378078 HS_from_MQbrain_1075_l 0.048378078 HS_from_MQbrain_1752_l 0.048378078 HS_from_MQbrain_1773_l 0.048378078 HS_from_MQbrain_472_r 0.048378078 HS_from_MQbrain_539_r 0.048378078 HS_from_MQbrain_92_l 0.048378078 hsa-mir-200c_r 0.048378078 hsa-mir-92b_r 0.048378078 HSbrain_1362_l 0.048378078 HSbrain_25_r 0.048378078 HSbrain_48_r 0.048378078 HSbrain_703_l 0.048378078 Hsd_from_Mmd_49_l 0.048378078 HS_171_r 0.050130838 HS_215_l 0.050130838 HS_93_r 0.050130838 HS_from_MQbrain_1042_r 0.050130838 HS_from_MQbrain_1283_l 0.050130838 HS_from_MQbrain_1610_r 0.050130838 HS_from_MQbrain_1642_l 0.050130838 HS_from_MQbrain_1686_l 0.050130838 HS_from_MQbrain_1771_l 0.050130838 HS_from_MQbrain_209_r 0.050130838 HS_from_MQbrain_315_l 0.050130838 HS_from_MQbrain_343_l 0.050130838 HS_from_MQbrain_542_r 0.050130838 HS_from_MQbrain_572_l 0.050130838 HS_from_MQbrain_691_l 0.050130838 HS_from_MQbrain_774_r 0.050130838 HS_from_MQbrain_842_l 0.050130838 HS_from_MQbrain_901_l 0.050130838 HS_from_PT_136_l 0.050130838 hsa-mir-141_r 0.050130838 hsa-mir-584_r 0.050130838 hsa-mir-668_l 0.050130838 hsa-mir-767_r 0.050130838 HSbrain_585_l 0.050130838 HSbrain_652_l 0.050130838 HSbrain_84_l 0.050130838 Hsd_65_l 0.050130838 HS_131_r 0.053159859 HS_from_MQbrain_1239_l 0.053159859 HS_from_MQbrain_1334_r 0.053159859 HS_from_MQbrain_1395_r 0.053159859 HS_from_MQbrain_1484_l 0.053159859 HS_from_MQbrain_1794_l 0.053159859 HS_from_MQbrain_1958_l 0.053159859 HS_from_MQbrain_723_l 0.053159859 HS_from_MQbrain_873_r 0.053159859 hsa-mir-520b_r 0.053159859 HSbrain_374_r 0.053159859 HSbrain_442_r 0.053159859 HSbrain_711_l 0.053159859 Hsd_18_r 0.053159859 Hsd_37_l 0.053159859 Hsd_6_l 0.053159859 Hsd_76_r 0.053159859 Hsd_from_Mmd_535_r 0.053159859 HS_59_l 0.05566524 HS_62_l 0.05566524 HS_from_MM_115_l 0.05566524 HS_from_MM_49_l 0.05566524 HS_from_MM_72_r 0.05566524 HS_from_MQbrain_1620_l 0.05566524 HS_from_MQbrain_1674_l 0.05566524 HS_from_MQbrain_1700_r 0.05566524 HS_from_MQbrain_38_r 0.05566524 HS_from_MQbrain_56_l 0.05566524 HS_from_MQbrain_579_l 0.05566524 HS_from_MQbrain_664_l 0.05566524 HS_from_PT_321_r 0.05566524 hsa-mir-372_r 0.05566524 hsa-mir-521-1_r 0.05566524 hsa-mir-652_l 0.05566524 HSbrain_239_l 0.05566524 HSbrain_419_l 0.05566524 HSbrain_671_r 0.05566524 HSbrain_704_l 0.05566524 HSbrain_719_l 0.05566524 HSbrain_85_l 0.05566524 HSbrain_916_r 0.05566524 Hsd_from_Mmd_500_r 0.05566524 HS_109_r 0.058253679 HS_156_l 0.058253679 HS_190_l 0.058253679 HS_from_MQbrain_1099_r 0.058253679 HS_from_MQbrain_1119_l 0.058253679 HS_from_MQbrain_1300_l 0.058253679 HS_from_MQbrain_1374_l 0.058253679 HS_from_MQbrain_796_l 0.058253679 HS_from_MQbrain_810_l 0.058253679 HS_from_MQbrain_883_r 0.058253679 HS_from_MQbrain_974_l 0.058253679 HS_from_PT_121_r 0.058253679 HS_from_PT_187_r 0.058253679 hsa-mir-148b_r 0.058253679 hsa-mir-20b_l 0.058253679 hsa-mir-514-1_r 0.058253679 hsa-mir-646_r 0.058253679 HSbrain_123_l 0.058253679 HSbrain_300_l 0.058253679 HSbrain_304_r 0.058253679 HSbrain_35_r 0.058253679 Hsd_19_r 0.058253679 Hsd_7_r 0.058253679 Hsd_from_Mmd_166_l 0.058253679 Hsd_from_Mmd_70_l 0.058253679 HS_150_l 0.061046963 HS_281_r 0.061046963 HS_304_r 0.061046963 HS_36_l 0.061046963 HS_from_MQbrain_128_r 0.061046963 HS_from_MQbrain_1354_l 0.061046963 HS_from_MQbrain_1404_r 0.061046963 HS_from_MQbrain_1412_l 0.061046963 HS_from_MQbrain_1500_l 0.061046963 HS_from_MQbrain_1862_l 0.061046963 HS_from_MQbrain_420_l 0.061046963 HS_from_MQbrain_43_l 0.061046963 HS_from_MQbrain_70_l 0.061046963 HS_from_MQbrain_991_r 0.061046963 HS_from_PT_242_l 0.061046963 HS_from_PT_340_l 0.061046963 hsa-mir-299_r 0.061046963 hsa-mir-412_r 0.061046963 hsa-mir-628_r 0.061046963 HSbrain_214_l 0.061046963 HSbrain_408_r 0.061046963 HSbrain_409_r 0.061046963 HSbrain_663_l 0.061046963 Hsd_from_Mmd_284_l 0.061046963 Hsd_from_Mmd_439_l 0.061046963 HS_180_r 0.064770288 HS_from_MM_6_r 0.064770288 HS_from_MQbrain_1235_l 0.064770288 HS_from_MQbrain_1446_l 0.064770288 HS_from_MQbrain_1450_r 0.064770288 HS_from_MQbrain_1696_l 0.064770288 HS_from_MQbrain_435_r 0.064770288 HS_from_MQbrain_750_r 0.064770288 HS_from_PT_308_l 0.064770288 HS_from_PT_41_r 0.064770288 hsa-mir-29c_r 0.064770288 HSbrain_116_l 0.064770288 HSbrain_1338_r 0.064770288 HSbrain_157_l 0.064770288 HSbrain_506_l 0.064770288 HSbrain_598_l 0.064770288 HSbrain_755_l 0.064770288 HSbrain_776_l 0.064770288 Hsd_81_r 0.064770288 HS_203_r 0.067503134 HS_from_MM_342_r 0.067503134 HS_from_MM_47_l 0.067503134 HS_from_MQbrain_1164_l 0.067503134 HS_from_MQbrain_1323_l 0.067503134 HS_from_MQbrain_1427_l 0.067503134 HS_from_MQbrain_1877_l 0.067503134 HS_from_MQbrain_239_r 0.067503134 HS_from_MQbrain_468_r 0.067503134 HS_from_MQbrain_549_r 0.067503134 HS_from_MQbrain_745_r 0.067503134 HS_from_PT_112_l 0.067503134 HS_from_PT_339_l 0.067503134 hsa-mir-137_l 0.067503134 hsa-mir-329-1_r 0.067503134 hsa-mir-518f_r 0.067503134 hsa-mir-524_l 0.067503134 HSbrain_139_l 0.067503134 HSbrain_212_l 0.067503134 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HS_from_MQbrain_485_l 0.12422104 HS_from_MQbrain_490_r 0.12422104 HS_from_MQbrain_789_l 0.12422104 HS_from_PT_237_l 0.12422104 HS_from_PT_283_r 0.12422104 hsa-mir-513-2_l 0.12422104 hsa-mir-622_l 0.12422104 HSbrain_1076_l 0.12422104 HSbrain_131_l 0.12422104 HSbrain_396_r 0.12422104 HSbrain_478_r 0.12422104 HSbrain_50_l 0.12422104 HSbrain_543_l 0.12422104 HSbrain_570_l 0.12422104 Hsd_17_l 0.12422104 Hsd_from_Mmd_183_r 0.12422104 Hsd_from_Mmd_237_l 0.12422104 Hsd_from_Mmd_328_r 0.12422104 Hsd_from_Mmd_489_r 0.12422104 HS_109_l 0.129399391 HS_22_r 0.129399391 HS_85_l 0.129399391 HS_from_MM_145_r 0.129399391 HS_from_MM_157_l 0.129399391 HS_from_MM_304_r 0.129399391 HS_from_MQbrain_129_r 0.129399391 HS_from_MQbrain_137_r 0.129399391 HS_from_MQbrain_1377_r 0.129399391 HS_from_MQbrain_1574_l 0.129399391 HS_from_MQbrain_1712_r 0.129399391 HS_from_MQbrain_1722_l 0.129399391 HS_from_MQbrain_1776_l 0.129399391 HS_from_MQbrain_1794_r 0.129399391 HS_from_MQbrain_1839_l 0.129399391 HS_from_MQbrain_36_r 0.129399391 HS_from_MQbrain_382_l 0.129399391 HS_from_MQbrain_466_l 0.129399391 HS_from_MQbrain_555_r 0.129399391 HS_from_MQbrain_597_l 0.129399391 HS_from_MQbrain_967_l 0.129399391 HS_from_PT_207_l 0.129399391 HS_from_PT_38_l 0.129399391 hsa-mir-412_l 0.129399391 hsa-mir-525_l 0.129399391 hsa-mir-622_r 0.129399391 hsa-mir-9-2_r 0.129399391 HSbrain_152_l 0.129399391 HSbrain_204_r 0.129399391 HSbrain_244_l 0.129399391 HSbrain_267_r 0.129399391 HSbrain_347_r 0.129399391 HSbrain_448_l 0.129399391 HSbrain_695_l 0.129399391 HSbrain_72_l 0.129399391 HSbrain_970_r 0.129399391 Hsd_from_Mmd_128_l 0.129399391 Hsd_from_Mmd_363_l 0.129399391 Hsd_from_Mmd_431_l 0.129399391 HS_189_r 0.134970683 HS_214_r 0.134970683 HS_261_l 0.134970683 HS_51_r 0.134970683 HS_from_MM_119_r 0.134970683 HS_from_MM_185_r 0.134970683 HS_from_MQbrain_1081_r 0.134970683 HS_from_MQbrain_1097_r 0.134970683 HS_from_MQbrain_1318_l 0.134970683 HS_from_MQbrain_1376_r 0.134970683 HS_from_MQbrain_1523_r 0.134970683 HS_from_MQbrain_1640_l 0.134970683 HS_from_MQbrain_1692_l 0.134970683 HS_from_MQbrain_1804_r 0.134970683 HS_from_MQbrain_1806_l 0.134970683 HS_from_MQbrain_234_r 0.134970683 HS_from_MQbrain_461_l 0.134970683 HS_from_MQbrain_540_l 0.134970683 HS_from_MQbrain_684_r 0.134970683 HS_from_MQbrain_89_l 0.134970683 HS_from_MQbrain_968_l 0.134970683 HS_from_MQbrain_99_r 0.134970683 HS_from_PT_194_r 0.134970683 HS_from_PT_250_r 0.134970683 hsa-mir-181a-1_r 0.134970683 hsa-mir-31_r 0.134970683 hsa-mir-550-1_r 0.134970683 hsa-mir-588_r 0.134970683 hsa-mir-609_r 0.134970683 HSbrain_496_r 0.134970683 HSbrain_687_r 0.134970683 HSbrain_715_l 0.134970683 Hsd_62_l 0.134970683 Hsd_74_r 0.134970683 Hsd_from_Mmd_101_r 0.134970683 Hsd_from_Mmd_291_l 0.134970683 Hsd_from_Mmd_388_l 0.134970683 Hsd_from_Mmd_524_l 0.134970683 HS_111_l 0.140323812 HS_121_r 0.140323812 HS_157_r 0.140323812 HS_161_r 0.140323812 HS_168_r 0.140323812 HS_175_l 0.140323812 HS_219_l 0.140323812 HS_241_r 0.140323812 HS_41_r 0.140323812 HS_53_r 0.140323812 HS_from_MM_109_l 0.140323812 HS_from_MM_84_r 0.140323812 HS_from_MQbrain_1110_l 0.140323812 HS_from_MQbrain_15_r 0.140323812 HS_from_MQbrain_1855_l 0.140323812 HS_from_MQbrain_22_r 0.140323812 HS_from_MQbrain_221_r 0.140323812 HS_from_MQbrain_235_r 0.140323812 HS_from_MQbrain_266_r 0.140323812 HS_from_MQbrain_467_l 0.140323812 HS_from_MQbrain_56_r 0.140323812 HS_from_MQbrain_664_r 0.140323812 HS_from_PT_170_r 0.140323812 HS_from_PT_178_l 0.140323812 HS_from_PT_250_l 0.140323812 hsa-mir-135a-1_r 0.140323812 hsa-mir-23a_l 0.140323812 hsa-mir-26a-1_l 0.140323812 hsa-mir-27b_r 0.140323812 hsa-mir-570_l 0.140323812 hsa-mir-599_r 0.140323812 HSbrain_108_l 0.140323812 HSbrain_126_r 0.140323812 HSbrain_144_r 0.140323812 HSbrain_361_l 0.140323812 HSbrain_425_l 0.140323812 HSbrain_522_r 0.140323812 HSbrain_541_r 0.140323812 HSbrain_716_l 0.140323812 HSbrain_737_r 0.140323812 Hsd_from_Mmd_123_l 0.140323812 Hsd_from_Mmd_523_l 0.140323812 HS_268_l 0.146822481 HS_76_r 0.146822481 HS_from_MQbrain_1030_l 0.146822481 HS_from_MQbrain_1036_r 0.146822481 HS_from_MQbrain_1222_r 0.146822481 HS_from_MQbrain_1250_r 0.146822481 HS_from_MQbrain_1381_r 0.146822481 HS_from_MQbrain_1462_r 0.146822481 HS_from_MQbrain_1493_r 0.146822481 HS_from_MQbrain_1675_r 0.146822481 HS_from_MQbrain_1695_r 0.146822481 HS_from_MQbrain_1759_l 0.146822481 HS_from_MQbrain_1807_l 0.146822481 HS_from_MQbrain_260_r 0.146822481 HS_from_MQbrain_283_r 0.146822481 HS_from_MQbrain_600_l 0.146822481 HS_from_MQbrain_67_l 0.146822481 HS_from_MQbrain_697_l 0.146822481 HS_from_MQbrain_97_r 0.146822481 HS_from_PT_219_l 0.146822481 HS_from_PT_271_l 0.146822481 HS_from_PT_284_r 0.146822481 hsa-mir-1-1_l 0.146822481 hsa-mir-521-1_l 0.146822481 HSbrain_107_r 0.146822481 HSbrain_1298_r 0.146822481 HSbrain_130_l 0.146822481 HSbrain_139_r 0.146822481 HSbrain_599_r 0.146822481 HSbrain_624_l 0.146822481 HSbrain_663_r 0.146822481 HSbrain_705_r 0.146822481 Hsd_77_r 0.146822481 Hsd_96_r 0.146822481 Hsd_from_Mmd_316_r 0.146822481 HS_115_r 0.152858542 HS_176_l 0.152858542 HS_from_MM_89_l 0.152858542 HS_from_MQbrain_1072_r 0.152858542 HS_from_MQbrain_1127_r 0.152858542 HS_from_MQbrain_153_l 0.152858542 HS_from_MQbrain_154_r 0.152858542 HS_from_MQbrain_1817_l 0.152858542 HS_from_MQbrain_1896_r 0.152858542 HS_from_MQbrain_338_l 0.152858542 HS_from_MQbrain_340_l 0.152858542 HS_from_MQbrain_355_r 0.152858542 HS_from_MQbrain_6_r 0.152858542 HS_from_MQbrain_689_l 0.152858542 HS_from_MQbrain_693_r 0.152858542 HS_from_MQbrain_707_l 0.152858542 HS_from_MQbrain_969_r 0.152858542 HS_from_PT_238_l 0.152858542 HS_from_PT_92_l 0.152858542 hsa-mir-17_l 0.152858542 hsa-mir-188_l 0.152858542 hsa-mir-641_r 0.152858542 HSbrain_130_r 0.152858542 HSbrain_1325_r 0.152858542 HSbrain_171_l 0.152858542 HSbrain_22_l 0.152858542 HSbrain_222_r 0.152858542 HSbrain_266_l 0.152858542 HSbrain_306_r 0.152858542 HSbrain_32_r 0.152858542 HSbrain_483_r 0.152858542 HSbrain_604_r 0.152858542 HSbrain_641_r 0.152858542 HSbrain_656_l 0.152858542 HSbrain_695_r 0.152858542 HSbrain_717_r 0.152858542 HSbrain_752_l 0.152858542 HSbrain_811_l 0.152858542 Hsd_38_r 0.152858542 Hsd_from_Mmd_280_l 0.152858542 Hsd_from_Mmd_346_l 0.152858542 HS_128_l 0.158799149 HS_18_l 0.158799149 HS_95_r 0.158799149 HS_from_MM_118_l 0.158799149 HS_from_MM_135_l 0.158799149 HS_from_MM_35_l 0.158799149 HS_from_MQbrain_1018_l 0.158799149 HS_from_MQbrain_1204_r 0.158799149 HS_from_MQbrain_140_l 0.158799149 HS_from_MQbrain_1501_r 0.158799149 HS_from_MQbrain_155_l 0.158799149 HS_from_MQbrain_1831_r 0.158799149 HS_from_MQbrain_2699_l 0.158799149 HS_from_MQbrain_281_r 0.158799149 HS_from_MQbrain_382_r 0.158799149 HS_from_MQbrain_414_l 0.158799149 HS_from_MQbrain_6_l 0.158799149 HS_from_MQbrain_625_l 0.158799149 HS_from_MQbrain_631_l 0.158799149 HS_from_MQbrain_675_l 0.158799149 HS_from_MQbrain_68_r 0.158799149 HS_from_MQbrain_900_r 0.158799149 HS_from_MQbrain_912_l 0.158799149 HS_from_PT_158_l 0.158799149 HS_from_PT_255_l 0.158799149 hsa-mir-151_l 0.158799149 hsa-mir-16-2_l 0.158799149 hsa-mir-422a_l 0.158799149 hsa-mir-518c_l 0.158799149 hsa-mir-98_r 0.158799149 HSbrain_121_l 0.158799149 HSbrain_248_l 0.158799149 HSbrain_320_l 0.158799149 HSbrain_347_l 0.158799149 HSbrain_413_l 0.158799149 HSbrain_55_l 0.158799149 HSbrain_653_l 0.158799149 HSbrain_669_r 0.158799149 HSbrain_673_l 0.158799149 HSbrain_768_l 0.158799149 HSbrain_783_l 0.158799149 Hsd_67_r 0.158799149 Hsd_from_Mmd_334_r 0.158799149 Hsd_from_Mmd_44_r 0.158799149 HS_181_l 0.163891418 HS_286_r 0.163891418 HS_74_r 0.163891418 HS_from_MM_218_l 0.163891418 HS_from_MM_340_r 0.163891418 HS_from_MQbrain_1028_l 0.163891418 HS_from_MQbrain_1090_r 0.163891418 HS_from_MQbrain_1119_l 0.163891418 HS_from_MQbrain_1212_l 0.163891418 HS_from_MQbrain_1223_l 0.163891418 HS_from_MQbrain_1426_l 0.163891418 HS_from_MQbrain_1520_l 0.163891418 HS_from_MQbrain_1535_r 0.163891418 HS_from_MQbrain_1721_l 0.163891418 HS_from_MQbrain_1724_l 0.163891418 HS_from_MQbrain_365_r 0.163891418 HS_from_MQbrain_449_l 0.163891418 HS_from_MQbrain_529_r 0.163891418 HS_from_MQbrain_566_r 0.163891418 HS_from_MQbrain_596_r 0.163891418 HS_from_MQbrain_629_r 0.163891418 HS_from_MQbrain_650_r 0.163891418 HS_from_MQbrain_824_r 0.163891418 HS_from_MQbrain_936_r 0.163891418 HS_from_MQbrain_941_r 0.163891418 HS_from_MQbrain_996_l 0.163891418 HS_from_PT_155_l 0.163891418 HS_from_PT_196_r 0.163891418 HS_from_PT_234_l 0.163891418 HS_from_PT_280_l 0.163891418 hsa-mir-124a-1_l 0.163891418 hsa-mir-30c-2_l 0.163891418 hsa-mir-33b_l 0.163891418 hsa-mir-652_r 0.163891418 HSbrain_275_r 0.163891418 HSbrain_304_l 0.163891418 HSbrain_305_l 0.163891418 HSbrain_376_l 0.163891418 HSbrain_402_l 0.163891418 HSbrain_438_r 0.163891418 HSbrain_446_r 0.163891418 HSbrain_578_l 0.163891418 HSbrain_598_r 0.163891418 HSbrain_680_l 0.163891418 HSbrain_784_r 0.163891418 HSbrain_804_l 0.163891418 HSbrain_95_l 0.163891418 Hsd_108_r 0.163891418 Hsd_84_r 0.163891418 Hsd_from_Mmd_19_l 0.163891418 Hsd_from_Mmd_455_l 0.163891418 Hsd_from_Mmd_52_r 0.163891418 Hsd_from_Mmd_94_l 0.163891418 HS_128_r 0.170271053 HS_151_r 0.170271053 HS_192_r 0.170271053 HS_197_r 0.170271053 HS_212_r 0.170271053 HS_223_r 0.170271053 HS_264_r 0.170271053 HS_78_r 0.170271053 HS_83_r 0.170271053 HS_from_MM_163_l 0.170271053 HS_from_MM_232_r 0.170271053 HS_from_MM_304_l 0.170271053 HS_from_MQbrain_1199_l 0.170271053 HS_from_MQbrain_1377_l 0.170271053 HS_from_MQbrain_1846_r 0.170271053 HS_from_MQbrain_1893_r 0.170271053 HS_from_MQbrain_281_l 0.170271053 HS_from_MQbrain_392_r 0.170271053 HS_from_MQbrain_468_l 0.170271053 HS_from_MQbrain_603_r 0.170271053 HS_from_MQbrain_841_l 0.170271053 HS_from_MQbrain_97_l 0.170271053 hsa-mir-192_r 0.170271053 hsa-mir-196b_r 0.170271053 hsa-mir-765_r 0.170271053 HSbrain_143_l 0.170271053 HSbrain_177_l 0.170271053 HSbrain_216_r 0.170271053 HSbrain_364_r 0.170271053 HSbrain_41_r 0.170271053 HSbrain_467_l 0.170271053 HSbrain_53_l 0.170271053 HSbrain_701_l 0.170271053 HSbrain_724_l 0.170271053 HSbrain_726_l 0.170271053 HSbrain_745_l 0.170271053 HSbrain_755_r 0.170271053 HSbrain_780_l 0.170271053 HSbrain_80_l 0.170271053 Hsd_47_r 0.170271053 Hsd_from_Mmd_235_r 0.170271053 Hsd_from_Mmd_306_l 0.170271053 Hsd_from_Mmd_35_l 0.170271053 Hsd_from_Mmd_367_l 0.170271053 Hsd_from_Mmd_410_l 0.170271053 HS_130_l 0.176183859 HS_145_r 0.176183859 HS_186_r 0.176183859 HS_204_r 0.176183859 HS_220_l 0.176183859 HS_from_MM_123_l 0.176183859 HS_from_MM_84_l 0.176183859 HS_from_MQbrain_1126_l 0.176183859 HS_from_MQbrain_1204_l 0.176183859 HS_from_MQbrain_1245_l 0.176183859 HS_from_MQbrain_135_l 0.176183859 HS_from_MQbrain_1444_l 0.176183859 HS_from_MQbrain_1497_l 0.176183859 HS_from_MQbrain_1565_l 0.176183859 HS_from_MQbrain_1566_r 0.176183859 HS_from_MQbrain_1773_l 0.176183859 HS_from_MQbrain_1832_r 0.176183859 HS_from_MQbrain_2087_r 0.176183859 HS_from_MQbrain_314_l 0.176183859 HS_from_MQbrain_365_l 0.176183859 HS_from_MQbrain_520_l 0.176183859 HS_from_MQbrain_628_l 0.176183859 HS_from_MQbrain_855_r 0.176183859 HS_from_MQbrain_984_l 0.176183859 HS_from_PT_27_r 0.176183859 hsa-mir-101-1_r 0.176183859 hsa-mir-144_r 0.176183859 hsa-mir-16-1_l 0.176183859 hsa-mir-432_l 0.176183859 hsa-mir-526a-1_r 0.176183859 hsa-mir-92-1_l 0.176183859 HSbrain_120_r 0.176183859 HSbrain_1418_r 0.176183859 HSbrain_151_r 0.176183859 HSbrain_32_l 0.176183859 HSbrain_334_r 0.176183859 HSbrain_491_l 0.176183859 HSbrain_590_l 0.176183859 HSbrain_626_l 0.176183859 HSbrain_707_r 0.176183859 HSbrain_771_l 0.176183859 Hsd_27_r 0.176183859 Hsd_65_r 0.176183859 Hsd_from_Mmd_123_r 0.176183859 Hsd_from_Mmd_212_r 0.176183859 Hsd_from_Mmd_296_l 0.176183859 Hsd_from_Mmd_328_l 0.176183859 Hsd_from_Mmd_344_r 0.176183859 Hsd_from_Mmd_391_r 0.176183859 Hsd_from_Mmd_412_r 0.176183859 Hsd_from_Mmd_92_l 0.176183859 HS_132_l 0.182758186 HS_167_l 0.182758186 HS_307_r 0.182758186 HS_from_MM_124_r 0.182758186 HS_from_MM_149_r 0.182758186 HS_from_MM_160_l 0.182758186 HS_from_MM_342_l 0.182758186 HS_from_MM_6_l 0.182758186 HS_from_MQbrain_1137_l 0.182758186 HS_from_MQbrain_1219_r 0.182758186 HS_from_MQbrain_1349_l 0.182758186 HS_from_MQbrain_1380_r 0.182758186 HS_from_MQbrain_147_l 0.182758186 HS_from_MQbrain_1509_r 0.182758186 HS_from_MQbrain_1576_r 0.182758186 HS_from_MQbrain_162_r 0.182758186 HS_from_MQbrain_1793_l 0.182758186 HS_from_MQbrain_1883_l 0.182758186 HS_from_MQbrain_361_l 0.182758186 HS_from_MQbrain_559_r 0.182758186 HS_from_MQbrain_635_l 0.182758186 HS_from_MQbrain_676_r 0.182758186 HS_from_MQbrain_694_r 0.182758186 HS_from_MQbrain_732_r 0.182758186 HS_from_MQbrain_736_r 0.182758186 HS_from_MQbrain_850_l 0.182758186 HS_from_MQbrain_881_l 0.182758186 HS_from_PT_104_l 0.182758186 HS_from_PT_161_l 0.182758186 HS_from_PT_188_l 0.182758186 hsa-mir-1-2_l 0.182758186 hsa-mir-190_r 0.182758186 hsa-mir-26a-2_l 0.182758186 hsa-mir-383_l 0.182758186 hsa-mir-432_r 0.182758186 hsa-mir-514-3_r 0.182758186 hsa-mir-520f_r 0.182758186 hsa-mir-624_l 0.182758186 hsa-mir-93_l 0.182758186 HSbrain_388_r 0.182758186 HSbrain_456_r 0.182758186 HSbrain_706_l 0.182758186 Hsd_from_Mmd_187_r 0.182758186 Hsd_from_Mmd_190_r 0.182758186 Hsd_from_Mmd_208_r 0.182758186 Hsd_from_Mmd_232_r 0.182758186 Hsd_from_Mmd_333_l 0.182758186 Hsd_from_Mmd_68_l 0.182758186 HS_190_r 0.188867139 HS_77_l 0.188867139 HS_from_MM_182_r 0.188867139 HS_from_MM_298_l 0.188867139 HS_from_MM_331_r 0.188867139 HS_from_MM_48_l 0.188867139 HS_from_MM_86_l 0.188867139 HS_from_MQbrain_105_l 0.188867139 HS_from_MQbrain_1073_r 0.188867139 HS_from_MQbrain_120_l 0.188867139 HS_from_MQbrain_1208_l 0.188867139 HS_from_MQbrain_1224_r 0.188867139 HS_from_MQbrain_1234_l 0.188867139 HS_from_MQbrain_1353_l 0.188867139 HS_from_MQbrain_1596_r 0.188867139 HS_from_MQbrain_1734_l 0.188867139 HS_from_MQbrain_1760_r 0.188867139 HS_from_MQbrain_178_r 0.188867139 HS_from_MQbrain_436_r 0.188867139 HS_from_MQbrain_487_r 0.188867139 HS_from_MQbrain_524_l 0.188867139 HS_from_MQbrain_65_l 0.188867139 HS_from_MQbrain_768_l 0.188867139 HS_from_MQbrain_791_r 0.188867139 HS_from_MQbrain_999_r 0.188867139 HS_from_PT_22_l 0.188867139 HS_from_PT_247_l 0.188867139 HS_from_PT_271_r 0.188867139 HS_from_PT_3_l 0.188867139 HS_from_PT_328_l 0.188867139 HS_from_PT_99_r 0.188867139 hsa-mir-183_r 0.188867139 hsa-mir-203_r 0.188867139 hsa-mir-21_l 0.188867139 hsa-mir-587_r 0.188867139 hsa-mir-604_l 0.188867139 HSbrain_153_r 0.188867139 HSbrain_156_l 0.188867139 HSbrain_198_l 0.188867139 HSbrain_210_l 0.188867139 HSbrain_242_l 0.188867139 HSbrain_270_l 0.188867139 HSbrain_370_r 0.188867139 HSbrain_403_l 0.188867139 HSbrain_471_r 0.188867139 HSbrain_553_l 0.188867139 HSbrain_571_l 0.188867139 HSbrain_627_r 0.188867139 Hsd_from_Mmd_120_l 0.188867139 Hsd_from_Mmd_180_r 0.188867139 Hsd_from_Mmd_253_l 0.188867139 Hsd_from_Mmd_274_r 0.188867139 Hsd_from_Mmd_314_r 0.188867139 Hsd_from_Mmd_325_r 0.188867139 HS_124_l 0.19639408 HS_198_l 0.19639408 HS_203_l 0.19639408 HS_265_l 0.19639408 HS_77_r 0.19639408 HS_from_MM_194_l 0.19639408 HS_from_MQbrain_1402_r 0.19639408 HS_from_MQbrain_1424_r 0.19639408 HS_from_MQbrain_1671_l 0.19639408 HS_from_MQbrain_1783_r 0.19639408 HS_from_MQbrain_188_l 0.19639408 HS_from_MQbrain_1883_r 0.19639408 HS_from_MQbrain_383_l 0.19639408 HS_from_MQbrain_389_l 0.19639408 HS_from_MQbrain_406_r 0.19639408 HS_from_MQbrain_648_l 0.19639408 HS_from_MQbrain_84_r 0.19639408 HS_from_MQbrain_901_r 0.19639408 HS_from_PT_130_r 0.19639408 HS_from_PT_196_l 0.19639408 HS_from_PT_204_r 0.19639408 HS_from_PT_48_l 0.19639408 hsa-mir-139_l 0.19639408 hsa-mir-324_l 0.19639408 hsa-mir-454_l 0.19639408 hsa-mir-662_l 0.19639408 HSbrain_143_r 0.19639408 HSbrain_180_l 0.19639408 HSbrain_237_l 0.19639408 HSbrain_295_r 0.19639408 HSbrain_325_r 0.19639408 HSbrain_433_r 0.19639408 HSbrain_476_r 0.19639408 HSbrain_615_l 0.19639408 HSbrain_616_r 0.19639408 HSbrain_658_l 0.19639408 HSbrain_690_r 0.19639408 HSbrain_70_r 0.19639408 HSbrain_810_l 0.19639408 Hsd_19_l 0.19639408 Hsd_25_l 0.19639408 Hsd_from_Mmd_197_l 0.19639408 Hsd_from_Mmd_259_r 0.19639408 Hsd_from_Mmd_326_l 0.19639408 Hsd_from_Mmd_399_r 0.19639408 ¹Wilcoxon analysis: cut off adj. p value <0.2

TABLE 2b Up- or downregulated small RNAs adenoma compared to control adenomas/ adeno- adenoma controls controls ma vs (avg (avg (ratio control expres- expres- expres- Systematic Name (adj. p)¹ sion) sion) sion)² HS_from_MQbrain_485_l 0.124 0.621 1.997 −1.377 HSbrain_412_l 0.113 0.278 1.614 −1.336 HS_from_MQbrain_1497_l 0.176 1.843 3.166 −1.323 HS_from_MQbrain_594_r 0.108 0.859 2.180 −1.321 HS_from_MQbrain_1109_l 0.124 0.527 1.813 −1.286 HS_from_MQbrain_967_l 0.129 0.867 2.144 −1.277 HS_from_MQbrain_137_r 0.129 0.859 2.113 −1.254 HS_from_MQbrain_1082_l 0.072 −1.727 −0.502 −1.225 HS_from_PT_155_l 0.164 1.326 2.524 −1.198 HS_from_MQbrain_1334_r 0.053 −1.612 −0.419 −1.192 HSbrain_724_l 0.170 −1.686 −0.535 −1.151 HS_from_MQbrain_340_l 0.153 0.732 1.879 −1.146 HSbrain_126_r 0.140 0.598 1.713 −1.115 HSbrain_653_l 0.159 0.620 1.725 −1.105 HS_from_PT_104_l 0.183 0.615 1.720 −1.105 HS_from_MQbrain_1353_l 0.189 −1.557 −0.453 −1.104 hsa-mir-124a-3_r 0.070 0.106 1.207 −1.101 HS_from_MQbrain_1793_l 0.183 0.546 1.638 −1.093 hsa-mir-124a-2_r 0.077 0.186 1.276 −1.090 HS_38_r 0.099 −1.398 −0.321 −1.077 HS_from_MQbrain_855_r 0.176 1.019 2.091 −1.072 HS_from_MQbrain_634_l 0.077 −1.384 −0.322 −1.063 hsa-mir-124a-1_r 0.080 0.236 1.287 −1.051 HS_from_MQbrain_1832_r 0.176 −1.661 −0.631 −1.030 HS_from_MQbrain_932_l 0.095 −1.329 −0.301 −1.028 HS_from_MQbrain_1424_r 0.196 −1.461 −0.448 −1.013 HS_from_MQbrain_281_r 0.159 −1.396 −0.386 −1.010 Hsd_from_Mmd_94_l 0.164 −0.053 0.946 −0.999 HS_from_MQbrain_825_r 0.012 −0.915 0.083 −0.998 HS_261_r 0.043 −1.240 −0.249 −0.992 HS_from_MQbrain_436_r 0.189 −1.739 −0.758 −0.981 HSbrain_491_l 0.176 −1.399 −0.425 −0.974 HS_from_PT_95_l 0.108 −1.290 −0.327 −0.963 HS_from_MM_163_l 0.170 −1.554 −0.612 −0.942 HS_from_MQbrain_1268_l 0.072 −1.227 −0.286 −0.941 HS_203_l 0.196 0.658 1.592 −0.934 HSbrain_680_r 0.099 −1.254 −0.338 −0.916 HS_from_MM_123_l 0.176 −1.163 −0.251 −0.912 HS_from_MQbrain_635_l 0.183 −1.339 −0.431 −0.908 HS_from_MQbrain_824_l 0.113 −1.224 −0.329 −0.895 HS_from_PT_130_r 0.196 0.515 1.410 −0.895 HS_71_l 0.004 −0.861 0.033 −0.893 HS_from_MQbrain_37_r 0.070 −1.191 −0.299 −0.892 Hsd_101_l 0.080 −1.212 −0.322 −0.889 HS_51_r 0.135 −1.387 −0.499 −0.888 Hsd_from_Mmd_326_l 0.196 −1.132 −0.252 −0.881 HS_from_MQbrain_968_l 0.135 −1.191 −0.319 −0.872 HSbrain_673_r 0.103 −1.174 −0.303 −0.871 HS_97_r 0.036 0.155 1.026 −0.871 HSbrain_1406_l 0.080 −0.299 0.569 −0.868 HS_262_l 0.001 −0.228 0.636 −0.864 HS_203_r 0.068 0.078 0.937 −0.859 HSbrain_458_r 0.020 −0.452 0.407 −0.858 HSbrain_687_r 0.135 −1.259 −0.403 −0.855 Hsd_from_Mmd_412_r 0.176 −1.668 −0.814 −0.855 HSbrain_270_l 0.189 0.524 1.376 −0.852 hsa-mir-449b_r 0.072 −0.894 −0.053 −0.841 HSbrain_684_r 0.103 −1.235 −0.412 −0.822 HS_from_MQbrain_991_l 0.072 0.438 1.259 −0.821 HS_from_PT_283_r 0.124 −1.162 −0.351 −0.812 HSbrain_695_l 0.129 −1.139 −0.329 −0.810 HS_106_r 0.119 −1.141 −0.333 −0.808 HS_from_MM_169_r 0.004 −0.743 0.062 −0.804 HS_from_MM_353_l 0.077 0.019 0.823 −0.804 HS_from_MQbrain_1502_l 0.113 −1.097 −0.293 −0.804 HSbrain_198_l 0.189 −1.309 −0.506 −0.803 HSbrain_711_r 0.084 0.379 1.174 −0.794 HSbrain_570_r 0.095 −1.044 −0.258 −0.786 hsa-mir-635_l 0.084 0.520 1.301 −0.781 HS_from_MQbrain_1561_r 0.040 −0.679 0.100 −0.779 HS_from_PT_36_l 0.013 −0.741 0.038 −0.778 hsa-mir-524_l 0.068 −0.064 0.713 −0.778 Hsd_from_Mmd_372_l 0.119 −0.938 −0.161 −0.776 HSbrain_669_r 0.159 −1.197 −0.432 −0.764 HS_from_MQbrain_1520_l 0.164 −1.097 −0.337 −0.760 HS_from_MQbrain_736_r 0.183 −1.132 −0.374 −0.758 HS_128_l 0.159 −0.990 −0.238 −0.752 HS_from_MQbrain_1085_l 0.005 −0.935 −0.185 −0.751 Hsd_from_Mmd_452_l 0.025 −0.286 0.462 −0.748 HSbrain_656_l 0.153 0.468 1.216 −0.747 HSbrain_296_l 0.030 0.085 0.828 −0.742 HSbrain_389_l 0.084 −0.915 −0.173 −0.742 HS_from_MM_118_r 0.004 −0.556 0.179 −0.735 Hsd_from_Mmd_328_l 0.176 0.566 1.299 −0.733 HSbrain_157_l 0.065 −0.837 −0.111 −0.726 HS_from_MQbrain_559_r 0.183 −1.064 −0.346 −0.718 HS_from_MQbrain_48_r 0.084 −0.848 −0.132 −0.715 HSbrain_41_r 0.170 −0.877 −0.162 −0.715 hsa-mir-185_r 0.108 0.201 0.911 −0.710 HS_from_MQbrain_15_r 0.140 −1.076 −0.367 −0.709 HS_from_MQbrain_301_l 0.119 −1.043 −0.336 −0.706 HSbrain_453_r 0.095 −0.857 −0.156 −0.701 Hsd_105_l 0.032 −0.841 −0.141 −0.700 hsa-mir-591_r 0.017 0.025 0.724 −0.699 HSbrain_47_r 0.113 −0.986 −0.288 −0.699 HS_from_PT_207_l 0.129 −0.921 −0.223 −0.697 HS_from_MQbrain_1087_l 0.038 −0.740 −0.043 −0.697 HS_from_MM_118_l 0.159 −0.915 −0.220 −0.695 HS_from_MQbrain_161_r 0.124 0.226 0.920 −0.694 HS_from_MQbrain_354_r 0.113 −0.882 −0.189 −0.692 HS_261_l 0.135 0.324 1.016 −0.692 HS_from_MQbrain_1648_r 0.095 0.036 0.726 −0.691 HS_from_MQbrain_1246_l 0.043 0.389 1.078 −0.689 HSbrain_616_r 0.196 0.375 1.064 −0.688 HS_98_l 0.072 −1.008 −0.320 −0.688 HSbrain_304_r 0.058 −0.783 −0.097 −0.687 HS_from_MQbrain_314_l 0.176 −0.924 −0.243 −0.681 HSbrain_583_l 0.021 −0.586 0.095 −0.681 HS_from_MQbrain_629_r 0.164 −0.976 −0.296 −0.680 Hsd_from_Mmd_485_r 0.025 −0.553 0.126 −0.679 HS_from_PT_3_l 0.189 0.352 1.026 −0.675 HS_from_MQbrain_1500_l 0.061 0.178 0.850 −0.672 HS_175_l 0.140 −0.909 −0.238 −0.671 HS_from_MQbrain_1219_r 0.183 −0.953 −0.285 −0.668 HSbrain_172_l 0.080 0.083 0.747 −0.664 Hsd_from_Mmd_117_r 0.025 −0.532 0.129 −0.661 hsa-mir-383_r 0.016 −0.034 0.626 −0.660 Hsd_107_l 0.024 −0.573 0.086 −0.659 HS_145_r 0.176 −1.153 −0.497 −0.657 HSbrain_690_r 0.196 −0.957 −0.301 −0.657 HSbrain_2_l 0.019 −0.562 0.092 −0.654 HS_181_l 0.164 −1.057 −0.406 −0.651 HS_176_l 0.153 −0.933 −0.282 −0.651 HS_from_MQbrain_1099_r 0.058 −0.662 −0.013 −0.649 HS_9_r 0.004 −0.731 −0.083 −0.649 hsa-mir-619_l 0.070 −0.336 0.309 −0.645 HS_from_MQbrain_694_r 0.183 0.350 0.995 −0.645 HS_from_MQbrain_1081_r 0.135 −0.031 0.613 −0.644 HS_241_r 0.140 0.465 1.104 −0.639 HS_from_MQbrain_458_l 0.095 −0.816 −0.178 −0.638 HSbrain_704_l 0.056 0.198 0.830 −0.632 HS_from_MQbrain_1444_l 0.008 −1.059 −0.429 −0.630 HSbrain_159_l 0.113 −1.013 −0.385 −0.628 HS_from_MM_135_l 0.159 −0.023 0.604 −0.627 HSbrain_344_l 0.077 −0.642 −0.017 −0.624 HS_from_MQbrain_520_l 0.176 −0.948 −0.325 −0.623 HSbrain_390_l 0.113 −0.817 −0.194 −0.622 HSbrain_657_l 0.070 −0.850 −0.228 −0.622 HS_from_MQbrain_901_r 0.196 0.174 0.796 −0.622 HSbrain_456_r 0.183 −0.828 −0.207 −0.621 HSbrain_120_r 0.176 0.508 1.125 −0.617 HS_from_PT_295_r 0.036 −0.497 0.120 −0.617 HS_from_MQbrain_1535_r 0.164 −0.833 −0.216 −0.617 HSbrain_695_r 0.153 0.176 0.791 −0.615 HSbrain_719_l 0.056 0.061 0.674 −0.613 HSbrain_305_l 0.164 −1.071 −0.461 −0.610 HS_from_MQbrain_1773_l 0.048 −0.942 −0.335 −0.607 HSbrain_571_l 0.189 −0.891 −0.291 −0.600 HSbrain_216_l 0.113 −0.857 −0.258 −0.599 HSbrain_107_r 0.147 −0.715 −0.116 −0.599 hsa-mir-661_r 0.099 −0.380 0.217 −0.597 HSbrain_122_l 0.088 −0.799 −0.204 −0.595 HS_132_l 0.183 −0.675 −0.082 −0.593 HSbrain_325_r 0.196 −1.053 −0.460 −0.592 HS_157_r 0.140 −0.878 −0.286 −0.592 HS_from_MQbrain_560_r 0.119 −0.731 −0.139 −0.592 HS_212_r 0.170 −0.314 0.278 −0.591 HS_from_PT_284_r 0.147 0.474 1.062 −0.589 HS_from_PT_103_l 0.032 −0.507 0.080 −0.587 HS_from_MQbrain_1042_r 0.050 −0.400 0.186 −0.586 HS_from_PT_41_r 0.065 −0.324 0.261 −0.585 HS_from_MQbrain_178_r 0.189 −0.684 −0.099 −0.584 Hsd_from_Mmd_120_l 0.189 −0.867 −0.285 −0.583 HS_from_MQbrain_1442_l 0.103 0.047 0.630 −0.583 HSbrain_707_r 0.176 −0.556 0.021 −0.577 Hsd_from_Mmd_296_l 0.176 −0.110 0.466 −0.576 HS_from_MQbrain_235_r 0.140 −0.811 −0.237 −0.575 Hsd_from_Mmd_346_l 0.153 −0.928 −0.355 −0.573 HS_from_PT_187_l 0.070 −0.656 −0.086 −0.570 HS_204_r 0.176 −0.741 −0.172 −0.569 HSbrain_177_l 0.170 −0.752 −0.183 −0.568 HS_173_l 0.095 −0.578 −0.009 −0.568 HS_from_MQbrain_1314_l 0.092 −0.577 −0.009 −0.568 HS_from_MQbrain_755_l 0.095 0.177 0.741 −0.564 HS_from_MQbrain_1753_r 0.099 0.239 0.803 −0.564 HS_from_MQbrain_1376_r 0.135 0.327 0.890 −0.563 HSbrain_530_l 0.088 −0.657 −0.097 −0.560 HSbrain_153_r 0.189 −0.773 −0.214 −0.559 HS_from_MQbrain_1478_l 0.113 −0.834 −0.275 −0.559 Hsd_67_r 0.159 −0.803 −0.245 −0.558 HS_from_MQbrain_129_r 0.129 −0.659 −0.101 −0.557 Hsd_from_Mmd_370_r 0.068 0.017 0.572 −0.555 Hsd_from_Mmd_473_l 0.025 −0.251 0.301 −0.553 Hsd_42_l 0.068 −0.650 −0.100 −0.550 HS_from_MM_276_l 0.040 −0.253 0.297 −0.550 HS_from_MM_39_l 0.005 −0.155 0.394 −0.549 HS_from_MQbrain_574_l 0.099 0.327 0.875 −0.548 HSbrain_777_r 0.070 −0.877 −0.332 −0.545 HSbrain_598_r 0.164 0.144 0.689 −0.545 HSbrain_726_l 0.170 −0.919 −0.375 −0.544 HS_98_l 0.072 −0.947 −0.406 −0.541 HS_from_MM_218_l 0.164 −0.955 −0.415 −0.540 HS_from_PT_201_l 0.070 −0.573 −0.034 −0.539 HS_from_MQbrain_1006_l 0.048 −0.593 −0.055 −0.538 HSbrain_22_l 0.153 −0.159 0.378 −0.537 HS_from_MQbrain_1204_l 0.176 −0.915 −0.381 −0.534 HS_from_MQbrain_65_l 0.189 −0.083 0.451 −0.534 HS_from_MQbrain_1633_r 0.103 −0.635 −0.102 −0.533 HS_from_MQbrain_1783_r 0.196 0.348 0.880 −0.532 HS_from_MQbrain_1402_r 0.196 −0.824 −0.294 −0.530 HS_from_MQbrain_1883_l 0.183 −0.608 −0.081 −0.527 HS_231_r 0.034 −0.796 −0.271 −0.525 HSbrain_713_r 0.023 −0.564 −0.041 −0.523 HSbrain_578_l 0.164 −0.619 −0.099 −0.520 HSbrain_442_r 0.053 0.220 0.740 −0.519 HS_from_MQbrain_437_l 0.108 −0.563 −0.049 −0.514 HS_from_MQbrain_1626_r 0.088 0.001 0.509 −0.509 Hsd_from_Mmd_324_l 0.095 −0.734 −0.227 −0.508 Hsd_from_Mmd_523_l 0.140 0.149 0.654 −0.505 HSbrain_703_r 0.023 −0.500 0.004 −0.504 HS_from_MQbrain_843_r 0.012 −0.512 −0.013 −0.499 HSbrain_347_r 0.129 −0.638 −0.143 −0.495 HS_from_MQbrain_1444_l 0.008 −0.527 −0.034 −0.494 HSbrain_1423_l 0.080 −0.583 −0.092 −0.491 HSbrain_343_l 0.103 −0.579 −0.093 −0.486 HSbrain_86_r 0.099 −0.605 −0.122 −0.483 HS_from_MQbrain_1877_l 0.068 −0.227 0.255 −0.482 HS_from_MQbrain_1103_l 0.005 −0.190 0.290 −0.480 HS_from_MQbrain_1893_r 0.170 0.202 0.682 −0.480 HSbrain_463_r 0.084 −0.222 0.257 −0.480 HSbrain_752_r 0.043 −0.613 −0.135 −0.478 HS_from_MQbrain_1377_r 0.129 0.283 0.761 −0.477 HSbrain_747_l 0.072 −0.034 0.441 −0.475 HS_62_l 0.056 −0.564 −0.091 −0.473 HS_from_MM_131_l 0.027 −0.261 0.210 −0.471 hsa-mir-640_l 0.034 −0.148 0.322 −0.470 HS_from_MQbrain_487_l 0.092 −0.841 −0.371 −0.470 HS_from_MQbrain_590_l 0.077 −0.280 0.189 −0.469 HS_135_l 0.124 −0.144 0.323 −0.467 hsa-mir-196a-2_r 0.015 −0.123 0.342 −0.465 HS_from_MQbrain_597_r 0.084 −0.606 −0.142 −0.464 HS_from_MQbrain_697_l 0.147 −0.518 −0.057 −0.462 HS_from_MQbrain_365_l 0.176 0.235 0.696 −0.461 Hsd_from_Mmd_212_r 0.176 −0.510 −0.051 −0.459 HSbrain_446_l 0.020 −0.397 0.062 −0.459 HSbrain_32_r 0.153 −0.616 −0.158 −0.458 HSbrain_483_r 0.153 0.145 0.602 −0.456 HSbrain_334_r 0.176 −0.377 0.076 −0.452 HS_from_MQbrain_1137_l 0.183 −0.675 −0.223 −0.452 Hsd_27_r 0.176 0.166 0.616 −0.450 HS_from_MQbrain_113_r 0.084 0.052 0.502 −0.450 hsa-mir-324_r 0.103 −0.112 0.337 −0.449 HSbrain_304_l 0.164 0.017 0.465 −0.448 HSbrain_629_l 0.023 −0.646 −0.199 −0.447 Hsd_from_Mmd_306_l 0.170 −0.590 −0.145 −0.445 hsa-mir-372_r 0.056 0.185 0.630 −0.444 HS_from_MQbrain_1317_r 0.007 −0.193 0.251 −0.444 hsa-mir-525_l 0.129 0.196 0.638 −0.442 HS_from_MQbrain_1806_l 0.135 −0.081 0.357 −0.438 HS_from_MM_298_r 0.124 −0.087 0.350 −0.437 hsa-mir-644_r 0.070 −0.262 0.173 −0.435 HS_from_MQbrain_814_l 0.084 0.092 0.526 −0.435 HS_from_MQbrain_906_r 0.103 −0.642 −0.208 −0.434 Hsd_from_Mmd_487_r 0.034 −0.529 −0.096 −0.433 HS_from_MQbrain_1208_l 0.189 0.334 0.765 −0.431 Hsd_from_Mmd_311_r 0.119 −0.006 0.423 −0.429 HS_from_MQbrain_1771_l 0.050 −0.654 −0.226 −0.429 HS_171_r 0.050 −0.274 0.154 −0.428 HS_from_MQbrain_1752_l 0.048 −0.014 0.411 −0.425 HS_from_MQbrain_1840_l 0.108 −0.025 0.399 −0.424 HSbrain_437_r 0.084 −0.052 0.373 −0.424 HS_from_MQbrain_1245_l 0.176 −0.711 −0.287 −0.424 HS_71_r 0.088 −0.153 0.270 −0.423 Hsd_88_r 0.077 −0.265 0.157 −0.422 HS_from_MQbrain_1437_l 0.092 −0.244 0.177 −0.421 HSbrain_755_l 0.065 −0.427 −0.006 −0.421 HS_from_MQbrain_1817_l 0.153 0.002 0.421 −0.420 HSbrain_151_r 0.176 −0.522 −0.103 −0.419 HS_from_MQbrain_567_r 0.108 −0.378 0.039 −0.417 HSbrain_155_r 0.070 −0.057 0.360 −0.417 HSbrain_43_r 0.077 −0.371 0.046 −0.417 hsa-mir-584_r 0.050 −0.203 0.213 −0.416 HS_from_PT_91_r 0.043 −0.068 0.345 −0.413 HS_from_PT_126_l 0.088 −0.052 0.358 −0.411 Hsd_from_Mmd_399_r 0.196 −0.367 0.042 −0.410 HS_from_MQbrain_1420_l 0.038 −0.388 0.019 −0.407 HSbrain_12_l 0.017 −0.292 0.112 −0.404 HSbrain_764_r 0.113 −0.045 0.357 −0.402 HS_from_MQbrain_1070_r 0.005 −0.290 0.110 −0.400 HS_223_l 0.080 −0.213 0.186 −0.399 HS_from_MQbrain_163_l 0.095 −0.645 −0.248 −0.397 HS_from_MQbrain_1119_l 0.058 −0.111 0.285 −0.397 HS_from_MQbrain_1748_r 0.072 −0.171 0.224 −0.394 HSbrain_319_l 0.103 −0.232 0.161 −0.393 HSbrain_116_l 0.065 −0.732 −0.339 −0.393 Hsd_65_l 0.050 −0.128 0.263 −0.390 HSbrain_1325_r 0.153 −0.451 −0.061 −0.390 HSbrain_755_r 0.170 −0.635 −0.246 −0.389 HSbrain_753_r 0.024 −0.232 0.156 −0.388 HS_from_PT_242_l 0.061 −0.402 −0.017 −0.386 HSbrain_48_r 0.048 −0.110 0.274 −0.384 HS_93_r 0.050 −0.412 −0.030 −0.382 Hsd_from_Mmd_120_r 0.092 −0.425 −0.048 −0.377 HS_from_MQbrain_1494_l 0.092 0.310 0.687 −0.376 HSbrain_481_r 0.095 −0.825 −0.449 −0.376 Hsd_63_l 0.103 −0.283 0.092 −0.375 HS_from_MM_219_l 0.077 −0.105 0.265 −0.370 HS_from_MQbrain_912_l 0.159 0.449 0.817 −0.369 HS_from_MQbrain_1073_r 0.189 −0.122 0.246 −0.368 HS_81_r 0.072 −0.099 0.269 −0.367 HS_from_MQbrain_842_l 0.050 0.049 0.415 −0.366 HS_from_PT_321_r 0.056 −0.070 0.295 −0.365 HSbrain_320_l 0.159 0.052 0.414 −0.362 HS_from_MQbrain_524_l 0.189 −0.475 −0.117 −0.358 HSbrain_135_l 0.119 −0.146 0.211 −0.358 HS_from_MQbrain_991_r 0.061 −0.017 0.337 −0.354 HS_from_PT_170_r 0.140 −0.438 −0.084 −0.354 HS_from_MQbrain_1051_r 0.119 0.156 0.509 −0.353 HS_from_MQbrain_391_r 0.029 −0.169 0.183 −0.352 HS_from_MQbrain_140_l 0.159 0.077 0.427 −0.350 HSbrain_438_r 0.164 −0.066 0.282 −0.348 HS_from_MQbrain_804_r 0.080 −0.287 0.061 −0.348 Hsd_from_Mmd_391_l 0.113 −0.103 0.245 −0.348 HSbrain_476_r 0.196 0.063 0.410 −0.347 HS_from_MQbrain_745_r 0.068 −0.292 0.053 −0.345 HS_from_MQbrain_1102_l 0.084 −0.516 −0.173 −0.343 HS_from_MQbrain_868_l 0.099 −0.413 −0.071 −0.342 HS_from_MQbrain_984_l 0.176 −0.423 −0.082 −0.341 HS_from_MQbrain_1792_r 0.010 −0.296 0.045 −0.341 HS_from_MQbrain_603_r 0.170 −0.178 0.161 −0.339 HS_from_MQbrain_365_r 0.164 −0.252 0.085 −0.337 HS_from_MQbrain_1075_l 0.048 −0.648 −0.312 −0.336 HS_172_r 0.103 0.080 0.416 −0.336 HSbrain_384_l 0.108 −0.164 0.172 −0.336 HS_from_MQbrain_406_l 0.124 −0.273 0.063 −0.336 HS_from_PT_339_l 0.068 −0.719 −0.383 −0.336 Hsd_from_Mmd_535_r 0.053 −0.453 −0.118 −0.335 Hsd_84_r 0.164 −0.195 0.136 −0.332 HS_from_MQbrain_1565_l 0.176 −0.209 0.123 −0.332 HS_from_MQbrain_420_l 0.061 −0.349 −0.020 −0.329 HS_from_PT_201_r 0.013 −0.178 0.150 −0.328 HS_265_l 0.196 0.045 0.372 −0.327 HS_from_MQbrain_1726_l 0.092 −0.112 0.214 −0.327 hsa-mir-197_l 0.016 −0.405 −0.080 −0.325 HS_from_MQbrain_114_r 0.108 −0.679 −0.354 −0.325 HS_from_MQbrain_355_r 0.153 0.155 0.479 −0.324 HSbrain_703_l 0.048 −0.443 −0.121 −0.323 Hsd_from_Mmd_155_l 0.025 −0.274 0.048 −0.322 HS_from_MQbrain_435_r 0.065 −0.103 0.219 −0.322 HS_from_MQbrain_1043_r 0.005 −0.624 −0.302 −0.322 HSbrain_1298_r 0.147 −0.271 0.050 −0.321 HS_from_MQbrain_1690_l 0.034 −0.631 −0.313 −0.318 HS_from_PT_250_l 0.140 0.222 0.539 −0.318 hsa-mir-377_l 0.113 −0.086 0.229 −0.316 HS_from_MQbrain_686_r 0.088 −0.636 −0.322 −0.314 HSbrain_691_l 0.095 −0.865 −0.552 −0.313 HSbrain_370_r 0.189 −0.088 0.225 −0.313 HS_from_MQbrain_1484_l 0.053 −0.038 0.271 −0.308 HS_from_MQbrain_89_l 0.135 −0.128 0.179 −0.307 HS_from_MQbrain_361_l 0.183 0.178 0.484 −0.306 HS_from_MQbrain_596_r 0.164 −0.114 0.192 −0.306 HS_from_MQbrain_600_l 0.147 −0.210 0.096 −0.306 HS_from_PT_92_l 0.153 −0.695 −0.390 −0.305 HS_from_MQbrain_1624_l 0.009 −0.245 0.058 −0.303 HS_from_PT_73_l 0.077 0.058 0.359 −0.301 HS_from_MQbrain_1374_l 0.058 −0.430 −0.130 −0.299 Hsd_49_r 0.025 −0.276 0.023 −0.299 HS_from_MQbrain_1596_r 0.189 −0.280 0.018 −0.298 HS_from_MM_174_l 0.124 −0.325 −0.027 −0.298 hsa-mir-204_r 0.072 −0.384 −0.087 −0.297 HS_from_MQbrain_1426_l 0.164 −0.698 −0.404 −0.293 HS_220_l 0.176 −0.135 0.158 −0.293 HS_from_MQbrain_1839_l 0.129 −0.692 −0.400 −0.292 HS_from_MM_346_r 0.103 −0.463 −0.173 −0.290 HS_from_MQbrain_1119_l 0.058 −0.615 −0.325 −0.290 HSbrain_1425_l 0.099 −0.622 −0.332 −0.290 Hsd_from_Mmd_363_l 0.129 −0.293 −0.003 −0.289 HS_from_MQbrain_162_r 0.183 −0.461 −0.172 −0.289 HS_198_l 0.196 −0.603 −0.314 −0.289 HS_from_PT_188_l 0.183 −0.268 0.020 −0.288 Hsd_50_l 0.070 −0.532 −0.244 −0.288 HSbrain_143_r 0.196 −0.381 −0.093 −0.287 HSbrain_663_l 0.061 −0.005 0.282 −0.287 HSbrain_109_l 0.040 −0.582 −0.296 −0.286 HS_from_MQbrain_382_l 0.129 −0.075 0.210 −0.285 HS_from_MQbrain_675_l 0.159 −0.628 −0.343 −0.285 HS_from_MQbrain_1671_l 0.196 −0.314 −0.030 −0.284 HS_from_MQbrain_999_r 0.189 −0.845 −0.563 −0.283 hsa-mir-148a_l 0.046 −0.199 0.082 −0.281 HS_from_MQbrain_974_l 0.058 −0.613 −0.333 −0.280 HS_from_MQbrain_1627_l 0.108 −0.614 −0.335 −0.280 HS_from_MM_359_l 0.034 −0.086 0.193 −0.279 HSbrain_25_r 0.048 −0.147 0.132 −0.279 HSbrain_568_r 0.113 −0.156 0.122 −0.278 HS_49_r 0.072 0.167 0.445 −0.278 HSbrain_316_l 0.034 −0.303 −0.025 −0.278 Hsd_108_r 0.164 −0.266 0.012 −0.278 HS_from_MQbrain_1678_r 0.092 −0.080 0.198 −0.277 HS_from_MQbrain_943_l 0.103 −0.647 −0.370 −0.277 HS_167_l 0.183 −0.391 −0.114 −0.277 HS_from_MQbrain_1566_r 0.176 −0.302 −0.026 −0.277 HS_from_MQbrain_466_l 0.129 −0.308 −0.034 −0.275 HS_from_MQbrain_99_r 0.135 −0.627 −0.352 −0.275 HS_from_PT_271_r 0.189 −0.271 0.002 −0.273 HSbrain_642_r 0.092 0.356 0.627 −0.271 HS_from_MQbrain_433_l 0.072 −0.495 −0.225 −0.270 hsa-mir-622_l 0.124 −0.337 −0.068 −0.269 HSbrain_717_l 0.095 −0.453 −0.184 −0.269 HS_from_PT_170_l 0.072 −0.362 −0.094 −0.269 HSbrain_85_l 0.056 0.065 0.333 −0.268 hsa-mir-483_l 0.108 −0.570 −0.302 −0.267 HS_from_PT_112_l 0.068 −0.217 0.050 −0.267 HS_from_MQbrain_1758_r 0.092 −0.494 −0.229 −0.264 HSbrain_139_l 0.068 −0.533 −0.269 −0.264 HSbrain_32_l 0.176 −0.350 −0.087 −0.263 HS_98_r 0.124 −0.635 −0.373 −0.261 HS_from_MM_342_l 0.183 0.142 0.402 −0.260 HSbrain_284_l 0.046 −0.589 −0.331 −0.258 HS_157_l 0.099 −0.493 −0.236 −0.257 HS_from_MQbrain_1777_l 0.080 −0.385 −0.131 −0.253 Hsd_from_Mmd_284_l 0.061 −0.006 0.246 −0.253 HS_102_l 0.088 −0.528 −0.276 −0.252 HS_from_MQbrain_1127_r 0.153 0.133 0.384 −0.251 HS_from_MQbrain_1620_l 0.056 −0.368 −0.118 −0.250 HS_from_MQbrain_734_l 0.027 −0.281 −0.031 −0.250 HSbrain_664_r 0.119 −0.538 −0.288 −0.250 HS_101_l 0.108 −0.480 −0.231 −0.249 HSbrain_94_l 0.103 −0.414 −0.165 −0.249 HS_from_MQbrain_56_r 0.140 0.263 0.512 −0.249 HS_264_r 0.170 −0.277 −0.033 −0.244 HS_from_MQbrain_1222_r 0.147 −0.456 −0.212 −0.244 hsa-mir-192_r 0.170 −0.033 0.211 −0.243 HSbrain_708_l 0.095 −0.485 −0.243 −0.242 HS_from_MM_103_l 0.099 −0.154 0.089 −0.242 HS_from_MM_251_r 0.113 −0.289 −0.047 −0.242 HS_168_r 0.140 −0.608 −0.367 −0.240 HS_from_MQbrain_1832_l 0.030 −0.372 −0.132 −0.240 HSbrain_433_r 0.196 0.076 0.312 −0.236 HSbrain_210_l 0.189 −0.350 −0.114 −0.235 HSbrain_522_r 0.140 −0.057 0.178 −0.235 HS_from_MQbrain_1574_l 0.129 −0.195 0.040 −0.235 HSbrain_471_r 0.189 −0.059 0.175 −0.234 HS_128_r 0.170 −0.408 −0.174 −0.234 HS_57_l 0.084 −0.132 0.101 −0.233 Hsd_from_Mmd_261_l 0.043 −0.223 0.009 −0.232 HS_from_PT_308_l 0.065 −0.164 0.067 −0.232 Hsd_from_Mmd_235_r 0.170 0.389 0.621 −0.231 HS_from_MM_339_r 0.005 −0.211 0.019 −0.230 Hsd_from_Mmd_436_l 0.068 0.065 0.294 −0.230 hsa-mir-765_r 0.170 −0.628 −0.399 −0.229 HS_from_MQbrain_406_r 0.196 −0.588 −0.362 −0.226 HS_from_MQbrain_1204_r 0.159 −0.475 −0.249 −0.226 hsa-mir-224_r 0.113 −0.139 0.087 −0.226 HS_from_MQbrain_1883_r 0.196 −0.343 −0.118 −0.225 HS_from_MQbrain_1630_l 0.009 −0.228 −0.005 −0.223 HS_25_r 0.124 −0.152 0.071 −0.223 HSbrain_152_l 0.129 −0.232 −0.009 −0.223 HS_from_PT_238_l 0.153 −0.588 −0.370 −0.218 HS_from_MQbrain_715_l 0.084 −0.218 −0.001 −0.217 HS_from_MQbrain_1834_r 0.119 −0.402 −0.186 −0.216 HSbrain_266_r 0.038 −0.094 0.121 −0.215 Hsd_from_Mmd_237_l 0.124 −0.154 0.061 −0.215 hsa-mir-211_r 0.108 −0.272 −0.058 −0.214 Hsd_from_Mmd_371_r 0.092 −0.247 −0.033 −0.214 HS_from_MQbrain_850_l 0.183 −0.340 −0.127 −0.214 Hsd_from_Mmd_274_r 0.189 −0.159 0.054 −0.213 HS_from_MQbrain_597_l 0.129 −0.577 −0.364 −0.213 HS_from_MQbrain_1750_r 0.119 −0.620 −0.408 −0.212 HS_83_r 0.170 −0.107 0.103 −0.210 Hsd_63_r 0.046 −0.051 0.158 −0.209 HS_from_MQbrain_1349_l 0.183 −0.464 −0.255 −0.209 HSbrain_402_l 0.164 −0.178 0.030 −0.209 Hsd_from_Mmd_78_r 0.103 −0.437 −0.228 −0.208 HSbrain_452_l 0.119 −0.192 0.016 −0.208 HS_from_MQbrain_70_l 0.061 −0.336 −0.131 −0.206 HS_from_MQbrain_1219_l 0.072 −0.421 −0.216 −0.205 HS_from_MM_115_l 0.056 −0.242 −0.037 −0.204 HSbrain_626_l 0.176 −0.007 0.197 −0.204 HS_from_MQbrain_281_l 0.170 −0.322 −0.118 −0.204 HS_from_MQbrain_628_l 0.176 −0.131 0.071 −0.202 HS_from_PT_247_l 0.189 −0.250 −0.049 −0.201 HS_119_l 0.080 −0.077 0.124 −0.200 HSbrain_783_l 0.159 −0.235 −0.035 −0.200 HS_from_MQbrain_1355_r 0.103 −0.064 0.136 −0.200 HSbrain_485_r 0.021 −0.292 −0.093 −0.199 HS_129_l 0.095 −0.341 −0.143 −0.198 HSbrain_80_l 0.170 −0.128 0.069 −0.198 HS_from_MQbrain_1110_l 0.140 −0.055 0.142 −0.197 HS_130_l 0.176 −0.004 0.190 −0.195 HS_from_MQbrain_1846_r 0.170 −0.164 0.030 −0.193 HSbrain_347_l 0.159 −0.392 −0.199 −0.193 HSbrain_548_l 0.084 −0.271 −0.079 −0.192 HS_from_MQbrain_338_l 0.153 0.011 0.202 −0.191 HSd_from_Mmd_52_r 0.164 −0.717 −0.527 −0.191 HSbrain_328_l 0.113 −0.209 −0.019 −0.190 HS_from_MQbrain_1228_r 0.095 −0.395 −0.205 −0.190 HS_from_MM_124_l 0.108 −0.173 0.017 −0.190 HSbrain_216_r 0.170 −0.228 −0.039 −0.189 HS_from_MQbrain_999_l 0.119 −0.229 −0.040 −0.189 HSbrain_56_l 0.084 −0.150 0.039 −0.189 HS_from_MQbrain_996_l 0.164 −0.341 −0.153 −0.188 HS_from_MQbrain_1509_r 0.183 −0.579 −0.391 −0.188 HS_from_MQbrain_550_l 0.092 −0.294 −0.106 −0.188 HSbrain_8_r 0.024 −0.390 −0.202 −0.188 HS_from_MQbrain_1036_r 0.147 −0.463 −0.276 −0.187 Hsd_from_Mmd_388_l 0.135 −0.135 0.051 −0.186 HS_from_MQbrain_566_r 0.164 −0.444 −0.258 −0.186 HS_from_MQbrain_941_r 0.164 −0.208 −0.023 −0.186 HS_from_MQbrain_1889_l 0.119 −0.155 0.030 −0.185 HS_from_MM_340_r 0.164 −0.442 −0.257 −0.185 HS_from_PT_158_l 0.159 −0.475 −0.291 −0.185 HS_from_MQbrain_1241_r 0.095 −0.169 0.014 −0.183 HSbrain_305_r 0.099 −0.303 −0.121 −0.182 HS_from_MQbrain_732_r 0.183 −0.164 0.018 −0.182 HS_197_r 0.170 −0.206 −0.025 −0.181 HS_from_MQbrain_1675_r 0.147 −0.400 −0.218 −0.181 HS_from_MQbrain_707_l 0.153 −0.068 0.111 −0.179 HSbrain_222_r 0.153 0.025 0.204 −0.179 HS_from_MQbrain_1380_r 0.183 −0.298 −0.120 −0.178 HSbrain_275_r 0.164 0.068 0.243 −0.176 HS_from_MQbrain_689_l 0.153 −0.177 −0.001 −0.175 HS_from_MQbrain_449_l 0.164 −0.336 −0.161 −0.175 HSbrain_306_r 0.153 −0.241 −0.069 −0.172 HSbrain_810_l 0.196 −0.211 −0.040 −0.172 HSbrain_240_l 0.099 −0.366 −0.195 −0.171 HSbrain_769_r 0.099 −0.129 0.041 −0.170 HS_from_MQbrain_38_r 0.056 0.045 0.213 −0.168 HS_from_MQbrain_546_l 0.108 −0.166 0.000 −0.165 HS_18_l 0.159 −0.250 −0.087 −0.164 HSbrain_53_l 0.170 −0.221 −0.058 −0.163 HS_from_PT_194_r 0.135 −0.001 0.161 −0.162 hsa-mir-647_r 0.027 −0.154 0.006 −0.161 HSbrain_599_r 0.147 −0.011 0.146 −0.157 HSbrain_4_l 0.113 −0.060 0.095 −0.155 HS_from_MQbrain_1523_r 0.135 −0.166 −0.012 −0.154 HSbrain_70_r 0.196 −0.402 −0.250 −0.153 Hsd_from_Mmd_197_l 0.196 −0.075 0.077 −0.152 HS_from_MQbrain_22_r 0.140 −0.252 −0.104 −0.148 HS_from_MQbrain_487_r 0.189 −0.100 0.046 −0.146 HS_22_r 0.129 0.023 0.168 −0.144 HSbrain_376_l 0.164 −0.016 0.126 −0.142 HSbrain_701_l 0.170 0.014 0.155 −0.141 HS_from_MQbrain_43_l 0.061 0.036 0.165 −0.130 Hsd_from_Mmd_128_l 0.129 0.121 0.249 −0.127 hsa-mir-570_l 0.140 −0.103 0.020 −0.123 HS_from_MQbrain_810_l 0.058 −0.182 −0.062 −0.120 HS_from_MQbrain_1863_l 0.032 0.106 0.224 −0.118 HS_from_MQbrain_1223_l 0.164 −0.156 −0.043 −0.113 Hsd_from_Mmd_333_l 0.183 −0.077 0.033 −0.110 HS_from_MQbrain_669_r 0.084 −0.015 0.089 −0.103 HS_from_MQbrain_1576_r 0.183 −0.006 0.095 −0.100 HS_from_MQbrain_97_l 0.170 −0.024 0.074 −0.098 HSbrain_541_r 0.140 −0.014 0.084 −0.098 HSbrain_545_r 0.029 −0.056 0.033 −0.089 HS_from_MQbrain_1018_l 0.159 −0.008 0.072 −0.081 HSbrain_469_l 0.068 0.016 0.093 −0.077 HSbrain_727_l 0.024 0.218 0.269 −0.051 Hsd_from_Mmd_259_r 0.196 0.066 0.098 −0.032 HS_from_MQbrain_1674_l 0.056 −0.451 −0.426 −0.025 HSbrain_723_l 0.024 0.071 0.049 0.022 Hsd_25_l 0.196 0.017 −0.038 0.054 HS_from_MQbrain_1637_l 0.108 0.088 0.027 0.061 HSbrain_244_l 0.129 0.095 0.032 0.062 hsa-mir-507_l 0.099 0.036 −0.035 0.071 HS_from_MQbrain_2087_r 0.176 0.070 −0.006 0.075 Hsd_from_Mmd_325_r 0.189 0.061 −0.016 0.077 hsa-mir-454_l 0.196 0.034 −0.044 0.078 HS_286_r 0.164 0.019 −0.061 0.081 Hsd_from_Mmd_391_r 0.176 0.056 −0.025 0.081 HS_from_PT_196_l 0.196 0.046 −0.035 0.081 hsa-mir-568_r 0.017 −0.020 −0.105 0.085 hsa-mir-518b_r 0.099 0.030 −0.056 0.086 HS_from_MQbrain_1379_r 0.040 0.049 −0.038 0.086 hsa-mir-139_l 0.196 −0.062 −0.150 0.088 Hsd_from_Mmd_500_r 0.056 0.034 −0.055 0.089 HS_from_MQbrain_897_l 0.119 0.080 −0.008 0.089 HS_from_MQbrain_2699_l 0.159 −0.016 −0.106 0.089 hsa-mir-33b_l 0.164 0.024 −0.067 0.091 HSbrain_1076_l 0.124 0.034 −0.059 0.093 hsa-mir-124a-1_l 0.164 0.129 0.036 0.094 HS_from_MQbrain_392_r 0.170 −0.007 −0.104 0.097 Hsd_from_Mmd_499_r 0.119 −0.033 −0.131 0.098 HS_from_MM_86_l 0.189 −0.144 −0.243 0.099 HS_from_MQbrain_779_l 0.092 0.055 −0.045 0.100 Hsd_from_Mmd_316_r 0.147 0.057 −0.043 0.100 HSbrain_478_r 0.124 0.052 −0.049 0.101 HS_from_MM_109_l 0.140 0.048 −0.057 0.104 hsa-mir-646_r 0.058 0.078 −0.027 0.105 HS_from_MQbrain_1224_r 0.189 −0.013 −0.118 0.105 HS_from_MQbrain_1804_r 0.135 0.061 −0.045 0.106 HS_262_r 0.029 0.010 −0.100 0.110 HSbrain_780_l 0.170 0.051 −0.064 0.115 HS_from_MQbrain_1687_l 0.010 −0.002 −0.120 0.118 HS_from_MQbrain_1721_l 0.164 0.118 −0.002 0.119 HSbrain_1418_r 0.176 −0.023 −0.143 0.121 HS_from_MQbrain_221_r 0.140 0.075 −0.051 0.125 Hsd_from_Mmd_190_r 0.183 0.120 −0.007 0.126 HS_from_MM_57_r 0.113 0.069 −0.061 0.130 HS_from_MM_150_r 0.095 0.038 −0.094 0.131 HSbrain_590_l 0.176 0.023 −0.109 0.132 HS_from_PT_99_r 0.189 0.057 −0.076 0.133 HS_from_MQbrain_1164_l 0.068 0.146 0.012 0.134 Hsd_from_Mmd_431_l 0.129 0.039 −0.096 0.135 HS_223_r 0.170 0.137 −0.001 0.138 HS_from_PT_27_r 0.176 0.155 0.014 0.140 Hsd_from_Mmd_253_l 0.189 0.013 −0.128 0.141 HS_from_PT_255_l 0.159 0.038 −0.106 0.144 HS_from_MQbrain_1283_l 0.050 0.125 −0.021 0.146 HSbrain_771_l 0.176 0.400 0.252 0.147 Hsd_from_Mmd_180_r 0.189 0.232 0.084 0.148 hsa-mir-432_r 0.183 0.031 −0.118 0.150 hsa-mir-423_r 0.036 0.179 0.022 0.156 hsa-mir-1-2_l 0.183 −0.180 −0.337 0.157 HS_from_MQbrain_648_l 0.196 0.152 −0.005 0.157 HSbrain_204_r 0.129 0.080 −0.082 0.163 HSbrain_615_l 0.196 0.011 −0.152 0.163 HSbrain_596_r 0.103 −0.097 −0.261 0.164 Hsd_from_Mmd_344_l 0.099 0.068 −0.098 0.166 HS_from_MQbrain_1722_l 0.129 0.368 0.201 0.167 HS_from_MQbrain_675_r 0.084 −0.002 −0.170 0.168 HS_from_MQbrain_67_r 0.043 0.127 −0.043 0.170 HSbrain_715_l 0.135 −0.021 −0.191 0.170 Hsd_38_r 0.153 0.356 0.185 0.171 HS_190_r 0.189 0.206 0.034 0.171 HS_219_l 0.140 0.293 0.121 0.173 hsa-mir-331_r 0.030 0.070 −0.103 0.173 hsa-mir-99a_r 0.103 0.047 −0.127 0.173 HS_from_MQbrain_1184_r 0.124 0.643 0.464 0.179 HSbrain_403_l 0.189 −0.069 −0.251 0.181 HS_77_l 0.189 0.160 −0.022 0.182 HSbrain_714_l 0.023 0.104 −0.078 0.182 HSbrain_792_r 0.034 0.095 −0.088 0.182 HS_from_MQbrain_1382_l 0.099 0.505 0.320 0.185 HS_109_l 0.129 0.348 0.162 0.186 HS_from_MQbrain_1561_l 0.072 0.162 −0.026 0.187 HS_292_l 0.038 0.093 −0.095 0.188 HS_124_l 0.196 −0.062 −0.251 0.189 HS_from_PT_21_r 0.046 0.060 −0.130 0.191 HS_from_MQbrain_824_r 0.164 0.234 0.043 0.191 HS_from_MQbrain_188_l 0.196 −0.006 −0.200 0.194 HSbrain_509_l 0.113 0.014 −0.180 0.194 HSbrain_643_l 0.108 0.178 −0.017 0.195 HSbrain_156_l 0.189 0.172 −0.024 0.196 HS_from_MM_49_l 0.056 0.366 0.168 0.198 HS_from_MQbrain_1862_l 0.061 0.022 −0.177 0.199 HS_from_MM_237_l 0.099 −0.083 −0.283 0.200 HSbrain_540_l 0.099 0.105 −0.097 0.202 HS_from_MM_48_l 0.189 0.191 −0.013 0.204 HS_from_MM_89_l 0.153 0.102 −0.105 0.207 HS_77_r 0.196 0.231 0.024 0.208 HS_from_MQbrain_1794_r 0.129 0.140 −0.069 0.209 Hsd_from_Mmd_204_l 0.080 0.324 0.115 0.209 HS_from_MQbrain_921_l 0.113 0.359 0.150 0.209 HSbrain_721_r 0.070 0.103 −0.106 0.209 HS_from_MQbrain_468_l 0.170 0.749 0.539 0.210 HSbrain_220_r 0.119 0.167 −0.044 0.211 HS_from_MM_79_l 0.124 0.689 0.478 0.211 HS_from_MQbrain_490_r 0.124 0.500 0.288 0.212 HS_from_MQbrain_1215_l 0.070 0.094 −0.118 0.212 HS_from_MQbrain_901_l 0.050 0.289 0.077 0.212 Hsd_111_r 0.103 −0.224 −0.436 0.212 HSbrain_717_r 0.153 −0.106 −0.318 0.213 HS_from_PT_204_r 0.196 0.033 −0.180 0.213 HSbrain_50_l 0.124 0.286 0.072 0.214 HS_191_l 0.040 0.118 −0.096 0.214 hsa-mir-196b_r 0.170 −0.001 −0.216 0.215 HS_from_PT_63_r 0.043 0.166 −0.050 0.216 HS_from_MQbrain_609_l 0.103 0.669 0.452 0.217 HS_from_MQbrain_461_l 0.135 0.120 −0.099 0.219 HS_from_MQbrain_1366_l 0.108 0.461 0.241 0.220 HSbrain_171_l 0.017 0.169 −0.050 0.220 hsa-mir-224_l 0.072 −0.139 −0.359 0.221 hsa-mir-181a-1_r 0.135 −0.157 −0.378 0.221 HSbrain_804_l 0.164 0.142 −0.079 0.221 HS_from_MQbrain_1896_r 0.153 −0.102 −0.324 0.222 HS_from_MQbrain_383_l 0.196 0.060 −0.163 0.223 Hsd_from_Mmd_215_r 0.080 0.014 −0.208 0.223 HSbrain_266_l 0.153 0.428 0.205 0.223 hsa-mir-31_r 0.135 −0.060 −0.283 0.224 HS_from_MQbrain_266_r 0.140 0.074 −0.150 0.224 HS_from_MM_92_r 0.099 0.030 −0.195 0.225 HS_from_MQbrain_1590_l 0.119 0.806 0.578 0.228 HS_from_MQbrain_1724_l 0.164 0.749 0.521 0.228 HSbrain_641_r 0.153 −0.024 −0.254 0.230 HSbrain_553_l 0.189 0.097 −0.133 0.230 HSbrain_248_l 0.159 0.632 0.402 0.230 HS_from_MQbrain_930_r 0.077 0.318 0.087 0.230 HSbrain_419_l 0.056 0.178 −0.053 0.230 HS_from_MQbrain_414_l 0.159 0.803 0.570 0.233 hsa-mir-453_l 0.030 0.185 −0.049 0.233 HSbrain_371_r 0.070 −0.018 −0.252 0.234 hsa-mir-604_l 0.189 0.046 −0.188 0.235 HSbrain_231_l 0.019 0.327 0.092 0.235 HS_from_MQbrain_1318_l 0.135 0.681 0.445 0.236 HS_from_PT_148_l 0.080 −0.106 −0.343 0.237 Hsd_from_Mmd_232_r 0.183 −0.015 −0.253 0.237 HS_from_PT_38_l 0.129 −0.280 −0.518 0.238 HS_from_MQbrain_1030_l 0.147 0.778 0.539 0.239 Hsd_62_l 0.068 0.623 0.383 0.240 HS_from_PT_313_r 0.084 0.047 −0.193 0.240 HS_from_MQbrain_1592_l 0.092 0.731 0.491 0.240 HSbrain_123_l 0.058 0.178 −0.062 0.241 Hsd_from_Mmd_19_l 0.164 0.089 −0.152 0.241 HSbrain_409_r 0.061 0.059 −0.182 0.241 Hsd_19_l 0.196 0.891 0.649 0.242 HS_76_r 0.147 0.057 −0.185 0.242 HS_from_MQbrain_1280_l 0.072 0.244 0.002 0.242 HSbrain_364_r 0.170 −0.099 −0.341 0.242 HS_from_MQbrain_1712_r 0.129 0.783 0.540 0.243 HS_from_MQbrain_1381_r 0.147 0.154 −0.090 0.243 HSbrain_731_r 0.024 0.232 −0.011 0.243 HSbrain_130_r 0.153 0.137 −0.106 0.244 HSbrain_543_l 0.124 0.114 −0.129 0.244 HS_from_MQbrain_1340_l 0.036 0.326 0.082 0.244 HS_from_PT_48_l 0.196 −0.395 −0.640 0.245 hsa-mir-617_l 0.088 −0.106 −0.351 0.245 HSbrain_506_r 0.108 −0.013 −0.258 0.245 HS_from_MQbrain_1487_r 0.119 0.314 0.069 0.245 HSbrain_374_r 0.053 0.005 −0.242 0.247 HSbrain_467_l 0.170 0.226 −0.022 0.248 HS_from_MQbrain_135_l 0.176 0.234 −0.016 0.250 HS_from_MQbrain_936_r 0.164 0.478 0.227 0.252 HSbrain_580_r 0.038 0.029 −0.222 0.252 HS_from_MQbrain_881_l 0.183 0.282 0.030 0.252 HS_from_MQbrain_283_r 0.147 −0.052 −0.303 0.252 HS_from_MQbrain_120_l 0.189 0.210 −0.042 0.252 HS_from_PT_22_l 0.103 0.076 −0.176 0.253 HSbrain_745_l 0.170 0.591 0.337 0.254 hsa-mir-324_l 0.196 0.036 −0.219 0.255 Hsd_from_Mmd_519_r 0.095 −0.172 −0.428 0.256 HS_304_r 0.061 0.774 0.518 0.256 HS_from_MQbrain_1700_l 0.080 0.739 0.482 0.257 HS_from_MQbrain_1212_l 0.164 0.012 −0.245 0.257 HS_from_MQbrain_604_l 0.113 0.592 0.334 0.257 HS_from_MM_194_l 0.196 −0.232 −0.489 0.258 HS_from_MQbrain_789_l 0.124 0.489 0.231 0.258 HSbrain_227_r 0.113 0.233 −0.025 0.258 hsa-mir-518c_l 0.159 −0.072 −0.331 0.259 HS_189_r 0.135 0.018 −0.241 0.260 HS_from_MQbrain_1443_r 0.032 0.499 0.239 0.260 HSbrain_144_r 0.140 0.402 0.142 0.260 HSbrain_212_l 0.068 0.365 0.105 0.260 HS_from_MM_145_r 0.129 0.539 0.278 0.261 HS_from_MQbrain_1412_l 0.061 0.235 −0.027 0.261 HSbrain_480_r 0.072 0.220 −0.041 0.262 HS_from_MM_182_r 0.189 0.012 −0.250 0.262 HS_from_MQbrain_29_r 0.070 0.169 −0.093 0.262 Hsd_from_Mmd_330_l 0.070 0.724 0.461 0.263 HS_from_MM_149_r 0.183 0.014 −0.249 0.263 HS_from_MQbrain_1841_r 0.070 0.453 0.190 0.263 Hsd_from_Mmd_378_l 0.092 0.016 −0.248 0.264 HSbrain_496_r 0.135 0.107 −0.158 0.265 HS_from_MQbrain_1637_r 0.080 0.669 0.404 0.265 HS_from_PT_299_l 0.030 0.560 0.295 0.266 HSbrain_431_r 0.068 −0.043 −0.310 0.266 HS_from_MQbrain_36_r 0.129 0.707 0.440 0.266 HSbrain_627_r 0.189 −0.199 −0.466 0.267 HSbrain_752_l 0.153 0.618 0.351 0.267 HS_from_MQbrain_1761_r 0.010 0.063 −0.204 0.267 HS_from_MQbrain_1686_l 0.050 0.556 0.287 0.268 HS_from_MQbrain_1593_r 0.084 0.010 −0.259 0.269 HSbrain_527_r 0.021 0.188 −0.082 0.270 HSbrain_680_l 0.164 0.643 0.371 0.271 HS_from_MQbrain_207_l 0.011 0.419 0.146 0.273 HS_from_MM_34_l 0.099 0.070 −0.204 0.274 HS_from_MQbrain_1658_l 0.092 −0.003 −0.277 0.274 hsa-mir-588_r 0.135 −0.038 −0.313 0.274 hsa-mir-599_r 0.140 −0.219 −0.494 0.275 HS_from_MQbrain_239_r 0.068 0.200 −0.077 0.277 HS_from_MQbrain_631_l 0.159 0.217 −0.060 0.277 HS_41_r 0.140 0.115 −0.163 0.277 hsa-mir-770_r 0.113 0.414 0.136 0.278 HS_from_PT_43_l 0.040 0.556 0.277 0.279 HS_from_MM_289_r 0.072 −0.112 −0.391 0.279 HS_from_MM_184_r 0.092 0.056 −0.224 0.280 Hsd_from_Mmd_344_r 0.176 0.401 0.121 0.280 HSbrain_130_l 0.147 −0.089 −0.370 0.281 HSbrain_361_l 0.140 0.500 0.216 0.283 HS_from_MQbrain_770_r 0.092 0.133 −0.150 0.283 HS_from_PT_328_l 0.189 0.916 0.633 0.283 HS_from_MQbrain_1090_r 0.164 0.785 0.502 0.284 HS_from_MQbrain_1640_l 0.135 −0.162 −0.446 0.284 HSbrain_113_r 0.095 0.246 −0.038 0.284 HSbrain_706_l 0.183 0.144 −0.140 0.284 HS_74_r 0.164 0.022 −0.262 0.284 HS_from_MM_229_r 0.088 0.239 −0.047 0.286 HSbrain_661_l 0.080 0.295 0.009 0.286 HSbrain_299_r 0.108 0.337 0.051 0.286 HS_from_MQbrain_234_r 0.135 0.095 −0.192 0.287 HSbrain_677_l 0.103 0.580 0.292 0.287 HS_306_r 0.099 0.086 −0.201 0.288 HS_from_MQbrain_1642_l 0.050 0.194 −0.094 0.289 HS_from_MQbrain_84_r 0.196 −0.016 −0.306 0.290 HSbrain_139_r 0.147 0.028 −0.263 0.290 HS_from_MM_331_r 0.189 0.087 −0.204 0.291 HS_from_MQbrain_540_l 0.135 0.527 0.235 0.292 HSbrain_271_l 0.077 0.277 −0.016 0.292 HSbrain_446_r 0.164 0.229 −0.064 0.293 hsa-mir-133a-2_r 0.015 0.045 −0.248 0.293 HS_from_MQbrain_828_r 0.113 −0.077 −0.370 0.293 HS_from_MM_165_l 0.088 0.274 −0.019 0.293 HS_115_r 0.153 0.076 −0.217 0.293 Hsd_from_Mmd_280_l 0.153 0.068 −0.227 0.294 HS_from_PT_178_l 0.140 0.365 0.070 0.295 HS_from_MQbrain_1706_l 0.080 0.011 −0.284 0.295 HSbrain_145_l 0.119 0.537 0.241 0.296 HS_73_r 0.113 0.093 −0.203 0.296 HS_from_MQbrain_769_r 0.084 −0.227 −0.524 0.297 HS_from_MQbrain_1759_l 0.147 −0.484 −0.781 0.297 Hsd_18_l 0.024 0.264 −0.034 0.298 HS_from_MQbrain_951_l 0.040 −0.184 −0.483 0.298 HS_from_PT_237_l 0.124 0.091 −0.207 0.299 HS_from_MM_1_l 0.070 0.044 −0.255 0.299 HS_109_r 0.058 0.140 −0.159 0.299 HS_95_r 0.159 0.115 −0.185 0.300 hsa-mir-622_r 0.129 0.125 −0.175 0.300 hsa-mir-550-2_r 0.038 0.054 −0.246 0.301 HS_from_MQbrain_883_r 0.058 0.108 −0.193 0.301 HSbrain_624_l 0.147 0.406 0.105 0.301 hsa-mir-550-1_r 0.135 0.070 −0.231 0.301 HSbrain_811_l 0.153 0.249 −0.053 0.301 HS_from_MM_124_r 0.183 0.245 −0.057 0.302 Hsd_from_Mmd_97_l 0.036 0.019 −0.283 0.302 Hsd_70_l 0.025 0.301 −0.001 0.302 HS_from_MM_84_r 0.140 0.278 −0.024 0.303 HS_from_MM_119_r 0.135 0.196 −0.107 0.303 hsa-mir-409_r 0.119 −0.062 −0.366 0.304 Hsd_77_r 0.147 0.582 0.277 0.304 HSbrain_84_l 0.050 0.033 −0.271 0.304 HS_from_MM_232_r 0.170 −0.130 −0.435 0.305 HS_66_r 0.077 0.016 −0.289 0.305 HS_from_MQbrain_260_r 0.147 0.919 0.614 0.305 HS_from_MQbrain_592_l 0.119 0.560 0.255 0.305 HSbrain_237_l 0.196 0.083 −0.222 0.305 HSbrain_301_l 0.072 −0.048 −0.354 0.306 HS_from_MQbrain_155_l 0.159 0.415 0.109 0.306 hsa-mir-190_r 0.183 −0.207 −0.513 0.306 HS_from_MQbrain_1260_r 0.005 0.078 −0.228 0.306 HS_111_l 0.140 0.182 −0.125 0.307 HSbrain_788_l 0.077 −0.018 −0.326 0.308 HSbrain_250_r 0.072 0.183 −0.125 0.308 HSbrain_415_l 0.099 0.852 0.544 0.308 HSbrain_673_l 0.159 0.614 0.306 0.309 Hsd_82_r 0.119 0.092 −0.217 0.309 HS_from_MQbrain_1602_l 0.092 0.607 0.298 0.309 HS_from_MQbrain_1459_l 0.103 0.242 −0.068 0.311 HS_from_MQbrain_1771_r 0.070 0.467 0.156 0.311 HSbrain_300_l 0.058 −0.034 −0.345 0.312 HSbrain_728_l 0.070 0.048 −0.265 0.313 HSbrain_495_r 0.113 0.278 −0.036 0.314 HS_from_MQbrain_67_l 0.147 0.278 −0.037 0.314 HSbrain_473_l 0.095 0.066 −0.249 0.314 HS_121_r 0.140 −0.247 −0.562 0.315 Hsd_from_Mmd_480_r 0.099 0.393 0.078 0.315 HS_from_MQbrain_768_l 0.189 −0.116 −0.431 0.315 HS_from_PT_237_r 0.013 0.375 0.060 0.315 Hsd_from_Mmd_524_r 0.068 −0.074 −0.391 0.317 HSbrain_1425_r 0.080 0.033 −0.284 0.317 HS_281_r 0.001 0.024 −0.293 0.317 HS_from_MQbrain_650_r 0.164 0.647 0.329 0.318 hsa-mir-30d_l 0.099 −0.193 −0.511 0.318 HSbrain_671_r 0.056 0.006 −0.314 0.319 HS_from_MQbrain_1684_r 0.092 0.219 −0.100 0.319 HSbrain_55_l 0.159 0.203 −0.117 0.319 HS_from_MQbrain_739_l 0.070 0.043 −0.276 0.319 Hsd_from_Mmd_49_l 0.048 0.374 0.054 0.320 HS_from_MQbrain_291_l 0.088 0.671 0.350 0.320 HSbrain_598_l 0.065 0.319 −0.002 0.320 hsa-mir-133a-1_r 0.034 0.140 −0.180 0.321 HSbrain_408_r 0.061 0.099 −0.223 0.322 HS_from_PT_220_l 0.108 0.774 0.452 0.322 HS_from_MQbrain_997_l 0.070 0.705 0.383 0.322 HS_from_MQbrain_502_r 0.119 −0.061 −0.384 0.322 HS_from_MQbrain_882_l 0.103 0.123 −0.200 0.323 hsa-mir-296_l 0.016 0.082 −0.243 0.325 HS_from_MQbrain_1446_l 0.065 0.056 −0.269 0.325 Hsd_20_r 0.099 0.121 −0.204 0.325 HSbrain_597_r 0.023 0.707 0.382 0.325 HS_from_MQbrain_1513_r 0.036 −0.284 −0.609 0.325 HSbrain_214_l 0.061 0.195 −0.131 0.326 HS_from_MQbrain_444_r 0.027 0.273 −0.053 0.326 HS_from_MQbrain_1744_r 0.103 0.357 0.031 0.326 HSbrain_722_l 0.024 0.457 0.130 0.327 HS_from_MQbrain_1884_r 0.010 0.365 0.038 0.327 HS_289_l 0.119 0.887 0.559 0.328 HS_from_MQbrain_1885_r 0.092 0.295 −0.033 0.329 Hsd_from_Mmd_93_r 0.092 0.393 0.064 0.329 HSbrain_716_l 0.140 0.504 0.175 0.329 HS_from_PT_161_l 0.183 −0.016 −0.345 0.329 Hsd_from_Mmd_298_l 0.095 0.067 −0.263 0.330 HS_214_r 0.135 −0.146 −0.475 0.330 HS_from_PT_27_l 0.103 0.062 −0.268 0.330 HS_from_MM_121_l 0.027 0.010 −0.320 0.330 HS_11_l 0.088 0.176 −0.154 0.330 hsa-mir-609_r 0.135 0.112 −0.219 0.331 HS_from_MQbrain_684_r 0.135 0.173 −0.159 0.332 HS_from_MQbrain_1427_l 0.068 0.511 0.179 0.332 Hsd_from_Mmd_44_r 0.159 −0.038 −0.370 0.333 hsa-mir-296_r 0.103 0.509 0.177 0.333 HSbrain_482_l 0.103 0.381 0.048 0.333 HS_from_MQbrain_1545_r 0.095 −0.248 −0.581 0.333 Hsd_from_Mmd_410_r 0.036 0.062 −0.272 0.335 HSbrain_1338_r 0.065 0.062 −0.272 0.335 HS_from_PT_299_r 0.036 0.123 −0.212 0.335 HS_from_MQbrain_467_l 0.140 0.164 −0.171 0.335 Hsd_from_Mmd_527_l 0.040 0.075 −0.261 0.335 hsa-mir-625_r 0.095 0.258 −0.078 0.336 HS_from_MQbrain_1250_r 0.147 0.014 −0.322 0.336 HS_from_MQbrain_723_l 0.053 0.126 −0.211 0.336 HSbrain_95_l 0.164 0.001 −0.336 0.337 hsa-mir-526b_r 0.108 −0.393 −0.731 0.338 HS_from_PT_70_r 0.046 0.477 0.139 0.338 HSbrain_1410_l 0.043 0.613 0.275 0.338 HS_from_MQbrain_698_r 0.077 0.215 −0.124 0.338 HSbrain_784_r 0.164 0.646 0.308 0.338 hsa-mir-767_r 0.050 0.043 −0.296 0.339 HSbrain_696_r 0.030 0.116 −0.223 0.340 HS_from_MQbrain_1445_l 0.032 0.638 0.298 0.340 HS_from_MQbrain_1684_l 0.027 0.214 −0.126 0.340 hsa-mir-323_l 0.016 0.418 0.077 0.341 HS_from_MM_295_r 0.072 0.439 0.098 0.341 HS_from_MQbrain_482_l 0.034 0.019 −0.322 0.341 Hsd_79_l 0.095 1.169 0.828 0.341 HSbrain_143_l 0.170 0.885 0.543 0.342 hsa-mir-93_l 0.183 −0.474 −0.816 0.342 HSbrain_75_l 0.024 0.433 0.089 0.344 HSbrain_124_l 0.088 0.821 0.477 0.345 Hsd_from_Mmd_489_r 0.124 0.044 −0.302 0.345 hsa-mir-554_l 0.017 0.159 −0.187 0.346 HS_from_MQbrain_1776_l 0.129 0.783 0.437 0.346 HSbrain_180_l 0.196 0.131 −0.215 0.346 HS_from_MQbrain_1267_r 0.088 0.024 −0.323 0.346 HSbrain_272_l 0.036 0.028 −0.319 0.347 HS_from_MQbrain_154_r 0.153 0.268 −0.079 0.347 HS_from_MQbrain_1855_l 0.140 0.079 −0.269 0.348 hsa-mir-412_r 0.061 0.236 −0.114 0.350 HS_from_MQbrain_848_l 0.088 0.124 −0.227 0.350 HSbrain_652_l 0.050 0.616 0.265 0.350 HS_287_l 0.124 0.889 0.538 0.351 HS_from_PT_102_l 0.080 0.854 0.502 0.352 Hsd_from_Mmd_101_r 0.135 0.182 −0.170 0.352 HSbrain_637_l 0.092 0.704 0.351 0.353 HS_from_PT_196_r 0.164 0.197 −0.157 0.353 HSbrain_92_l 0.040 0.572 0.219 0.353 HS_from_MQbrain_253_r 0.072 0.028 −0.326 0.354 HS_from_MQbrain_664_l 0.056 0.763 0.409 0.354 hsa-let-7f-1_r 0.092 −0.042 −0.397 0.355 HS_from_MQbrain_900_r 0.159 0.051 −0.304 0.355 HS_from_MQbrain_664_r 0.140 0.304 −0.051 0.355 HS_4_r 0.092 0.812 0.456 0.356 hsa-mir-1-1_l 0.147 −0.033 −0.389 0.356 HS_from_MQbrain_1632_r 0.010 0.174 −0.182 0.356 HS_from_MQbrain_282_l 0.038 0.489 0.132 0.357 hsa-mir-506_r 0.092 −0.034 −0.392 0.358 HS_from_MQbrain_1760_r 0.189 0.864 0.504 0.359 HS_from_MQbrain_251_r 0.070 0.860 0.500 0.360 hsa-mir-500_l 0.029 −0.234 −0.594 0.360 HS_from_MQbrain_1745_r 0.080 0.373 0.013 0.360 HS_from_MQbrain_343_l 0.050 0.119 −0.241 0.360 Hsd_from_Mmd_161_l 0.092 0.865 0.505 0.360 HSbrain_1337_l 0.080 0.129 −0.232 0.361 HSbrain_242_l 0.189 −0.254 −0.616 0.362 Hsd_from_Mmd_217_r 0.119 −0.028 −0.390 0.362 HS_59_l 0.056 0.579 0.216 0.363 hsa-mir-98_r 0.159 −0.065 −0.429 0.364 HS_from_MQbrain_131_r 0.007 0.219 −0.146 0.365 hsa-mir-628_r 0.061 0.184 −0.181 0.365 HS_from_MM_304_r 0.129 0.878 0.512 0.366 HS_from_MQbrain_1253_r 0.084 −0.014 −0.380 0.366 hsa-mir-134_r 0.030 0.237 −0.130 0.366 hsa-mir-148b_r 0.058 −0.018 −0.384 0.367 Hsd_18_r 0.053 0.102 −0.264 0.367 HSbrain_472_l 0.020 0.126 −0.242 0.367 HS_from_MQbrain_1126_l 0.176 −0.380 −0.748 0.368 HS_from_PT_280_l 0.164 0.002 −0.367 0.369 hsa-mir-532_l 0.099 0.005 −0.365 0.370 hsa-mir-521-2_r 0.088 0.301 −0.069 0.370 hsa-mir-106b_r 0.032 −0.338 −0.708 0.370 HS_from_MQbrain_1227_l 0.043 0.034 −0.337 0.371 hsa-mir-379_l 0.077 0.882 0.511 0.371 Hsd_from_Mmd_291_r 0.108 0.939 0.568 0.371 HS_from_MM_32_r 0.048 0.081 −0.291 0.371 HSbrain_722_r 0.099 0.202 −0.170 0.372 HSbrain_388_r 0.183 0.180 −0.192 0.372 hsa-mir-616_l 0.070 0.022 −0.350 0.373 HS_from_PT_146_r 0.013 0.243 −0.130 0.373 Hsd_102_l 0.036 0.430 0.056 0.374 hsa-mir-641_r 0.153 −0.082 −0.456 0.374 HS_from_MQbrain_74_r 0.029 0.718 0.344 0.374 HSbrain_121_l 0.159 0.626 0.252 0.374 HS_from_PT_95_r 0.092 0.960 0.585 0.375 HSbrain_1360_l 0.092 0.947 0.572 0.375 HS_from_MQbrain_1450_r 0.065 0.418 0.042 0.376 HS_268_l 0.147 0.175 −0.201 0.376 Hsd_17_l 0.124 1.038 0.662 0.376 HS_from_PT_50_r 0.095 0.346 −0.031 0.376 Hsd_from_Mmd_333_r 0.072 0.268 −0.108 0.376 HSbrain_1363_l 0.072 0.910 0.534 0.376 HS_from_MQbrain_841_l 0.170 0.990 0.613 0.377 HSbrain_720_l 0.099 0.115 −0.262 0.377 Hsd_74_r 0.135 0.166 −0.212 0.377 HSbrain_570_l 0.124 0.507 0.129 0.378 HSbrain_396_r 0.124 0.104 −0.275 0.379 HS_from_MQbrain_56_l 0.056 0.687 0.307 0.379 HS_from_MQbrain_549_r 0.068 0.182 −0.198 0.380 hsa-mir-659_l 0.017 0.060 −0.320 0.380 HS_from_MQbrain_128_r 0.061 0.606 0.226 0.381 HS_213_l 0.080 0.138 −0.243 0.381 HSbrain_225_r 0.019 0.308 −0.073 0.381 HS_from_MM_202_l 0.084 −0.296 −0.677 0.381 HSbrain_1413_l 0.017 0.287 −0.094 0.381 HS_from_PT_235_l 0.070 −0.047 −0.429 0.382 HS_from_MQbrain_1213_l 0.099 0.632 0.250 0.382 HS_from_MQbrain_542_r 0.050 0.330 −0.054 0.384 HS_from_MQbrain_1703_r 0.040 0.010 −0.374 0.384 HS_from_MQbrain_806_l 0.088 −0.347 −0.731 0.384 hsa-mir-151_l 0.159 0.139 −0.245 0.384 HSbrain_114_r 0.030 0.080 −0.305 0.385 HS_from_MQbrain_800_r 0.034 0.393 0.007 0.386 HS_from_MQbrain_88_l 0.108 −0.341 −0.727 0.386 HS_288_l 0.095 0.923 0.537 0.386 HS_from_MQbrain_1462_r 0.147 −0.133 −0.519 0.386 HS_from_MQbrain_1781_l 0.092 0.038 −0.348 0.386 HS_from_MQbrain_1234_l 0.189 0.323 −0.064 0.387 Hsd_from_Mmd_334_r 0.159 0.078 −0.309 0.387 HS_from_MM_354_r 0.038 0.226 −0.162 0.388 HS_212_l 0.048 0.075 −0.313 0.388 Hsd_from_Mmd_166_r 0.095 −0.192 −0.581 0.389 HS_from_PT_219_l 0.147 0.844 0.455 0.389 HSbrain_359_l 0.027 0.281 −0.108 0.389 hsa-mir-92-1_l 0.176 0.482 0.092 0.389 HSbrain_1364_l 0.072 0.934 0.545 0.390 HSbrain_74_r 0.024 0.209 −0.181 0.390 HSbrain_749_r 0.072 0.610 0.218 0.392 HS_from_MQbrain_796_l 0.058 0.183 −0.209 0.393 HSbrain_504_r 0.103 0.288 −0.105 0.393 HS_from_MQbrain_1831_r 0.159 0.310 −0.083 0.393 HS_from_MQbrain_693_r 0.153 1.457 1.064 0.393 HS_from_MM_6_l 0.183 0.197 −0.197 0.393 HS_281_r 0.001 0.083 −0.312 0.395 HS_from_MQbrain_1808_r 0.010 0.575 0.180 0.395 Hsd_6_l 0.053 0.033 −0.362 0.395 HS_from_MQbrain_55_l 0.011 0.103 −0.292 0.395 HS_from_MM_342_r 0.068 0.301 −0.094 0.395 hsa-mir-521-1_l 0.147 0.094 −0.302 0.396 HS_from_MQbrain_509_r 0.027 −0.223 −0.619 0.396 HS_from_MQbrain_641_r 0.070 0.072 −0.325 0.397 HSbrain_711_l 0.053 0.239 −0.158 0.397 HS_from_MQbrain_209_r 0.050 0.217 −0.180 0.398 HS_from_MQbrain_1097_r 0.135 0.614 0.217 0.398 hsa-mir-641_l 0.080 −0.273 −0.674 0.400 hsa-mir-624_l 0.183 −0.154 −0.555 0.401 HS_164_l 0.108 0.684 0.284 0.401 hsa-mir-23a_l 0.140 0.530 0.129 0.401 HS_from_MQbrain_1747_r 0.040 0.184 −0.217 0.401 HS_56_r 0.040 0.327 −0.074 0.401 Hsd_from_Mmd_328_r 0.124 0.199 −0.202 0.401 HS_204_l 0.113 −0.449 −0.850 0.401 HS_from_PT_271_l 0.147 0.142 −0.260 0.402 HS_114_l 0.048 0.800 0.399 0.402 HS_from_MQbrain_154_l 0.084 0.912 0.509 0.403 HS_from_MQbrain_1376_l 0.070 0.643 0.239 0.404 HS_from_MQbrain_555_r 0.129 0.281 −0.123 0.404 Hsd_from_Mmd_478_l 0.108 0.326 −0.078 0.404 hsa-mir-513-2_l 0.124 0.153 −0.251 0.404 HS_from_PT_20_r 0.084 0.660 0.256 0.404 HS_from_PT_187_r 0.058 0.122 −0.283 0.405 HSbrain_483_l 0.021 0.160 −0.245 0.405 Hsd_from_Mmd_422_l 0.046 0.067 −0.340 0.407 HS_from_MQbrain_1354_l 0.061 0.424 0.016 0.408 HSbrain_330_l 0.068 0.856 0.448 0.408 HS_150_l 0.061 0.702 0.294 0.409 HS_from_MQbrain_1493_r 0.147 1.414 1.005 0.409 hsa-mir-634_l 0.119 0.595 0.184 0.410 Hsd_from_Mmd_23_l 0.036 −0.045 −0.455 0.410 HSbrain_158_l 0.017 0.272 −0.139 0.411 HS_from_MQbrain_97_r 0.147 0.512 0.101 0.411 HSbrain_425_l 0.140 −0.124 −0.537 0.412 hsa-mir-219-1_r 0.072 −0.224 −0.636 0.412 HSbrain_448_l 0.129 0.690 0.277 0.413 HSbrain_171_l 0.017 0.374 −0.039 0.413 HS_from_PT_32_r 0.013 0.064 −0.349 0.413 HSbrain_572_r 0.068 −0.109 −0.523 0.414 Hsd_from_Mmd_208_r 0.183 −0.459 −0.874 0.415 hsa-let-7a-2_r 0.040 0.127 −0.290 0.416 HS_from_MQbrain_1377_l 0.170 0.499 0.083 0.416 HS_from_MM_195_r 0.084 0.990 0.574 0.417 hsa-mir-652_r 0.164 −0.221 −0.638 0.418 HSbrain_50_r 0.029 0.027 −0.391 0.418 hsa-mir-662_l 0.196 1.115 0.697 0.419 HSbrain_619_r 0.092 −0.156 −0.576 0.419 HS_from_MQbrain_1199_l 0.170 1.278 0.858 0.420 HS_from_MQbrain_723_r 0.070 0.837 0.417 0.421 Hsd_from_Mmd_325_l 0.099 −0.149 −0.570 0.421 Hsd_42_r 0.043 0.390 −0.031 0.421 HSbrain_604_r 0.153 0.110 −0.313 0.422 HS_from_PT_101_r 0.013 0.168 −0.255 0.423 HS_131_r 0.053 0.774 0.349 0.424 hsa-mir-30c-2_l 0.164 −0.140 −0.564 0.424 HS_from_MQbrain_948_r 0.088 0.369 −0.055 0.424 HS_from_MQbrain_1695_r 0.147 0.274 −0.150 0.424 HSbrain_1362_l 0.048 0.903 0.478 0.425 HS_from_PT_121_r 0.058 0.745 0.320 0.425 HSbrain_108_l 0.140 0.073 −0.354 0.427 HS_from_MQbrain_1717_r 0.046 0.133 −0.294 0.427 HSbrain_768_l 0.159 0.729 0.302 0.427 hsa-mir-653_l 0.046 0.091 −0.336 0.427 HS_166_r 0.077 0.573 0.145 0.428 HS_from_MM_289_l 0.043 0.004 −0.424 0.428 HS_from_MQbrain_782_r 0.043 1.069 0.639 0.430 HS_from_MQbrain_1658_r 0.072 0.047 −0.383 0.430 HSbrain_35_r 0.058 0.689 0.259 0.431 HS_186_r 0.176 0.490 0.058 0.432 HS_from_MQbrain_1201_r 0.095 0.803 0.371 0.432 hsa-mir-518f_r 0.068 −0.162 −0.595 0.433 HS_53_r 0.140 1.218 0.785 0.434 HS_118_l 0.032 0.766 0.332 0.435 HS_from_MQbrain_412_l 0.103 −0.533 −0.968 0.435 Hsd_62_l 0.068 0.256 −0.179 0.435 HSbrain_1377_l 0.017 0.175 −0.261 0.436 HSbrain_420_r 0.020 0.485 0.049 0.436 HS_from_MQbrain_566_l 0.011 0.175 −0.260 0.436 HSbrain_6_r 0.023 0.587 0.151 0.437 HS_from_MQbrain_1392_r 0.032 0.978 0.541 0.437 HS_from_MQbrain_105_l 0.113 −0.007 −0.443 0.437 Hsd_from_Mmd_123_l 0.140 0.183 −0.253 0.437 HS_from_MQbrain_105_l 0.113 0.102 −0.335 0.437 HSbrain_797_r 0.080 0.079 −0.358 0.437 HS_from_MQbrain_940_r 0.013 0.435 −0.002 0.437 hsa-mir-633_r 0.119 −0.150 −0.589 0.439 HS_from_MQbrain_6_r 0.153 0.882 0.443 0.439 hsa-mir-648_l 0.088 0.768 0.328 0.439 HS_from_MQbrain_1700_r 0.056 0.279 −0.160 0.440 HS_from_PT_340_l 0.061 0.116 −0.325 0.441 HS_61_l 0.095 −0.372 −0.814 0.442 HSbrain_520_l 0.113 1.209 0.767 0.442 HSbrain_658_l 0.196 0.001 −0.442 0.443 HS_from_MQbrain_969_l 0.034 0.265 −0.178 0.443 HS_from_MM_157_l 0.129 −0.293 −0.736 0.443 HS_from_MQbrain_1794_l 0.053 0.300 −0.144 0.443 HS_from_MQbrain_1404_r 0.061 0.787 0.343 0.444 hsa-mir-521-1_r 0.056 0.323 −0.121 0.444 Hsd_from_Mmd_187_r 0.183 0.428 −0.016 0.445 HS_from_MQbrain_1414_r 0.077 0.603 0.158 0.445 HSbrain_713_l 0.030 0.842 0.397 0.445 HS_from_MQbrain_873_r 0.053 1.085 0.639 0.445 Hsd_19_r 0.058 0.191 −0.254 0.446 HS_from_MQbrain_1773_l 0.048 0.663 0.217 0.446 HS_from_MQbrain_1807_l 0.147 0.503 0.056 0.447 hsa-mir-30b_l 0.070 0.049 −0.398 0.447 HS_from_MQbrain_315_l 0.050 0.531 0.083 0.448 HS_from_MQbrain_1395_r 0.053 0.783 0.334 0.449 HSbrain_507_l 0.072 0.081 −0.369 0.449 HS_from_MQbrain_1696_l 0.065 −0.575 −1.025 0.449 HS_from_MQbrain_100_l 0.005 0.316 −0.134 0.450 Hsd_from_Mmd_92_l 0.176 1.146 0.696 0.450 HS_from_MQbrain_1239_l 0.053 −0.109 −0.560 0.451 HS_from_MQbrain_1388_l 0.043 1.152 0.701 0.451 hsa-mir-630_r 0.099 −0.056 −0.509 0.452 HS_190_l 0.058 0.834 0.381 0.453 hsa-mir-375_l 0.088 0.394 −0.059 0.453 HS_from_MQbrain_2380_r 0.011 0.503 0.049 0.454 HS_from_PT_339_r 0.095 −0.091 −0.545 0.454 Hsd_from_Mmd_70_l 0.058 0.351 −0.104 0.455 Hsd_from_Mmd_519_l 0.025 0.065 −0.390 0.455 HS_from_MQbrain_1520_r 0.080 0.629 0.173 0.456 HSbrain_413_l 0.159 −0.215 −0.671 0.456 HSbrain_610_r 0.070 0.783 0.327 0.456 HS_from_MQbrain_676_r 0.183 1.535 1.079 0.456 HS_from_MQbrain_1565_r 0.072 0.564 0.106 0.458 HS_from_MM_160_l 0.183 −0.049 −0.507 0.458 HS_from_MQbrain_349_l 0.011 0.160 −0.301 0.461 HS_from_PT_250_r 0.135 1.045 0.583 0.462 HSbrain_102_r 0.017 0.677 0.215 0.462 hsa-mir-329-1_r 0.068 −0.013 −0.476 0.463 hsa-mir-135a-2_r 0.015 0.264 −0.199 0.463 Hsd_from_Mmd_367_l 0.170 −0.305 −0.769 0.464 HS_from_MQbrain_576_l 0.080 0.570 0.106 0.465 HS_from_MQbrain_917_r 0.013 −0.163 −0.628 0.465 HSbrain_794_r 0.024 0.758 0.292 0.466 HSbrain_295_r 0.196 −0.277 −0.743 0.466 HSbrain_280_l 0.108 1.581 1.114 0.467 HS_33_l 0.038 0.378 −0.091 0.469 hsa-mir-329-2_r 0.040 0.039 −0.430 0.469 HSbrain_506_l 0.065 0.253 −0.218 0.471 hsa-mir-193a_l 0.070 1.119 0.648 0.471 HS_from_MQbrain_498_r 0.038 1.096 0.624 0.472 HS_from_MM_319_l 0.004 0.890 0.418 0.472 HS_from_MQbrain_854_r 0.012 0.170 −0.303 0.473 HSbrain_148_r 0.017 0.430 −0.043 0.473 HSbrain_705_r 0.147 1.198 0.724 0.474 HS_from_MQbrain_191_l 0.010 0.502 0.028 0.475 hsa-mir-331_l 0.070 −0.128 −0.603 0.475 hsa-let-7c_r 0.040 0.146 −0.330 0.475 HS_from_MQbrain_20_r 0.011 −0.133 −0.608 0.475 HSbrain_700_r 0.038 0.218 −0.259 0.477 HS_from_MQbrain_350_l 0.011 0.166 −0.311 0.478 hsa-mir-513-1_l 0.099 0.213 −0.265 0.478 hsa-mir-299_l 0.016 0.126 −0.354 0.480 HS_from_MQbrain_791_r 0.189 −0.470 −0.951 0.481 hsa-mir-144_r 0.176 −0.446 −0.927 0.481 HSbrain_754_r 0.024 0.162 −0.320 0.481 HSbrain_165_l 0.034 1.001 0.519 0.482 hsa-mir-412_l 0.129 0.195 −0.288 0.483 hsa-mir-422a_l 0.159 1.153 0.670 0.483 HSbrain_317_l 0.080 0.542 0.059 0.483 HS_from_MQbrain_529_r 0.164 0.548 0.065 0.483 HS_from_MQbrain_375_l 0.011 0.196 −0.288 0.484 HS_from_MM_47_l 0.068 0.020 −0.464 0.484 Hsd_from_Mmd_480_l 0.025 0.193 −0.291 0.484 HS_189_l 0.040 0.881 0.395 0.485 HS_from_MM_72_r 0.056 −0.012 −0.498 0.486 Hsd_from_Mmd_527_r 0.025 −0.455 −0.942 0.487 HS_from_MQbrain_224_l 0.077 0.677 0.190 0.487 HS_from_MQbrain_1456_l 0.009 0.744 0.256 0.488 HS_from_MQbrain_655_l 0.011 0.084 −0.404 0.489 HS_from_MQbrain_1363_l 0.007 0.297 −0.192 0.490 HSbrain_1076_r 0.017 0.188 −0.303 0.491 hsa-mir-155_l 0.103 −0.206 −0.697 0.491 HS_85_l 0.129 1.342 0.850 0.492 HS_from_MM_18_l 0.004 0.221 −0.273 0.494 HS_from_MQbrain_1384_r 0.124 0.458 −0.038 0.496 Hsd_46_l 0.025 0.367 −0.129 0.496 hsa-let-7c_l 0.099 −0.464 −0.964 0.500 HS_from_MQbrain_288_r 0.011 0.196 −0.306 0.502 HS_from_MQbrain_951_l 0.040 0.919 0.416 0.503 HS_307_r 0.183 −0.456 −0.959 0.503 HSbrain_557_r 0.095 1.309 0.804 0.504 hsa-mir-516-4_l 0.016 0.429 −0.076 0.505 hsa-let-7d_l 0.029 −0.159 −0.664 0.505 HS_78_r 0.170 0.725 0.220 0.505 Hsd_26_l 0.025 0.212 −0.293 0.505 HS_79_l 0.004 0.213 −0.293 0.505 HS_from_MQbrain_1064_r 0.088 0.645 0.139 0.506 Hsd_from_Mmd_93_l 0.119 1.178 0.672 0.507 HS_from_MQbrain_1522_r 0.009 0.032 −0.476 0.508 HS_from_MQbrain_468_r 0.068 0.332 −0.176 0.509 HS_from_MQbrain_750_r 0.065 0.894 0.385 0.509 hsa-mir-516-3_l 0.016 0.360 −0.151 0.511 Hsd_from_Mmd_410_l 0.170 −0.321 −0.832 0.511 Hsd_47_r 0.170 1.086 0.574 0.512 HS_from_MQbrain_969_r 0.153 0.561 0.048 0.512 HS_from_PT_136_l 0.050 1.198 0.686 0.513 HSbrain_709_l 0.023 0.841 0.327 0.513 HS_from_MQbrain_1028_l 0.164 1.570 1.057 0.513 HSbrain_585_l 0.050 0.904 0.390 0.514 hsa-mir-125a_r 0.014 0.758 0.243 0.515 HS_from_MM_178_r 0.004 0.170 −0.345 0.515 hsa-mir-135a-1_r 0.140 0.615 0.100 0.515 Hsd_from_Mmd_176_l 0.099 0.008 −0.508 0.516 HS_from_MQbrain_1844_r 0.043 0.622 0.106 0.516 HSbrain_259_r 0.030 0.708 0.192 0.516 HSbrain_261_l 0.038 0.190 −0.326 0.516 hsa-mir-497_r 0.016 0.312 −0.205 0.517 HS_from_MQbrain_1692_l 0.135 1.678 1.160 0.518 HSbrain_359_r 0.020 0.957 0.437 0.520 HS_from_MM_295_l 0.004 0.192 −0.328 0.520 Hsd_from_Mmd_302_r 0.029 0.158 −0.363 0.521 HS_from_PT_74_r 0.095 1.193 0.672 0.521 HS_from_MQbrain_774_r 0.050 0.494 −0.027 0.521 hsa-mir-587_r 0.189 −0.141 −0.663 0.522 hsa-mir-383_l 0.183 0.011 −0.513 0.524 HSbrain_458_l 0.034 −0.681 −1.206 0.525 HSbrain_321_r 0.019 0.716 0.191 0.525 hsa-mir-125b-1_r 0.108 0.830 0.304 0.526 HS_from_MQbrain_330_r 0.011 0.687 0.161 0.526 hsa-mir-183_r 0.189 1.388 0.861 0.526 HS_from_MM_347_l 0.088 1.264 0.738 0.527 Hsd_37_l 0.053 1.037 0.510 0.528 HS_from_MQbrain_1485_l 0.009 0.128 −0.400 0.528 hsa-mir-502_l 0.092 −0.266 −0.794 0.528 HS_15_l 0.043 1.549 1.020 0.529 HSbrain_72_l 0.129 1.342 0.812 0.529 hsa-mir-10a_r 0.103 0.156 −0.375 0.531 HS_106_l 0.030 0.650 0.119 0.532 hsa-mir-514-3_r 0.183 −0.317 −0.849 0.532 HSbrain_691_l 0.095 −0.348 −0.881 0.533 HS_from_MQbrain_1417_l 0.092 0.735 0.199 0.536 HSbrain_318_l 0.029 0.876 0.338 0.537 HS_from_MQbrain_472_r 0.048 0.832 0.294 0.538 HS_from_MM_87_l 0.124 −0.292 −0.830 0.538 HS_from_MQbrain_671_r 0.011 1.040 0.502 0.538 HS_from_MQbrain_1072_r 0.153 −0.043 −0.582 0.539 HS_217_l 0.001 0.658 0.118 0.540 HS_from_PT_234_l 0.164 0.188 −0.352 0.540 HS_from_MQbrain_1304_r 0.124 0.507 −0.034 0.542 HS_from_MQbrain_1393_r 0.007 0.873 0.331 0.542 HSbrain_617_l 0.023 1.098 0.556 0.542 HSbrain_276_l 0.088 0.101 −0.443 0.544 HS_161_r 0.140 −0.342 −0.886 0.544 hsa-mir-137_l 0.068 0.471 −0.075 0.546 Hsd_from_Mmd_223_r 0.095 −0.374 −0.922 0.548 HS_from_MM_298_l 0.189 −0.268 −0.817 0.549 HSbrain_811_r 0.024 −0.031 −0.580 0.549 hsa-mir-188_l 0.153 0.494 −0.056 0.549 Hsd_from_Mmd_439_l 0.061 −0.262 −0.811 0.549 HS_from_MM_313_l 0.099 −0.694 −1.245 0.551 HS_from_MQbrain_1139_r 0.099 −0.337 −0.890 0.552 Hsd_from_Mmd_34_r 0.046 0.650 0.095 0.555 HS_from_MQbrain_629_l 0.011 0.906 0.350 0.556 HSbrain_503_r 0.021 0.793 0.236 0.557 Hsd_from_Mmd_501_r 0.084 0.618 0.060 0.558 HS_from_MQbrain_147_l 0.183 0.715 0.156 0.559 hsa-mir-598_l 0.027 0.957 0.398 0.559 HS_180_r 0.065 0.240 −0.319 0.559 HSbrain_663_r 0.147 −0.320 −0.880 0.560 HS_215_l 0.050 1.344 0.784 0.560 Hsd_11_l 0.080 0.507 −0.054 0.561 Hsd_96_r 0.147 −0.209 −0.772 0.563 HS_from_MQbrain_441_l 0.011 0.246 −0.320 0.565 HS_from_MQbrain_1297_l 0.007 0.454 −0.113 0.566 Hsd_from_Mmd_219_r 0.025 −0.010 −0.577 0.567 HSbrain_536_r 0.108 −0.351 −0.919 0.569 HSbrain_286_l 0.084 1.278 0.709 0.569 Hsd_from_Mmd_314_r 0.189 −0.315 −0.885 0.569 HS_from_MQbrain_212_r 0.011 0.049 −0.523 0.573 HSbrain_455_r 0.080 1.623 1.049 0.573 hsa-mir-101-1_r 0.176 −0.476 −1.050 0.574 HS_from_MQbrain_384_r 0.084 −0.235 −0.809 0.574 Hsd_from_Mmd_249_r 0.108 0.047 −0.528 0.575 HS_from_MQbrain_6_l 0.159 1.944 1.368 0.576 HS_from_MQbrain_625_l 0.159 0.255 −0.323 0.577 HSbrain_546_r 0.030 0.510 −0.070 0.581 hsa-mir-95_r 0.030 −0.158 −0.739 0.581 HSbrain_131_l 0.124 1.302 0.720 0.582 HS_from_MQbrain_1300_r 0.007 −0.097 −0.680 0.583 hsa-mir-506_l 0.070 −0.318 −0.901 0.583 hsa-mir-203_r 0.189 0.895 0.310 0.584 hsa-mir-668_l 0.050 1.334 0.749 0.585 Hsd_from_Mmd_68_l 0.183 −0.614 −1.200 0.587 hsa-mir-432_l 0.176 0.356 −0.232 0.588 HS_from_MQbrain_435_l 0.034 0.566 −0.022 0.588 HS_from_MQbrain_1080_l 0.040 −0.105 −0.694 0.589 HS_from_MQbrain_1501_r 0.159 1.467 0.877 0.590 Hsd_from_Mmd_518_r 0.119 0.521 −0.070 0.591 hsa-mir-30c-1_l 0.036 −0.002 −0.594 0.592 HS_from_MQbrain_839_r 0.012 0.055 −0.537 0.592 HS_from_MQbrain_1625_r 0.009 0.910 0.318 0.592 HSbrain_801_r 0.024 0.462 −0.130 0.592 HSbrain_267_r 0.129 0.470 −0.123 0.593 HS_from_MQbrain_2670_r 0.099 0.673 0.079 0.594 HS_from_MQbrain_68_r 0.159 −0.182 −0.776 0.594 hsa-mir-571_r 0.113 −0.086 −0.680 0.594 hsa-mir-616_r 0.017 −0.025 −0.620 0.595 HS_from_MQbrain_1610_r 0.050 1.004 0.409 0.595 HS_from_MQbrain_549_l 0.011 0.234 −0.361 0.595 HS_156_l 0.058 −0.022 −0.618 0.595 HS_from_MQbrain_1037_r 0.092 0.808 0.213 0.595 HSbrain_543_r 0.038 0.457 −0.139 0.596 hsa-mir-125a_l 0.014 0.117 −0.480 0.597 HSbrain_268_r 0.019 0.831 0.233 0.598 HSbrain_399_l 0.020 0.270 −0.327 0.598 HS_from_MQbrain_1292_r 0.007 0.078 −0.521 0.599 Hsd_from_Mmd_92_r 0.025 0.770 0.168 0.602 HS_from_MQbrain_1300_l 0.058 1.357 0.754 0.603 HS_from_MQbrain_1056_l 0.005 −0.166 −0.771 0.605 HS_from_MQbrain_1695_l 0.113 −0.143 −0.751 0.607 HS_from_MQbrain_1315_l 0.038 1.524 0.913 0.611 HS_from_MM_309_r 0.004 0.695 0.083 0.612 HS_from_MQbrain_1469_r 0.032 −0.333 −0.945 0.612 HS_from_MQbrain_1665_r 0.080 0.501 −0.111 0.613 Hsd_from_Mmd_123_r 0.176 0.949 0.335 0.614 hsa-mir-27b_r 0.140 −0.809 −1.423 0.614 HS_from_MQbrain_389_l 0.196 0.842 0.226 0.616 HS_from_MQbrain_1657_r 0.010 0.032 −0.586 0.618 HSbrain_778_r 0.024 −0.435 −1.053 0.618 HS_151_r 0.170 −0.548 −1.168 0.619 Hsd_76_r 0.053 0.546 −0.074 0.620 Hsd_7_r 0.058 0.261 −0.359 0.620 HS_from_PT_22_l 0.103 0.699 0.077 0.621 hsa-mir-655_l 0.017 0.099 −0.523 0.622 hsa-mir-302d_l 0.016 −0.382 −1.009 0.626 HSbrain_245_r 0.070 1.023 0.396 0.627 Hsd_from_Mmd_311_l 0.068 −0.222 −0.850 0.628 HSbrain_41_l 0.034 0.714 0.086 0.628 HSbrain_635_l 0.072 1.042 0.413 0.628 HS_218_r 0.001 0.740 0.110 0.630 HS_from_MQbrain_92_l 0.048 1.368 0.731 0.637 HS_from_MM_84_l 0.176 −0.246 −0.884 0.639 hsa-mir-514-1_r 0.058 −0.315 −0.954 0.639 hsa-mir-325_l 0.016 0.410 −0.231 0.641 Hsd_65_r 0.176 1.939 1.298 0.641 HS_141_l 0.001 1.087 0.444 0.643 HSbrain_267_l 0.113 0.441 −0.203 0.644 hsa-mir-652_l 0.056 0.524 −0.122 0.646 HS_from_MQbrain_382_r 0.159 1.932 1.286 0.646 Hsd_from_Mmd_318_l 0.099 −0.552 −1.199 0.647 HS_from_MM_241_l 0.004 −0.739 −1.386 0.648 HSbrain_767_r 0.077 0.727 0.079 0.648 HS_from_MQbrain_470_l 0.040 1.293 0.645 0.648 Hsd_from_Mmd_455_l 0.164 −0.593 −1.248 0.655 HSbrain_776_l 0.065 1.480 0.821 0.659 hsa-mir-526a-1_r 0.176 −0.304 −0.964 0.660 hsa-mir-520b_r 0.053 −0.035 −0.696 0.661 HSbrain_243_l 0.019 0.648 −0.014 0.661 HS_from_MQbrain_751_l 0.103 0.570 −0.094 0.663 HS_from_MQbrain_1628_r 0.009 0.216 −0.451 0.667 Hsd_from_Mmd_35_l 0.170 1.367 0.700 0.667 HS_from_MM_185_r 0.135 0.727 0.059 0.668 HS_from_PT_254_r 0.088 1.031 0.363 0.668 hsa-mir-140_l 0.038 −0.345 −1.022 0.677 HS_from_MQbrain_883_l 0.038 0.781 0.099 0.683 HSbrain_540_r 0.021 0.504 −0.178 0.683 HS_from_MQbrain_1485_r 0.009 0.440 −0.243 0.683 HS_from_MQbrain_619_r 0.011 0.807 0.123 0.685 HS_from_MQbrain_1311_r 0.007 0.146 −0.542 0.688 Hsd_from_Mmd_183_r 0.124 1.219 0.529 0.690 HSbrain_106_r 0.017 0.772 0.081 0.691 Hsd_from_Mmd_166_l 0.058 −0.375 −1.071 0.696 HS_from_MQbrain_1031_l 0.092 1.334 0.638 0.696 hsa-mir-573_l 0.017 −0.081 −0.781 0.700 HS_from_MQbrain_539_r 0.048 1.051 0.345 0.705 HSbrain_970_r 0.129 −0.385 −1.091 0.706 HS_from_MQbrain_1143_r 0.046 0.735 0.029 0.706 HSbrain_239_l 0.056 0.875 0.169 0.706 HS_from_MQbrain_71_r 0.011 1.050 0.341 0.708 HS_from_MM_63_l 0.005 0.331 −0.382 0.714 HS_232_l 0.001 1.105 0.389 0.716 HS_36_l 0.061 0.394 −0.323 0.716 HSbrain_426_r 0.020 0.553 −0.164 0.717 hsa-mir-520f_r 0.183 −0.259 −0.981 0.721 hsa-mir-141_r 0.050 0.053 −0.670 0.723 HS_from_PT_257_r 0.013 0.313 −0.410 0.723 HS_from_MQbrain_255_l 0.095 0.976 0.251 0.725 hsa-mir-199a-2_r 0.072 −0.373 −1.102 0.729 HS_from_PT_190_r 0.013 1.545 0.815 0.730 Hsd_17_r 0.032 0.906 0.175 0.732 HSbrain_737_r 0.140 0.684 −0.048 0.732 HSbrain_383_l 0.119 −1.312 −2.045 0.732 HS_from_MM_35_l 0.159 1.499 0.757 0.743 hsa-mir-17_l 0.153 −0.669 −1.413 0.744 HS_from_MQbrain_1100_l 0.005 0.617 −0.128 0.745 HSbrain_170_r 0.088 −0.538 −1.284 0.746 hsa-mir-373_r 0.029 0.750 0.003 0.748 HS_from_MQbrain_691_l 0.050 1.657 0.909 0.748 hsa-mir-199a-1_r 0.080 −0.277 −1.025 0.748 HS_177_l 0.043 0.069 −0.680 0.748 HSbrain_590_r 0.088 0.695 −0.053 0.748 hsa-mir-378_r 0.029 1.004 0.252 0.752 hsa-mir-299_r 0.061 0.678 −0.075 0.753 HS_from_MQbrain_1410_l 0.099 0.318 −0.438 0.755 HS_from_PT_40_r 0.013 0.229 −0.528 0.757 Hsd_from_Mmd_436_r 0.040 0.764 0.005 0.759 hsa-mir-98_l 0.017 −0.441 −1.200 0.759 HS_215_r 0.001 0.927 0.167 0.760 HS_from_MQbrain_1227_l 0.043 0.258 −0.508 0.766 hsa-mir-668_r 0.034 0.802 0.032 0.769 hsa-let-7a-2_l 0.013 −0.333 −1.106 0.773 HS_from_MQbrain_1169_l 0.030 0.600 −0.173 0.773 hsa-mir-16-1_l 0.176 0.361 −0.415 0.776 HS_from_MQbrain_918_l 0.030 1.730 0.948 0.782 HS_from_MM_6_r 0.065 0.900 0.115 0.785 Hsd_33_l 0.080 0.576 −0.214 0.791 HSbrain_760_l 0.034 0.241 −0.550 0.791 hsa-let-7a-3_l 0.014 −0.259 −1.051 0.792 HSbrain_636_l 0.023 1.330 0.534 0.796 Hsd_from_Mmd_533_l 0.025 0.327 −0.469 0.796 HS_from_MQbrain_1183_l 0.005 1.249 0.452 0.797 hsa-mir-126_r 0.014 −0.136 −0.937 0.802 hsa-let-7a-1_l 0.013 −0.237 −1.039 0.802 HS_from_MQbrain_1325_r 0.084 1.734 0.932 0.802 HS_from_MQbrain_1734_l 0.189 2.197 1.394 0.802 hsa-mir-16-2_l 0.159 0.466 −0.337 0.803 HS_from_MQbrain_1128_l 0.005 0.944 0.140 0.804 HS_from_MQbrain_1823_r 0.010 −0.086 −0.892 0.806 hsa-mir-454_r 0.016 −0.337 −1.148 0.811 HS_from_MM_304_l 0.170 1.858 1.046 0.812 HS_from_MQbrain_366_r 0.070 0.788 −0.046 0.835 HSbrain_916_r 0.056 1.228 0.387 0.841 HS_from_MQbrain_80_l 0.108 1.137 0.295 0.843 Hsd_from_Mmd_291_l 0.135 1.914 1.066 0.848 hsa-mir-633_l 0.017 0.566 −0.285 0.850 HS_291_r 0.002 0.012 −0.838 0.851 HS_192_r 0.170 2.486 1.634 0.853 HS_21_r 0.001 1.909 1.055 0.855 HSbrain_916_l 0.024 1.825 0.966 0.859 HS_from_MQbrain_374_r 0.108 0.701 −0.162 0.863 hsa-mir-148a_r 0.043 0.200 −0.668 0.867 HS_from_MQbrain_965_l 0.013 0.734 −0.138 0.872 HS_from_MQbrain_579_l 0.056 1.113 0.240 0.872 Hsd_from_Mmd_524_l 0.135 −0.469 −1.342 0.873 hsa-mir-181a-2_l 0.040 −0.194 −1.074 0.880 HSbrain_1384_r 0.017 0.605 −0.276 0.881 HSbrain_52_r 0.021 0.850 −0.035 0.885 Hsd_from_Mmd_81_l 0.034 0.626 −0.266 0.892 HS_from_MM_1_r 0.048 −0.144 −1.036 0.892 Hsd_60_r 0.119 1.274 0.371 0.902 hsa-mir-130a_r 0.014 0.355 −0.547 0.903 HSbrain_224_r 0.019 0.732 −0.170 0.903 hsa-mir-26a-2_l 0.183 0.327 −0.583 0.910 HS_from_MQbrain_194_l 0.011 1.076 0.165 0.911 hsa-mir-92b_r 0.048 0.316 −0.596 0.912 HSbrain_253_l 0.019 1.286 0.372 0.914 HS_from_MQbrain_1462_l 0.009 0.967 0.048 0.919 hsa-mir-129-1_r 0.108 1.280 0.361 0.919 Hsd_from_Mmd_298_r 0.025 −0.298 −1.219 0.921 HSbrain_1_l 0.017 0.936 0.012 0.924 HSbrain_337_l 0.020 0.406 −0.521 0.927 HSbrain_19_l 0.092 1.886 0.952 0.934 HS_from_MQbrain_1958_l 0.053 1.083 0.142 0.941 HS_from_MM_334_l 0.004 0.627 −0.324 0.951 hsa-mir-26b_l 0.036 −0.144 −1.099 0.955 HS_169_l 0.001 1.737 0.779 0.958 HS_80_l 0.088 2.217 1.258 0.959 HSbrain_362_r 0.020 1.193 0.230 0.963 HS_255_l 0.001 1.422 0.454 0.968 HS_from_MM_264_l 0.004 1.081 0.110 0.972 HSbrain_500_l 0.034 1.101 0.116 0.984 Hsd_81_r 0.065 −0.348 −1.336 0.989 hsa-let-7g_l 0.014 −0.344 −1.333 0.989 hsa-mir-26a-1_l 0.140 0.271 −0.719 0.990 hsa-mir-181a-1_l 0.015 −0.200 −1.192 0.992 Hsd_from_Mmd_387_l 0.025 1.078 0.082 0.996 HSbrain_500_r 0.021 1.019 0.021 0.998 HS_68_l 0.103 −1.388 −2.391 1.003 HS_from_MQbrain_1985_l 0.030 1.111 0.108 1.004 hsa-mir-20a_l 0.088 −0.516 −1.527 1.010 hsa-mir-146a_l 0.030 0.140 −0.872 1.012 hsa-mir-20b_l 0.058 −0.713 −1.732 1.019 hsa-let-7f-1_l 0.014 −0.167 −1.192 1.025 HS_215_r 0.001 1.669 0.641 1.028 HS_from_MQbrain_572_l 0.050 −0.092 −1.130 1.038 HSbrain_209_l 0.095 1.410 0.371 1.039 HS_from_MQbrain_1784_r 0.103 1.648 0.601 1.047 HSbrain_1305_l 0.017 1.470 0.421 1.049 hsa-let-7f-2_l 0.030 −0.121 −1.173 1.052 HS_266_r 0.046 1.371 0.315 1.056 HSbrain_398_r 0.020 1.061 0.004 1.057 hsa-mir-200b_r 0.072 1.035 −0.027 1.062 HSbrain_1_r 0.119 1.821 0.740 1.081 hsa-mir-363_l 0.072 1.689 0.587 1.102 HS_from_PT_26_r 0.013 1.314 0.210 1.104 HS_from_MQbrain_1235_l 0.065 1.757 0.631 1.127 hsa-mir-200c_r 0.048 0.810 −0.339 1.149 HS_291_r 0.002 0.965 −0.193 1.158 HS_from_MQbrain_153_l 0.153 3.559 2.394 1.165 HS_from_MQbrain_241_l 0.113 2.115 0.949 1.166 hsa-mir-421_r 0.016 1.426 0.252 1.175 hsa-mir-29c_r 0.065 −0.757 −1.938 1.181 HS_from_MQbrain_79_r 0.012 1.972 0.787 1.185 hsa-mir-181c_l 0.015 0.066 −1.122 1.188 hsa-mir-145_l 0.032 0.280 −0.909 1.189 HSbrain_237_r 0.092 1.411 0.214 1.197 HS_from_MQbrain_687_r 0.077 2.596 1.397 1.199 HS_from_PT_7_r 0.108 2.612 1.393 1.218 HS_from_MQbrain_1323_l 0.068 1.783 0.539 1.244 HSbrain_1437_r 0.017 1.047 −0.202 1.248 hsa-mir-21_l 0.189 −1.905 −3.155 1.249 hsa-mir-768_r 0.017 1.069 −0.182 1.251 HSbrain_398_l 0.020 0.748 −0.536 1.285 HS_from_MQbrain_2700_r 0.011 1.133 −0.188 1.321 hsa-mir-29a_r 0.016 −0.431 −1.810 1.379 hsa-mir-9-2_r 0.129 1.894 0.500 1.393 HS_from_PT_139_l 0.029 2.178 0.775 1.403 hsa-mir-27a_r 0.016 −0.620 −2.050 1.430 hsa-mir-9-1_r 0.080 1.925 0.491 1.434 hsa-mir-92-2_r 0.017 0.583 −0.929 1.512 HSbrain_411_r 0.020 0.519 −0.994 1.512 hsa-mir-9-3_r 0.070 1.982 0.460 1.522 hsa-mir-92-1_r 0.017 0.637 −0.942 1.579 HSbrain_377_r 0.020 1.073 −0.614 1.687 HS_from_PT_114_l 0.013 0.542 −1.365 1.907 HSbrain_377_l 0.020 0.817 −1.136 1.952 HS_from_PT_114_r 0.013 0.790 −1.277 2.067 ¹Wilcoxon analysis: cut off adj p value <0.2 ²upregulation of small RNA when ratio expression >1 downregulation of small RNA when ratio expression <1

TABLE 2c Small RNAs that are upregulated in colorectal adenomas compared to control samples HS_from_MQbrain_1985_l HS_from_MQbrain_1235_l HSbrain_398_l hsa-mir-20a_l hsa-mir-200c_r HS_from_MQbrain_2700_r hsa-mir-146a_l HS_291_r hsa-mir-29a_r hsa-mir-20b_l HS_from_MQbrain_153_l hsa-mir-9-2_r hsa-let-7f-1_l HS_from_MQbrain_241_l HS_from_PT_139_l HS_215_r hsa-mir-421_r hsa-mir-27a_r HS_from_MQbrain_572_l hsa-mir-29c_r hsa-mir-9-1_r HSbrain_209_l HS_from_MQbrain_79_r hsa-mir-92-2_r HS_from_MQbrain_1784_r hsa-mir-181c_l HSbrain_411_r HSbrain_1305_l hsa-mir-145_l hsa-mir-9-3_r hsa-let-7f-2_l HSbrain_237_r hsa-mir-92-1_r HS_266_r HS_from_MQbrain_687_r HSbrain_377_r HSbrain_398_r HS_from_PT_7_r HS_from_PT_114_l hsa-mir-200b_r HS_from_MQbrain_1323_l HSbrain_377_l HSbrain_1_r HSbrain_1437_r HS_from_PT_114_r hsa-mir-363_l hsa-mir-21_l HS_from_PT_26_r hsa-mir-768_r

TABLE 2d Small RNAs that are downregulated in colorectal adenomas compared to control samples HS_101_l HS_102_l HS_106_l HS_106_r HS_109_l HS_109_r HS_11_l HS_111_l HS_114_l HS_115_r HS_118_l HS_119_l HS_121_r HS_124_l HS_128_l HS_128_r HS_129_l HS_130_l HS_131_r HS_132_l HS_135_l HS_141_l HS_145_r HS_15_l HS_150_l HS_151_r HS_156_l HS_157_l HS_157_r HS_161_r HS_164_l HS_166_r HS_167_l HS_168_r HS_169_l HS_171_r HS_172_r HS_173_l HS_175_l HS_176_l HS_177_l HS_18_l HS_180_r HS_181_l HS_186_r HS_189_l HS_189_r HS_190_l HS_190_r HS_191_l HS_192_r HS_197_r HS_198_l HS_203_l HS_203_r HS_204_l HS_204_r HS_21_r HS_212_l HS_212_r HS_213_l HS_214_r HS_215_l HS_215_r HS_217_l HS_218_r HS_219_l HS_22_r HS_220_l HS_223_l HS_223_r HS_231_r HS_232_l HS_241_r HS_25_r HS_255_l HS_261_l HS_261_r HS_262_l HS_262_r HS_264_r HS_265_l HS_268_l HS_281_r HS_281_r HS_286_r HS_287_l HS_288_l HS_289_l HS_291_r HS_292_l HS_304_r HS_306_r HS_307_r HS_33_l HS_36_l HS_38_r HS_4_r HS_41_r HS_49_r HS_51_r HS_53_r HS_56_r HS_57_l HS_59_l HS_61_l HS_62_l HS_66_r HS_71_l HS_71_r HS_73_r HS_74_r HS_76_r HS_77_l HS_77_r HS_78_r HS_79_l HS_80_l HS_81_r HS_83_r HS_85_l HS_9_r HS_93_r HS_95_r HS_97_r HS_98_l HS_98_l HS_98_r HS_from_MM_1_l HS_from_MM_1_r HS_from_MM_103_l HS_from_MM_109_l HS_from_MM_115_l HS_from_MM_118_l HS_from_MM_118_r HS_from_MM_119_r HS_from_MM_121_l HS_from_MM_123_l HS_from_MM_124_l HS_from_MM_124_r HS_from_MM_131_l HS_from_MM_135_l HS_from_MM_145_r HS_from_MM_149_r HS_from_MM_150_r HS_from_MM_157_l HS_from_MM_160_l HS_from_MM_163_l HS_from_MM_165_l HS_from_MM_169_r HS_from_MM_174_l HS_from_MM_178_r HS_from_MM_18_l HS_from_MM_182_r HS_from_MM_184_r HS_from_MM_185_r HS_from_MM_194_l HS_from_MM_195_r HS_from_MM_202_l HS_from_MM_218_l HS_from_MM_219_l HS_from_MM_229_r HS_from_MM_232_r HS_from_MM_237_l HS_from_MM_241_l HS_from_MM_251_r HS_from_MM_264_l HS_from_MM_276_l HS_from_MM_289_l HS_from_MM_289_r HS_from_MM_295_l HS_from_MM_295_r HS_from_MM_298_l HS_from_MM_298_r HS_from_MM_304_l HS_from_MM_304_r HS_from_MM_309_r HS_from_MM_313_l HS_from_MM_319_l HS_from_MM_32_r HS_from_MM_331_r HS_from_MM_334_l HS_from_MM_339_r HS_from_MM_34_l HS_from_MM_340_r HS_from_MM_342_l HS_from_MM_342_r HS_from_MM_346_r HS_from_MM_347_l HS_from_MM_35_l HS_from_MM_353_l HS_from_MM_354_r HS_from_MM_359_l HS_from_MM_39_l HS_from_MM_47_l HS_from_MM_48_l HS_from_MM_49_l HS_from_MM_57_r HS_from_MM_6_l HS_from_MM_6_r HS_from_MM_63_l HS_from_MM_72_r HS_from_MM_79_l HS_from_MM_84_l HS_from_MM_84_r HS_from_MM_86_l HS_from_MM_87_l HS_from_MM_89_l HS_from_MM_92_r HS_from_MQbrain_100_l HS_from_MQbrain_1006_l HS_from_MQbrain_1018_l HS_from_MQbrain_1028_l HS_from_MQbrain_1030_l HS_from_MQbrain_1031_l HS_from_MQbrain_1036_r HS_from_MQbrain_1037_r HS_from_MQbrain_1042_r HS_from_MQbrain_1043_r HS_from_MQbrain_105_l HS_from_MQbrain_105_l HS_from_MQbrain_1051_r HS_from_MQbrain_1056_l HS_from_MQbrain_1064_r HS_from_MQbrain_1070_r HS_from_MQbrain_1072_r HS_from_MQbrain_1073_r HS_from_MQbrain_1075_l HS_from_MQbrain_1080_l HS_from_MQbrain_1081_r HS_from_MQbrain_1082_l HS_from_MQbrain_1085_l HS_from_MQbrain_1087_l HS_from_MQbrain_1090_r HS_from_MQbrain_1097_r HS_from_MQbrain_1099_r HS_from_MQbrain_1100_l HS_from_MQbrain_1102_l HS_from_MQbrain_1103_l HS_from_MQbrain_1109_l HS_from_MQbrain_1110_l HS_from_MQbrain_1119_l HS_from_MQbrain_1119_l HS_from_MQbrain_1126_l HS_from_MQbrain_1127_r HS_from_MQbrain_1128_l HS_from_MQbrain_113_r HS_from_MQbrain_1137_l HS_from_MQbrain_1139_r HS_from_MQbrain_114_r HS_from_MQbrain_1143_r HS_from_MQbrain_1164_l HS_from_MQbrain_1169_l HS_from_MQbrain_1183_l HS_from_MQbrain_1184_r HS_from_MQbrain_1199_l HS_from_MQbrain_120_l HS_from_MQbrain_1201_r HS_from_MQbrain_1204_l HS_from_MQbrain_1204_r HS_from_MQbrain_1208_l HS_from_MQbrain_1212_l HS_from_MQbrain_1213_l HS_from_MQbrain_1215_l HS_from_MQbrain_1219_l HS_from_MQbrain_1219_r HS_from_MQbrain_1222_r HS_from_MQbrain_1223_l HS_from_MQbrain_1224_r HS_from_MQbrain_1227_l HS_from_MQbrain_1227_l HS_from_MQbrain_1228_r HS_from_MQbrain_1234_l HS_from_MQbrain_1239_l HS_from_MQbrain_1241_r HS_from_MQbrain_1245_l HS_from_MQbrain_1246_l HS_from_MQbrain_1250_r HS_from_MQbrain_1253_r HS_from_MQbrain_1260_r HS_from_MQbrain_1267_r HS_from_MQbrain_1268_l HS_from_MQbrain_128_r HS_from_MQbrain_1280_l HS_from_MQbrain_1283_l HS_from_MQbrain_129_r HS_from_MQbrain_1292_r HS_from_MQbrain_1297_l HS_from_MQbrain_1300_l HS_from_MQbrain_1300_r HS_from_MQbrain_1304_r HS_from_MQbrain_131_r HS_from_MQbrain_1311_r HS_from_MQbrain_1314_l HS_from_MQbrain_1315_l HS_from_MQbrain_1317_r HS_from_MQbrain_1318_l HS_from_MQbrain_1325_r HS_from_MQbrain_1334_r HS_from_MQbrain_1340_l HS_from_MQbrain_1349_l HS_from_MQbrain_135_l HS_from_MQbrain_1353_l HS_from_MQbrain_1354_l HS_from_MQbrain_1355_r HS_from_MQbrain_1363_l HS_from_MQbrain_1366_l HS_from_MQbrain_137_r HS_from_MQbrain_1374_l HS_from_MQbrain_1376_l HS_from_MQbrain_1376_r HS_from_MQbrain_1377_l HS_from_MQbrain_1377_r HS_from_MQbrain_1379_r HS_from_MQbrain_1380_r HS_from_MQbrain_1381_r HS_from_MQbrain_1382_l HS_from_MQbrain_1384_r HS_from_MQbrain_1388_l HS_from_MQbrain_1392_r HS_from_MQbrain_1393_r HS_from_MQbrain_1395_r HS_from_MQbrain_140_l HS_from_MQbrain_1402_r HS_from_MQbrain_1404_r HS_from_MQbrain_1410_l HS_from_MQbrain_1412_l HS_from_MQbrain_1414_r HS_from_MQbrain_1417_l HS_from_MQbrain_1420_l HS_from_MQbrain_1424_r HS_from_MQbrain_1426_l HS_from_MQbrain_1427_l HS_from_MQbrain_1437_l HS_from_MQbrain_1442_l HS_from_MQbrain_1443_r HS_from_MQbrain_1444_l HS_from_MQbrain_1444_l HS_from_MQbrain_1445_l HS_from_MQbrain_1446_l HS_from_MQbrain_1450_r HS_from_MQbrain_1456_l HS_from_MQbrain_1459_l HS_from_MQbrain_1462_l HS_from_MQbrain_1462_r HS_from_MQbrain_1469_r HS_from_MQbrain_147_l HS_from_MQbrain_1478_l HS_from_MQbrain_1484_l HS_from_MQbrain_1485_l HS_from_MQbrain_1485_r HS_from_MQbrain_1487_r HS_from_MQbrain_1493_r HS_from_MQbrain_1494_l HS_from_MQbrain_1497_l HS_from_MQbrain_15_r HS_from_MQbrain_1500_l HS_from_MQbrain_1501_r HS_from_MQbrain_1502_l HS_from_MQbrain_1509_r HS_from_MQbrain_1513_r HS_from_MQbrain_1520_l HS_from_MQbrain_1520_r HS_from_MQbrain_1522_r HS_from_MQbrain_1523_r HS_from_MQbrain_1535_r HS_from_MQbrain_154_l HS_from_MQbrain_154_r HS_from_MQbrain_1545_r HS_from_MQbrain_155_l HS_from_MQbrain_1561_l HS_from_MQbrain_1561_r HS_from_MQbrain_1565_l HS_from_MQbrain_1565_r HS_from_MQbrain_1566_r HS_from_MQbrain_1574_l HS_from_MQbrain_1576_r HS_from_MQbrain_1590_l HS_from_MQbrain_1592_l HS_from_MQbrain_1593_r HS_from_MQbrain_1596_r HS_from_MQbrain_1602_l HS_from_MQbrain_161_r HS_from_MQbrain_1610_r HS_from_MQbrain_162_r HS_from_MQbrain_1620_l HS_from_MQbrain_1624_l HS_from_MQbrain_1625_r HS_from_MQbrain_1626_r HS_from_MQbrain_1627_l HS_from_MQbrain_1628_r HS_from_MQbrain_163_l HS_from_MQbrain_1630_l HS_from_MQbrain_1632_r HS_from_MQbrain_1633_r HS_from_MQbrain_1637_l HS_from_MQbrain_1637_r HS_from_MQbrain_1640_l HS_from_MQbrain_1642_l HS_from_MQbrain_1648_r HS_from_MQbrain_1657_r HS_from_MQbrain_1658_l HS_from_MQbrain_1658_r HS_from_MQbrain_1665_r HS_from_MQbrain_1671_l HS_from_MQbrain_1674_l HS_from_MQbrain_1675_r HS_from_MQbrain_1678_r HS_from_MQbrain_1684_l HS_from_MQbrain_1684_r HS_from_MQbrain_1686_l HS_from_MQbrain_1687_l HS_from_MQbrain_1690_l HS_from_MQbrain_1692_l HS_from_MQbrain_1695_l HS_from_MQbrain_1695_r HS_from_MQbrain_1696_l HS_from_MQbrain_1700_l HS_from_MQbrain_1700_r HS_from_MQbrain_1703_r HS_from_MQbrain_1706_l HS_from_MQbrain_1712_r HS_from_MQbrain_1717_r HS_from_MQbrain_1721_l HS_from_MQbrain_1722_l HS_from_MQbrain_1724_l HS_from_MQbrain_1726_l HS_from_MQbrain_1734_l HS_from_MQbrain_1744_r HS_from_MQbrain_1745_r HS_from_MQbrain_1747_r HS_from_MQbrain_1748_r HS_from_MQbrain_1750_r HS_from_MQbrain_1752_l HS_from_MQbrain_1753_r HS_from_MQbrain_1758_r HS_from_MQbrain_1759_l HS_from_MQbrain_1760_r HS_from_MQbrain_1761_r HS_from_MQbrain_1771_l HS_from_MQbrain_1771_r HS_from_MQbrain_1773_l HS_from_MQbrain_1773_l HS_from_MQbrain_1776_l HS_from_MQbrain_1777_l HS_from_MQbrain_178_r HS_from_MQbrain_1781_l HS_from_MQbrain_1783_r HS_from_MQbrain_1792_r HS_from_MQbrain_1793_l HS_from_MQbrain_1794_l HS_from_MQbrain_1794_r HS_from_MQbrain_1804_r HS_from_MQbrain_1806_l HS_from_MQbrain_1807_l HS_from_MQbrain_1808_r HS_from_MQbrain_1817_l HS_from_MQbrain_1823_r HS_from_MQbrain_1831_r HS_from_MQbrain_1832_l HS_from_MQbrain_1832_r HS_from_MQbrain_1834_r HS_from_MQbrain_1839_l HS_from_MQbrain_1840_l HS_from_MQbrain_1841_r HS_from_MQbrain_1844_r HS_from_MQbrain_1846_r HS_from_MQbrain_1855_l HS_from_MQbrain_1862_l HS_from_MQbrain_1863_l HS_from_MQbrain_1877_l HS_from_MQbrain_188_l HS_from_MQbrain_1883_l HS_from_MQbrain_1883_r HS_from_MQbrain_1884_r HS_from_MQbrain_1885_r HS_from_MQbrain_1889_l HS_from_MQbrain_1893_r HS_from_MQbrain_1896_r HS_from_MQbrain_191_l HS_from_MQbrain_194_l HS_from_MQbrain_1958_l HS_from_MQbrain_20_r HS_from_MQbrain_207_l HS_from_MQbrain_2087_r HS_from_MQbrain_209_r HS_from_MQbrain_212_r HS_from_MQbrain_22_r HS_from_MQbrain_221_r HS_from_MQbrain_224_l HS_from_MQbrain_234_r HS_from_MQbrain_235_r HS_from_MQbrain_2380_r HS_from_MQbrain_239_r HS_from_MQbrain_251_r HS_from_MQbrain_253_r HS_from_MQbrain_255_l HS_from_MQbrain_260_r HS_from_MQbrain_266_r HS_from_MQbrain_2670_r HS_from_MQbrain_2699_l HS_from_MQbrain_281_l HS_from_MQbrain_281_r HS_from_MQbrain_282_l HS_from_MQbrain_283_r HS_from_MQbrain_288_r HS_from_MQbrain_29_r HS_from_MQbrain_291_l HS_from_MQbrain_301_l HS_from_MQbrain_314_l HS_from_MQbrain_315_l HS_from_MQbrain_330_r HS_from_MQbrain_338_l HS_from_MQbrain_340_l HS_from_MQbrain_343_l HS_from_MQbrain_349_l HS_from_MQbrain_350_l HS_from_MQbrain_354_r HS_from_MQbrain_355_r HS_from_MQbrain_36_r HS_from_MQbrain_361_l HS_from_MQbrain_365_l HS_from_MQbrain_365_r HS_from_MQbrain_366_r HS_from_MQbrain_37_r HS_from_MQbrain_374_r HS_from_MQbrain_375_l HS_from_MQbrain_38_r HS_from_MQbrain_382_l HS_from_MQbrain_382_r HS_from_MQbrain_383_l HS_from_MQbrain_384_r HS_from_MQbrain_389_l HS_from_MQbrain_391_r HS_from_MQbrain_392_r HS_from_MQbrain_406_l HS_from_MQbrain_406_r HS_from_MQbrain_412_l HS_from_MQbrain_414_l HS_from_MQbrain_420_l HS_from_MQbrain_43_l HS_from_MQbrain_433_l HS_from_MQbrain_435_l HS_from_MQbrain_435_r HS_from_MQbrain_436_r HS_from_MQbrain_437_l HS_from_MQbrain_441_l HS_from_MQbrain_444_r HS_from_MQbrain_449_l HS_from_MQbrain_458_l HS_from_MQbrain_461_l HS_from_MQbrain_466_l HS_from_MQbrain_467_l HS_from_MQbrain_468_l HS_from_MQbrain_468_r HS_from_MQbrain_470_l HS_from_MQbrain_472_r HS_from_MQbrain_48_r HS_from_MQbrain_482_l HS_from_MQbrain_485_l HS_from_MQbrain_487_l HS_from_MQbrain_487_r HS_from_MQbrain_490_r HS_from_MQbrain_498_r HS_from_MQbrain_502_r HS_from_MQbrain_509_r HS_from_MQbrain_520_l HS_from_MQbrain_524_l HS_from_MQbrain_529_r HS_from_MQbrain_539_r HS_from_MQbrain_540_l HS_from_MQbrain_542_r HS_from_MQbrain_546_l HS_from_MQbrain_549_l HS_from_MQbrain_549_r HS_from_MQbrain_55_l HS_from_MQbrain_550_l HS_from_MQbrain_555_r HS_from_MQbrain_559_r HS_from_MQbrain_56_l HS_from_MQbrain_56_r HS_from_MQbrain_560_r HS_from_MQbrain_566_l HS_from_MQbrain_566_r HS_from_MQbrain_567_r HS_from_MQbrain_574_l HS_from_MQbrain_576_l HS_from_MQbrain_579_l HS_from_MQbrain_590_l HS_from_MQbrain_592_l HS_from_MQbrain_594_r HS_from_MQbrain_596_r HS_from_MQbrain_597_l HS_from_MQbrain_597_r HS_from_MQbrain_6_l HS_from_MQbrain_6_r HS_from_MQbrain_600_l HS_from_MQbrain_603_r HS_from_MQbrain_604_l HS_from_MQbrain_609_l HS_from_MQbrain_619_r HS_from_MQbrain_625_l HS_from_MQbrain_628_l HS_from_MQbrain_629_l HS_from_MQbrain_629_r HS_from_MQbrain_631_l HS_from_MQbrain_634_l HS_from_MQbrain_635_l HS_from_MQbrain_641_r HS_from_MQbrain_6481 HS_from_MQbrain_65_l HS_from_MQbrain_650_r HS_from_MQbrain_655_l HS_from_MQbrain_664_l HS_from_MQbrain_664_r HS_from_MQbrain_669_r HS_from_MQbrain_67_l HS_from_MQbrain_67_r HS_from_MQbrain_671_r HS_from_MQbrain_675_l HS_from_MQbrain_675_r HS_from_MQbrain_676_r HS_from_MQbrain_68_r HS_from_MQbrain_684_r HS_from_MQbrain_686_r HS_from_MQbrain_689_l HS_from_MQbrain_691_l HS_from_MQbrain_693_r HS_from_MQbrain_694_r HS_from_MQbrain_697_l HS_from_MQbrain_698_r HS_from_MQbrain_701_l HS_from_MQbrain_707_l HS_from_MQbrain_71_r HS_from_MQbrain_715_l HS_from_MQbrain_723_l HS_from_MQbrain_723_r HS_from_MQbrain_732_r HS_from_MQbrain_734_l HS_from_MQbrain_736_r HS_from_MQbrain_739_l HS_from_MQbrain_74_r HS_from_MQbrain_745_r HS_from_MQbrain_750_r HS_from_MQbrain_751_l HS_from_MQbrain_755_l HS_from_MQbrain_768_l HS_from_MQbrain_769_r HS_from_MQbrain_770_r HS_from_MQbrain_774_r HS_from_MQbrain_779_l HS_from_MQbrain_782_r HS_from_MQbrain_789_l HS_from_MQbrain_791_r HS_from_MQbrain_796_l HS_from_MQbrain_80_l HS_from_MQbrain_800_r HS_from_MQbrain_804_r HS_from_MQbrain_806_l HS_from_MQbrain_810_l HS_from_MQbrain_814_l HS_from_MQbrain_824_l HS_from_MQbrain_824_r HS_from_MQbrain_825_r HS_from_MQbrain_828_r HS_from_MQbrain_839_r HS_from_MQbrain_84_r HS_from_MQbrain_841_l HS_from_MQbrain_842_l HS_from_MQbrain_843_r HS_from_MQbrain_848_l HS_from_MQbrain_850_l HS_from_MQbrain_854_r HS_from_MQbrain_855_r HS_from_MQbrain_868_l HS_from_MQbrain_873_r HS_from_MQbrain_88_l HS_from_MQbrain_881_l HS_from_MQbrain_882_l HS_from_MQbrain_883_l HS_from_MQbrain_883_r HS_from_MQbrain_89_l HS_from_MQbrain_897_l HS_from_MQbrain_900_r HS_from_MQbrain_901_l HS_from_MQbrain_901_r HS_from_MQbrain_906_r HS_from_MQbrain_912_l HS_from_MQbrain_917_r HS_from_MQbrain_918_l HS_from_MQbrain_92_l HS_from_MQbrain_921_l HS_from_MQbrain_930_r HS_from_MQbrain_932_l HS_from_MQbrain_936_r HS_from_MQbrain_940_r HS_from_MQbrain_941_r HS_from_MQbrain_943_l HS_from_MQbrain_948_r HS_from_MQbrain_951_l HS_from_MQbrain_951_l HS_from_MQbrain_965_l HS_from_MQbrain_967_l HS_from_MQbrain_968_l HS_from_MQbrain_969_l HS_from_MQbrain_969_r HS_from_MQbrain_97_l HS_from_MQbrain_97_r HS_from_MQbrain_974_l HS_from_MQbrain_984_l HS_from_MQbrain_99_r HS_from_MQbrain_991_l HS_from_MQbrain_991_r HS_from_MQbrain_996_l HS_from_MQbrain_997_l HS_from_MQbrain_999_l HS_from_MQbrain_999_r HS_from_PT_101_r HS_from_PT_102_l HS_from_PT_103_l HS_from_PT_104_l HS_from_PT_112_l HS_from_PT_121_r HS_from_PT_126_l HS_from_PT_130_r HS_from_PT_136_l HS_from_PT_146_r HS_from_PT_148_l HS_from_PT_155_l HS_from_PT_158_l HS_from_PT_161_l HS_from_PT_170_l HS_from_PT_170_r HS_from_PT_178_l HS_from_PT_187_l HS_from_PT_187_r HS_from_PT_188_l HS_from_PT_190_r HS_from_PT_194_r HS_from_PT_196_l HS_from_PT_196_r HS_from_PT_20_r HS_from_PT_201_l HS_from_PT_201_r HS_from_PT_204_r HS_from_PT_207_l HS_from_PT_21_r HS_from_PT_219_l HS_from_PT_22_l HS_from_PT_22_l HS_from_PT_220_l HS_from_PT_234_l HS_from_PT_235_l HS_from_PT_237_l HS_from_PT_237_r HS_from_PT_238_l HS_from_PT_242_l HS_from_PT_247_l HS_from_PT_250_l HS_from_PT_250_r HS_from_PT_254_r HS_from_PT_255_l HS_from_PT_257_r HS_from_PT_27_l HS_from_PT_27_r HS_from_PT_271_l HS_from_PT_271_r HS_from_PT_280_l HS_from_PT_283_r HS_from_PT_284_r HS_from_PT_295_r HS_from_PT_299_l HS_from_PT_299_r HS_from_PT_3_l HS_from_PT_308_l HS_from_PT_313_r HS_from_PT_32_r HS_from_PT_321_r HS_from_PT_328_l HS_from_PT_339_l HS_from_PT_339_r HS_from_PT_340_l HS_from_PT_36_l HS_from_PT_38_l HS_from_PT_40_r HS_from_PT_41_r HS_from_PT_43_l HS_from_PT_48_l HS_from_PT_50_r HS_from_PT_63_r HS_from_PT_70_r HS_from_PT_73_l HS_from_PT_74_r HS_from_PT_91_r HS_from_PT_92_l HS_from_PT_95_l HS_from_PT_95_r HS_from_PT_99_r hsa-let-7a-1_l hsa-let-7a-2_l hsa-let-7a-2_r hsa-let-7a-3_l hsa-let-7c_l hsa-let-7c_r hsa-let-7d_l hsa-let-7f-1_r hsa-let-7g_l hsa-mir-101-1_r hsa-mir-106b_r hsa-mir-10a_r hsa-mir-1-1_l hsa-mir-1-2_l hsa-mir-124a-1_l hsa-mir-124a-1_r hsa-mir-124a-2_r hsa-mir-124a-3_r hsa-mir-125a_l hsa-mir-125a_r hsa-mir-125b-1_r hsa-mir-126_r hsa-mir-129-1_r hsa-mir-130a_r hsa-mir-133a-1_r hsa-mir-133a-2_r hsa-mir-134_r hsa-mir-135a-1_r hsa-mir-135a-2_r hsa-mir-137_l hsa-mir-139_l hsa-mir-140_l hsa-mir-141_r hsa-mir-144_r hsa-mir-148a_l hsa-mir-148a_r hsa-mir-148b_r hsa-mir-151_l hsa-mir-155_l hsa-mir-16-1_l hsa-mir-16-2_l hsa-mir-17_l hsa-mir-181a-1_l hsa-mir-181a-1_r hsa-mir-181a-2_l hsa-mir-183_r hsa-mir-185_r hsa-mir-188_l hsa-mir-190_r hsa-mir-192_r hsa-mir-193a_l hsa-mir-196a-2_r hsa-mir-196b_r hsa-mir-197_l hsa-mir-199a-1_r hsa-mir-199a-2_r hsa-mir-203_r hsa-mir-204_r hsa-mir-211_r hsa-mir-219-1_r hsa-mir-224_l hsa-mir-224_r hsa-mir-23a_l hsa-mir-26a-1_l hsa-mir-26a-2_l hsa-mir-26b_l hsa-mir-27b_r hsa-mir-296_l hsa-mir-296_r hsa-mir-299_l hsa-mir-299_r hsa-mir-302d_l hsa-mir-30b_l hsa-mir-30c-1_l hsa-mir-30c-2_l hsa-mir-30d_l hsa-mir-31_r hsa-mir-323_l hsa-mir-324_l hsa-mir-324_r hsa-mir-325_l hsa-mir-329-1_r hsa-mir-329-2_r hsa-mir-331_l hsa-mir-331_r hsa-mir-33b_l hsa-mir-372_r hsa-mir-373_r hsa-mir-375_l hsa-mir-377_l hsa-mir-378_r hsa-mir-379_l hsa-mir-383_l hsa-mir-383_r hsa-mir-409_r hsa-mir-412_l hsa-mir-412_r hsa-mir-422a_l hsa-mir-423_r hsa-mir-432_l hsa-mir-432_r hsa-mir-449b_r hsa-mir-453_l hsa-mir-454_l hsa-mir-454_r hsa-mir-483_l hsa-mir-497_r hsa-mir-500_l hsa-mir-502_l hsa-mir-506_l hsa-mir-506_r hsa-mir-507_l hsa-mir-513-1_l hsa-mir-513-2_l hsa-mir-514-1_r hsa-mir-514-3_r hsa-mir-516-3_l hsa-mir-516-4_l hsa-mir-518b_r hsa-mir-518c_l hsa-mir-518f_r hsa-mir-520b_r hsa-mir-520f_r hsa-mir-521-1_l hsa-mir-521-1_r hsa-mir-521-2_r hsa-mir-524_l hsa-mir-525_l hsa-mir-526a-1_r hsa-mir-526b_r hsa-mir-532_l hsa-mir-550-1_r hsa-mir-550-2_r hsa-mir-554_l hsa-mir-568_r hsa-mir-570_l hsa-mir-571_r hsa-mir-573_l hsa-mir-584_r hsa-mir-587_r hsa-mir-588_r hsa-mir-591_r hsa-mir-598_l hsa-mir-599_r hsa-mir-604_l hsa-mir-609_r hsa-mir-616_l hsa-mir-616_r hsa-mir-617_l hsa-mir-619_l hsa-mir-622_l hsa-mir-622_r hsa-mir-624_l hsa-mir-625_r hsa-mir-628_r hsa-mir-630_r hsa-mir-633_l hsa-mir-633_r hsa-mir-634_l hsa-mir-635_l hsa-mir-640_l hsa-mir-641_l hsa-mir-641_r hsa-mir-644_r hsa-mir-646_r hsa-mir-647_r hsa-mir-648_l hsa-mir-652_l hsa-mir-652_r hsa-mir-653_l hsa-mir-655_l hsa-mir-659_l hsa-mir-661_r hsa-mir-662_l hsa-mir-668_l hsa-mir-668_r hsa-mir-765_r hsa-mir-767_r hsa-mir-770_r hsa-mir-92-1_l hsa-mir-92b_r hsa-mir-93_l hsa-mir-95_r hsa-mir-98_l hsa-mir-98_r hsa-mir-99a_r HSbrain_1_l HSbrain_102_r HSbrain_106_r HSbrain_107_r HSbrain_1076_l HSbrain_1076_r HSbrain_108_l HSbrain_109_l HSbrain_113_r HSbrain_114_r HSbrain_116_l HSbrain_12_l HSbrain_120_r HSbrain_121_l HSbrain_122_l HSbrain_123_l HSbrain_124_l HSbrain_126_r HSbrain_1298_r HSbrain_130_l HSbrain_130_r HSbrain_131_l HSbrain_1325_r HSbrain_1337_l HSbrain_1338_r HSbrain_135_l HSbrain_1360_l HSbrain_1362_l HSbrain_1363_l HSbrain_1364_l HSbrain_1377_l HSbrain_1384_r HSbrain_139_l HSbrain_139_r HSbrain_1406_l HSbrain_1410_l HSbrain_1413_l HSbrain_1418_r HSbrain_1423_l HSbrain_1425_l HSbrain_1425_r HSbrain_143_l HSbrain_143_r HSbrain_144_r HSbrain_145_l HSbrain_148_r HSbrain_151_r HSbrain_152_l HSbrain_153_r HSbrain_155_r HSbrain_156_l HSbrain_157_l HSbrain_158_l HSbrain_159_l HSbrain_165_l HSbrain_170_r HSbrain_171_l HSbrain_171_l HSbrain_172_l HSbrain_177_l HSbrain_180_l HSbrain_19_l HSbrain_198_l HSbrain_2_l HSbrain_204_r HSbrain_210_l HSbrain_212_l HSbrain_214_l HSbrain_216_l HSbrain_216_r HSbrain_22_l HSbrain_220_r HSbrain_222_r HSbrain_224_r HSbrain_225_r HSbrain_227_r HSbrain_231_l HSbrain_237_l HSbrain_239_l HSbrain_240_l HSbrain_242_l HSbrain_243_l HSbrain_244_l HSbrain_245_r HSbrain_248_l HSbrain_25_r HSbrain_250_r HSbrain_253_l HSbrain_259_r HSbrain_261_l HSbrain_266_l HSbrain_266_r HSbrain_267_l HSbrain_267_r HSbrain_268_r HSbrain_270_l HSbrain_271_l HSbrain_272_l HSbrain_275_r HSbrain_276_l HSbrain_280_l HSbrain_284_l HSbrain_286_l HSbrain_295_r HSbrain_296_l HSbrain_299_r HSbrain_300_l HSbrain_301_l HSbrain_304_l HSbrain_304_r HSbrain_305_l HSbrain_305_r HSbrain_306_r HSbrain_316_l HSbrain_317_l HSbrain_318_l HSbrain_319_l HSbrain_32_l HSbrain_32_r HSbrain_320_l HSbrain_321_r HSbrain_325_r HSbrain_328_l HSbrain_330_l HSbrain_334_r HSbrain_337_l HSbrain_343_l HSbrain_344_l HSbrain_347_l HSbrain_347_r HSbrain_35_r HSbrain_359_l HSbrain_359_r HSbrain_361_l HSbrain_362_r HSbrain_364_r HSbrain_370_r HSbrain_371_r HSbrain_374_r HSbrain_376_l HSbrain_383_l HSbrain_384_l HSbrain_388_r HSbrain_389_l HSbrain_390_l HSbrain_396_r HSbrain_399_l HSbrain_4_l HSbrain_402_l HSbrain_403_l HSbrain_408_r HSbrain_409_r HSbrain_41_l HSbrain_41_r HSbrain_412_l HSbrain_413_l HSbrain_415_l HSbrain_419_l HSbrain_420_r HSbrain_425_l HSbrain_426_r HSbrain_43_r HSbrain_431_r HSbrain_433_r HSbrain_437_r HSbrain_438_r HSbrain_442_r HSbrain_446_l HSbrain_446_r HSbrain_448_l HSbrain_452_l HSbrain_453_r HSbrain_455_r HSbrain_456_r HSbrain_458_l HSbrain_458_r HSbrain_463_r HSbrain_467_l HSbrain_469_l HSbrain_47_r HSbrain_471_r HSbrain_472_l HSbrain_473_l HSbrain_476_r HSbrain_478_r HSbrain_48_r HSbrain_480_r HSbrain_481_r HSbrain_482_l HSbrain_483_l HSbrain_483_r HSbrain_485_r HSbrain_491_l HSbrain_495_r HSbrain_496_r HSbrain_50_l HSbrain_50_r HSbrain_500_l HSbrain_500_r HSbrain_503_r HSbrain_504_r HSbrain_506_l HSbrain_506_r HSbrain_507_l HSbrain_509_l HSbrain_52_r HSbrain_520_l HSbrain_522_r HSbrain_527_r HSbrain_53_l HSbrain_530_l HSbrain_536_r HSbrain_540_l HSbrain_540_r HSbrain_541_r HSbrain_543_l HSbrain_543_r HSbrain_545_r HSbrain_546_r HSbrain_548_l HSbrain_55_l HSbrain_553_l HSbrain_557_r HSbrain_56_l HSbrain_568_r HSbrain_570_l HSbrain_570_r HSbrain_571_l HSbrain_572_r HSbrain_578_l HSbrain_580_r HSbrain_583_l HSbrain_585_l HSbrain_590_l HSbrain_590_r HSbrain_596_r HSbrain_597_r HSbrain_598_l HSbrain_598_r HSbrain_599_r HSbrain_6_r HSbrain_604_r HSbrain_610_r HSbrain_615_l HSbrain_616_r HSbrain_617_l HSbrain_619_r HSbrain_624_l HSbrain_626_l HSbrain_627_r HSbrain_629_l HSbrain_635_l HSbrain_636_l HSbrain_637_l HSbrain_641_r HSbrain_642_r HSbrain_643_l HSbrain_652_l HSbrain_653_l HSbrain_656_l HSbrain_657_l HSbrain_658_l HSbrain_661_l HSbrain_663_l HSbrain_663_r HSbrain_664_r HSbrain_669_r HSbrain_671_r HSbrain_673_l HSbrain_673_r HSbrain_677_l HSbrain_680_l HSbrain_680_r HSbrain_684_r HSbrain_687_r HSbrain_690_r HSbrain_691_l HSbrain_691_l HSbrain_695_l HSbrain_695_r HSbrain_696_r HSbrain_70_r HSbrain_700_r HSbrain_701_l HSbrain_703_l HSbrain_703_r HSbrain_704_l HSbrain_705_r HSbrain_706_l HSbrain_707_r HSbrain_708_l HSbrain_709_l HSbrain_711_l HSbrain_711_r HSbrain_713_l HSbrain_713_r HSbrain_714_l HSbrain_715_l HSbrain_716_l HSbrain_717_l HSbrain_717_r HSbrain_719_l HSbrain_72_l HSbrain_720_l HSbrain_721_r HSbrain_722_l HSbrain_722_r HSbrain_723_l HSbrain_724_l HSbrain_726_l HSbrain_727_l HSbrain_728_l HSbrain_731_r HSbrain_737_r HSbrain_74_r HSbrain_745_l HSbrain_747_l HSbrain_749_r HSbrain_75_l HSbrain_752_l HSbrain_752_r HSbrain_753_r HSbrain_754_r HSbrain_755_l HSbrain_755_r HSbrain_760_l HSbrain_764_r HSbrain_767_r HSbrain_768_l HSbrain_769_r HSbrain_771_l HSbrain_776_l HSbrain_777_r HSbrain_778_r HSbrain_780_l HSbrain_783_l HSbrain_784_r HSbrain_788_l HSbrain_792_r HSbrain_794_r HSbrain_797_r HSbrain_8_r HSbrain_80_l HSbrain_801_r HSbrain_804_l HSbrain_810_l HSbrain_811_l HSbrain_811_r HSbrain_84_l HSbrain_85_l HSbrain_86_r HSbrain_916_l HSbrain_916_r HSbrain_92_l HSbrain_94_l HSbrain_95_l HSbrain_970_r Hsd_101_l Hsd_102_l Hsd_105_l Hsd_107_l Hsd_108_r Hsd_11_l Hsd_111_r Hsd_17_l Hsd_17_r Hsd_18_l Hsd_18_r Hsd_19_l Hsd_19_r Hsd_20_r Hsd_25_l Hsd_26_l Hsd_27_r Hsd_33_l Hsd_37_l Hsd_38_r Hsd_42_l Hsd_42_r Hsd_46_l Hsd_47_r Hsd_49_r Hsd_50_l Hsd_6_l Hsd_60_r Hsd_62_l Hsd_62_l Hsd_63_l Hsd_63_r Hsd_65_l Hsd_65_r Hsd_67_r Hsd_7_r Hsd_70_l Hsd_74_r Hsd_76_r Hsd_77_r Hsd_79_l Hsd_81_r Hsd_82_r Hsd_84_r Hsd_88_r Hsd_96_r Hsd_from_Mmd_101_r Hsd_from_Mmd_117_r Hsd_from_Mmd_120_l Hsd_from_Mmd_120_r Hsd_from_Mmd_123_l Hsd_from_Mmd_123_r Hsd_from_Mmd_128_l Hsd_from_Mmd_155_l Hsd_from_Mmd_161_l Hsd_from_Mmd_166_l Hsd_from_Mmd_166_r Hsd_from_Mmd_176_l Hsd_from_Mmd_180_r Hsd_from_Mmd_183_r Hsd_from_Mmd_187_r Hsd_from_Mmd_19_l Hsd_from_Mmd_190_r Hsd_from_Mmd_197_l Hsd_from_Mmd_204_l Hsd_from_Mmd_208_r Hsd_from_Mmd_212_r Hsd_from_Mmd_215_r Hsd_from_Mmd_217_r Hsd_from_Mmd_219_r Hsd_from_Mmd_223_r Hsd_from_Mmd_23_l Hsd_from_Mmd_232_r Hsd_from_Mmd_235_r Hsd_from_Mmd_237_l Hsd_from_Mmd_249_r Hsd_from_Mmd_253_l Hsd_from_Mmd_259_r Hsd_from_Mmd_261_l Hsd_from_Mmd_274_r Hsd_from_Mmd_280_l Hsd_from_Mmd_284_l Hsd_from_Mmd_291_l Hsd_from_Mmd_291_r Hsd_from_Mmd_296_l Hsd_from_Mmd_298_l Hsd_from_Mmd_298_r Hsd_from_Mmd_302_r Hsd_from_Mmd_306_l Hsd_from_Mmd_311_l Hsd_from_Mmd_311_r Hsd_from_Mmd_314_r Hsd_from_Mmd_316_r Hsd_from_Mmd_318_l Hsd_from_Mmd_324_l Hsd_from_Mmd_325_l Hsd_from_Mmd_325_r Hsd_from_Mmd_326_l Hsd_from_Mmd_328_l Hsd_from_Mmd_328_r Hsd_from_Mmd_330_l Hsd_from_Mmd_333_l Hsd_from_Mmd_333_r Hsd_from_Mmd_334_r Hsd_from_Mmd_34_r Hsd_from_Mmd_344_l Hsd_from_Mmd_344_r Hsd_from_Mmd_346_l Hsd_from_Mmd_35_l Hsd_from_Mmd_363_l Hsd_from_Mmd_367_l Hsd_from_Mmd_370_r Hsd_from_Mmd_371_r Hsd_from_Mmd_372_l Hsd_from_Mmd_378_l Hsd_from_Mmd_387_l Hsd_from_Mmd_388_l Hsd_from_Mmd_391_l Hsd_from_Mmd_391_r Hsd_from_Mmd_399_r Hsd_from_Mmd_410_l Hsd_from_Mmd_410_r Hsd_from_Mmd_412_r Hsd_from_Mmd_422_l Hsd_from_Mmd_431_l Hsd_from_Mmd_436_l Hsd_from_Mmd_436_r Hsd_from_Mmd_439_l Hsd_from_Mmd_44_r Hsd_from_Mmd_452_l Hsd_from_Mmd_455_l Hsd_from_Mmd_473_l Hsd_from_Mmd_478_l Hsd_from_Mmd_480_l Hsd_from_Mmd_480_r Hsd_from_Mmd_485_r Hsd_from_Mmd_487_r Hsd_from_Mmd_489_r Hsd_from_Mmd_49_l Hsd_from_Mmd_499_r Hsd_from_Mmd_500_r Hsd_from_Mmd_501_r Hsd_from_Mmd_518_r Hsd_from_Mmd_519_l Hsd_from_Mmd_519_r Hsd_from_Mmd_52_r Hsd_from_Mmd_523_l Hsd_from_Mmd_524_l Hsd_from_Mmd_524_r Hsd_from_Mmd_527_l Hsd_from_Mmd_527_r Hsd_from_Mmd_533_l Hsd_from_Mmd_535_r Hsd_from_Mmd_68_l Hsd_from_Mmd_70_l Hsd_from_Mmd_78_r Hsd_from_Mmd_81_l Hsd_from_Mmd_92_l Hsd_from_Mmd_92_r Hsd_from_Mmd_93_l Hsd_from_Mmd_93_r Hsd_from_Mmd_94_l Hsd_from_Mmd_97_l

TABLE 3a Small RNAs that are differentially expressed between control and adenocarcinoma carcinoma vs Systematic Name control adj p¹ hsa-mir-573_l 0.008895418 HSbrain_801_r 0.016433541 HSbrain_377_l 0.016433541 HSbrain_426_r 0.016433541 HSbrain_148_r 0.016433541 hsa-mir-92b_r 0.019274533 hsa-mir-92-1_r 0.019274533 HS_from_PT_146_r 0.019274533 hsa-mir-92-2_r 0.022921248 HS_from_MQbrain_207_l 0.022921248 HS_from_PT_114_r 0.027924358 HS_from_PT_114_l 0.027924358 HS_from_MQbrain_100_l 0.030988376 hsa-mir-145_l 0.031989408 HS_from_MQbrain_350_l 0.031989408 hsa-mir-302d_l 0.031989408 HS_from_MQbrain_1628_r 0.031989408 HS_from_MQbrain_349_l 0.031989408 hsa-mir-325_l 0.0342406 HS_from_MQbrain_20_r 0.0342406 HSbrain_458_r 0.035303066 Hsd_102_l 0.035303066 HSbrain_377_r 0.035303066 HS_from_MQbrain_2700_r 0.045228199 HS_from_MQbrain_1687_l 0.045228199 HS_from_MQbrain_1311_r 0.067337504 Hsd_from_Mmd_519_l 0.067337504 HS_from_MQbrain_343_l 0.07566513 HS_from_MQbrain_1169_l 0.084904114 HS_from_MQbrain_965_l 0.086503988 HS_from_MM_178_r 0.086503988 hsa-mir-98_l 0.086503988 HS_from_MQbrain_549_l 0.086503988 hsa-mir-616_r 0.090694253 HSbrain_731_r 0.090694253 Hsd_from_Mmd_328_r 0.090694253 hsa-mir-768_r 0.090694253 HSbrain_709_l 0.090694253 HSbrain_398_r 0.090694253 HS_from_PT_340_l 0.090694253 HS_from_MQbrain_1884_r 0.090694253 hsa-let-7a-3_l 0.090694253 HSbrain_106_r 0.099652833 HS_from_MQbrain_2380_r 0.099652833 HSbrain_494_l 0.104922786 HSbrain_177_r 0.104922786 HSbrain_321_r 0.104922786 HS_from_MM_289_l 0.104922786 HS_from_MQbrain_191_l 0.110995143 HS_291_r 0.110995143 HS_from_MQbrain_128_r 0.110995143 hsa-let-7g_l 0.110995143 hsa-mir-633_l 0.120015634 HSbrain_500_r 0.120015634 HS_156_l 0.120015634 HS_from_MM_118_r 0.120843678 Hsd_from_Mmd_485_r 0.120843678 hsa-mir-655_l 0.120843678 HSbrain_617_l 0.120843678 HS_71_l 0.120843678 hsa-mir-20b_l 0.120843678 HS_from_MQbrain_71_r 0.120843678 hsa-mir-199a-2_r 0.120843678 hsa-mir-500_l 0.120843678 HSbrain_411_r 0.120843678 HS_from_MQbrain_930_r 0.120843678 hsa-mir-9-3_r 0.120843678 HS_from_MQbrain_769_r 0.120843678 hsa-mir-372_r 0.120843678 hsa-let-7a-2_l 0.120843678 hsa-let-7f-1_l 0.120843678 HSbrain_1437_r 0.126655157 hsa-mir-9-2_r 0.126655157 hsa-mir-181c_l 0.126655157 HS_from_MQbrain_1696_l 0.126655157 HS_from_MQbrain_572_l 0.126655157 hsa-let-7a-1_l 0.126655157 HS_from_MQbrain_1823_r 0.149145996 HS_from_MQbrain_1485_r 0.149145996 HS_from_MQbrain_1100_l 0.149145996 Hsd_18_l 0.149145996 hsa-mir-9-1_r 0.149145996 hsa-mir-29a_r 0.149145996 Hsd_111_r 0.149145996 hsa-mir-492_r 0.159103307 HSbrain_299_r 0.159103307 HSbrain_598_l 0.159103307 Hsd_26_l 0.159103307 HSbrain_261_l 0.159103307 hsa-mir-570_l 0.166408872 hsa-mir-363_l 0.166408872 hsa-mir-126_r 0.166408872 hsa-mir-192_r 0.166408872 HS_from_MQbrain_1459_l 0.166408872 HS_from_MQbrain_1624_l 0.166408872 HSbrain_458_l 0.166408872 HS_from_MQbrain_131_r 0.179914563 HSbrain_629_l 0.179914563 HS_304_r 0.179914563 hsa-let-7d_l 0.179914563 HS_141_l 0.19263196 HS_from_MQbrain_55_l 0.19263196 HSbrain_230_l 0.19263196 HSbrain_782_l 0.19263196 HS_from_MQbrain_1513_r 0.19263196 ¹Wilcoxon: cut off adjusted p value < 0.2

TABLE 3b Up- or downregulated small RNAs in adenocarcinomas compared to control carcinoma carcinomas controls vs control (avg (avg carcinomas/controls Systematic Name (adj p)¹ expression) expression) (Ratio expression)² HS_71_l 0.3 −0.709677388 0.032756041 −0.742433429 HSbrain_458_r 0.42 −0.266452891 0.406777661 −0.673230551 hsa-mir-372_r 0.12 0.060069121 0.629631623 −0.569562502 HS_from_MM_118_r 0.69 −0.237583049 0.179327953 −0.416911001 hsa-mir-192_r 0.17 −0.201240874 0.210651366 −0.411892241 Hsd_from_Mmd_485_r 0.66 −0.252579592 0.125681597 −0.378261188 HS_from_MQbrain_1624_l 0.15 −0.246477896 0.058106578 −0.304584474 HSbrain_629_l 0.09 −0.491364645 −0.198765886 −0.292598759 hsa-mir-570_l 0.17 −0.130852458 0.019615717 −0.150468175 hsa-mir-492_r 0.16 −0.011846275 0.099781053 −0.111627327 HSbrain_731_r 0.35 0.090460773 −0.011239856 0.101700629 HS_from_MQbrain_1687_l 0.12 −0.015384304 −0.120029361 0.104645056 HS_304_r 0.18 0.725994298 0.518291894 0.207702404 Hsd_18_l 0.16 0.185427251 −0.033505144 0.218932395 HSbrain_177_r 0.1 −0.187948884 −0.433561411 0.245612527 Hsd_111_r 0.15 −0.186817378 −0.43572008 0.248902702 HS_from_MQbrain_131_r 0.31 0.122733107 −0.145810795 0.268543902 HS_from_MQbrain_55_l 0.09 −0.014185779 −0.291616347 0.277430568 HS_from_MQbrain_207_l 0.36 0.435514985 0.145542632 0.289972354 HS_from_MQbrain_930_r 0.12 0.389172004 0.087275842 0.301896162 hsa-mir-500_l 0.12 −0.277848327 −0.593537873 0.315689546 HS_from_MQbrain_1884_r 0.52 0.356353217 0.037880875 0.318472342 HS_from_MQbrain_1513_r 0.19 −0.290006166 −0.609064857 0.319058691 HS_from_MQbrain_1459_l 0.17 0.275771992 −0.068316304 0.344088296 HS_from_MQbrain_191_l 0.68 0.374600902 0.027587412 0.34701349 HS_from_MQbrain_2380_r 0.09 0.419048482 0.049240856 0.369807627 HS_from_MQbrain_769_r 0.12 −0.14336964 −0.523899384 0.380529744 Hsd_102_l 0.04 0.443532 0.055860645 0.387671354 HS_from_MQbrain_128_r 0.11 0.617596666 0.225747368 0.391849298 HS_141_l 0.12 0.8422647 0.443686813 0.398577887 HSbrain_709_l 0.12 0.733394659 0.327477824 0.405916836 HSbrain_321_r 0.42 0.600940185 0.190823509 0.410116675 HSbrain_617_l 0.02 0.966810264 0.555939869 0.410870395 HS_from_MQbrain_100_l 0.42 0.278755917 −0.134292565 0.413048482 HSbrain_299_r 0.16 0.470656977 0.050970084 0.419686894 HSbrain_782_l 0.19 0.394023714 −0.030111689 0.424135402 HSbrain_230_l 0.19 0.420548412 −0.007405663 0.427954074 HS_from_MQbrain_343_l 0.08 0.191928075 −0.240864595 0.432792669 hsa-mir-616_r 0.65 −0.186021179 −0.619960119 0.43393894 HSbrain_598_l 0.16 0.432451861 −0.001594407 0.434046268 hsa-let-7d_l 0.18 −0.214090094 −0.663813813 0.449723719 HS_from_MQbrain_20_r 0.25 −0.154082272 −0.608413911 0.454331639 HS_from_MQbrain_350_l 0.09 0.146762687 −0.311281719 0.458044406 HSbrain_494_l 0.1 0.06720096 −0.396374725 0.463575685 HSbrain_801_r 0.15 0.33891208 −0.13043269 0.46934477 hsa-mir-655_l 0.13 −0.049016209 −0.523332673 0.474316464 HS_from_PT_146_r 0.41 0.344948777 −0.130022489 0.474971266 Hsd_26_l 0.58 0.185069914 −0.292706346 0.47777626 HS_from_MQbrain_349_l 0.09 0.181998814 −0.301075838 0.483074652 HSbrain_148_r 0.3 0.440551449 −0.043142521 0.48369397 HSbrain_106_r 0.33 0.575843279 0.080837435 0.495005844 hsa-mir-633_l 0.03 0.215123255 −0.284566041 0.499689296 HS_from_MM_289_l 0.1 0.092159319 −0.424119594 0.516278912 HS_from_MQbrain_71_r 0.24 0.86119198 0.341225696 0.519966285 HSbrain_261_l 0.16 0.200748997 −0.325726286 0.526475284 Hsd_from_Mmd_328_r 0.09 0.336779316 −0.20245187 0.539231186 Hsd_from_Mmd_519_l 0.42 0.156016612 −0.390158334 0.546174946 HS_from_MM_178_r 0.03 0.215653589 −0.344575388 0.560228977 HSbrain_458_l 0.17 −0.623680905 −1.206064715 0.58238381 HS_from_MQbrain_1485_r 0.28 0.341195456 −0.243332697 0.584528153 HS_from_MQbrain_1628_r 0.79 0.139811659 −0.450916985 0.590728644 hsa-mir-302d_l 0.37 −0.417071628 −1.008783793 0.591712165 HS_156_l 0.12 −0.025280933 −0.617537087 0.592256154 HS_from_MQbrain_1823_r 0.03 −0.296865659 −0.892007201 0.595141542 hsa-mir-325_l 0.69 0.363886014 −0.231356523 0.595242537 HS_from_MQbrain_1696_l 0.13 −0.405403011 −1.024758234 0.619355223 HS_from_MQbrain_549_l 0.37 0.266837912 −0.360518665 0.627356576 HS_from_MQbrain_1311_r 0.64 0.085649422 −0.542358185 0.628007606 HS_from_PT_340_l 0.09 0.304986748 −0.325416792 0.630403539 HS_from_MQbrain_1100_l 0.3 0.502916758 −0.128399246 0.631316004 HSbrain_426_r 0.37 0.499080863 −0.16430699 0.663387852 HS_from_MQbrain_965_l 0.75 0.559300427 −0.137794367 0.697094794 hsa-mir-573_l 0.03 −0.059472954 −0.78119509 0.721722137 HS_from_MQbrain_1169_l 0.08 0.560023874 −0.172737263 0.732761137 hsa-mir-126_r 0.42 −0.201075637 −0.937409046 0.736333409 hsa-mir-98_l 0.86 −0.358721365 −1.199711347 0.840989982 hsa-let-7a-2_l 0.54 −0.252165432 −1.106318992 0.85415356 HSbrain_398_r 0.74 0.878616993 0.004337368 0.874279624 hsa-let-7a-1_l 0.12 −0.130600434 −1.038969263 0.908368829 hsa-let-7a-3_l 0.73 −0.139853217 −1.051229242 0.911376026 HSbrain_500_r 0.77 0.944568594 0.020888827 0.923679767 hsa-mir-199a-2_r 0.12 −0.169461658 −1.102399679 0.932938022 hsa-let-7g_l 0.34 −0.324092373 −1.332989933 1.008897559 HS_291_r 0.3 0.833287938 −0.193284833 1.026572771 hsa-mir-768_r 0.73 0.861619701 −0.182102011 1.043721712 HSbrain_1437_r 0.79 0.870808091 −0.201624857 1.072432947 hsa-mir-181c_l 0.55 −0.036071696 −1.122096366 1.086024669 hsa-let-7f-1_l 0.3 −0.079122123 −1.192010342 1.112888218 HS_from_MQbrain_572_l 0.13 0.0201842 −1.13040159 1.15058579 HS_from_MQbrain_2700_r 0.58 0.98864825 −0.187941077 1.176589327 HSbrain_411_r 0.02 0.267080657 −0.993945285 1.261025942 hsa-mir-363_l 0.17 1.940171184 0.587265163 1.352906021 hsa-mir-92b_r 0.02 0.784118073 −0.596107394 1.380225467 hsa-mir-20b_l 0.12 −0.302677154 −1.731722022 1.429044868 hsa-mir-29a_r 0.05 −0.289379384 −1.809571559 1.520192175 hsa-mir-9-2_r 0.13 2.216369234 0.500287664 1.71608157 hsa-mir-9-1_r 0.15 2.217636141 0.490685702 1.726950439 HSbrain_377_r 0.02 1.13757316 −0.614439492 1.752012652 hsa-mir-9-3_r 0.12 2.225977245 0.459667748 1.766309498 hsa-mir-145_l 0.03 0.930167523 −0.909054029 1.839221552 HSbrain_377_l 0.28 0.800203766 −1.135562989 1.935766755 hsa-mir-92-2_r 0.21 1.186285863 −0.928692902 2.114978765 hsa-mir-92-1_r 0.73 1.223717878 −0.942146802 2.16586468 HS_from_PT_114_l 0.3 0.966988882 −1.364997051 2.331985933 HS_from_PT_114_r 0.57 1.256897347 −1.276764924 2.533662271 ¹Wilcoxon: cut off adjusted p value < 0.2 ²Upregulated small RNAs have a ratio for expression >1 (below line in table) Downregulated small RNAs have a ratio for expression <1 (above line in table)

TABLE 3c Small RNAs that are upregulated in colorectal adenocarcinomas compared to control samples hsa-let-7g_l HSbrain_411_r hsa-mir-9-3_r HS_291_r hsa-mir-363_l hsa-mir-145_l hsa-mir-768_r hsa-mir-92b_r HSbrain_377_l HSbrain_1437_r hsa-mir-20b_l hsa-mir-92-2_r hsa-mir-181c_l hsa-mir-29a_r hsa-mir-92-1_r hsa-let-7f-1_l hsa-mir-9-2_r HS_from_PT_114_l HS_from_MQbrain_572_l hsa-mir-9-1_r HS_from_PT_114_r HS_from_MQbrain_2700_r HSbrain_377_r

TABLE 3d Small RNAs that are downregulated in colorectal adenocarcinomas compared to control samples HS_141_l HS_from_PT_340_l HSbrain_731_r HS_156_l hsa-let-7a-1_l HSbrain_782_l HS_304_r hsa-let-7a-2_l HSbrain_801_r HS_71_l hsa-let-7a-3_l Hsd_102_l HS_from_MM_118_r hsa-let-7d_l Hsd_111_r HS_from_MM_178_r hsa-mir-126_r Hsd_18_l HS_from_MM_289_l hsa-mir-192_r Hsd_26_l HS_from_MQbrain_100_l hsa-mir-199a-2_r Hsd_from_Mmd_328_r HS_from_MQbrain_1100_l hsa-mir-302d_l Hsd_from_Mmd_485_r HS_from_MQbrain_1169_l hsa-mir-325_l Hsd_from_Mmd_519_l HS_from_MQbrain_128_r hsa-mir-372_r HS_from_MQbrain_131_r hsa-mir-492_r HS_from_MQbrain_1311_r hsa-mir-500_l HS_from_MQbrain_1459_l hsa-mir-570_l HS_from_MQbrain_1485_r hsa-mir-573_l HS_from_MQbrain_1513_r hsa-mir-616_r HS_from_MQbrain_1624_l hsa-mir-633_l HS_from_MQbrain_1628_r hsa-mir-655_l HS_from_MQbrain_1687_l hsa-mir-98_l HS_from_MQbrain_1696_l HSbrain_106_r HS_from_MQbrain_1823_r HSbrain_148_r HS_from_MQbrain_1884_r HSbrain_177_r HS_from_MQbrain_191_l HSbrain_230_l HS_from_MQbrain_20_r HSbrain_261_l HS_from_MQbrain_207_l HSbrain_299_r HS_from_MQbrain_2380_r HSbrain_321_r HS_from_MQbrain_343_l HSbrain_398_r HS_from_MQbrain_349_l HSbrain_426_r HS_from_MQbrain_350_l HSbrain_458_l HS_from_MQbrain_549_l HSbrain_458_r HS_from_MQbrain_55_l HSbrain_494_l HS_from_MQbrain_71_r HSbrain_500_r HS_from_MQbrain_769_r HSbrain_598_l HS_from_MQbrain_930_r HSbrain_617_l HS_from_MQbrain_965_l HSbrain_629_l HS_from_PT_146_r HSbrain_709_l

TABLE 4a Small RNAs that are differentially expressed between adenoma and adenocarcinoma adenocarcinoma vs adenoma Systematic Name (adj p)¹ HS_from_MQbrain_1426_r 0.00750624 HS_from_MQbrain_638_l 0.00750624 HS_from_MQbrain_1391_l 0.012664553 HS_from_MQbrain_420_l 0.012664553 HS_from_PT_36_l 0.012664553 HSbrain_390_l 0.012664553 HS_from_MM_242_r 0.014169909 HS_136_r 0.014224152 HS_8_r 0.014224152 HS_from_PT_201_l 0.014224152 HSbrain_545_r 0.014224152 HS_176_l 0.014416465 HS_71_r 0.014416465 HS_from_MM_169_r 0.014416465 HS_from_MM_92_r 0.015226536 HSbrain_293_l 0.015226536 HS_from_MQbrain_1334_r 0.015599346 HS_from_MQbrain_590_l 0.015599346 HS_from_MQbrain_63_r 0.015599346 HSbrain_334_r 0.015599346 HS_299_l 0.016786613 HS_276_l 0.016904198 HS_from_MQbrain_1137_l 0.016904198 HS_from_MQbrain_377_l 0.016904198 HS_from_MQbrain_941_r 0.016904198 HS_from_MQbrain_1082_l 0.018319912 HS_from_MQbrain_1792_r 0.018494113 HS_from_MQbrain_458_l 0.018494113 hsa-mir-24-2_l 0.018494113 HS_157_r 0.020545593 HS_from_MM_295_l 0.020545593 HS_from_MQbrain_1297_l 0.020545593 HSbrain_217_r 0.020545593 HS_from_MQbrain_1072_l 0.021132076 HS_from_MQbrain_1350_l 0.022396706 HS_from_PT_226_l 0.022396706 HS_from_MQbrain_1500_l 0.023919533 hsa-mir-346_l 0.023919533 hsa-mir-767_r 0.023919533 HSbrain_306_r 0.023919533 hsa-mir-324_r 0.024694474 HS_124_r 0.024910624 HS_51_r 0.024910624 HS_from_MQbrain_1363_l 0.02517728 HS_from_MQbrain_1620_r 0.02517728 HSbrain_811_l 0.026045397 HS_from_MQbrain_825_r 0.026388496 Hsd_from_Mmd_157_r 0.026388496 HS_from_MQbrain_133_r 0.026776445 HSbrain_583_l 0.026776445 HSbrain_796_r 0.027740873 HS_from_MQbrain_441_l 0.028202169 hsa-mir-653_l 0.028202169 HS_from_MQbrain_1485_l 0.029237065 HS_from_MQbrain_1042_r 0.030313454 HSbrain_680_r 0.031432755 HS_from_MQbrain_828_l 0.032034428 HSbrain_399_l 0.032034428 HS_from_PT_187_r 0.032679147 hsa-mir-453_l 0.032679147 hsa-mir-548b_l 0.033913448 HS_from_MQbrain_1204_l 0.034662803 HS_from_MQbrain_1469_l 0.034662803 hsa-mir-331_l 0.034662803 hsa-mir-523_r 0.034662803 HSbrain_384_l 0.034662803 HSbrain_570_r 0.034662803 HSbrain_687_r 0.034662803 HSbrain_7_r 0.034662803 Hsd_85_r 0.034662803 HS_from_MQbrain_1099_r 0.035037528 hsa-mir-412_l 0.035037528 Hsd_70_r 0.035037528 HS_46_l 0.035941334 HSbrain_1425_l 0.035941334 HS_from_MQbrain_1781_l 0.036886609 HS_from_PT_250_l 0.036886609 HS_from_MM_174_l 0.037874034 HS_from_MQbrain_1750_r 0.037874034 HS_from_MM_251_r 0.039250091 HS_from_MM_84_r 0.039250091 HS_from_MQbrain_43_r 0.039250091 HS_from_MQbrain_984_l 0.039250091 hsa-mir-375_r 0.039250091 hsa-mir-377_l 0.039250091 HSbrain_272_l 0.039250091 HSbrain_276_l 0.039250091 HSbrain_351_r 0.039250091 Hsd_18_r 0.039250091 HSbrain_1325_r 0.040852758 HS_from_MQbrain_365_r 0.042516991 HS_from_MM_118_r 0.044599949 HS_from_MQbrain_603_r 0.044599949 HS_from_MQbrain_686_r 0.044599949 HS_from_MQbrain_854_r 0.044599949 HSbrain_669_r 0.044599949 HS_from_PT_287_r 0.045945376 Hsd_from_Mmd_452_l 0.045945376 hsa-mir-136_l 0.047341086 hsa-mir-383_r 0.047341086 HS_from_MQbrain_1985_l 0.047394461 HS_from_MQbrain_2669_l 0.047394461 HSbrain_476_r 0.047394461 HSbrain_77_l 0.047394461 Hsd_108_l 0.047394461 HS_281_r 0.04754573 HS_from_MQbrain_1253_r 0.04754573 hsa-mir-661_r 0.04754573 HSbrain_304_r 0.04754573 HSbrain_438_r 0.04754573 HS_213_l 0.048205391 HS_79_l 0.048205391 HS_from_MQbrain_542_r 0.048205391 HSbrain_177_l 0.048205391 HS_from_MQbrain_1212_l 0.049767746 HSbrain_122_l 0.049767746 HS_212_l 0.050135128 HS_from_MQbrain_1565_l 0.050135128 HS_from_MQbrain_163_l 0.050135128 hsa-let-7c_r 0.050135128 hsa-mir-591_r 0.050135128 HSbrain_187_r 0.050135128 HSbrain_226_r 0.050135128 HSbrain_437_r 0.050135128 HSbrain_780_r 0.050135128 Hsd_from_Mmd_166_l 0.050135128 Hsd_from_Mmd_485_r 0.050135128 HS_from_MQbrain_660_l 0.051819249 HS_from_PT_101_r 0.051819249 hsa-mir-148a_l 0.052756328 HSbrain_252_l 0.052756328 HSbrain_673_r 0.052756328 HSbrain_684_r 0.052756328 HS_17_l 0.053747925 HS_from_MQbrain_1444_l 0.053747925 HSbrain_494_l 0.053747925 HSbrain_55_l 0.053747925 HS_from_MM_218_l 0.055185029 HS_from_MQbrain_1263_r 0.055185029 HSbrain_538_r 0.055185029 HSbrain_803_l 0.057478906 HS_189_r 0.058218978 HS_from_MQbrain_71_l 0.058218978 hsa-mir-411_r 0.058218978 hsa-mir-497_r 0.058218978 Hsd_from_Mmd_371_r 0.058218978 HS_from_MQbrain_1340_l 0.058254254 HS_from_PT_308_l 0.058254254 hsa-mir-638_r 0.058254254 HSbrain_374_r 0.058254254 HSbrain_420_r 0.058254254 HSbrain_583_r 0.058254254 Hsd_from_Mmd_49_l 0.058254254 HS_262_l 0.059897432 HS_from_MQbrain_346_l 0.059897432 HSbrain_791_l 0.059897432 HSbrain_25_r 0.062381992 hsa-mir-301_l 0.06455063 Hsd_from_Mmd_413_r 0.06455063 HS_from_MQbrain_209_r 0.0659723 HS_from_MQbrain_579_l 0.0659723 hsa-mir-659_l 0.0659723 HSbrain_1076_r 0.0659723 HS_from_MQbrain_65_l 0.068270026 HS_from_MQbrain_932_l 0.068270026 HS_261_r 0.068590471 HS_from_MQbrain_108_r 0.068590471 HS_from_MQbrain_1134_r 0.068590471 HS_from_MQbrain_120_l 0.068590471 hsa-mir-133a-1_r 0.068590471 hsa-mir-155_r 0.068590471 hsa-mir-604_l 0.068590471 HS_from_MQbrain_664_r 0.070590475 Hsd_88_r 0.070590475 Hsd_from_Mmd_391_l 0.070590475 HS_from_MQbrain_1832_l 0.071451516 HS_from_MQbrain_58_l 0.071451516 HS_from_MQbrain_736_r 0.071451516 HS_from_MQbrain_93_r 0.071451516 HSbrain_468_r 0.071451516 Hsd_from_Mmd_237_l 0.071451516 HS_from_MM_1_l 0.072275086 HS_from_MM_39_l 0.072275086 HS_from_MQbrain_1006_l 0.072275086 HS_from_MQbrain_1958_l 0.072275086 HS_from_MQbrain_504_r 0.072275086 HS_from_MQbrain_921_r 0.072275086 HS_from_PT_237_r 0.072275086 HS_from_PT_299_r 0.072275086 hsa-mir-124a-1_l 0.072275086 HSbrain_182_r 0.072275086 HSbrain_518_r 0.072275086 HSbrain_62_r 0.072275086 HSbrain_93_r 0.072275086 Hsd_107_l 0.072275086 Hsd_from_Mmd_222_l 0.072275086 HS_200_r 0.072654718 HS_from_MM_232_r 0.072654718 HS_from_MQbrain_1246_l 0.072654718 HS_from_MQbrain_1301_r 0.072654718 HS_from_MQbrain_301_l 0.072654718 HS_from_MQbrain_435_r 0.072654718 HS_from_MQbrain_869_l 0.072654718 HSbrain_1406_l 0.072654718 HS_from_MM_339_l 0.074901054 HS_from_MQbrain_74_r 0.074901054 HSbrain_419_l 0.074901054 HS_219_l 0.075028175 HS_307_r 0.075028175 HS_from_MM_103_l 0.075028175 HS_from_MM_32_r 0.075028175 HS_from_MQbrain_1001_r 0.075028175 HS_from_MQbrain_1740_r 0.075028175 HS_from_MQbrain_266_r 0.075028175 HS_from_MQbrain_470_l 0.075028175 HS_from_MQbrain_969_l 0.075028175 HS_from_PT_254_l 0.075028175 hsa-mir-1-1_l 0.075028175 hsa-mir-130b_l 0.075028175 hsa-mir-365-2_l 0.075028175 hsa-mir-98_r 0.075028175 HSbrain_1298_r 0.075028175 HSbrain_47_r 0.075028175 HSbrain_580_r 0.075028175 Hsd_from_Mmd_215_r 0.075028175 Hsd_from_Mmd_473_l 0.075028175 hsa-mir-190_r 0.07641095 hsa-mir-619_l 0.07641095 HSbrain_6_r 0.07641095 Hsd_from_Mmd_189_l 0.07641095 Hsd_from_Mmd_410_r 0.07641095 Hsd_from_Mmd_464_l 0.07641095 HS_118_l 0.07715065 HS_119_l 0.07715065 HS_292_l 0.07715065 HS_from_MM_18_r 0.07715065 HS_from_MM_275_r 0.07715065 HS_from_MM_342_r 0.07715065 HS_from_MQbrain_117_r 0.07715065 HS_from_MQbrain_154_r 0.07715065 HS_from_MQbrain_1896_r 0.07715065 HS_from_MQbrain_881_r 0.07715065 HS_from_MQbrain_972_r 0.07715065 hsa-mir-299_l 0.07715065 hsa-mir-433_r 0.07715065 HSbrain_204_r 0.07715065 HSbrain_231_l 0.07715065 HSbrain_250_r 0.07715065 HSbrain_431_r 0.07715065 HSbrain_703_r 0.07715065 Hsd_105_l 0.07715065 hsa-mir-362_r 0.07965977 HSbrain_319_l 0.07965977 HSbrain_442_r 0.07965977 HS_95_r 0.080676612 HS_from_MQbrain_355_l 0.080676612 HS_from_PT_196_l 0.080676612 HS_from_PT_308_l 0.080676612 HSbrain_236_l 0.080676612 HSbrain_361_l 0.080676612 HSbrain_473_l 0.080676612 HSbrain_792_r 0.080676612 HS_from_MQbrain_1260_r 0.08237725 HS_from_PT_27_r 0.08237725 HSbrain_1360_r 0.08237725 HSbrain_328_l 0.08237725 HSbrain_757_r 0.08237725 HSbrain_799_r 0.08237725 HS_67_r 0.083833911 HS_from_MQbrain_1087_l 0.083833911 HS_from_MQbrain_1374_r 0.083833911 HS_from_MQbrain_1569_l 0.083833911 HS_from_MQbrain_634_r 0.083833911 HSbrain_627_l 0.083833911 Hsd_42_l 0.083833911 HS_54_r 0.084885584 HS_from_MM_18_l 0.084885584 HS_from_MQbrain_1294_l 0.084885584 HS_from_MQbrain_1443_r 0.084885584 HS_from_MQbrain_1494_r 0.084885584 HS_from_MQbrain_1623_r 0.084885584 HS_from_MQbrain_1675_r 0.084885584 HS_from_MQbrain_597_r 0.084885584 HS_from_MQbrain_823_l 0.084885584 HS_from_MQbrain_824_l 0.084885584 HS_from_MQbrain_901_r 0.084885584 hsa-mir-146a_r 0.084885584 hsa-mir-412_r 0.084885584 hsa-mir-652_r 0.084885584 HSbrain_1423_l 0.084885584 HSbrain_389_l 0.084885584 HSbrain_95_l 0.084885584 Hsd_106_l 0.084885584 Hsd_from_Mmd_261_l 0.084885584 Hsd_from_Mmd_302_r 0.084885584 Hsd_from_Mmd_44_r 0.084885584 HS_208_l 0.085697388 HS_83_r 0.085697388 HS_from_MQbrain_330_r 0.085697388 HS_from_MQbrain_468_r 0.085697388 HS_from_MQbrain_534_l 0.085697388 HS_from_MQbrain_928_r 0.085697388 hsa-let-7a-1_r 0.085697388 hsa-mir-584_r 0.085697388 HSbrain_764_r 0.085697388 Hsd_101_l 0.085697388 HS_49_r 0.088269125 HS_from_MQbrain_1593_r 0.088269125 HS_from_PT_13_l 0.088269125 Hsd_from_Mmd_511_r 0.088269125 HS_from_MQbrain_1355_r 0.089491072 HS_from_MQbrain_1481_l 0.089491072 HS_from_MQbrain_597_l 0.089491072 hsa-mir-624_l 0.089491072 HSbrain_365_l 0.089491072 HSbrain_512_l 0.089491072 HSbrain_695_l 0.089491072 HSbrain_705_l 0.089491072 Hsd_27_r 0.089491072 HS_145_r 0.091337111 HS_151_r 0.091337111 HS_from_MM_219_l 0.091337111 HS_from_MM_72_r 0.091337111 HS_from_MQbrain_1771_r 0.091337111 HS_from_MQbrain_1877_l 0.091337111 HS_from_MQbrain_392_l 0.091337111 HS_from_MQbrain_631_l 0.091337111 HS_from_MQbrain_72_r 0.091337111 HS_from_MQbrain_723_l 0.091337111 HS_from_MQbrain_765_l 0.091337111 HS_from_MQbrain_81_l 0.091337111 HS_from_PT_282_l 0.091337111 HSbrain_359_l 0.091337111 HSbrain_371_r 0.091337111 HSbrain_472_l 0.091337111 HSbrain_594_l 0.091337111 HSbrain_717_r 0.091337111 Hsd_46_l 0.091337111 Hsd_from_Mmd_324_l 0.091337111 Hsd_from_Mmd_93_r 0.091337111 HS_14_r 0.092780591 HS_from_MQbrain_1264_l 0.092780591 HS_from_MQbrain_566_l 0.092780591 HS_from_MQbrain_634_l 0.092780591 HSbrain_114_r 0.092780591 HSbrain_773_r 0.092780591 Hsd_from_Mmd_225_l 0.092780591 Hsd_from_Mmd_422_l 0.092780591 Hsd_from_Mmd_491_r 0.092780591 HS_171_r 0.094556199 HS_from_MQbrain_1901_r 0.094556199 HSbrain_135_l 0.094556199 HSbrain_465_l 0.094556199 HSbrain_591_l 0.094556199 HSbrain_728_l 0.094556199 HSbrain_754_r 0.094556199 Hsd_from_Mmd_330_l 0.094556199 HS_74_r 0.096132958 HS_from_MM_121_l 0.096132958 HS_from_MQbrain_1717_r 0.096132958 HS_from_MQbrain_1793_r 0.096132958 hsa-mir-224_r 0.096132958 HSbrain_123_l 0.096132958 HSbrain_532_l 0.096132958 Hsd_30_l 0.096132958 Hsd_83_l 0.096132958 HS_from_MQbrain_1771_l 0.098301345 HS_from_MQbrain_181_l 0.098301345 HS_from_MQbrain_1893_r 0.098301345 HSbrain_316_l 0.098301345 HSbrain_452_l 0.098301345 HSbrain_52_r 0.098301345 HSbrain_553_r 0.098301345 HS_288_r 0.099488281 HS_86_r 0.099488281 HS_from_MM_150_r 0.099488281 HS_from_MQbrain_1031_r 0.099488281 HS_from_MQbrain_1649_r 0.099488281 HS_from_MQbrain_1840_l 0.099488281 hsa-mir-193a_l 0.099488281 hsa-mir-646_r 0.099488281 HSbrain_235_l 0.099488281 HSbrain_719_l 0.099488281 Hsd_from_Mmd_524_l 0.099488281 HS_from_MM_84_l 0.101009439 HS_from_MQbrain_1085_l 0.101009439 HS_from_MQbrain_1700_r 0.101009439 HS_from_MQbrain_1748_r 0.101009439 HS_from_MQbrain_1806_l 0.101009439 HS_from_MQbrain_1827_l 0.101009439 HS_from_PT_140_l 0.101009439 HSbrain_14_r 0.101009439 HSbrain_703_l 0.101009439 Hsd_from_Mmd_346_l 0.101009439 HS_287_r 0.102601153 HS_from_MQbrain_129_r 0.102601153 HS_from_MQbrain_1677_r 0.102601153 HS_from_MQbrain_221_r 0.102601153 HS_from_MQbrain_628_l 0.102601153 HS_from_MQbrain_716_l 0.102601153 HSbrain_507_l 0.102601153 HSbrain_661_l 0.102601153 Hsd_from_Mmd_117_r 0.102601153 Hsd_from_Mmd_138_l 0.102601153 HS_from_MQbrain_1116_r 0.104515233 HS_from_MQbrain_1374_l 0.104515233 HS_from_MQbrain_433_l 0.104515233 HS_from_MQbrain_62_l 0.104515233 HS_from_MQbrain_722_r 0.104515233 hsa-mir-633_r 0.104515233 HSbrain_266_r 0.104515233 Hsd_37_r 0.104515233 Hsd_from_Mmd_405_l 0.104515233 HS_99_r 0.105993846 HS_from_MQbrain_1127_r 0.105993846 HS_from_MQbrain_1537_r 0.105993846 HS_from_MQbrain_1545_r 0.105993846 HS_from_MQbrain_1783_r 0.105993846 HS_from_MQbrain_22_r 0.105993846 HS_from_MQbrain_534_r 0.105993846 HS_from_MQbrain_852_l 0.105993846 HS_from_MQbrain_900_r 0.105993846 hsa-let-7f-1_r 0.105993846 Hsd_from_Mmd_166_r 0.105993846 HS_from_MQbrain_1541_l 0.107794024 HS_from_MQbrain_574_l 0.107794024 HS_from_MQbrain_921_l 0.107794024 HS_from_MQbrain_951_l 0.107794024 HS_from_MQbrain_996_l 0.107794024 hsa-mir-625_r 0.107794024 HSbrain_106_r 0.107794024 HSbrain_184_r 0.107794024 HSbrain_696_r 0.107794024 Hsd_from_Mmd_255_l 0.107794024 HS_from_MM_86_l 0.11066006 HS_from_MQbrain_1339_r 0.11066006 HS_from_MQbrain_2087_r 0.11066006 HSbrain_677_l 0.11066006 Hsd_from_Mmd_266_r 0.11066006 Hsd_from_Mmd_52_r 0.11066006 HS_from_MQbrain_1185_l 0.113095726 HS_from_MQbrain_29_l 0.113095726 HS_from_MQbrain_777_r 0.113095726 HSbrain_1413_l 0.113095726 HSbrain_440_l 0.113095726 HSbrain_50_l 0.113095726 HSbrain_588_l 0.113095726 Hsd_12_r 0.113095726 HS_102_l 0.114595796 HS_38_r 0.114595796 HS_from_MM_276_l 0.114595796 HS_from_MQbrain_1164_r 0.114595796 HS_from_MQbrain_1817_l 0.114595796 HS_from_MQbrain_184_l 0.114595796 HS_from_MQbrain_56_l 0.114595796 HS_from_MQbrain_842_l 0.114595796 HSbrain_461_r 0.114595796 HSbrain_621_r 0.114595796 HSbrain_677_r 0.114595796 HSbrain_795_r 0.114595796 HS_from_MM_119_r 0.115928328 HS_from_MM_331_r 0.115928328 HS_from_MQbrain_1292_r 0.115928328 HS_from_MQbrain_1637_r 0.115928328 HS_from_MQbrain_501_l 0.115928328 HS_from_MQbrain_609_l 0.115928328 HS_from_PT_128_l 0.115928328 HS_from_PT_139_r 0.115928328 hsa-mir-450-2_r 0.115928328 HSbrain_1362_r 0.115928328 HSbrain_26_r 0.115928328 HSbrain_480_r 0.115928328 Hsd_from_Mmd_181_r 0.115928328 HS_246_l 0.117828853 HS_76_r 0.117828853 HS_from_MM_157_l 0.117828853 HS_from_MM_208_r 0.117828853 HS_from_MM_260_l 0.117828853 HS_from_MM_34_l 0.117828853 HS_from_MQbrain_1470_l 0.117828853 HS_from_MQbrain_273_r 0.117828853 HS_from_MQbrain_354_r 0.117828853 HS_from_MQbrain_791_r 0.117828853 HSbrain_720_l 0.117828853 HS_from_MM_180_r 0.119559457 HS_from_MM_184_r 0.119559457 HS_from_MQbrain_974_l 0.119559457 HS_from_PT_60_l 0.119559457 hsa-mir-30b_l 0.119559457 hsa-mir-491_r 0.119559457 HSbrain_225_r 0.119559457 HSbrain_325_r 0.119559457 HSbrain_441_r 0.119559457 HSbrain_606_l 0.119559457 HSbrain_708_l 0.119559457 Hsd_from_Mmd_23_l 0.119559457 HS_154_r 0.121604253 HS_from_MQbrain_161_r 0.121604253 HS_from_MQbrain_1632_l 0.121604253 HS_from_MQbrain_1776_r 0.121604253 HS_from_MQbrain_648_r 0.121604253 HS_from_MQbrain_940_r 0.121604253 hsa-mir-548c_l 0.121604253 hsa-mir-640_l 0.121604253 HSbrain_305_r 0.121604253 Hsd_82_r 0.121604253 Hsd_from_Mmd_136_l 0.121604253 HS_from_MQbrain_1075_l 0.12300785 HS_from_MQbrain_1261_r 0.12300785 HS_from_MQbrain_1412_l 0.12300785 HS_from_MQbrain_266_l 0.12300785 HS_from_MQbrain_340_r 0.12300785 HS_from_MQbrain_760_l 0.12300785 HS_from_PT_117_r 0.12300785 hsa-mir-16-1_r 0.12300785 HSbrain_155_r 0.12300785 HSbrain_256_r 0.12300785 HSbrain_402_l 0.12300785 HSbrain_50_r 0.12300785 HSbrain_541_r 0.12300785 Hsd_from_Mmd_314_r 0.12300785 HS_from_MQbrain_1097_r 0.124263194 HS_from_MQbrain_1633_r 0.124263194 HS_from_MQbrain_1806_l 0.124263194 HS_from_MQbrain_210_r 0.124263194 HS_from_MQbrain_268_r 0.124263194 HS_from_MQbrain_619_l 0.124263194 HS_from_MQbrain_681_l 0.124263194 HS_from_MQbrain_814_l 0.124263194 hsa-mir-329-1_r 0.124263194 hsa-mir-451_l 0.124263194 hsa-mir-517c_l 0.124263194 hsa-mir-632_l 0.124263194 HSbrain_1338_r 0.124263194 HSbrain_393_l 0.124263194 Hsd_from_Mmd_154_l 0.124263194 HS_97_r 0.126757752 HS_from_MQbrain_1183_l 0.126757752 HS_from_MQbrain_1675_l 0.126757752 HS_from_MQbrain_314_l 0.126757752 HS_from_MQbrain_822_l 0.126757752 HS_from_MQbrain_897_r 0.126757752 hsa-mir-299_r 0.126757752 hsa-mir-616_l 0.126757752 HSbrain_43_r 0.126757752 HSbrain_771_l 0.126757752 HS_290_r 0.129555956 HS_77_r 0.129555956 HS_88_r 0.129555956 HS_from_MQbrain_1102_l 0.129555956 HS_from_MQbrain_140_l 0.129555956 HS_from_MQbrain_1413_l 0.129555956 HS_from_MQbrain_453_l 0.129555956 HS_from_MQbrain_800_l 0.129555956 HSbrain_393_r 0.129555956 HS_50_r 0.130803986 HS_56_l 0.130803986 HS_from_MQbrain_1684_r 0.130803986 HS_from_MQbrain_1808_r 0.130803986 HS_from_MQbrain_216_l 0.130803986 HS_from_MQbrain_37_r 0.130803986 HS_from_MQbrain_672_l 0.130803986 HS_from_MQbrain_722_l 0.130803986 HS_from_PT_313_l 0.130803986 hsa-mir-206_l 0.130803986 hsa-mir-573_r 0.130803986 HSbrain_380_r 0.130803986 HSbrain_776_l 0.130803986 HSbrain_783_l 0.130803986 Hsd_from_Mmd_503_l 0.130803986 Hsd_from_Mmd_94_l 0.130803986 HS_101_l 0.132596379 HS_from_MM_200_l 0.132596379 HS_from_MQbrain_1070_r 0.132596379 HS_from_MQbrain_1520_l 0.132596379 HS_from_MQbrain_1845_l 0.132596379 HS_from_MQbrain_38_r 0.132596379 HS_from_MQbrain_382_l 0.132596379 HS_from_MQbrain_715_l 0.132596379 HS_from_MQbrain_868_l 0.132596379 HSbrain_12_l 0.132596379 HSbrain_1364_r 0.132596379 HSbrain_691_l 0.132596379 HSbrain_726_l 0.132596379 Hsd_from_Mmd_155_l 0.132596379 HS_62_l 0.134691663 HS_from_MM_102_r 0.134691663 HS_from_MQbrain_1420_l 0.134691663 HS_from_MQbrain_1549_l 0.134691663 hsa-mir-454_r 0.134691663 hsa-mir-516-1_r 0.134691663 hsa-mir-520h_l 0.134691663 HSbrain_220_r 0.134691663 HSbrain_484_l 0.134691663 HSbrain_590_l 0.134691663 HSbrain_636_l 0.134691663 Hsd_42_r 0.134691663 Hsd_7_r 0.134691663 HS_237_r 0.136637202 HS_289_r 0.136637202 HS_from_MM_48_l 0.136637202 HS_from_MQbrain_1725_l 0.136637202 HS_from_MQbrain_281_r 0.136637202 HS_from_MQbrain_348_r 0.136637202 HS_from_MQbrain_600_l 0.136637202 HS_from_PT_44_l 0.136637202 HS_from_PT_95_l 0.136637202 hsa-mir-454_l 0.136637202 hsa-mir-671_l 0.136637202 HSbrain_174_r 0.136637202 HSbrain_222_r 0.136637202 HSbrain_970_r 0.136637202 HS_278_l 0.138217661 HS_91_l 0.138217661 HS_from_MQbrain_1525_r 0.138217661 HS_from_MQbrain_161_l 0.138217661 HS_from_MQbrain_1824_l 0.138217661 HS_from_MQbrain_1836_l 0.138217661 HS_from_MQbrain_315_l 0.138217661 HS_from_MQbrain_697_l 0.138217661 HS_from_MQbrain_70_l 0.138217661 hsa-mir-196a-2_r 0.138217661 hsa-mir-345_r 0.138217661 hsa-mir-369_l 0.138217661 hsa-mir-517a_l 0.138217661 HSbrain_250_l 0.138217661 HSbrain_753_r 0.138217661 Hsd_69_l 0.138217661 HS_277_l 0.139019426 HS_from_MQbrain_1493_r 0.139019426 HS_from_MQbrain_1657_r 0.139019426 HS_from_MQbrain_1756_l 0.139019426 HS_from_MQbrain_178_r 0.139019426 HS_from_MQbrain_399_l 0.139019426 HS_from_MQbrain_804_r 0.139019426 HS_from_MQbrain_809_l 0.139019426 HS_from_MQbrain_886_r 0.139019426 HS_from_MQbrain_90_r 0.139019426 HSbrain_1377_l 0.139019426 HSbrain_1416_r 0.139019426 HSbrain_3_l 0.139019426 HSbrain_337_r 0.139019426 HSbrain_509_l 0.139019426 HSbrain_726_r 0.139019426 HSbrain_779_r 0.139019426 Hsd_13_l 0.139019426 Hsd_32_r 0.139019426 Hsd_from_Mmd_396_l 0.139019426 HS_223_r 0.141416815 HS_39_r 0.141416815 HS_98_r 0.141416815 HS_from_MQbrain_1331_r 0.141416815 HS_from_MQbrain_1417_l 0.141416815 HS_from_MQbrain_332_l 0.141416815 HS_from_MQbrain_812_l 0.141416815 HS_from_MQbrain_845_r 0.141416815 hsa-mir-328_r 0.141416815 hsa-mir-488_l 0.141416815 HSbrain_698_r 0.141416815 Hsd_from_Mmd_398_r 0.141416815 Hsd_from_Mmd_487_r 0.141416815 HS_from_MQbrain_1143_l 0.14474535 HS_from_MQbrain_770_r 0.14474535 HS_from_MQbrain_824_r 0.14474535 HS_from_MQbrain_914_l 0.14474535 hsa-mir-204_r 0.14474535 hsa-mir-510_r 0.14474535 HSbrain_369_r 0.14474535 HSbrain_82_r 0.14474535 Hsd_from_Mmd_123_r 0.14474535 HS_175_l 0.145370181 HS_207_l 0.145370181 HS_54_l 0.145370181 HS_from_MM_288_l 0.145370181 HS_from_MQbrain_1164_l 0.145370181 HS_from_MQbrain_1204_r 0.145370181 HS_from_MQbrain_1227_l 0.145370181 HS_from_MQbrain_180_r 0.145370181 HS_from_MQbrain_1810_l 0.145370181 HS_from_MQbrain_535_r 0.145370181 HS_from_MQbrain_64_l 0.145370181 HS_from_PT_283_r 0.145370181 hsa-mir-30b_r 0.145370181 hsa-mir-517b_l 0.145370181 HSbrain_117_r 0.145370181 HSbrain_139_r 0.145370181 HSbrain_214_l 0.145370181 HSbrain_381_l 0.145370181 HSbrain_620_l 0.145370181 HSbrain_716_l 0.145370181 HSbrain_787_l 0.145370181 Hsd_from_Mmd_82_r 0.145370181 HS_133_l 0.146325218 HS_190_r 0.146325218 HS_281_r 0.146325218 HS_306_l 0.146325218 HS_from_MM_136_l 0.146325218 HS_from_MM_199_l 0.146325218 HS_from_MQbrain_283_r 0.146325218 HS_from_MQbrain_429_l 0.146325218 HS_from_MQbrain_606_r 0.146325218 HS_from_MQbrain_906_l 0.146325218 HS_from_MQbrain_973_l 0.146325218 hsa-mir-217_r 0.146325218 hsa-mir-368_l 0.146325218 hsa-mir-520g_l 0.146325218 hsa-mir-647_l 0.146325218 hsa-mir-655_l 0.146325218 HSbrain_307_r 0.146325218 HSbrain_75_l 0.146325218 Hsd_from_Mmd_246_r 0.146325218 Hsd_from_Mmd_500_l 0.146325218 Hsd_from_Mmd_535_r 0.146325218 HS_141_l 0.148196723 HS_286_r 0.148196723 HS_66_r 0.148196723 HS_from_MM_118_l 0.148196723 HS_from_MQbrain_1224_r 0.148196723 HS_from_MQbrain_1292_l 0.148196723 HS_from_MQbrain_1817_l 0.148196723 hsa-mir-365-2_r 0.148196723 HSbrain_102_r 0.148196723 HSbrain_244_l 0.148196723 HSbrain_495_r 0.148196723 HSbrain_624_l 0.148196723 HSbrain_627_r 0.148196723 HSbrain_647_r 0.148196723 HSbrain_794_r 0.148196723 Hsd_from_Mmd_501_l 0.148196723 Hsd_from_Mmd_70_l 0.148196723 HS_110_r 0.149149579 HS_139_l 0.149149579 HS_306_l 0.149149579 HS_58_l 0.149149579 HS_from_MQbrain_1088_l 0.149149579 HS_from_MQbrain_1419_r 0.149149579 HS_from_MQbrain_1773_l 0.149149579 HS_from_MQbrain_666_l 0.149149579 HS_from_MQbrain_817_l 0.149149579 HS_from_PT_134_l 0.149149579 HS_from_PT_188_l 0.149149579 hsa-mir-30c-1_l 0.149149579 hsa-mir-524_r 0.149149579 HSbrain_1363_r 0.149149579 HSbrain_1384_r 0.149149579 HSbrain_177_r 0.149149579 HSbrain_198_l 0.149149579 HSbrain_313_l 0.149149579 HSbrain_425_l 0.149149579 HSbrain_622_r 0.149149579 Hsd_81_r 0.149149579 Hsd_from_Mmd_516_r 0.149149579 HS_111_r 0.152177614 HS_204_r 0.152177614 HS_45_r 0.152177614 HS_from_PT_20_r 0.152177614 hsa-mir-191_r 0.152177614 HSbrain_304_l 0.152177614 HSbrain_41_l 0.152177614 HSbrain_625_l 0.152177614 HSbrain_717_l 0.152177614 Hsd_66_l 0.152177614 Hsd_from_Mmd_261_r 0.152177614 Hsd_from_Mmd_509_l 0.152177614 HS_from_MQbrain_1433_r 0.155479351 HS_from_MQbrain_536_r 0.155479351 HS_from_MQbrain_629_r 0.155479351 HS_from_MQbrain_88_l 0.155479351 hsa-mir-10b_r 0.155479351 hsa-mir-31_l 0.155479351 hsa-mir-338_l 0.155479351 hsa-mir-579_r 0.155479351 hsa-mir-616_r 0.155479351 HSbrain_578_r 0.155479351 Hsd_from_Mmd_424_l 0.155479351 HS_113_l 0.15865589 HS_220_l 0.15865589 HS_from_MQbrain_1168_l 0.15865589 HS_from_MQbrain_1601_r 0.15865589 HS_from_MQbrain_686_l 0.15865589 HS_from_MQbrain_936_l 0.15865589 HSbrain_431_l 0.15865589 HSbrain_506_r 0.15865589 HSbrain_652_l 0.15865589 HSbrain_673_l 0.15865589 Hsd_from_Mmd_197_l 0.15865589 Hsd_from_Mmd_58_r 0.15865589 HS_167_r 0.159708794 HS_265_l 0.159708794 HS_292_r 0.159708794 HS_from_MQbrain_1110_l 0.159708794 HS_from_MQbrain_1753_r 0.159708794 HS_from_MQbrain_1882_r 0.159708794 HS_from_MQbrain_529_r 0.159708794 HS_from_MQbrain_604_l 0.159708794 HS_from_MQbrain_833_l 0.159708794 HS_from_PT_254_r 0.159708794 HS_from_PT_91_r 0.159708794 hsa-mir-382_r 0.159708794 hsa-mir-516-2_r 0.159708794 hsa-mir-622_l 0.159708794 HSbrain_158_l 0.159708794 HSbrain_202_r 0.159708794 HSbrain_305_l 0.159708794 HSbrain_571_l 0.159708794 HSbrain_644_r 0.159708794 HSbrain_692_l 0.159708794 HSbrain_91_r 0.159708794 Hsd_from_Mmd_347_l 0.159708794 Hsd_from_Mmd_480_r 0.159708794 HS_181_l 0.161647438 HS_288_l 0.161647438 HS_from_MM_124_l 0.161647438 HS_from_MQbrain_1215_l 0.161647438 HS_from_MQbrain_1722_l 0.161647438 HS_from_MQbrain_1839_l 0.161647438 HS_from_MQbrain_1877_r 0.161647438 HS_from_MQbrain_2441_r 0.161647438 HS_from_MQbrain_587_l 0.161647438 HS_from_MQbrain_635_l 0.161647438 HS_from_MQbrain_868_l 0.161647438 hsa-mir-588_r 0.161647438 HSbrain_16_l 0.161647438 HSbrain_218_l 0.161647438 HSbrain_408_r 0.161647438 HSbrain_599_r 0.161647438 HSbrain_663_l 0.161647438 HSbrain_72_l 0.161647438 Hsd_106_r 0.161647438 HS_130_l 0.16463875 HS_208_r 0.16463875 HS_from_MQbrain_1229_r 0.16463875 HS_from_MQbrain_1645_l 0.16463875 HS_from_MQbrain_288_r 0.16463875 HS_from_MQbrain_444_r 0.16463875 HS_from_MQbrain_808_l 0.16463875 HS_from_PT_41_l 0.16463875 hsa-mir-296_l 0.16463875 HSbrain_111_l 0.16463875 HSbrain_1415_r 0.16463875 HSbrain_220_l 0.16463875 HSbrain_366_r 0.16463875 Hsd_from_Mmd_223_r 0.16463875 HS_from_MM_311_l 0.167313007 HS_from_MQbrain_1268_l 0.167313007 HS_from_MQbrain_1372_l 0.167313007 HS_from_MQbrain_1376_r 0.167313007 HS_from_MQbrain_1876_r 0.167313007 HS_from_MQbrain_2670_r 0.167313007 HS_from_MQbrain_401_l 0.167313007 HS_from_MQbrain_42_l 0.167313007 HS_from_MQbrain_699_r 0.167313007 HS_from_PT_338_l 0.167313007 hsa-mir-125b-2_l 0.167313007 hsa-mir-132_l 0.167313007 hsa-mir-190_l 0.167313007 HSbrain_168_l 0.167313007 HSbrain_513_r 0.167313007 Hsd_from_Mmd_443_l 0.167313007 HS_114_l 0.170255758 HS_61_r 0.170255758 HS_from_MQbrain_1235_l 0.170255758 HS_from_MQbrain_1627_r 0.170255758 HS_from_MQbrain_1667_r 0.170255758 HS_from_MQbrain_1855_l 0.170255758 HS_from_MQbrain_482_l 0.170255758 HS_from_MQbrain_496_r 0.170255758 HS_from_MQbrain_710_r 0.170255758 hsa-mir-520f_r 0.170255758 HSbrain_113_r 0.170255758 HSbrain_626_r 0.170255758 HSbrain_85_r 0.170255758 Hsd_from_Mmd_107_r 0.170255758 Hsd_from_Mmd_176_r 0.170255758 HS_29_l 0.173467438 HS_from_MM_6_r 0.173467438 HS_from_MQbrain_560_r 0.173467438 HS_from_MQbrain_57_l 0.173467438 hsa-mir-643_r 0.173467438 HSbrain_157_l 0.173467438 HSbrain_336_l 0.173467438 HSbrain_483_r 0.173467438 HSbrain_614_l 0.173467438 HSbrain_777_r 0.173467438 Hsd_80_r 0.173467438 Hsd_from_Mmd_35_r 0.173467438 Hsd_from_Mmd_370_r 0.173467438 Hsd_from_Mmd_97_l 0.173467438 HS_191_r 0.175200251 HS_231_l 0.175200251 HS_from_MQbrain_1091_l 0.175200251 HS_from_MQbrain_1463_l 0.175200251 HS_from_MQbrain_1556_r 0.175200251 HS_from_MQbrain_1708_l 0.175200251 HS_from_MQbrain_1752_l 0.175200251 HS_from_MQbrain_1777_l 0.175200251 HS_from_MQbrain_437_l 0.175200251 HS_from_MQbrain_555_r 0.175200251 HS_from_MQbrain_734_l 0.175200251 HS_from_MQbrain_85_l 0.175200251 HS_from_PT_115_r 0.175200251 HS_from_PT_34_r 0.175200251 hsa-mir-770_r 0.175200251 HSbrain_429_l 0.175200251 HSbrain_540_l 0.175200251 HSbrain_643_l 0.175200251 HSbrain_687_l 0.175200251 HSbrain_916_l 0.175200251 HSbrain_970_l 0.175200251 Hsd_from_Mmd_527_l 0.175200251 HS_109_r 0.177405071 HS_217_l 0.177405071 HS_from_MQbrain_1126_l 0.177405071 HS_from_MQbrain_1323_l 0.177405071 HS_from_MQbrain_1442_l 0.177405071 HS_from_MQbrain_1470_r 0.177405071 HS_from_MQbrain_386_r 0.177405071 HS_from_PT_190_r 0.177405071 HS_from_PT_211_r 0.177405071 hsa-mir-374_l 0.177405071 HSbrain_1414_r 0.177405071 HSbrain_347_l 0.177405071 HSbrain_568_r 0.177405071 HSbrain_690_l 0.177405071 HSbrain_692_r 0.177405071 HSbrain_744_l 0.177405071 HSbrain_794_l 0.177405071 Hsd_from_Mmd_167_r 0.177405071 Hsd_from_Mmd_42_r 0.177405071 Hsd_from_Mmd_480_l 0.177405071 HS_266_r 0.180260145 HS_285_r 0.180260145 HS_292_r 0.180260145 HS_47_l 0.180260145 HS_from_MQbrain_1110_r 0.180260145 HS_from_MQbrain_1631_r 0.180260145 HS_from_MQbrain_550_l 0.180260145 HS_from_MQbrain_661_r 0.180260145 HS_from_MQbrain_991_r 0.180260145 hsa-mir-365-1_l 0.180260145 HSbrain_1331_r 0.180260145 HSbrain_180_l 0.180260145 HSbrain_263_r 0.180260145 HSbrain_593_r 0.180260145 HSbrain_689_r 0.180260145 Hsd_from_Mmd_217_r 0.180260145 Hsd_from_Mmd_286_r 0.180260145 HS_138_l 0.184337179 HS_177_l 0.184337179 HS_182_r 0.184337179 HS_243_l 0.184337179 HS_from_MM_131_l 0.184337179 HS_from_MQbrain_1227_l 0.184337179 HS_from_MQbrain_188_l 0.184337179 HSbrain_621_l 0.184337179 HSbrain_778_l 0.184337179 Hsd_84_r 0.184337179 Hsd_from_Mmd_120_r 0.184337179 HS_142_l 0.185815478 HS_303_r 0.185815478 HS_77_l 0.185815478 HS_from_MM_256_r 0.185815478 HS_from_MM_310_l 0.185815478 HS_from_MQbrain_111_l 0.185815478 HS_from_MQbrain_1354_r 0.185815478 HS_from_MQbrain_1394_l 0.185815478 HS_from_MQbrain_17_r 0.185815478 HS_from_MQbrain_1778_r 0.185815478 HS_from_MQbrain_22_l 0.185815478 HS_from_MQbrain_272_l 0.185815478 HS_from_MQbrain_453_r 0.185815478 HS_from_MQbrain_914_l 0.185815478 HS_from_PT_157_r 0.185815478 hsa-mir-135a-2_r 0.185815478 hsa-mir-557_l 0.185815478 hsa-mir-593_r 0.185815478 HSbrain_1364_l 0.185815478 HSbrain_166_l 0.185815478 HSbrain_32_l 0.185815478 HSbrain_662_r 0.185815478 HSbrain_80_l 0.185815478 Hsd_8_r 0.185815478 Hsd_from_Mmd_48_r 0.185815478 HS_189_l 0.188706417 HS_241_r 0.188706417 HS_50_l 0.188706417 HS_from_MQbrain_1346_r 0.188706417 HS_from_MQbrain_194_l 0.188706417 HS_from_MQbrain_36_r 0.188706417 HS_from_MQbrain_691_r 0.188706417 HS_from_MQbrain_745_r 0.188706417 HS_from_MQbrain_859_l 0.188706417 HS_from_PT_126_l 0.188706417 hsa-mir-367_r 0.188706417 hsa-mir-518e_r 0.188706417 HSbrain_141_r 0.188706417 HSbrain_270_r 0.188706417 HSbrain_497_l 0.188706417 HSbrain_570_l 0.188706417 Hsd_96_r 0.188706417 Hsd_from_Mmd_471_r 0.188706417 HS_105_l 0.190550803 HS_166_l 0.190550803 HS_from_MM_80_l 0.190550803 HS_from_MQbrain_1300_r 0.190550803 HS_from_MQbrain_1347_r 0.190550803 HS_from_MQbrain_1365_l 0.190550803 HS_from_MQbrain_1437_l 0.190550803 HS_from_MQbrain_397_l 0.190550803 HS_from_MQbrain_405_r 0.190550803 HS_from_MQbrain_626_r 0.190550803 HS_from_MQbrain_653_l 0.190550803 HS_from_MQbrain_675_l 0.190550803 HS_from_MQbrain_819_r 0.190550803 HS_from_MQbrain_968_r 0.190550803 HS_from_MQbrain_97_r 0.190550803 HS_from_PT_238_l 0.190550803 HS_from_PT_27_l 0.190550803 hsa-mir-222_r 0.190550803 hsa-mir-502_l 0.190550803 HSbrain_809_r 0.190550803 Hsd_62_l 0.190550803 Hsd_95_l 0.190550803 Hsd_from_Mmd_163_r 0.190550803 Hsd_from_Mmd_253_l 0.190550803 HS_from_MM_198_r 0.194339793 HS_from_MM_35_r 0.194339793 HS_from_MQbrain_1272_l 0.194339793 HS_from_MQbrain_1421_l 0.194339793 HS_from_MQbrain_375_l 0.194339793 HS_from_MQbrain_55_l 0.194339793 HS_from_PT_149_r 0.194339793 hsa-mir-550-2_r 0.194339793 hsa-mir-623_r 0.194339793 hsa-mir-648_l 0.194339793 HSbrain_259_r 0.194339793 HSbrain_755_l 0.194339793 Hsd_from_Mmd_530_l 0.194339793 Hsd_from_Mmd_81_r 0.194339793 HS_from_MM_190_l 0.197457594 HS_from_MQbrain_1159_l 0.197457594 HS_from_MQbrain_1514_r 0.197457594 HS_from_MQbrain_467_l 0.197457594 HS_from_MQbrain_500_r 0.197457594 HS_from_MQbrain_635_r 0.197457594 HS_from_MQbrain_789_r 0.197457594 HS_from_MQbrain_968_l 0.197457594 hsa-mir-204_l 0.197457594 hsa-mir-219-1_r 0.197457594 HSbrain_1337_l 0.197457594 HSbrain_190_r 0.197457594 HSbrain_210_l 0.197457594 HSbrain_289_r 0.197457594 HSbrain_479_l 0.197457594 HSbrain_755_r 0.197457594 Hsd_24_r 0.197457594 Hsd_from_Mmd_178_l 0.197457594 HS_from_MQbrain_1100_r 0.199721903 HS_from_MQbrain_1210_l 0.199721903 HS_from_MQbrain_1250_l 0.199721903 HS_from_MQbrain_1357_l 0.199721903 HS_from_MQbrain_1405_l 0.199721903 HS_from_MQbrain_1415_r 0.199721903 HS_from_MQbrain_1517_r 0.199721903 HS_from_MQbrain_1747_l 0.199721903 HS_from_MQbrain_212_r 0.199721903 HS_from_MQbrain_229_l 0.199721903 HS_from_MQbrain_235_r 0.199721903 HS_from_MQbrain_280_l 0.199721903 hsa-mir-138-2_l 0.199721903 hsa-mir-524_l 0.199721903 hsa-mir-568_l 0.199721903 hsa-mir-95_r 0.199721903 HSbrain_22_l 0.199721903 HSbrain_388_r 0.199721903 HSbrain_482_l 0.199721903 HSbrain_588_r 0.199721903 HSbrain_651_r 0.199721903 Hsd_41_r 0.199721903 Hsd_from_Mmd_478_l 0.199721903 ¹Wilcoxon analysis: cut off adjusted p value < 0.2

TABLE 4b Up- or downregulated small RNAs adenocarcinoma compared to adenoma adenoma/carcinoma carcinoma adenoma carcinoma/adenoma SystematicName (adj p)¹ (avg expression) (avg expression) (ratio expression)² hsa-mir-375_r 0.0393 −0.1480 0.8295 −0.9775 HS_from_MQbrain_1985_l 0.0474 0.3803 1.1112 −0.7308 HS_from_MQbrain_579_l 0.0660 0.3918 1.1126 −0.7208 HS_from_MQbrain_1958_l 0.0723 0.3762 1.0830 −0.7067 HS_from_MQbrain_1235_l 0.1703 1.1233 1.7573 −0.6340 HS_from_MQbrain_1323_l 0.1774 1.1608 1.7828 −0.6220 HS_from_MQbrain_1525_r 0.1382 0.3320 0.9272 −0.5951 HS_from_MQbrain_972_r 0.0772 0.2041 0.7900 −0.5859 HSbrain_636_l 0.1347 0.8158 1.3298 −0.5141 HS_266_r 0.1803 0.8889 1.3712 −0.4823 HS_from_PT_13_l 0.0883 −0.9932 −0.5123 −0.4809 HS_from_MQbrain_529_r 0.1597 0.0776 0.5481 −0.4705 HS_from_MQbrain_470_l 0.0750 0.8272 1.2930 −0.4658 hsa-mir-10b_r 0.1555 −0.0924 0.3721 −0.4645 Hsd_from_Mmd_166_l 0.0501 −0.8357 −0.3751 −0.4607 Hsd_from_Mmd_136_l 0.1216 −1.2261 −0.7690 −0.4571 hsa-mir-451_l 0.3459 −0.4469 0.0020 −0.4489 Hsd_from_Mmd_524_l 0.0995 −0.9078 −0.4694 −0.4385 HSbrain_773_r 0.0928 −1.1665 −0.7301 −0.4364 HS_from_MQbrain_828_l 0.0320 0.2589 0.6920 −0.4331 hsa-mir-190_l 0.1673 −1.4076 −0.9760 −0.4316 HS_from_MM_6_r 0.1735 0.4691 0.9005 −0.4314 hsa-mir-573_r 0.1308 −1.2345 −0.8053 −0.4291 hsa-mir-193a_l 0.0995 0.6922 1.1195 −0.4273 HS_from_MM_84_l 0.1010 −0.6664 −0.2459 −0.4205 HS_from_PT_190_r 0.1774 1.1254 1.5446 −0.4192 Hsd_from_Mmd_123_r 0.1447 0.5308 0.9486 −0.4178 HS_151_r 0.0913 −0.9626 −0.5484 −0.4141 HSbrain_1384_r 0.1491 0.1926 0.6048 −0.4122 hsa-mir-368_l 0.1463 −0.1578 0.2436 −0.4014 hsa-mir-520f_r 0.1703 −0.6603 −0.2591 −0.4012 HS_from_MQbrain_1229_r 0.1646 −0.0990 0.3017 −0.4007 HSbrain_276_l 0.0393 −0.2953 0.1014 −0.3967 HS_from_MQbrain_1417_l 0.1414 0.3389 0.7346 −0.3957 HSbrain_220_l 0.1646 −0.2992 0.0905 −0.3897 HS_from_MM_136_l 0.1463 −1.0881 −0.7064 −0.3816 hsa-mir-450-2_r 0.1159 −0.4279 −0.0493 −0.3785 HSbrain_916_l 0.1752 1.4491 1.8251 −0.3760 hsa-mir-516-1_r 0.1347 −0.9059 −0.5366 −0.3693 HS_124_r 0.0249 −0.2279 0.1382 −0.3661 HSbrain_776_l 0.1308 1.1157 1.4804 −0.3647 Hsd_from_Mmd_107_r 0.1703 −1.2270 −0.8628 −0.3643 HS_from_MQbrain_1771_r 0.0913 0.1028 0.4671 −0.3643 hsa-mir-367_r 0.1887 −0.2475 0.1160 −0.3636 HSbrain_52_r 0.0983 0.4883 0.8497 −0.3614 HSbrain_399_l 0.0320 −0.0904 0.2705 −0.3609 HS_from_MQbrain_1901_r 0.0946 −0.4682 −0.1080 −0.3602 HSbrain_259_r 0.1943 0.3494 0.7076 −0.3581 hsa-mir-548b_l 0.0339 −0.3487 0.0094 −0.3581 hsa-mir-454_r 0.1347 −0.6903 −0.3370 −0.3534 HSbrain_570_l 0.1887 0.1544 0.5074 −0.3530 HS_from_MQbrain_111_l 0.1858 −0.2182 0.1331 −0.3513 HS_307_r 0.0750 −0.8051 −0.4560 −0.3491 HSbrain_538_r 0.0552 −0.0160 0.3321 −0.3481 HSbrain_513_r 0.1673 −0.6112 −0.2644 −0.3469 Hsd_81_r 0.1491 −0.6940 −0.3476 −0.3465 HS_from_MQbrain_1485_l 0.0292 −0.2157 0.1282 −0.3439 hsa-mir-648_l 0.1943 0.4250 0.7676 −0.3427 hsa-mir-331_l 0.0347 −0.4701 −0.1282 −0.3419 HS_from_MQbrain_951_l 0.1078 0.5785 0.9191 −0.3405 HSbrain_72_l 0.1616 1.0011 1.3415 −0.3405 HS_from_MQbrain_315_l 0.1382 0.1929 0.5309 −0.3381 HS_from_MM_180_r 0.1196 −0.6729 −0.3357 −0.3372 HS_from_PT_20_r 0.1522 0.3244 0.6602 −0.3358 Hsd_from_Mmd_48_r 0.1858 −0.3148 0.0209 −0.3358 hsa-mir-433_r 0.0772 −0.1074 0.2280 −0.3354 hsa-mir-516-2_r 0.1597 −0.8140 −0.4802 −0.3337 HS_from_MQbrain_441_l 0.4342 −0.0869 0.2455 −0.3324 HSbrain_117_r 0.1454 0.0411 0.3731 −0.3321 HS_from_MQbrain_330_r 0.0857 0.3556 0.6874 −0.3318 hsa-mir-299_r 0.1268 0.3466 0.6783 −0.3317 HS_from_MQbrain_1493_r 0.1390 1.0831 1.4142 −0.3310 HS_from_MQbrain_1413_l 0.1296 0.0572 0.3880 −0.3308 hsa-mir-548c_l 0.1216 −0.6506 −0.3199 −0.3307 HSbrain_420_r 0.0583 0.1546 0.4847 −0.3301 HSbrain_6_r 0.0764 0.2574 0.5872 −0.3298 HS_from_MM_295_l 0.0205 −0.1367 0.1924 −0.3291 HS_from_MQbrain_2670_r 0.1673 0.3448 0.6730 −0.3282 HSbrain_716_l 0.1454 0.1785 0.5044 −0.3260 HS_from_PT_282_l 0.0913 −0.0644 0.2604 −0.3248 Hsd_from_Mmd_314_r 0.1230 −0.6381 −0.3153 −0.3227 HS_from_MQbrain_468_r 0.0857 0.0111 0.3325 −0.3213 HS_from_MQbrain_501_l 0.1159 0.1924 0.5136 −0.3212 HSbrain_369_r 0.1447 −0.1235 0.1952 −0.3188 hsa-mir-653_l 0.0282 −0.2258 0.0912 −0.3170 HS_118_l 0.3927 0.4518 0.7665 −0.3147 hsa-mir-652_r 0.0849 −0.5348 −0.2206 −0.3142 HS_from_MM_310_l 0.1858 −0.5347 −0.2217 −0.3130 HSbrain_95_l 0.0849 −0.3123 0.0005 −0.3128 HS_from_MQbrain_29_l 0.1131 0.4126 0.7253 −0.3127 HSbrain_174_r 0.1366 −0.7406 −0.4286 −0.3120 Hsd_7_r 0.1347 −0.0496 0.2607 −0.3103 hsa-mir-524_r 0.1491 −0.0033 0.3055 −0.3087 hsa-mir-412_l 0.0350 −0.1137 0.1947 −0.3085 HS_177_l 0.1843 −0.2397 0.0685 −0.3082 HS_from_MM_342_r 0.0772 −0.0065 0.3015 −0.3080 HSbrain_970_r 0.1366 −0.6926 −0.3850 −0.3076 HS_from_PT_187_r 0.0327 −0.1851 0.1217 −0.3068 HS_from_MQbrain_1227_l 0.1843 −0.0475 0.2585 −0.3059 HS_from_MQbrain_97_r 0.1906 0.2065 0.5122 −0.3058 HS_from_MQbrain_1756_l 0.1390 0.2193 0.5248 −0.3055 hsa-let-7c_r 0.0501 −0.1593 0.1458 −0.3051 Hsd_from_Mmd_82_r 0.1454 −0.5385 −0.2337 −0.3048 hsa-mir-624_l 0.0895 −0.4583 −0.1544 −0.3039 HS_from_MQbrain_1183_l 0.1268 0.9448 1.2486 −0.3038 HS_from_MM_72_r 0.0913 −0.3145 −0.0123 −0.3022 hsa-mir-497_r 0.0582 0.0098 0.3116 −0.3018 HS_207_l 0.1454 −0.7159 −0.4144 −0.3016 HS_from_MQbrain_1297_l 0.0205 0.1527 0.4538 −0.3012 HSbrain_794_r 0.1482 0.4585 0.7581 −0.2996 HS_from_PT_254_r 0.1597 0.7318 1.0312 −0.2994 HS_from_MM_256_r 0.1858 −0.8368 −0.5378 −0.2990 Hsd_from_Mmd_225_l 0.0928 −0.5076 −0.2092 −0.2984 HS_from_MQbrain_1363_l 0.0252 0.0001 0.2974 −0.2973 HS_277_l 0.1390 −0.3910 −0.0947 −0.2963 HS_from_MQbrain_1227_l 0.1843 −0.2622 0.0336 −0.2958 Hsd_96_r 0.1887 −0.5046 −0.2090 −0.2956 HS_79_l 0.0482 −0.0825 0.2126 −0.2951 HS_from_MQbrain_664_r 0.0706 0.0091 0.3041 −0.2950 HSbrain_796_r 0.0277 −0.1402 0.1547 −0.2949 Hsd_18_r 0.0393 −0.1922 0.1024 −0.2946 HS_292_r 0.1803 −0.6801 −0.3855 −0.2946 HSbrain_624_l 0.1482 0.1118 0.4059 −0.2941 HS_from_MQbrain_1097_r 0.1243 0.3204 0.6142 −0.2939 hsa-mir-190_r 0.0764 −0.5001 −0.2067 −0.2934 HS_from_MQbrain_180_r 0.1454 0.0609 0.3529 −0.2920 HS_189_l 0.1887 0.5895 0.8806 −0.2911 HSbrain_381_l 0.1454 −0.8145 −0.5240 −0.2905 HSbrain_1076_r 0.0660 −0.1027 0.1878 −0.2905 hsa-mir-299_l 0.0772 −0.1635 0.1264 −0.2899 HSbrain_388_r 0.1997 −0.1095 0.1800 −0.2896 HS_from_MQbrain_1781_l 0.0369 −0.2509 0.0384 −0.2893 HS_from_MM_232_r 0.0727 −0.4188 −0.1303 −0.2886 HSbrain_1331_r 0.1803 −0.0587 0.2288 −0.2875 hsa-mir-633_r 0.1045 −0.4375 −0.1504 −0.2870 HS_246_l 0.1178 −0.4272 −0.1410 −0.2862 Hsd_42_r 0.1347 0.1048 0.3903 −0.2855 hsa-mir-767_r 0.0239 −0.2413 0.0431 −0.2845 HS_292_r 0.1803 −0.6740 −0.3896 −0.2844 HS_from_MQbrain_154_r 0.0772 −0.0165 0.2678 −0.2844 HS_from_MM_34_l 0.3286 −0.2129 0.0705 −0.2833 HSbrain_507_l 0.1026 −0.2025 0.0806 −0.2831 hsa-mir-130b_l 0.0750 −0.4336 −0.1518 −0.2818 HS_from_MQbrain_1300_r 0.1906 −0.3783 −0.0970 −0.2812 Hsd_from_Mmd_157_r 0.0264 −0.1988 0.0821 −0.2808 hsa-mir-1-1_l 0.0750 −0.3136 −0.0329 −0.2807 Hsd_from_Mmd_58_r 0.1587 −0.8765 −0.5960 −0.2805 HS_from_MQbrain_194_l 0.1887 0.7959 1.0759 −0.2801 HS_213_l 0.0482 −0.1424 0.1376 −0.2799 HS_from_MM_32_r 0.0750 −0.1992 0.0806 −0.2797 HS_from_MQbrain_74_r 0.0749 0.4392 0.7181 −0.2789 Hsd_46_l 0.0913 0.0904 0.3671 −0.2768 HS_from_PT_41_l 0.1646 0.0162 0.2925 −0.2764 HS_from_MM_208_r 0.1178 0.0831 0.3590 −0.2759 HS_212_l 0.0501 −0.2004 0.0752 −0.2756 HSbrain_482_l 0.8056 0.1051 0.3806 −0.2754 HS_166_l 0.1906 0.9732 1.2478 −0.2746 HS_288_l 0.1616 0.6490 0.9235 −0.2744 HS_from_MM_157_l 0.1178 −0.5670 −0.2926 −0.2744 hsa-mir-206_l 0.1308 −0.5186 −0.2448 −0.2738 HS_from_PT_101_r 0.0518 −0.1057 0.1677 −0.2735 Hsd_108_l 0.0474 −0.0852 0.1879 −0.2730 HSbrain_532_l 0.0961 −0.1027 0.1698 −0.2725 HS_114_l 0.4078 0.5279 0.8004 −0.2725 HS_from_MM_18_l 0.0849 −0.0504 0.2213 −0.2717 HSbrain_361_l 0.0807 0.2281 0.4996 −0.2715 HS_from_MQbrain_1700_r 0.1010 0.0114 0.2793 −0.2679 HS_from_MQbrain_1877_r 0.1616 0.7927 1.0605 −0.2679 HSbrain_614_l 0.1735 −0.0743 0.1918 −0.2661 HS_from_MQbrain_824_r 0.1447 −0.0312 0.2344 −0.2656 hsa-mir-616_l 0.1268 −0.2425 0.0224 −0.2650 Hsd_from_Mmd_44_r 0.0849 −0.3018 −0.0377 −0.2641 HS_from_MQbrain_88_l 0.1555 −0.6048 −0.3408 −0.2639 HS_from_MQbrain_1717_r 0.0961 −0.1303 0.1329 −0.2632 HS_29_l 0.8454 −0.5409 −0.2781 −0.2629 Hsd_from_Mmd_49_l 0.0583 0.1113 0.3738 −0.2625 HS_from_PT_237_r 0.0723 0.1130 0.3753 −0.2623 HSbrain_41_l 0.1522 0.4515 0.7137 −0.2622 HSbrain_811_l 0.0260 −0.0122 0.2490 −0.2611 HS_219_l 0.0750 0.0321 0.2931 −0.2610 HS_from_MQbrain_672_l 0.1308 0.2914 0.5518 −0.2604 HSbrain_419_l 0.0749 −0.0824 0.1776 −0.2600 HSbrain_55_l 0.0537 −0.0575 0.2025 −0.2600 HS_from_MM_331_r 0.1159 −0.1726 0.0869 −0.2594 HS_from_MQbrain_85_l 0.1752 0.7506 1.0100 −0.2594 HS_from_MQbrain_900_r 0.1060 −0.2078 0.0506 −0.2584 HS_from_MQbrain_854_r 0.0446 −0.0875 0.1696 −0.2571 HS_from_MQbrain_210_r 0.1243 −0.1029 0.1535 −0.2564 Hsd_from_Mmd_422_l 0.0928 −0.1881 0.0673 −0.2554 HS_from_PT_149_r 0.1943 −0.5868 −0.3316 −0.2552 hsa-mir-593_r 0.1858 −0.2304 0.0240 −0.2545 HS_from_MQbrain_833_l 0.1597 −0.5419 −0.2877 −0.2542 Hsd_from_Mmd_167_r 0.1774 0.1417 0.3959 −0.2541 HS_from_MQbrain_1374_r 0.0838 −0.2929 −0.0392 −0.2536 HS_from_MQbrain_791_r 0.1178 −0.7234 −0.4697 −0.2536 HS_281_r 0.1463 −0.1708 0.0827 −0.2536 HS_from_MQbrain_555_r 0.1752 0.0272 0.2808 −0.2535 HS_from_MQbrain_1126_l 0.1774 −0.6334 −0.3799 −0.2535 HS_from_MQbrain_90_r 0.1390 −0.2479 0.0050 −0.2529 HS_17_l 0.0537 −0.0256 0.2273 −0.2529 HS_from_MQbrain_120_l 0.0686 −0.0417 0.2098 −0.2515 hsa-mir-30c-1_l 0.1491 −0.2525 −0.0024 −0.2500 HS_from_MQbrain_1159_l 0.1975 0.4929 0.7421 −0.2491 hsa-mir-647_l 0.1463 −0.0654 0.1833 −0.2487 HS_from_MQbrain_1212_l 0.0498 −0.2370 0.0116 −0.2486 Hsd_from_Mmd_166_r 0.1060 −0.4404 −0.1919 −0.2485 HS_from_MQbrain_42_l 0.1673 −0.1400 0.1078 −0.2478 hsa-mir-382_r 0.1597 −0.2563 −0.0087 −0.2476 HS_from_MM_184_r 0.1196 −0.1915 0.0560 −0.2475 Hsd_from_Mmd_478_l 0.1997 0.0790 0.3263 −0.2474 HSbrain_1415_r 0.1646 −0.7870 −0.5399 −0.2471 HS_141_l 0.1482 0.8423 1.0869 −0.2446 HS_from_MQbrain_1740_r 0.0750 0.1451 0.3893 −0.2442 hsa-let-7f-1_r 0.1060 −0.2858 −0.0417 −0.2440 HSbrain_180_l 0.1803 −0.1130 0.1309 −0.2440 HS_from_MQbrain_609_l 0.1159 0.4251 0.6690 −0.2439 Hsd_from_Mmd_302_r 0.0849 −0.0855 0.1577 −0.2432 HSbrain_1364_l 0.1858 0.6922 0.9342 −0.2420 HSbrain_425_l 0.1491 −0.3661 −0.1243 −0.2418 Hsd_from_Mmd_261_r 0.1522 −0.3958 −0.1542 −0.2416 HS_from_MQbrain_1725_l 0.1366 −0.2059 0.0357 −0.2416 HS_from_MQbrain_542_r 0.0482 0.0882 0.3297 −0.2416 Hsd_from_Mmd_163_r 0.1906 0.0070 0.2484 −0.2414 hsa-mir-98_r 0.0750 −0.3063 −0.0650 −0.2413 HS_from_MQbrain_812_l 0.1414 −0.7725 −0.5315 −0.2410 HS_from_MQbrain_209_r 0.0660 −0.0235 0.2170 −0.2406 HSbrain_250_r 0.0772 −0.0569 0.1834 −0.2403 Hsd_70_r 0.0350 −0.2673 −0.0273 −0.2400 HSbrain_272_l 0.0393 −0.2116 0.0282 −0.2398 HSbrain_473_l 0.0807 −0.1738 0.0656 −0.2394 HS_from_MQbrain_936_l 0.1587 −0.4116 −0.1725 −0.2391 HSbrain_50_r 0.1230 −0.2109 0.0273 −0.2383 HS_from_MQbrain_619_l 0.1243 −0.1904 0.0476 −0.2380 hsa-mir-502_l 0.1906 −0.5042 −0.2665 −0.2377 Hsd_from_Mmd_154_l 0.1243 −0.1971 0.0389 −0.2360 HS_from_MQbrain_216_l 0.1308 −0.1971 0.0379 −0.2350 HSbrain_1377_l 0.1390 −0.0599 0.1746 −0.2345 HS_95_r 0.0807 −0.1187 0.1150 −0.2338 HS_from_MQbrain_631_l 0.0913 −0.0162 0.2174 −0.2336 Hsd_62_l 0.9557 0.0230 0.2565 −0.2334 HSbrain_754_r 0.0946 −0.0715 0.1618 −0.2334 HS_from_MQbrain_467_l 0.1975 −0.0689 0.1635 −0.2324 hsa-let-7a-1_r 0.0857 −0.3519 −0.1201 −0.2319 HS_from_MM_84_r 0.0393 0.0468 0.2782 −0.2314 HS_from_PT_254_l 0.0750 −0.3623 −0.1323 −0.2300 HS_from_MQbrain_1419_r 0.1491 0.1676 0.3961 −0.2285 HS_from_MQbrain_1675_l 0.1268 −0.2295 −0.0011 −0.2284 HS_from_MQbrain_117_r 0.0772 −0.2392 −0.0108 −0.2284 hsa-mir-95_r 0.1997 −0.3852 −0.1575 −0.2277 hsa-mir-204_l 0.1975 −0.5553 −0.3280 −0.2273 hsa-mir-362_r 0.0797 −0.3608 −0.1337 −0.2271 HS_from_MQbrain_604_l 0.1597 0.3646 0.5916 −0.2271 hsa-mir-625_r 0.1078 0.0307 0.2577 −0.2270 HS_from_MQbrain_1824_l 0.1382 0.0296 0.2559 −0.2263 hsa-mir-329-1_r 0.1243 −0.2387 −0.0133 −0.2254 HSbrain_114_r 0.0928 −0.1452 0.0796 −0.2248 HSbrain_627_r 0.1482 −0.4235 −0.1994 −0.2241 hsa-mir-770_r 0.1752 0.1895 0.4135 −0.2240 HS_from_MQbrain_1253_r 0.0475 −0.2381 −0.0141 −0.2240 Hsd_from_Mmd_480_r 0.1597 0.1689 0.3926 −0.2237 Hsd_from_Mmd_70_l 0.1482 0.1279 0.3513 −0.2234 Hsd_83_l 0.0961 −0.1407 0.0815 −0.2221 HS_from_MQbrain_1855_l 0.6805 −0.1434 0.0785 −0.2220 HSbrain_594_l 0.0913 0.4548 0.6763 −0.2215 HSbrain_113_r 0.1703 0.0255 0.2461 −0.2206 HS_from_PT_60_l 0.1196 0.1413 0.3612 −0.2199 hsa-mir-30b_l 0.1196 −0.1692 0.0494 −0.2186 HS_from_MQbrain_940_r 0.1216 0.2172 0.4353 −0.2181 HS_from_MQbrain_1469_l 0.0347 0.0551 0.2730 −0.2179 HS_74_r 0.0961 −0.1955 0.0222 −0.2177 hsa-mir-412_r 0.0849 0.0196 0.2359 −0.2163 HS_from_MM_119_r 0.1159 −0.0200 0.1956 −0.2156 HS_189_r 0.0582 −0.1970 0.0183 −0.2154 HS_from_MQbrain_653_l 0.1906 −0.6406 −0.4255 −0.2150 HSbrain_652_l 0.1587 0.4008 0.6155 −0.2147 HSbrain_720_l 0.1178 −0.0996 0.1151 −0.2147 HS_86_r 0.0995 −0.1634 0.0513 −0.2147 HSbrain_1338_r 0.1243 −0.1516 0.0624 −0.2140 HSbrain_687_l 0.1752 0.3318 0.5455 −0.2138 HS_from_MQbrain_1433_r 0.1555 0.1663 0.3794 −0.2131 HS_from_MQbrain_36_r 0.1887 0.4938 0.7067 −0.2130 hsa-mir-604_l 0.0686 −0.1664 0.0462 −0.2126 Hsd_from_Mmd_330_l 0.0946 0.5116 0.7241 −0.2125 HS_from_MQbrain_56_l 0.1146 0.4742 0.6867 −0.2125 HSbrain_158_l 0.1597 0.0593 0.2717 −0.2124 Hsd_from_Mmd_527_l 0.1752 −0.1375 0.0745 −0.2120 HSbrain_744_l 0.1774 −0.3668 −0.1557 −0.2111 Hsd_from_Mmd_23_l 0.1196 −0.2557 −0.0446 −0.2111 HS_from_MQbrain_1294_l 0.5817 −0.2517 −0.0407 −0.2110 HSbrain_184_r 0.1078 −0.1485 0.0626 −0.2110 hsa-mir-659_l 0.0660 −0.1505 0.0602 −0.2107 hsa-mir-155_r 0.0686 −0.1892 0.0210 −0.2102 HSbrain_673_l 0.1587 0.4044 0.6144 −0.2100 Hsd_from_Mmd_93_r 0.0913 0.1826 0.3925 −0.2100 HS_from_PT_27_r 0.0824 −0.0549 0.1546 −0.2095 HSbrain_728_l 0.0946 −0.1601 0.0485 −0.2086 HS_from_MQbrain_1001_r 0.0750 −0.2688 −0.0603 −0.2085 HSbrain_365_l 0.0895 −0.0665 0.1420 −0.2084 HS_from_MQbrain_1684_r 0.1308 0.0111 0.2188 −0.2077 HS_from_MQbrain_1340_l 0.0583 0.1185 0.3262 −0.2077 HSbrain_661_l 0.1026 0.0881 0.2952 −0.2071 HSbrain_102_r 0.1482 0.4705 0.6774 −0.2069 HS_50_l 0.1887 0.0232 0.2298 −0.2065 HS_from_PT_44_l 0.1366 −0.1863 0.0201 −0.2064 HSbrain_85_r 0.1703 −0.2468 −0.0407 −0.2062 HS_from_MQbrain_921_l 0.1078 0.1529 0.3587 −0.2058 Hsd_from_Mmd_223_r 0.1646 −0.5801 −0.3745 −0.2056 HS_from_MM_92_r 0.0152 −0.1753 0.0302 −0.2056 HS_285_r 0.1803 0.0291 0.2342 −0.2051 Hsd_from_Mmd_471_r 0.1887 −0.1205 0.0841 −0.2046 HS_from_MQbrain_1637_r 0.1159 0.4653 0.6694 −0.2041 HSbrain_578_r 0.1555 −0.1478 0.0561 −0.2039 HS_from_MQbrain_288_r 0.1646 −0.0080 0.1957 −0.2038 HS_from_MQbrain_1292_r 0.1159 −0.1252 0.0783 −0.2034 HS_from_PT_299_r 0.0723 −0.0790 0.1233 −0.2022 HS_from_MQbrain_534_l 0.0857 −0.1529 0.0489 −0.2018 Hsd_82_r 0.1216 −0.1081 0.0918 −0.1999 HS_from_MM_198_r 0.1943 −0.0866 0.1132 −0.1998 HSbrain_677_l 0.1107 0.3804 0.5796 −0.1991 HS_77_r 0.1296 0.0324 0.2315 −0.1991 HSbrain_480_r 0.1159 0.0211 0.2202 −0.1991 HS_67_r 0.0838 −0.2695 −0.0706 −0.1989 hsa-mir-411_r 0.0582 −0.1454 0.0535 −0.1989 HS_from_MQbrain_789_r 0.1975 0.1901 0.3883 −0.1982 hsa-mir-219-1_r 0.1975 −0.4213 −0.2238 −0.1975 HSbrain_106_r 0.1078 0.5758 0.7719 −0.1961 HS_from_MM_121_l 0.0961 −0.1851 0.0104 −0.1954 hsa-mir-643_r 0.1735 −0.2678 −0.0729 −0.1949 hsa-mir-523_r 0.0347 −0.0856 0.1090 −0.1946 HS_from_MQbrain_1260_r 0.0824 −0.1165 0.0778 −0.1943 hsa-mir-135a-2_r 0.1858 0.0702 0.2640 −0.1938 HS_303_r 0.8378 0.3686 0.5622 −0.1936 HS_281_r 0.1463 −0.1699 0.0236 −0.1935 HS_from_MQbrain_969_l 0.0750 0.0714 0.2648 −0.1934 HSbrain_431_r 0.0772 −0.2366 −0.0434 −0.1932 HSbrain_705_l 0.0895 −0.0495 0.1436 −0.1931 HS_from_MQbrain_723_l 0.0913 −0.0666 0.1256 −0.1922 HS_142_l 0.1858 −0.0642 0.1274 −0.1916 HSbrain_359_l 0.0913 0.0903 0.2810 −0.1907 HS_from_MM_1_l 0.0723 −0.1459 0.0441 −0.1900 HS_99_r 0.1060 −0.0002 0.1891 −0.1893 HSbrain_393_l 0.1243 −0.4464 −0.2580 −0.1883 HSbrain_204_r 0.0772 −0.1078 0.0804 −0.1881 hsa-mir-301_l 0.0646 −0.1249 0.0628 −0.1877 HS_from_MQbrain_1292_l 0.1482 −0.4554 −0.2683 −0.1870 Hsd_from_Mmd_405_l 0.1045 −0.2070 −0.0201 −0.1869 HSbrain_408_r 0.1616 −0.0881 0.0988 −0.1869 HS_from_MQbrain_770_r 0.1447 −0.0536 0.1332 −0.1868 HS_from_MQbrain_429_l 0.1463 −0.2247 −0.0393 −0.1854 HS_208_r 0.1646 0.3023 0.4876 −0.1854 HS_from_MQbrain_133_r 0.0268 −0.0861 0.0992 −0.1853 HSbrain_621_r 0.1146 −0.2361 −0.0510 −0.1851 HSbrain_225_r 0.1196 0.1234 0.3079 −0.1844 HS_66_r 0.1482 −0.1679 0.0160 −0.1839 HSbrain_371_r 0.0913 −0.2014 −0.0177 −0.1837 HS_from_MQbrain_1372_l 0.1673 −0.0771 0.1064 −0.1835 HS_from_MQbrain_108_r 0.0686 −0.1894 −0.0065 −0.1828 HS_from_MQbrain_1088_l 0.1491 −0.2475 −0.0649 −0.1827 HS_from_MQbrain_375_l 0.1943 0.0136 0.1961 −0.1825 Hsd_from_Mmd_480_l 0.1774 0.0106 0.1927 −0.1821 HS_91_l 0.1382 0.0988 0.2809 −0.1821 HS_from_MQbrain_1657_r 0.1390 −0.1499 0.0316 −0.1815 HS_from_MQbrain_1808_r 0.1308 0.3936 0.5746 −0.1810 hsa-mir-365-2_r 0.1482 −0.5563 −0.3755 −0.1808 HSbrain_606_l 0.1196 0.1888 0.3691 −0.1803 hsa-mir-453_l 0.0327 0.0047 0.1848 −0.1802 HS_from_PT_117_r 0.1230 −0.0026 0.1772 −0.1797 HS_217_l 0.1774 0.4782 0.6578 −0.1796 HS_from_MQbrain_1394_l 0.1858 −0.6321 −0.4525 −0.1796 HSbrain_374_r 0.0583 −0.1743 0.0053 −0.1796 HS_from_MQbrain_635_r 0.1975 −0.6176 −0.4391 −0.1784 HSbrain_717_r 0.0913 −0.2831 −0.1057 −0.1774 Hsd_37_r 0.1045 −0.1041 0.0732 −0.1773 Hsd_from_Mmd_347_l 0.1597 −0.0685 0.1087 −0.1771 hsa-mir-191_r 0.1522 −0.2760 −0.0991 −0.1769 HS_from_MQbrain_1649_r 0.0995 −0.2685 −0.0919 −0.1766 HS_from_MQbrain_1272_l 0.9974 −0.0850 0.0916 −0.1766 HSbrain_123_l 0.0961 0.0016 0.1781 −0.1765 HSbrain_689_r 0.1803 −0.2996 −0.1232 −0.1764 HS_from_PT_139_r 0.1159 0.0516 0.2272 −0.1756 HSbrain_16_l 0.4115 −0.1118 0.0634 −0.1752 HSbrain_1413_l 0.1131 0.1125 0.2869 −0.1745 HS_from_MQbrain_62_l 0.1045 −0.2962 −0.1218 −0.1744 HS_from_MQbrain_1896_r 0.0772 −0.2758 −0.1017 −0.1741 HS_from_MQbrain_93_r 0.0715 −0.1611 0.0130 −0.1740 HS_105_l 0.1906 0.0160 0.1900 −0.1740 HS_from_MQbrain_283_r 0.1463 −0.2255 −0.0518 −0.1738 HSbrain_580_r 0.0750 −0.1445 0.0292 −0.1737 HS_from_MQbrain_914_l 0.1447 −0.1587 0.0150 −0.1737 HS_from_MQbrain_1545_r 0.1060 −0.4218 −0.2482 −0.1736 Hsd_from_Mmd_410_r 0.0764 −0.1101 0.0625 −0.1725 HS_from_MQbrain_268_r 0.1243 −0.0744 0.0978 −0.1722 HS_76_r 0.1178 −0.1154 0.0566 −0.1720 HS_from_MQbrain_1593_r 0.0883 −0.1606 0.0103 −0.1709 HS_from_MQbrain_681_l 0.1243 0.0405 0.2111 −0.1707 hsa-mir-133a-1_r 0.0686 −0.0303 0.1403 −0.1706 Hsd_from_Mmd_138_l 0.1026 −0.1817 −0.0111 −0.1705 HSbrain_509_l 0.1390 −0.1567 0.0138 −0.1705 HS_from_MQbrain_229_l 0.1997 −0.3770 −0.2069 −0.1701 HSbrain_1337_l 0.1975 −0.0408 0.1291 −0.1698 HS_from_MQbrain_1773_l 0.1491 0.4936 0.6634 −0.1698 HSbrain_62_r 0.0723 0.0515 0.2213 −0.1698 Hsd_from_Mmd_215_r 0.0750 −0.1552 0.0144 −0.1697 hsa-mir-588_r 0.1616 −0.2072 −0.0385 −0.1687 HSbrain_643_l 0.1752 0.0096 0.1777 −0.1680 Hsd_from_Mmd_217_r 0.1803 −0.1955 −0.0280 −0.1675 HS_from_MQbrain_1031_r 0.0995 −0.3459 −0.1786 −0.1673 HSbrain_468_r 0.0715 0.0630 0.2298 −0.1669 HS_from_MQbrain_1556_r 0.1752 −0.3436 −0.1771 −0.1665 HS_from_MQbrain_1708_l 0.1752 0.0083 0.1743 −0.1661 HS_from_MQbrain_212_r 0.1997 −0.1164 0.0494 −0.1658 Hsd_from_Mmd_81_r 0.1943 −0.2170 −0.0521 −0.1649 HS_from_MQbrain_691_r 0.1887 −0.3130 −0.1483 −0.1647 HS_from_PT_27_l 0.1906 −0.1018 0.0621 −0.1639 HS_190_r 0.1463 0.0420 0.2057 −0.1637 HS_from_MQbrain_566_l 0.0928 0.0128 0.1755 −0.1627 HSbrain_461_r 0.1146 −0.1663 −0.0037 −0.1626 HS_47_l 0.1803 −0.2518 −0.0898 −0.1620 HS_from_MQbrain_332_l 0.1414 −0.2211 −0.0595 −0.1616 HS_from_MQbrain_266_r 0.0750 −0.0878 0.0737 −0.1615 HS_61_r 0.1703 −0.5331 −0.3716 −0.1615 HS_from_MQbrain_710_r 0.1703 0.1180 0.2786 −0.1606 hsa-mir-616_r 0.1555 −0.1860 −0.0254 −0.1606 HS_from_MQbrain_482_l 0.1703 −0.1412 0.0188 −0.1600 HS_from_MM_80_l 0.1906 −0.1170 0.0431 −0.1600 hsa-mir-30b_r 0.1454 0.1418 0.3007 −0.1589 Hsd_from_Mmd_424_l 0.1555 −0.1584 0.0002 −0.1586 HS_292_l 0.4115 −0.0648 0.0934 −0.1582 Hsd_from_Mmd_396_l 0.1390 −0.3295 −0.1716 −0.1579 HS_from_MQbrain_1722_l 0.1616 0.2108 0.3684 −0.1576 HSbrain_591_l 0.0946 0.2730 0.4305 −0.1575 HSbrain_794_l 0.1774 0.2067 0.3638 −0.1571 HS_from_MM_311_l 0.1673 −0.2655 −0.1088 −0.1567 Hsd_12_r 0.1131 −0.2890 −0.1328 −0.1562 HS_from_MQbrain_1443_r 0.0849 0.3428 0.4988 −0.1560 HSbrain_506_r 0.1587 −0.1682 −0.0125 −0.1557 HSbrain_472_l 0.0913 −0.0300 0.1255 −0.1555 HSbrain_50_l 0.1131 0.1314 0.2857 −0.1543 HS_from_PT_115_r 0.1752 −0.1110 0.0432 −0.1542 HSbrain_696_r 0.1078 −0.0376 0.1164 −0.1540 HSbrain_495_r 0.1482 0.1239 0.2778 −0.1539 HS_50_r 0.1308 −0.1876 −0.0341 −0.1535 HSbrain_809_r 0.1906 0.2931 0.4465 −0.1534 HS_from_MQbrain_1549_l 0.1347 −0.2547 −0.1022 −0.1525 HS_77_l 0.1858 0.0084 0.1598 −0.1514 HS_from_MQbrain_699_r 0.1673 0.1013 0.2519 −0.1506 HSbrain_111_l 0.5053 −0.1097 0.0400 −0.1497 hsa-mir-365-2_l 0.0750 0.0933 0.2418 −0.1484 hsa-mir-655_l 0.1463 −0.0490 0.0991 −0.1481 HSbrain_214_l 0.4679 0.0466 0.1946 −0.1480 HS_138_l 0.1843 −0.1893 −0.0420 −0.1474 HSbrain_139_r 0.1454 −0.1193 0.0278 −0.1471 Hsd_95_l 0.1906 −0.6306 −0.4846 −0.1460 HS_from_MQbrain_397_l 0.1906 −0.1741 −0.0283 −0.1458 HS_from_MQbrain_444_r 0.1646 0.1288 0.2734 −0.1446 HS_from_MM_190_l 0.1975 −0.4987 −0.3542 −0.1445 HSbrain_690_l 0.1774 0.0326 0.1771 −0.1445 hsa-mir-146a_r 0.0849 −0.0432 0.1010 −0.1442 hsa-mir-550-2_r 0.1943 −0.0900 0.0541 −0.1441 hsa-mir-296_l 0.1646 −0.0608 0.0819 −0.1427 HS_182_r 0.1843 −0.2247 −0.0828 −0.1419 Hsd_from_Mmd_176_r 0.1703 −0.0565 0.0852 −0.1417 HS_109_r 0.1774 −0.0011 0.1404 −0.1415 HSbrain_651_r 0.1997 0.2192 0.3603 −0.1411 HS_from_MQbrain_1517_r 0.1997 0.1558 0.2969 −0.1411 HSbrain_231_l 0.0772 0.1866 0.3274 −0.1407 Hsd_from_Mmd_511_r 0.0883 −0.2432 −0.1055 −0.1378 Hsd_from_Mmd_530_l 0.1943 −0.2262 −0.0894 −0.1368 HS_from_MQbrain_1365_l 0.1906 0.0966 0.2333 −0.1366 HS_from_MQbrain_886_r 0.1390 0.0272 0.1632 −0.1360 HSbrain_771_l 0.1268 0.2639 0.3996 −0.1357 HS_from_MQbrain_272_l 0.1858 0.0712 0.2065 −0.1353 hsa-mir-217_r 0.1463 −0.2236 −0.0892 −0.1344 HS_from_MQbrain_1776_r 0.1216 0.0480 0.1819 −0.1338 HS_54_r 0.0849 −0.0037 0.1294 −0.1332 HSbrain_588_r 0.1997 0.1444 0.2767 −0.1324 Hsd_from_Mmd_501_l 0.1482 −0.4092 −0.2770 −0.1321 HSbrain_220_r 0.1347 0.0358 0.1672 −0.1314 hsa-mir-374_l 0.1774 −0.3352 −0.2048 −0.1304 Hsd_from_Mmd_509_l 0.9380 −0.1612 −0.0309 −0.1303 HS_from_MQbrain_1215_l 0.1616 −0.0358 0.0941 −0.1300 HS_from_MQbrain_968_r 0.1906 0.2716 0.4008 −0.1292 HSbrain_75_l 0.1463 0.3039 0.4328 −0.1289 HSbrain_593_r 0.1803 0.0733 0.2020 −0.1286 HS_from_MQbrain_1677_r 0.1026 −0.1597 −0.0327 −0.1271 hsa-mir-579_r 0.1555 −0.2613 −0.1347 −0.1266 HS_from_MQbrain_496_r 0.1703 0.1682 0.2947 −0.1265 hsa-mir-365-1_l 0.1803 0.0808 0.2059 −0.1251 Hsd_from_Mmd_500_l 0.1463 −0.1701 −0.0480 −0.1221 Hsd_from_Mmd_97_l 0.1735 −0.1030 0.0191 −0.1221 HS_from_MM_86_l 0.8260 −0.2663 −0.1444 −0.1219 HS_from_MQbrain_1667_r 0.1703 −0.1889 −0.0693 −0.1197 HSbrain_970_l 0.1752 0.0116 0.1296 −0.1180 HS_from_MQbrain_55_l 0.1943 −0.0142 0.1033 −0.1175 HS_from_MM_18_r 0.0772 −0.0044 0.1124 −0.1168 HS_from_MQbrain_266_l 0.1230 −0.1340 −0.0176 −0.1164 HS_from_MQbrain_626_r 0.1906 −0.2955 −0.1793 −0.1162 HS_from_MQbrain_188_l 0.1843 −0.1215 −0.0061 −0.1154 hsa-mir-510_r 0.1447 −0.1753 −0.0616 −0.1137 HS_from_MQbrain_22_l 0.1858 −0.1168 −0.0031 −0.1137 HS_from_MQbrain_405_r 0.1906 0.0400 0.1535 −0.1135 hsa-mir-132_l 0.1673 −0.1141 −0.0028 −0.1113 HS_from_MQbrain_536_r 0.1555 0.0700 0.1803 −0.1103 HS_from_MQbrain_686_l 0.1587 −0.1259 −0.0163 −0.1096 hsa-mir-488_l 0.1414 −0.0494 0.0599 −0.1094 HS_278_l 0.1382 0.1250 0.2333 −0.1083 HSbrain_590_l 0.1347 −0.0842 0.0232 −0.1075 HS_from_MQbrain_1164_l 0.1454 0.0403 0.1464 −0.1061 HSbrain_621_l 0.1843 −0.0817 0.0237 −0.1054 HS_from_MM_200_l 0.1326 −0.1041 0.0013 −0.1054 HSbrain_583_r 0.0583 −0.1173 −0.0120 −0.1053 HS_from_MQbrain_1412_l 0.1230 0.1293 0.2345 −0.1053 HSbrain_337_r 0.1390 −0.0716 0.0318 −0.1034 hsa-mir-568_l 0.1997 −0.1221 −0.0196 −0.1025 hsa-mir-518e_r 0.1887 −0.1142 −0.0117 −0.1025 HS_from_MQbrain_1346_r 0.1887 −0.2318 −0.1299 −0.1019 HSbrain_540_l 0.1752 0.0056 0.1047 −0.0991 HS_from_MQbrain_1261_r 0.1230 −0.0828 0.0160 −0.0988 hsa-mir-124a-1_l 0.0723 0.0336 0.1293 −0.0957 HS_from_MQbrain_1470_l 0.1178 −0.0139 0.0777 −0.0916 HS_from_MQbrain_722_l 0.1308 −0.0176 0.0720 −0.0896 Hsd_from_Mmd_443_l 0.1673 −0.0381 0.0485 −0.0866 HS_from_MQbrain_1224_r 0.1482 −0.0994 −0.0129 −0.0865 Hsd_from_Mmd_181_r 0.1159 −0.0374 0.0490 −0.0864 HS_223_r 0.1414 0.0531 0.1369 −0.0838 Hsd_from_Mmd_503_l 0.1308 −0.1190 −0.0353 −0.0836 HS_from_MM_288_l 0.1454 −0.0096 0.0740 −0.0836 hsa-mir-646_r 0.0995 −0.0048 0.0781 −0.0829 hsa-mir-638_r 0.0583 0.0812 0.1608 −0.0796 HS_56_l 0.1308 −0.0116 0.0680 −0.0796 HS_from_MQbrain_221_r 0.1026 −0.0042 0.0746 −0.0788 Hsd_from_Mmd_253_l 0.1906 −0.0633 0.0133 −0.0767 HS_from_MQbrain_1347_r 0.1906 −0.0721 0.0038 −0.0759 hsa-mir-454_l 0.1366 −0.0405 0.0339 −0.0744 HS_from_MM_102_r 0.1347 −0.0463 0.0268 −0.0731 Hsd_from_Mmd_178_l 0.1975 −0.1519 −0.0804 −0.0715 HS_from_MQbrain_1301_r 0.0727 0.0246 0.0959 −0.0712 HS_from_PT_196_l 0.0807 −0.0244 0.0458 −0.0702 HS_88_r 0.1296 0.0150 0.0851 −0.0702 Hsd_30_l 0.0961 0.0292 0.0977 −0.0685 HSbrain_792_r 0.0807 0.0264 0.0947 −0.0683 HS_133_l 0.1463 −0.0065 0.0603 −0.0668 HS_from_MM_48_l 0.1366 0.1246 0.1911 −0.0665 HS_from_MM_150_r 0.0995 −0.0279 0.0375 −0.0654 HSbrain_698_r 0.1414 −0.0004 0.0647 −0.0651 HS_from_MQbrain_355_l 0.0807 −0.0045 0.0599 −0.0644 hsa-mir-623_r 0.1943 −0.0515 0.0121 −0.0636 HS_from_MQbrain_897_r 0.1268 −0.0204 0.0421 −0.0626 hsa-mir-369_l 0.1382 −0.0286 0.0338 −0.0624 Hsd_8_r 0.1858 −0.0038 0.0586 −0.0623 HS_237_r 0.1366 0.0169 0.0784 −0.0616 hsa-mir-16-1_r 0.1230 −0.0390 0.0196 −0.0586 HS_from_MQbrain_161_l 0.1382 0.0008 0.0592 −0.0584 HS_from_MQbrain_2087_r 0.1107 0.0153 0.0700 −0.0547 HS_from_MQbrain_348_r 0.1366 −0.0149 0.0393 −0.0543 HSbrain_244_l 0.1482 0.0418 0.0947 −0.0529 HS_286_r 0.1482 −0.0309 0.0193 −0.0502 HSbrain_791_l 0.4298 0.0097 0.0585 −0.0488 HS_from_MQbrain_716_l 0.1026 0.0412 0.0882 −0.0470 HSbrain_692_l 0.1597 0.0513 0.0981 −0.0468 HS_from_MQbrain_661_r 0.1803 0.0243 0.0554 −0.0310 HSbrain_541_r 0.1230 0.0318 −0.0137 0.0456 HS_45_r 0.1522 0.0495 −0.0050 0.0546 HS_from_MQbrain_1569_l 0.2259 0.0655 0.0071 0.0584 HSbrain_599_r 0.1616 0.0538 −0.0110 0.0648 HS_from_MQbrain_181_l 0.0983 0.1268 0.0570 0.0698 HS_from_MQbrain_1263_r 0.0552 0.0127 −0.0594 0.0720 HSbrain_222_r 0.1366 0.1026 0.0247 0.0779 HS_from_MQbrain_859_l 0.1887 0.2026 0.1234 0.0791 HS_from_MM_124_l 0.1616 −0.0937 −0.1730 0.0794 HS_from_MQbrain_660_l 0.0518 0.0998 0.0085 0.0913 HSbrain_166_l 0.1858 −0.0447 −0.1380 0.0932 Hsd_from_Mmd_398_r 0.1414 −0.0587 −0.1524 0.0937 HS_113_l 0.1587 0.0450 −0.0512 0.0962 HS_from_MQbrain_1100_r 0.1997 0.0682 −0.0296 0.0979 HSbrain_80_l 0.1858 −0.0297 −0.1284 0.0987 HS_from_MQbrain_1110_l 0.1597 0.0443 −0.0555 0.0998 HS_from_MQbrain_1127_r 0.1060 0.2349 0.1325 0.1024 HS_from_MQbrain_38_r 0.1326 0.1501 0.0452 0.1048 HSbrain_545_r 0.0142 0.0498 −0.0564 0.1061 HSbrain_757_r 0.0824 −0.0055 −0.1133 0.1078 HS_from_PT_211_r 0.1774 −0.0027 −0.1119 0.1092 HS_from_MQbrain_1091_l 0.1752 0.0075 −0.1034 0.1110 HS_from_MQbrain_1354_r 0.1858 −0.0965 −0.2127 0.1162 HS_from_PT_91_r 0.1597 0.0486 −0.0679 0.1164 HS_from_MQbrain_1421_l 0.1943 0.1286 0.0121 0.1165 Hsd_from_Mmd_197_l 0.1587 0.0412 −0.0754 0.1166 HS_130_l 0.9053 0.1136 −0.0044 0.1180 HSbrain_266_r 0.1045 0.0253 −0.0941 0.1194 HS_from_MQbrain_1845_l 0.1326 −0.0250 −0.1500 0.1250 HS_from_MQbrain_734_l 0.1752 −0.1549 −0.2813 0.1264 HS_from_MQbrain_1777_l 0.1752 −0.2554 −0.3845 0.1292 HS_from_MQbrain_1747_l 0.1997 0.1017 −0.0294 0.1310 HSbrain_177_r 0.1491 −0.1879 −0.3196 0.1316 HS_from_MQbrain_1632_l 0.1216 0.0119 −0.1227 0.1346 Hsd_32_r 0.1390 0.0226 −0.1123 0.1350 HSbrain_803_l 0.0575 −0.0430 −0.1804 0.1374 Hsd_from_Mmd_189_l 0.0764 −0.1958 −0.3349 0.1391 HS_from_MQbrain_1405_l 0.1997 0.5801 0.4407 0.1394 HSbrain_663_l 0.1616 0.1353 −0.0050 0.1403 HS_from_MQbrain_1876_r 0.1673 0.1051 −0.0379 0.1431 HS_from_PT_134_l 0.1491 −0.2217 −0.3658 0.1441 HS_265_l 0.1597 0.1908 0.0446 0.1463 hsa-mir-338_l 0.1555 −0.1400 −0.2904 0.1503 HS_from_MQbrain_715_l 0.1326 −0.0648 −0.2180 0.1532 HS_from_MQbrain_550_l 0.1803 −0.1402 −0.2938 0.1536 HSbrain_270_r 0.1887 0.4395 0.2855 0.1540 HS_from_MQbrain_1070_r 0.1326 −0.1357 −0.2898 0.1541 HSbrain_32_l 0.1858 −0.1929 −0.3496 0.1568 HS_from_MQbrain_1134_r 0.0686 −0.0065 −0.1636 0.1571 HSbrain_316_l 0.3713 −0.1454 −0.3027 0.1573 HS_83_r 0.0857 0.0508 −0.1071 0.1580 hsa-mir-204_r 0.1447 −0.2259 −0.3840 0.1581 HS_from_MQbrain_57_l 0.1735 0.0953 −0.0629 0.1582 HSbrain_305_r 0.1216 −0.1436 −0.3029 0.1593 HSbrain_347_l 0.1774 −0.2324 −0.3918 0.1594 Hsd_24_r 0.1975 −0.0114 −0.1712 0.1598 HS_from_MQbrain_991_r 0.1803 0.1429 −0.0174 0.1603 HS_from_MM_199_l 0.1463 0.3322 0.1697 0.1625 HSbrain_307_r 0.1463 −0.1357 −0.2985 0.1628 HS_from_MQbrain_70_l 0.1382 −0.1727 −0.3365 0.1638 HS_from_MQbrain_675_l 0.1906 −0.4637 −0.6279 0.1641 Hsd_from_Mmd_155_l 0.1326 −0.1095 −0.2741 0.1646 HS_from_MQbrain_58_l 0.0715 0.1904 0.0244 0.1660 HS_from_MQbrain_435_r 0.0727 0.0635 −0.1030 0.1665 hsa-mir-224_r 0.0961 0.0285 −0.1386 0.1671 HS_from_MQbrain_1331_r 0.1414 −0.1794 −0.3465 0.1671 HS_from_MQbrain_1793_r 0.0961 −0.1079 −0.2750 0.1671 HS_from_MQbrain_500_r 0.1975 0.3684 0.2013 0.1671 hsa-mir-622_l 0.1597 −0.1693 −0.3370 0.1676 hsa-mir-196a-2_r 0.1382 0.0451 −0.1226 0.1677 HSbrain_799_r 0.0824 0.2293 0.0603 0.1690 HSbrain_588_l 0.1131 0.0224 −0.1503 0.1727 HSbrain_622_r 0.1491 0.1098 −0.0630 0.1728 HS_from_MQbrain_382_l 0.1326 0.0976 −0.0752 0.1728 Hsd_from_Mmd_371_r 0.0582 −0.0728 −0.2467 0.1739 HSbrain_440_l 0.1131 −0.0596 −0.2359 0.1763 HS_from_MQbrain_600_l 0.1366 −0.0334 −0.2099 0.1765 HS_from_PT_140_l 0.1010 0.2516 0.0718 0.1799 HS_from_PT_238_l 0.1906 −0.4074 −0.5879 0.1805 HSbrain_717_l 0.1522 −0.2717 −0.4527 0.1810 HS_167_r 0.1597 0.2377 0.0559 0.1818 HS_from_PT_34_r 0.1752 −0.1093 −0.2912 0.1819 HS_from_MQbrain_1355_r 0.0895 0.1201 −0.0637 0.1838 HSbrain_779_r 0.1390 0.1375 −0.0471 0.1846 HSbrain_753_r 0.1382 −0.0459 −0.2316 0.1857 Hsd_from_Mmd_237_l 0.0715 0.0317 −0.1542 0.1859 HS_from_MQbrain_974_l 0.1196 −0.4263 −0.6131 0.1868 HSbrain_235_l 0.0995 0.0495 −0.1380 0.1875 HS_from_MQbrain_1143_l 0.1447 0.4623 0.2739 0.1884 HS_from_MQbrain_1836_l 0.1382 0.0869 −0.1029 0.1899 HS_208_l 0.0857 0.1582 −0.0327 0.1910 Hsd_from_Mmd_535_r 0.1463 −0.2617 −0.4530 0.1912 HS_from_MQbrain_1631_r 0.1803 −0.2025 −0.3937 0.1913 HSbrain_402_l 0.1230 0.0139 −0.1784 0.1923 HSbrain_483_r 0.1735 0.3383 0.1454 0.1928 HS_from_MQbrain_1204_r 0.1454 −0.2815 −0.4745 0.1930 Hsd_84_r 0.1843 −0.0011 −0.1954 0.1944 HSbrain_755_l 0.1943 −0.2320 −0.4270 0.1950 HS_from_MQbrain_842_l 0.1146 0.2444 0.0494 0.1950 HS_from_PT_126_l 0.1887 0.1428 −0.0524 0.1953 Hsd_85_r 0.0347 0.0470 −0.1495 0.1964 HS_from_MQbrain_81_l 0.0913 −0.1585 −0.3556 0.1971 HS_from_MQbrain_401_l 0.1673 −0.1565 −0.3546 0.1981 HS_from_MQbrain_1752_l 0.1752 0.1844 −0.0138 0.1982 HS_from_MM_103_l 0.0750 0.0450 −0.1537 0.1987 HS_from_MQbrain_1420_l 0.1347 −0.1887 −0.3875 0.1989 HS_111_r 0.1522 −0.2558 −0.4548 0.1990 HSbrain_627_l 0.0838 −0.0780 −0.2773 0.1993 HSbrain_1414_r 0.1774 −0.2852 −0.4850 0.1998 HS_101_l 0.1326 −0.2799 −0.4797 0.1998 HSbrain_289_r 0.1975 0.4494 0.2486 0.2008 HSbrain_236_l 0.0807 0.0995 −0.1022 0.2017 Hsd_106_l 0.0849 −0.1324 −0.3348 0.2025 HS_from_MQbrain_628_l 0.8957 0.0715 −0.1310 0.2025 hsa-mir-148a_l 0.0528 0.0097 −0.1991 0.2088 HS_from_MM_251_r 0.0393 −0.0801 −0.2890 0.2089 HS_220_l 0.1587 0.0739 −0.1351 0.2090 HSbrain_568_r 0.1774 0.0532 −0.1559 0.2091 HSbrain_783_l 0.1308 −0.0263 −0.2354 0.2091 HS_from_MQbrain_1748_r 0.1010 0.0386 −0.1705 0.2092 HS_from_MM_131_l 0.1843 −0.0517 −0.2614 0.2097 HS_from_MQbrain_819_r 0.1906 −0.3540 −0.5641 0.2101 HS_from_MQbrain_1075_l 0.1230 −0.4380 −0.6483 0.2102 HS_119_l 0.0772 0.1335 −0.0767 0.2102 HS_from_MQbrain_1494_r 0.0849 −0.0801 −0.2906 0.2105 HS_from_MQbrain_1832_l 0.0715 −0.1609 −0.3718 0.2109 Hsd_from_Mmd_261_l 0.0849 −0.0120 −0.2232 0.2112 HS_39_r 0.1414 −0.2181 −0.4298 0.2117 HS_from_MQbrain_1645_l 0.1646 −0.0691 −0.2820 0.2130 HS_62_l 0.1347 −0.3506 −0.5637 0.2131 HSbrain_187_r 0.0501 0.0264 −0.1868 0.2133 HSbrain_787_l 0.1454 0.4111 0.1961 0.2150 HS_from_MQbrain_1470_r 0.1774 0.4504 0.2350 0.2154 HS_from_MQbrain_869_l 0.0727 −0.1902 −0.4057 0.2155 HSbrain_780_r 0.0501 0.1250 −0.0914 0.2164 HSbrain_755_r 0.1975 −0.4185 −0.6350 0.2165 HS_58_l 0.1491 0.2550 0.0375 0.2175 HSbrain_328_l 0.0824 0.0093 −0.2094 0.2187 HS_54_l 0.1454 −0.0577 −0.2771 0.2194 HSbrain_644_r 0.1597 0.3969 0.1772 0.2197 HS_from_MQbrain_72_r 0.0913 −0.0812 −0.3023 0.2212 HS_102_l 0.1146 −0.3072 −0.5284 0.2212 HSbrain_692_r 0.1774 0.1442 −0.0771 0.2213 HS_from_MQbrain_1164_r 0.1146 0.0905 −0.1309 0.2214 HSbrain_25_r 0.0624 0.0766 −0.1466 0.2232 HSbrain_336_l 0.6371 0.3315 0.1075 0.2240 HSbrain_708_l 0.1196 −0.2608 −0.4850 0.2242 Hsd_from_Mmd_487_r 0.1414 −0.3042 −0.5289 0.2248 HS_49_r 0.0883 0.3921 0.1671 0.2250 HS_from_MQbrain_22_r 0.1060 −0.0274 −0.2525 0.2251 Hsd_from_Mmd_52_r 0.1107 −0.4921 −0.7174 0.2253 HSbrain_479_l 0.1975 0.3579 0.1326 0.2253 HS_from_PT_188_l 0.1491 −0.0426 −0.2680 0.2255 HS_110_r 0.1491 −0.4924 −0.7179 0.2255 HS_from_MQbrain_941_r 0.0169 0.0176 −0.2083 0.2259 HSbrain_210_l 0.1975 −0.1228 −0.3499 0.2270 HSbrain_452_l 0.0983 0.0356 −0.1920 0.2276 HSbrain_647_r 0.1482 −0.0282 −0.2564 0.2282 HSbrain_431_l 0.1587 −0.3079 −0.5368 0.2290 HSbrain_82_r 0.1447 0.2629 0.0330 0.2300 HSbrain_182_r 0.0723 −0.1808 −0.4110 0.2302 HSbrain_226_r 0.0501 0.1638 −0.0666 0.2304 HS_from_MQbrain_1102_l 0.1296 −0.2855 −0.5159 0.2305 HS_204_r 0.1522 −0.5105 −0.7412 0.2306 Hsd_27_r 0.0895 0.3963 0.1656 0.2307 HSbrain_12_l 0.8957 −0.0603 −0.2920 0.2317 hsa-mir-328_r 0.1414 −0.4172 −0.6491 0.2319 HS_from_MQbrain_1437_l 0.1906 −0.0115 −0.2437 0.2323 HS_from_MQbrain_745_r 0.1887 −0.0589 −0.2916 0.2328 HS_191_r 0.1752 −0.3362 −0.5699 0.2336 Hsd_from_Mmd_120_r 0.1843 −0.1897 −0.4250 0.2353 HSbrain_155_r 0.1230 0.1793 −0.0573 0.2366 HS_from_MQbrain_1339_r 0.1107 −0.0438 −0.2806 0.2367 HSbrain_135_l 0.0946 0.0917 −0.1464 0.2382 HSbrain_476_r 0.0474 0.3016 0.0629 0.2386 HS_from_MQbrain_1072_l 0.0211 0.2237 −0.0152 0.2389 HS_from_MQbrain_914_l 0.1447 −0.5145 −0.7543 0.2398 HSbrain_1298_r 0.0750 −0.0314 −0.2713 0.2399 HS_from_PT_308_l 0.0807 0.0766 −0.1644 0.2410 HS_from_MQbrain_433_l 0.1045 −0.2539 −0.4951 0.2413 HS_139_l 0.1491 −0.1113 −0.3536 0.2422 hsa-mir-138-2_l 0.1997 0.0850 −0.1584 0.2433 HS_98_r 0.3012 −0.3911 −0.6348 0.2436 HS_from_MQbrain_1442_l 0.1774 0.2928 0.0472 0.2456 HS_from_MQbrain_1415_r 0.1997 −0.3303 −0.5761 0.2458 HSbrain_380_r 0.1308 −0.1815 −0.4274 0.2459 HS_171_r 0.0946 −0.0267 −0.2742 0.2476 HSbrain_726_r 0.1390 0.0170 −0.2306 0.2476 HS_from_MQbrain_504_r 0.0723 −0.1830 −0.4323 0.2493 HS_from_PT_226_l 0.0224 0.1161 −0.1333 0.2494 hsa-mir-584_r 0.0857 0.0466 −0.2029 0.2495 HSbrain_256_r 0.1230 0.8466 0.5964 0.2502 HS_from_MQbrain_1185_l 0.1131 −0.4464 −0.6973 0.2509 HSbrain_703_r 0.0772 −0.2492 −0.5002 0.2510 HSbrain_91_r 0.1597 −0.3890 −0.6401 0.2510 HS_from_MQbrain_852_l 0.1060 0.3566 0.1052 0.2514 HS_from_MQbrain_868_l 0.1616 −0.1609 −0.4128 0.2519 HS_from_PT_157_r 0.1858 −0.3869 −0.6391 0.2522 HS_97_r 0.1268 0.4079 0.1554 0.2524 hsa-mir-640_l 0.1216 0.1046 −0.1481 0.2527 HS_from_MQbrain_804_r 0.1390 −0.0330 −0.2871 0.2541 HS_from_MQbrain_1116_r 0.1045 −0.4187 −0.6729 0.2542 Hsd_from_Mmd_491_r 0.0928 0.0936 −0.1626 0.2562 HSbrain_3_l 0.1390 0.5138 0.2568 0.2570 HS_from_MQbrain_1839_l 0.1616 −0.4341 −0.6922 0.2581 HS_from_MQbrain_1357_l 0.1997 −0.0965 −0.3549 0.2584 HS_from_MQbrain_1753_r 0.1597 0.4978 0.2387 0.2590 hsa-mir-222_r 0.1906 0.2426 −0.0186 0.2612 HS_from_PT_128_l 0.1159 −0.1656 −0.4278 0.2622 HSbrain_441_r 0.1196 −0.2577 −0.5199 0.2622 HS_from_MM_219_l 0.0913 0.1577 −0.1047 0.2624 HSbrain_703_l 0.1010 −0.1804 −0.4430 0.2627 HS_from_MQbrain_1893_r 0.0983 0.4642 0.2015 0.2627 HS_from_MQbrain_365_r 0.0425 0.0118 −0.2520 0.2638 HS_from_MQbrain_1750_r 0.0379 −0.3565 −0.6204 0.2639 HS_from_MQbrain_1374_l 0.1045 −0.1628 −0.4296 0.2668 HSbrain_141_r 0.1887 −0.0643 −0.3312 0.2669 HSbrain_691_l 0.5142 −0.5974 −0.8650 0.2676 HS_from_MQbrain_814_l 0.1243 0.3611 0.0916 0.2695 HS_from_MQbrain_1426_r 0.0075 0.2004 −0.0691 0.2695 HS_from_MQbrain_392_l 0.0913 0.1809 −0.0887 0.2696 HS_from_MQbrain_1514_r 0.1975 −0.5681 −0.8383 0.2703 HS_from_MQbrain_996_l 0.1078 −0.0702 −0.3413 0.2712 HS_from_MQbrain_1882_r 0.1597 0.5063 0.2350 0.2712 HS_from_MQbrain_140_l 0.1296 0.3493 0.0774 0.2719 Hsd_from_Mmd_391_l 0.0706 0.1694 −0.1026 0.2720 HS_from_MQbrain_597_l 0.0895 −0.3044 −0.5765 0.2722 HS_from_MQbrain_437_l 0.1752 −0.2897 −0.5627 0.2730 HSbrain_384_l 0.0347 0.1094 −0.1638 0.2732 HS_from_MQbrain_984_l 0.0393 −0.1493 −0.4234 0.2742 HSbrain_497_l 0.1887 −0.5058 −0.7804 0.2746 HSbrain_1416_r 0.1390 −0.5420 −0.8166 0.2746 HS_from_MQbrain_163_l 0.0501 −0.3703 −0.6453 0.2750 HSbrain_43_r 0.1268 −0.0957 −0.3712 0.2755 Hsd_80_r 0.1735 −0.6000 −0.8786 0.2786 HS_from_PT_287_r 0.0459 0.1585 −0.1203 0.2788 HS_from_MM_260_l 0.1178 0.4785 0.1992 0.2793 HSbrain_626_r 0.1703 −0.4710 −0.7508 0.2798 HS_from_MQbrain_1537_r 0.1060 −0.2818 −0.5642 0.2824 Hsd_from_Mmd_413_r 0.0646 −0.1419 −0.4246 0.2827 Hsd_from_Mmd_370_r 0.1735 0.3001 0.0169 0.2832 HS_154_r 0.1216 −0.4284 −0.7119 0.2836 HS_from_MM_276_l 0.1146 0.0308 −0.2531 0.2839 Hsd_106_r 0.1616 0.4018 0.1163 0.2855 HSbrain_22_l 0.1997 0.1279 −0.1588 0.2867 hsa-mir-125b-2_l 0.1673 0.0719 −0.2185 0.2904 Hsd_from_Mmd_473_l 0.0750 0.0392 −0.2513 0.2905 HS_from_MQbrain_1376_r 0.1673 0.6193 0.3272 0.2921 HS_from_MQbrain_1675_r 0.0849 −0.1068 −0.3996 0.2929 HS_from_MQbrain_1565_l 0.0501 0.0842 −0.2086 0.2929 HS_from_MM_39_l 0.0723 0.1386 −0.1547 0.2934 HSbrain_662_r 0.1858 0.7747 0.4809 0.2938 HS_from_MM_174_l 0.0379 −0.0310 −0.3253 0.2943 Hsd_from_Mmd_222_l 0.0723 0.5247 0.2299 0.2947 HSbrain_494_l 0.6640 0.0672 −0.2279 0.2951 hsa-mir-524_l 0.1997 0.2315 −0.0642 0.2958 HS_from_MQbrain_1006_l 0.0723 −0.2964 −0.5932 0.2968 HS_from_MM_275_r 0.0772 0.1444 −0.1526 0.2969 HS_from_MQbrain_1444_l 0.5661 −0.2300 −0.5274 0.2974 HS_from_MQbrain_597_r 0.0849 −0.3089 −0.6064 0.2975 HSbrain_190_r 0.1975 0.8006 0.5006 0.3001 Hsd_from_Mmd_485_r 0.0501 −0.2526 −0.5532 0.3006 HSbrain_250_l 0.1382 −0.0881 −0.3897 0.3015 HS_from_MQbrain_697_l 0.1382 −0.2157 −0.5181 0.3024 HS_from_MQbrain_560_r 0.1735 −0.4285 −0.7312 0.3027 HS_from_MQbrain_629_r 0.1555 −0.6726 −0.9758 0.3032 HSbrain_465_l 0.0946 −0.2773 −0.5814 0.3040 HSbrain_252_l 0.0528 −0.1922 −0.4989 0.3067 HS_from_MQbrain_1817_l 0.1482 0.6469 0.3397 0.3072 HSbrain_795_r 0.1146 −0.3575 −0.6648 0.3072 Hsd_from_Mmd_117_r 0.1026 −0.2234 −0.5320 0.3086 HSbrain_1406_l 0.0727 0.0109 −0.2986 0.3095 HSbrain_77_l 0.0474 −0.0601 −0.3710 0.3109 HS_from_MQbrain_71_l 0.0582 −0.3977 −0.7098 0.3120 HS_from_MQbrain_906_l 0.1463 −0.0012 −0.3135 0.3124 HSbrain_14_r 0.1010 0.2815 −0.0313 0.3128 HSbrain_778_l 0.1843 0.0025 −0.3107 0.3132 HSbrain_305_l 0.1597 −0.7574 −1.0710 0.3136 HSbrain_726_l 0.1326 −0.6046 −0.9189 0.3143 HSbrain_319_l 0.0797 0.0842 −0.2316 0.3159 HS_from_MQbrain_178_r 0.1390 −0.3678 −0.6837 0.3160 HS_from_PT_338_l 0.1673 −0.3606 −0.6772 0.3166 HSbrain_438_r 0.0475 0.2503 −0.0664 0.3167 HSbrain_764_r 0.0857 0.2727 −0.0448 0.3176 HS_from_MM_118_r 0.0446 −0.2376 −0.5555 0.3179 HS_from_MQbrain_64_l 0.1454 0.2943 −0.0251 0.3193 HS_175_l 0.1454 −0.5896 −0.9091 0.3195 HS_from_MQbrain_1877_l 0.0913 0.0926 −0.2269 0.3195 HS_200_r 0.0727 −0.3033 −0.6237 0.3204 HSbrain_157_l 0.1735 −0.5154 −0.8373 0.3219 HS_from_MQbrain_777_r 0.1131 −0.1654 −0.4873 0.3220 HSbrain_437_r 0.0501 0.2708 −0.0515 0.3223 HS_from_MQbrain_587_l 0.1616 −0.4611 −0.7836 0.3226 HS_from_MQbrain_1792_r 0.0185 0.0272 −0.2956 0.3228 HSbrain_168_l 0.1673 −0.3405 −0.6643 0.3238 HS_from_MQbrain_399_l 0.1390 0.2627 −0.0624 0.3251 Hsd_42_l 0.0838 −0.3226 −0.6499 0.3272 hsa-mir-632_l 0.1243 0.3509 0.0234 0.3275 HSbrain_719_l 0.0995 0.3897 0.0612 0.3285 HS_from_MQbrain_1623_r 0.0849 −0.1231 −0.4520 0.3290 HS_from_MQbrain_1085_l 0.1010 −0.6056 −0.9354 0.3298 HS_46_l 0.0359 −0.0381 −0.3685 0.3304 HS_from_MQbrain_235_r 0.1997 −0.4807 −0.8115 0.3308 HSbrain_571_l 0.1597 −0.5591 −0.8905 0.3314 HS_from_MQbrain_1633_r 0.1243 −0.3035 −0.6354 0.3319 HS_from_MQbrain_760_l 0.1230 −0.4651 −0.7974 0.3323 Hsd_from_Mmd_324_l 0.0913 −0.3968 −0.7344 0.3376 Hsd_from_Mmd_516_r 0.1491 0.3870 0.0483 0.3387 HS_from_MQbrain_603_r 0.0446 0.1619 −0.1777 0.3396 Hsd_from_Mmd_452_l 0.0459 0.0541 −0.2865 0.3406 HS_from_MM_118_l 0.1482 −0.5729 −0.9150 0.3421 HS_from_MQbrain_1817_l 0.1482 0.3444 0.0015 0.3429 HS_243_l 0.1843 0.5174 0.1741 0.3433 HS_181_l 0.1616 −0.7137 −1.0574 0.3437 HS_from_MQbrain_648_r 0.1216 −0.4144 −0.7588 0.3444 HS_71_r 0.0144 0.1919 −0.1534 0.3452 HSbrain_1423_l 0.0849 −0.2372 −0.5827 0.3455 Hsd_66_l 0.1522 0.8168 0.4707 0.3462 HSbrain_306_r 0.0239 0.1049 −0.2415 0.3464 Hsd_88_r 0.0706 0.0816 −0.2651 0.3466 HS_from_MQbrain_1350_l 0.0224 0.0909 −0.2567 0.3476 HSbrain_1325_r 0.0409 −0.1016 −0.4506 0.3490 HS_from_PT_250_l 0.0369 0.5709 0.2216 0.3493 HS_from_MQbrain_1627_r 0.1703 −0.5353 −0.8861 0.3508 HSbrain_512_l 0.0895 −0.5385 −0.8915 0.3530 Hsd_from_Mmd_464_l 0.0764 −0.1277 −0.4807 0.3530 HSbrain_442_r 0.0797 0.5744 0.2202 0.3542 HSbrain_1425_l 0.0359 −0.2671 −0.6216 0.3544 HS_from_MQbrain_129_r 0.1026 −0.3030 −0.6587 0.3556 HS_from_MQbrain_928_r 0.0857 −0.1851 −0.5409 0.3558 HSbrain_777_r 0.1735 −0.5204 −0.8772 0.3567 HS_from_MQbrain_184_l 0.1146 0.7307 0.3738 0.3569 HS_262_l 0.0599 0.1304 −0.2281 0.3584 HS_from_MQbrain_765_l 0.0913 −0.2399 −0.5992 0.3593 HS_from_MQbrain_968_l 0.1975 −0.8313 −1.1911 0.3598 HS_from_MQbrain_634_r 0.0838 0.5520 0.1913 0.3607 HSbrain_7_r 0.0347 −0.2163 −0.5775 0.3612 HS_from_MQbrain_2669_l 0.0474 −0.1120 −0.4735 0.3615 HS_from_MQbrain_686_r 0.0446 −0.2735 −0.6359 0.3624 HS_from_MQbrain_822_l 0.1268 0.5832 0.2203 0.3629 HS_from_PT_308_l 0.0807 −0.0319 −0.3958 0.3639 HSbrain_393_r 0.1296 0.2759 −0.0882 0.3642 HS_from_MQbrain_1827_l 0.5863 0.2089 −0.1554 0.3643 Hsd_105_l 0.0772 −0.4763 −0.8408 0.3645 Hsd_from_Mmd_346_l 0.1010 −0.5632 −0.9279 0.3647 HS_from_MQbrain_346_l 0.0599 −0.1826 −0.5479 0.3652 HS_from_MQbrain_1806_l 0.1243 0.6662 0.3008 0.3653 HSbrain_93_r 0.0723 −0.0190 −0.3846 0.3656 HS_from_MQbrain_1840_l 0.0995 0.3436 −0.0251 0.3686 Hsd_107_l 0.0723 −0.2032 −0.5725 0.3693 HS_from_MQbrain_1810_l 0.1454 0.1897 −0.1807 0.3705 HSbrain_122_l 0.0498 −0.4275 −0.7990 0.3715 HS_from_MQbrain_1806_l 0.1243 0.2919 −0.0815 0.3734 HS_from_MQbrain_1264_l 0.0928 0.7104 0.3360 0.3744 HSbrain_583_l 0.0268 −0.2068 −0.5861 0.3793 Hsd_69_l 0.1382 0.6284 0.2466 0.3819 HS_from_MQbrain_280_l 0.1997 0.5624 0.1804 0.3820 HS_from_MQbrain_314_l 0.1268 −0.5418 −0.9241 0.3824 HS_from_MQbrain_574_l 0.1078 0.7104 0.3274 0.3830 HS_299_l 0.5233 −0.0392 −0.4238 0.3846 HSbrain_389_l 0.0849 −0.5284 −0.9148 0.3864 HS_from_MQbrain_1250_l 0.1997 −0.4297 −0.8163 0.3866 HS_from_MQbrain_823_l 0.0849 0.5688 0.1821 0.3867 hsa-mir-591_r 0.0501 0.4116 0.0245 0.3870 HS_from_MQbrain_354_r 0.1178 −0.4911 −0.8816 0.3905 HS_from_PT_283_r 0.1454 −0.7717 −1.1624 0.3907 HSbrain_351_r 0.0393 −0.2481 −0.6402 0.3921 Hsd_from_Mmd_255_l 0.1078 −0.2783 −0.6711 0.3928 HS_from_MQbrain_1210_l 0.1997 1.0100 0.6149 0.3951 HS_from_MQbrain_2441_r 0.1616 0.7908 0.3948 0.3960 HS_from_MQbrain_37_r 0.1308 −0.7936 −1.1910 0.3974 HS_from_MQbrain_1268_l 0.1673 −0.8281 −1.2273 0.3991 hsa-mir-491_r 0.1196 −0.2543 −0.6566 0.4023 HS_from_MQbrain_43_r 0.0393 −0.1919 −0.5962 0.4043 hsa-mir-377_l 0.0393 0.3186 −0.0863 0.4049 HS_from_MQbrain_377_l 0.0169 0.2996 −0.1079 0.4075 HS_from_MM_242_r 0.0142 −0.1385 −0.5463 0.4078 HS_from_MQbrain_1087_l 0.0838 −0.3314 −0.7403 0.4089 hsa-mir-31_l 0.1555 0.1679 −0.2419 0.4098 HS_from_MQbrain_845_r 0.1414 0.2544 −0.1576 0.4120 HS_from_MQbrain_535_r 0.1454 1.2319 0.8186 0.4133 HS_from_MQbrain_1771_l 0.0983 −0.2405 −0.6542 0.4138 HS_from_MQbrain_1391_l 0.0127 −0.1673 −0.5838 0.4165 HSbrain_304_r 0.0475 −0.3663 −0.7834 0.4171 HS_from_MQbrain_534_r 0.1060 0.0934 −0.3256 0.4191 HS_from_MQbrain_635_l 0.1616 −0.9169 −1.3392 0.4223 HS_from_MQbrain_1520_l 0.1326 −0.6739 −1.0973 0.4233 HS_from_PT_95_l 0.1366 −0.8666 −1.2903 0.4236 HS_from_MQbrain_1042_r 0.0303 0.0247 −0.3995 0.4242 Hsd_from_Mmd_42_r 0.1774 −0.7209 −1.1484 0.4275 HSbrain_177_l 0.0482 −0.3234 −0.7516 0.4282 HS_from_MQbrain_1481_l 0.0895 1.1221 0.6936 0.4285 HS_from_MM_218_l 0.0552 −0.5267 −0.9554 0.4287 HS_from_MQbrain_301_l 0.0727 −0.6137 −1.0427 0.4290 hsa-mir-324_r 0.0247 0.3174 −0.1119 0.4293 HS_14_r 0.0928 0.4778 0.0470 0.4308 HS_from_MQbrain_420_l 0.0127 0.0841 −0.3489 0.4329 HS_from_MM_169_r 0.0144 −0.3087 −0.7426 0.4339 HS_from_MQbrain_1137_l 0.0169 −0.2359 −0.6754 0.4395 HSbrain_677_r 0.1146 −0.6569 −1.0979 0.4410 Hsd_41_r 0.1997 0.9793 0.5380 0.4413 HS_from_MQbrain_1500_l 0.0239 0.6213 0.1785 0.4429 HS_from_MQbrain_1783_r 0.1060 0.7915 0.3475 0.4439 hsa-mir-346_l 0.0239 0.0099 −0.4354 0.4453 HS_from_MQbrain_634_l 0.0928 −0.9387 −1.3843 0.4457 HS_from_MQbrain_1246_l 0.0727 0.8358 0.3894 0.4464 HS_from_MQbrain_901_r 0.0849 0.6231 0.1739 0.4492 HS_276_l 0.0169 −0.0815 −0.5325 0.4510 HSbrain_198_l 0.1491 −0.8575 −1.3085 0.4511 HSbrain_202_r 0.1597 0.3027 −0.1517 0.4544 HS_from_MQbrain_1778_r 0.1858 1.0726 0.6180 0.4546 HS_241_r 0.1887 0.9239 0.4646 0.4593 HSbrain_695_l 0.0895 −0.6791 −1.1390 0.4599 HS_from_MQbrain_590_l 0.0156 0.1826 −0.2798 0.4624 Hsd_101_l 0.0857 −0.7444 −1.2116 0.4672 HS_from_MQbrain_281_r 0.1366 −0.9223 −1.3963 0.4740 HS_from_MQbrain_161_r 0.1216 0.7005 0.2259 0.4747 HS_from_MQbrain_1541_l 0.1078 0.8304 0.3555 0.4749 HS_from_MQbrain_65_l 0.0683 0.3926 −0.0826 0.4752 hsa-mir-24-2_l 0.0185 −0.0415 −0.5184 0.4769 HSbrain_518_r 0.0723 0.3909 −0.0880 0.4789 hsa-mir-661_r 0.0475 0.0992 −0.3802 0.4793 HS_261_r 0.0686 −0.7602 −1.2402 0.4800 hsa-mir-383_r 0.0473 0.4476 −0.0344 0.4821 HSbrain_47_r 0.0750 −0.5031 −0.9862 0.4831 HS_from_MQbrain_881_r 0.0772 0.6213 0.1375 0.4839 HSbrain_293_l 0.0152 −0.1832 −0.6701 0.4869 HS_from_MQbrain_825_r 0.0264 −0.4284 −0.9154 0.4869 HS_157_r 0.0205 −0.3871 −0.8785 0.4914 HS_from_MQbrain_1601_r 0.1587 0.5820 0.0892 0.4928 HSbrain_313_l 0.1491 −0.6644 −1.1573 0.4929 HSbrain_218_l 0.1616 −0.9500 −1.4464 0.4964 HSbrain_263_r 0.1803 0.4141 −0.0842 0.4982 HS_from_MQbrain_736_r 0.0715 −0.6335 −1.1319 0.4985 HS_from_MQbrain_824_l 0.0849 −0.7246 −1.2242 0.4995 HSbrain_217_r 0.0205 −0.2148 −0.7164 0.5017 HSbrain_625_l 0.1522 1.1058 0.6021 0.5037 HSbrain_304_l 0.1522 0.5220 0.0170 0.5051 HS_136_r 0.0142 −0.2220 −0.7315 0.5095 HS_from_PT_36_l 0.0127 −0.2277 −0.7409 0.5131 HS_from_MQbrain_340_r 0.1230 1.1696 0.6511 0.5185 HS_from_PT_201_l 0.0142 −0.0537 −0.5727 0.5190 HS_from_MQbrain_1204_l 0.0347 −0.3953 −0.9152 0.5199 HS_38_r 0.1146 −0.8733 −1.3976 0.5243 HSbrain_334_r 0.0156 0.1507 −0.3766 0.5273 HS_8_r 0.0142 0.1320 −0.4002 0.5322 HSbrain_390_l 0.0127 −0.2812 −0.8165 0.5353 hsa-mir-619_l 0.0764 0.1999 −0.3361 0.5360 HS_145_r 0.0913 −0.6142 −1.1533 0.5391 HS_from_MQbrain_1099_r 0.0350 −0.1187 −0.6621 0.5434 HSbrain_1363_r 0.1491 1.1096 0.5657 0.5439 HSbrain_570_r 0.0347 −0.4967 −1.0440 0.5473 Hsd_from_Mmd_286_r 0.1803 1.3502 0.8009 0.5494 hsa-mir-557_l 0.1858 1.7522 1.2007 0.5515 HS_289_r 0.1366 1.0558 0.5014 0.5544 HSbrain_325_r 0.1196 −0.4936 −1.0526 0.5590 HSbrain_553_r 0.0983 0.6125 0.0529 0.5596 HS_288_r 0.0995 1.0441 0.4818 0.5623 HSbrain_673_r 0.0528 −0.6094 −1.1736 0.5642 HSbrain_669_r 0.0446 −0.6296 −1.1967 0.5671 HSbrain_684_r 0.0528 −0.6646 −1.2346 0.5700 HS_from_MQbrain_921_r 0.0723 0.3348 −0.2353 0.5702 HS_290_r 0.1296 1.1141 0.5400 0.5740 HS_from_MQbrain_932_l 0.0683 −0.7432 −1.3291 0.5859 HS_from_MQbrain_458_l 0.0185 −0.2287 −0.8159 0.5872 hsa-mir-136_l 0.0473 −0.4760 −1.0693 0.5933 HS_176_l 0.0144 −0.3321 −0.9329 0.6008 HSbrain_1362_r 0.1159 1.0942 0.4901 0.6041 HS_from_MM_339_l 0.0749 −0.5146 −1.1191 0.6046 HSbrain_1364_r 0.1326 1.1234 0.5126 0.6108 hsa-mir-345_r 0.1382 1.1389 0.5259 0.6130 HS_from_MQbrain_606_r 0.1463 1.5231 0.9058 0.6173 HS_from_MQbrain_386_r 0.1774 0.9824 0.3650 0.6174 HSbrain_680_r 0.0314 −0.6300 −1.2537 0.6237 HS_287_r 0.1026 1.0883 0.4644 0.6239 HSbrain_687_r 0.0347 −0.6327 −1.2586 0.6259 HS_from_MQbrain_453_r 0.1858 1.9060 1.2728 0.6332 HS_from_MQbrain_1463_l 0.1752 1.5905 0.9464 0.6441 Hsd_from_Mmd_246_r 0.1463 0.0400 −0.6096 0.6496 HS_from_MQbrain_17_r 0.1858 1.0675 0.4114 0.6561 HS_from_MQbrain_638_l 0.0075 −0.3793 −1.0461 0.6668 HS_from_MQbrain_809_l 0.1390 1.3436 0.6759 0.6676 HS_231_l 0.1752 1.9739 1.3049 0.6690 HS_from_MQbrain_1168_l 0.1587 1.3948 0.7208 0.6740 HSbrain_429_l 0.1752 1.8593 1.1848 0.6745 Hsd_from_Mmd_266_r 0.1107 0.1541 −0.5262 0.6803 HS_from_MQbrain_63_r 0.0156 −0.2442 −0.9291 0.6849 HS_from_MQbrain_973_l 0.1463 1.6221 0.9293 0.6928 HS_51_r 0.0249 −0.6916 −1.3872 0.6956 HS_from_MQbrain_808_l 0.1646 1.4040 0.7031 0.7008 HS_from_MQbrain_868_l 0.1616 0.6606 −0.0426 0.7031 hsa-mir-517a_l 0.1382 2.0127 1.3048 0.7079 HSbrain_620_l 0.1454 1.2829 0.5748 0.7081 HSbrain_1360_r 0.0824 1.1672 0.4558 0.7113 HSbrain_484_l 0.1347 0.4330 −0.2891 0.7221 HS_from_MM_35_r 0.1943 2.2043 1.4807 0.7236 Hsd_from_Mmd_35_r 0.1735 2.2635 1.5337 0.7297 HS_from_MQbrain_453_l 0.1296 2.5221 1.7765 0.7455 hsa-mir-517b_l 0.1454 2.1153 1.3684 0.7469 HS_from_MQbrain_800_l 0.1296 1.4132 0.6626 0.7506 HS_from_MQbrain_666_l 0.1491 1.7216 0.9704 0.7511 HS_from_MQbrain_1110_r 0.1803 2.2951 1.5252 0.7699 HS_from_MQbrain_1620_r 0.0252 −0.2132 −0.9994 0.7862 hsa-mir-517c_l 0.1243 2.1320 1.3398 0.7922 HSbrain_26_r 0.1159 2.0135 1.2097 0.8037 hsa-mir-520g_l 0.1463 1.4240 0.6190 0.8050 HSbrain_366_r 0.1646 1.6560 0.8440 0.8120 HS_from_MQbrain_1334_r 0.0156 −0.7830 −1.6118 0.8288 Hsd_13_l 0.1390 1.8885 1.0496 0.8390 HS_306_l 0.1463 1.9410 1.0848 0.8561 HS_306_l 0.1463 1.9702 1.1069 0.8633 HS_from_MQbrain_817_l 0.1491 1.7886 0.9243 0.8643 hsa-mir-671_l 0.1366 1.9361 1.0647 0.8714 HS_from_MQbrain_1082_l 0.0183 −0.8412 −1.7267 0.8855 HS_from_PT_313_l 0.1308 1.9518 1.0482 0.9036 hsa-mir-520h_l 0.1347 1.5659 0.6398 0.9261 Hsd_from_Mmd_94_l 0.1308 0.8926 −0.0531 0.9457 HS_from_MQbrain_273_r 0.1178 1.9679 1.0064 0.9615 HS_from_MQbrain_722_r 0.1045 1.4659 0.4622 1.0037 ¹Wilcoxon analysis: cut off p value < 0.2 ²Upregulated small RNA expression when ratio >1 (below line) Downregulated small RNA expression when ratio <1 (above line)

TABLE 4c Small RNAs that are upregulated in colorectal adenocarcinomas compared to adenomas HS_from_MQbrain_722_r

TABLE 4d Small RNAs that are downregulated in colorectal adenocarcinomas compared to adenomas HS_101_l HS_102_l HS_105_l HS_109_r HS_110_r HS_111_r HS_113_l HS_114_l HS_118_l HS_119_l HS_124_r HS_130_l HS_133_l HS_136_r HS_138_l HS_139_l HS_14_r HS_141_l HS_142_l HS_145_r HS_151_r HS_154_r HS_157_r HS_166_l HS_167_r HS_17_l HS_171_r HS_175_l HS_176_l HS_177_l HS_181_l HS_182_r HS_189_l HS_189_r HS_190_r HS_191_r HS_200_r HS_204_r HS_207_l HS_208_l HS_208_r HS_212_l HS_213_l HS_217_l HS_219_l HS_220_l HS_223_r HS_231_l HS_237_r HS_241_r HS_243_l HS_246_l HS_261_r HS_262_l HS_265_l HS_266_r HS_276_l HS_277_l HS_278_l HS_281_r HS_281_r HS_285_r HS_286_r HS_287_r HS_288_l HS_288_r HS_289_r HS_29_l HS_290_r HS_292_l HS_292_r HS_292_r HS_299_l HS_303_r HS_306_l HS_306_l HS_307_r HS_38_r HS_39_r HS_45_r HS_46_l HS_47_l HS_49_r HS_50_l HS_50_r HS_51_r HS_54_l HS_54_r HS_56_l HS_58_l HS_61_r HS_62_l HS_66_r HS_67_r HS_71_r HS_74_r HS_76_r HS_77_l HS_77_r HS_79_l HS_8_r HS_83_r HS_86_r HS_88_r HS_91_l HS_95_r HS_97_r HS_98_r HS_99_r HS_from_MM_1_l HS_from_MM_102_r HS_from_MM_103_l HS_from_MM_118_l HS_from_MM_118_r HS_from_MM_119_r HS_from_MM_121_l HS_from_MM_124_l HS_from_MM_131_l HS_from_MM_136_l HS_from_MM_150_r HS_from_MM_157_l HS_from_MM_169_r HS_from_MM_174_l HS_from_MM_18_l HS_from_MM_18_r HS_from_MM_180_r HS_from_MM_184_r HS_from_MM_190_l HS_from_MM_198_r HS_from_MM_199_l HS_from_MM_200_l HS_from_MM_208_r HS_from_MM_218_l HS_from_MM_219_l HS_from_MM_232_r HS_from_MM_242_r HS_from_MM_251_r HS_from_MM_256_r HS_from_MM_260_l HS_from_MM_275_r HS_from_MM_276_l HS_from_MM_288_l HS_from_MM_295_l HS_from_MM_310_l HS_from_MM_311_l HS_from_MM_32_r HS_from_MM_331_r HS_from_MM_339_l HS_from_MM_34_l HS_from_MM_342_r HS_from_MM_35_r HS_from_MM_39_l HS_from_MM_48_l HS_from_MM_6_r HS_from_MM_72_r HS_from_MM_80_l HS_from_MM_84_l HS_from_MM_84_r HS_from_MM_86_l HS_from_MM_92_r HS_from_MQbrain_1001_r HS_from_MQbrain_1006_l HS_from_MQbrain_1031_r HS_from_MQbrain_1042_r HS_from_MQbrain_1070_r HS_from_MQbrain_1072_l HS_from_MQbrain_1075_l HS_from_MQbrain_108_r HS_from_MQbrain_1082_l HS_from_MQbrain_1085_l HS_from_MQbrain_1087_l HS_from_MQbrain_1088_l HS_from_MQbrain_1091_l HS_from_MQbrain_1097_r HS_from_MQbrain_1099_r HS_from_MQbrain_1100_r HS_from_MQbrain_1102_l HS_from_MQbrain_111_l HS_from_MQbrain_1110_l HS_from_MQbrain_1110_r HS_from_MQbrain_1116_r HS_from_MQbrain_1126_l HS_from_MQbrain_1127_r HS_from_MQbrain_1134_r HS_from_MQbrain_1137_r HS_from_MQbrain_1143_l HS_from_MQbrain_1159_l HS_from_MQbrain_1164_l HS_from_MQbrain_1164_r HS_from_MQbrain_1168_l HS_from_MQbrain_117_r HS_from_MQbrain_1183_l HS_from_MQbrain_1185_l HS_from_MQbrain_120_l HS_from_MQbrain_1204_l HS_from_MQbrain_1204_r HS_from_MQbrain_1210_l HS_from_MQbrain_1212_l HS_from_MQbrain_1215_l HS_from_MQbrain_1224_r HS_from_MQbrain_1227_l HS_from_MQbrain_1227_l HS_from_MQbrain_1229_r HS_from_MQbrain_1235_l HS_from_MQbrain_1246_l HS_from_MQbrain_1250_l HS_from_MQbrain_1253_r HS_from_MQbrain_1260_r HS_from_MQbrain_1261_r HS_from_MQbrain_1263_r HS_from_MQbrain_1264_l HS_from_MQbrain_1268_l HS_from_MQbrain_1272_l HS_from_MQbrain_129_r HS_from_MQbrain_1292_l HS_from_MQbrain_1292_r HS_from_MQbrain_1294_l HS_from_MQbrain_1297_l HS_from_MQbrain_1300_r HS_from_MQbrain_1301_r HS_from_MQbrain_1323_l HS_from_MQbrain_133_r HS_from_MQbrain_1331_r HS_from_MQbrain_1334_r HS_from_MQbrain_1339_r HS_from_MQbrain_1340_l HS_from_MQbrain_1346_r HS_from_MQbrain_1347_r HS_from_MQbrain_1350_l HS_from_MQbrain_1354_r HS_from_MQbrain_1355_r HS_from_MQbrain_1357_l HS_from_MQbrain_1363_l HS_from_MQbrain_1365_l HS_from_MQbrain_1372_l HS_from_MQbrain_1374_l HS_from_MQbrain_1374_r HS_from_MQbrain_1376_r HS_from_MQbrain_1391_l HS_from_MQbrain_1394_l HS_from_MQbrain_140_l HS_from_MQbrain_1405_l HS_from_MQbrain_1412_l HS_from_MQbrain_1413_l HS_from_MQbrain_1415_r HS_from_MQbrain_1417_l HS_from_MQbrain_1419_r HS_from_MQbrain_1420_l HS_from_MQbrain_1421_l HS_from_MQbrain_1426_r HS_from_MQbrain_1433_r HS_from_MQbrain_1437_l HS_from_MQbrain_1442_l HS_from_MQbrain_1443_r HS_from_MQbrain_1444_l HS_from_MQbrain_1463_l HS_from_MQbrain_1469_l HS_from_MQbrain_1470_l HS_from_MQbrain_1470_r HS_from_MQbrain_1481_l HS_from_MQbrain_1485_l HS_from_MQbrain_1493_r HS_from_MQbrain_1494_r HS_from_MQbrain_1500_l HS_from_MQbrain_1514_r HS_from_MQbrain_1517_r HS_from_MQbrain_1520_l HS_from_MQbrain_1525_r HS_from_MQbrain_1537_r HS_from_MQbrain_154_r HS_from_MQbrain_1541_l HS_from_MQbrain_1545_r HS_from_MQbrain_1549_l HS_from_MQbrain_1556_r HS_from_MQbrain_1565_l HS_from_MQbrain_1569_l HS_from_MQbrain_1593_r HS_from_MQbrain_1601_r HS_from_MQbrain_161_l HS_from_MQbrain_161_r HS_from_MQbrain_1620_r HS_from_MQbrain_1623_r HS_from_MQbrain_1627_r HS_from_MQbrain_163_l HS_from_MQbrain_1631_r HS_from_MQbrain_1632_l HS_from_MQbrain_1633_r HS_from_MQbrain_1637_r HS_from_MQbrain_1645_l HS_from_MQbrain_1649_r HS_from_MQbrain_1657_r HS_from_MQbrain_1667_r HS_from_MQbrain_1675_l HS_from_MQbrain_1675_r HS_from_MQbrain_1677_r HS_from_MQbrain_1684_r HS_from_MQbrain_17_r HS_from_MQbrain_1700_r HS_from_MQbrain_1708_l HS_from_MQbrain_1717_r HS_from_MQbrain_1722_l HS_from_MQbrain_1725_l HS_from_MQbrain_1740_r HS_from_MQbrain_1747_l HS_from_MQbrain_1748_r HS_from_MQbrain_1750_r HS_from_MQbrain_1752_l HS_from_MQbrain_1753_r HS_from_MQbrain_1756_l HS_from_MQbrain_1771_l HS_from_MQbrain_1771_r HS_from_MQbrain_1773_l HS_from_MQbrain_1776_r HS_from_MQbrain_1777_l HS_from_MQbrain_1778_r HS_from_MQbrain_178_r HS_from_MQbrain_1781_l HS_from_MQbrain_1783_r HS_from_MQbrain_1792_r HS_from_MQbrain_1793_r HS_from_MQbrain_180_r HS_from_MQbrain_1806_l HS_from_MQbrain_1806_l HS_from_MQbrain_1808_r HS_from_MQbrain_181_l HS_from_MQbrain_1810_l HS_from_MQbrain_1817_l HS_from_MQbrain_1817_l HS_from_MQbrain_1824_l HS_from_MQbrain_1827_l HS_from_MQbrain_1832_l HS_from_MQbrain_1836_l HS_from_MQbrain_1839_l HS_from_MQbrain_184_l HS_from_MQbrain_1840_l HS_from_MQbrain_1845_l HS_from_MQbrain_1855_r HS_from_MQbrain_1876_l HS_from_MQbrain_1877_l HS_from_MQbrain_1877_r HS_from_MQbrain_188_l HS_from_MQbrain_1882_r HS_from_MQbrain_1893_r HS_from_MQbrain_1896_r HS_from_MQbrain_1901_l HS_from_MQbrain_194_l HS_from_MQbrain_1958_l HS_from_MQbrain_1985_l HS_from_MQbrain_2087_r HS_from_MQbrain_209_r HS_from_MQbrain_210_r HS_from_MQbrain_212_r HS_from_MQbrain_216_l HS_from_MQbrain_22_l HS_from_MQbrain_22_r HS_from_MQbrain_221_r HS_from_MQbrain_229_l HS_from_MQbrain_235_r HS_from_MQbrain_2441_r HS_from_MQbrain_266_l HS_from_MQbrain_266_r HS_from_MQbrain_2669_l HS_from_MQbrain_2670_r HS_from_MQbrain_268_r HS_from_MQbrain_272_l HS_from_MQbrain_273_r HS_from_MQbrain_280_l HS_from_MQbrain_281_r HS_from_MQbrain_283_r HS_from_MQbrain_288_r HS_from_MQbrain_29_l HS_from_MQbrain_301_l HS_from_MQbrain_314_l HS_from_MQbrain_315_l HS_from_MQbrain_330_r HS_from_MQbrain_332_l HS_from_MQbrain_340_r HS_from_MQbrain_346_l HS_from_MQbrain_348_r HS_from_MQbrain_354_r HS_from_MQbrain_355_l HS_from_MQbrain_36_r HS_from_MQbrain_365_r HS_from_MQbrain_37_r HS_from_MQbrain_375_l HS_from_MQbrain_377_l HS_from_MQbrain_38_r HS_from_MQbrain_382_l HS_from_MQbrain_386_r HS_from_MQbrain_392_l HS_from_MQbrain_397_l HS_from_MQbrain_399_l HS_from_MQbrain_401_l HS_from_MQbrain_405_r HS_from_MQbrain_42_l HS_from_MQbrain_420_l HS_from_MQbrain_429_l HS_from_MQbrain_43_r HS_from_MQbrain_433_l HS_from_MQbrain_435_r HS_from_MQbrain_437_l HS_from_MQbrain_441_l HS_from_MQbrain_444_r HS_from_MQbrain_453_l HS_from_MQbrain_453_r HS_from_MQbrain_458_l HS_from_MQbrain_467_l HS_from_MQbrain_468_r HS_from_MQbrain_470_l HS_from_MQbrain_482_l HS_from_MQbrain_496_r HS_from_MQbrain_500_r HS_from_MQbrain_501_l HS_from_MQbrain_504_r HS_from_MQbrain_529_r HS_from_MQbrain_534_l HS_from_MQbrain_534_r HS_from_MQbrain_535_r HS_from_MQbrain_536_r HS_from_MQbrain_542_r HS_from_MQbrain_55_l HS_from_MQbrain_550_l HS_from_MQbrain_555_r HS_from_MQbrain_56_l HS_from_MQbrain_560_r HS_from_MQbrain_566_l HS_from_MQbrain_57_l HS_from_MQbrain_574_l HS_from_MQbrain_579_l HS_from_MQbrain_58_l HS_from_MQbrain_587_l HS_from_MQbrain_590_l HS_from_MQbrain_597_l HS_from_MQbrain_597_r HS_from_MQbrain_600_l HS_from_MQbrain_603_r HS_from_MQbrain_604_l HS_from_MQbrain_606_r HS_from_MQbrain_609_l HS_from_MQbrain_619_l HS_from_MQbrain_62_l HS_from_MQbrain_626_r HS_from_MQbrain_628_l HS_from_MQbrain_629_r HS_from_MQbrain_63_r HS_from_MQbrain_631_l HS_from_MQbrain_634_l HS_from_MQbrain_634_r HS_from_MQbrain_635_l HS_from_MQbrain_635_r HS_from_MQbrain_638_l HS_from_MQbrain_64_l HS_from_MQbrain_648_r HS_from_MQbrain_65_l HS_from_MQbrain_653_l HS_from_MQbrain_660_l HS_from_MQbrain_661_r HS_from_MQbrain_664_r HS_from_MQbrain_666_l HS_from_MQbrain_672_l HS_from_MQbrain_675_l HS_from_MQbrain_681_l HS_from_MQbrain_686_l HS_from_MQbrain_686_r HS_from_MQbrain_691_r HS_from_MQbrain_697_l HS_from_MQbrain_699_r HS_from_MQbrain_70_l HS_from_MQbrain_71_l HS_from_MQbrain_710_r HS_from_MQbrain_715_l HS_from_MQbrain_716_l HS_from_MQbrain_72_r HS_from_MQbrain_722_l HS_from_MQbrain_723_l HS_from_MQbrain_734_l HS_from_MQbrain_736_r HS_from_MQbrain_74_r HS_from_MQbrain_745_r HS_from_MQbrain_760_l HS_from_MQbrain_765_l HS_from_MQbrain_770_r HS_from_MQbrain_777_r HS_from_MQbrain_789_r HS_from_MQbrain_791_r HS_from_MQbrain_800_l HS_from_MQbrain_804_r HS_from_MQbrain_808_l HS_from_MQbrain_809_l HS_from_MQbrain_81_l HS_from_MQbrain_812_l HS_from_MQbrain_814_l HS_from_MQbrain_817_l HS_from_MQbrain_819_r HS_from_MQbrain_822_l HS_from_MQbrain_823_l HS_from_MQbrain_824_l HS_from_MQbrain_824_r HS_from_MQbrain_825_r HS_from_MQbrain_828_l HS_from_MQbrain_833_l HS_from_MQbrain_842_l HS_from_MQbrain_845_r HS_from_MQbrain_85_l HS_from_MQbrain_852_l HS_from_MQbrain_854_r HS_from_MQbrain_859_l HS_from_MQbrain_868_l HS_from_MQbrain_868_l HS_from_MQbrain_869_l HS_from_MQbrain_88_l HS_from_MQbrain_881_r HS_from_MQbrain_886_r HS_from_MQbrain_897_r HS_from_MQbrain_90_r HS_from_MQbrain_900_r HS_from_MQbrain_901_r HS_from_MQbrain_906_l HS_from_MQbrain_914_l HS_from_MQbrain_914_l HS_from_MQbrain_921_l HS_from_MQbrain_921_r HS_from_MQbrain_928_r HS_from_MQbrain_93_r HS_from_MQbrain_932_l HS_from_MQbrain_936_l HS_from_MQbrain_940_r HS_from_MQbrain_941_r HS_from_MQbrain_951_l HS_from_MQbrain_968_l HS_from_MQbrain_968_r HS_from_MQbrain_969_l HS_from_MQbrain_97_r HS_from_MQbrain_972_r HS_from_MQbrain_973_l HS_from_MQbrain_974_l HS_from_MQbrain_984_l HS_from_MQbrain_991_r HS_from_MQbrain_996_l HS_from_PT_101_r HS_from_PT_115_r HS_from_PT_117_r HS_from_PT_126_l HS_from_PT_128_l HS_from_PT_13_l HS_from_PT_134_l HS_from_PT_139_r HS_from_PT_140_l HS_from_PT_149_r HS_from_PT_157_r HS_from_PT_187_r HS_from_PT_188_l HS_from_PT_190_r HS_from_PT_196_l HS_from_PT_20_r HS_from_PT_201_l HS_from_PT_211_r HS_from_PT_226_l HS_from_PT_237_r HS_from_PT_238_l HS_from_PT_250_l HS_from_PT_254_l HS_from_PT_254_r HS_from_PT_27_l HS_from_PT_27_r HS_from_PT_282_l HS_from_PT_283_r HS_from_PT_287_r HS_from_PT_299_r HS_from_PT_308_l HS_from_PT_308_l HS_from_PT_313_l HS_from_PT_338_l HS_from_PT_34_r HS_from_PT_36_l HS_from_PT_41_l HS_from_PT_44_l HS_from_PT_60_l HS_from_PT_91_r HS_from_PT_95_l hsa-let-7a-1_r hsa-Iet-7c_r hsa-let-7f-1_r hsa-mir-10b_r hsa-mir-1-1_l hsa-mir-124a-1_l hsa-mir-125b-2_l hsa-mir-130b_l hsa-mir-132_l hsa-mir-133a-1_r hsa-mir-135a-2_r hsa-mir-136_l hsa-mir-138-2_l hsa-mir-146a_r hsa-mir-148a_l hsa-mir-155_r hsa-mir-16-1_r hsa-mir-190_l hsa-mir-190_r hsa-mir-191_r hsa-mir-193a_l hsa-mir-196a-2_r hsa-mir-204_l hsa-mir-204_r hsa-mir-206_l hsa-mir-217_r hsa-mir-219-1_r hsa-mir-222_r hsa-mir-224_r hsa-mir-24-2_l hsa-mir-296_l hsa-mir-299_l hsa-mir-299_r hsa-mir-301_l hsa-mir-30b_l hsa-mir-30b_r hsa-mir-30c-1_l hsa-mir-31_l hsa-mir-324_r hsa-mir-328_r hsa-mir-329-1_r hsa-mir-331_l hsa-mir-338_l hsa-mir-345_r hsa-mir-346_l hsa-mir-362_r hsa-mir-365-1_l hsa-mir-365-2_l hsa-mir-365-2_r hsa-mir-367_r hsa-mir-368_l hsa-mir-369_l hsa-mir-374_l hsa-mir-375_r hsa-mir-377_l hsa-mir-382_r hsa-mir-383_r hsa-mir-411_r hsa-mir-412_l hsa-mir-412_r hsa-mir-433_r hsa-mir-450-2_r hsa-mir-451_l hsa-mir-453_l hsa-mir-454_l hsa-mir-454_r hsa-mir-488_l hsa-mir-491_r hsa-mir-497_r hsa-mir-502_l hsa-mir-510_r hsa-mir-516-1_r hsa-mir-516-2_r hsa-mir-517a_l hsa-mir-517b_l hsa-mir-517c_l hsa-mir-518e_r hsa-mir-520f_r hsa-mir-520g_l hsa-mir-520h_l hsa-mir-523_r hsa-mir-524_l hsa-mir-524_r hsa-mir-548b_l hsa-mir-548c_l hsa-mir-550-2_r hsa-mir-557_l hsa-mir-568_l hsa-mir-573_r hsa-mir-579_r hsa-mir-584_r hsa-mir-588_r hsa-mir-591_r hsa-mir-593_r hsa-mir-604_l hsa-mir-616_l hsa-mir-616_r hsa-mir-619_l hsa-mir-622_l hsa-mir-623_r hsa-mir-624_l hsa-mir-625_r hsa-mir-632_l hsa-mir-633_r hsa-mir-638_r hsa-mir-640_l hsa-mir-643_r hsa-mir-646_r hsa-mir-647_l hsa-mir-648_l hsa-mir-652_r hsa-mir-653_l hsa-mir-655_l hsa-mir-659_l hsa-mir-661_r hsa-mir-671_l hsa-mir-767_r hsa-mir-770_r hsa-mir-95_r hsa-mir-98_r HSbrain_102_r HSbrain_106_r HSbrain_1076_r HSbrain_111_l HSbrain_113_r HSbrain_114_r HSbrain_117_r HSbrain_12_l HSbrain_122_l HSbrain_123_l HSbrain_1298_r HSbrain_1325_r HSbrain_1331_r HSbrain_1337_l HSbrain_1338_r HSbrain_135_l HSbrain_1360_r HSbrain_1362_r HSbrain_1363_r HSbrain_1364_l HSbrain_1364_r HSbrain_1377_l HSbrain_1384_r HSbrain_139_r HSbrain_14_r HSbrain_1406_l HSbrain_141_r HSbrain_1413_l HSbrain_1414_r HSbrain_1415_r HSbrain_1416_r HSbrain_1423_l HSbrain_1425_l HSbrain_155_r HSbrain_157_l HSbrain_158_l HSbrain_16_l HSbrain_166_l HSbrain_168_l HSbrain_174_r HSbrain_177_l HSbrain_177_r HSbrain_180_l HSbrain_182_r HSbrain_184_r HSbrain_187_r HSbrain_190_r HSbrain_198_l HSbrain_202_r HSbrain_204_r HSbrain_210_l HSbrain_214_l HSbrain_217_r HSbrain_218_l HSbrain_22_l HSbrain_220_l HSbrain_220_r HSbrain_222_r HSbrain_225_r HSbrain_226_r HSbrain_231_l HSbrain_235_l HSbrain_236_l HSbrain_244_l HSbrain_25_r HSbrain_250_l HSbrain_250_r HSbrain_252_l HSbrain_256_r HSbrain_259_r HSbrain_26_r HSbrain_263_r HSbrain_266_r HSbrain_270_r HSbrain_272_l HSbrain_276_l HSbrain_289_r HSbrain_293_l HSbrain_3_l HSbrain_304_l HSbrain_304_r HSbrain_305_l HSbrain_305_r HSbrain_306_r HSbrain_307_r HSbrain_313_l HSbrain_316_l HSbrain_319_l HSbrain_32_l HSbrain_325_r HSbrain_328_l HSbrain_334_r HSbrain_336_l HSbrain_337_r HSbrain_347_l HSbrain_351_r HSbrain_359_l HSbrain_361_l HSbrain_365_l HSbrain_366_r HSbrain_369_r HSbrain_371_r HSbrain_374_r HSbrain_380_r HSbrain_381_l HSbrain_384_l HSbrain_388_r HSbrain_389_l HSbrain_390_l HSbrain_393_l HSbrain_393_r HSbrain_399_l HSbrain_402_l HSbrain_408_r HSbrain_41_l HSbrain_419_l HSbrain_420_r HSbrain_425_l HSbrain_429_l HSbrain_43_r HSbrain_431_l HSbrain_431_r HSbrain_437_r HSbrain_438_r HSbrain_440_l HSbrain_441_r HSbrain_442_r HSbrain_452_l HSbrain_461_r HSbrain_465_l HSbrain_468_r HSbrain_47_r HSbrain_472_l HSbrain_473_l HSbrain_476_r HSbrain_479_l HSbrain_480_r HSbrain_482_l HSbrain_483_r HSbrain_484_l HSbrain_494_l HSbrain_495_r HSbrain_497_l HSbrain_50_l HSbrain_50_r HSbrain_506_r HSbrain_507_l HSbrain_509_l HSbrain_512_l HSbrain_513_r HSbrain_518_r HSbrain_52_r HSbrain_532_l HSbrain_538_r HSbrain_540_l HSbrain_541_r HSbrain_545_r HSbrain_55_l HSbrain_553_r HSbrain_568_r HSbrain_570_l HSbrain_570_r HSbrain_571_l HSbrain_578_r HSbrain_580_r HSbrain_583_l HSbrain_583_r HSbrain_588_l HSbrain_588_r HSbrain_590_l HSbrain_591_l HSbrain_593_r HSbrain_594_l HSbrain_599_r HSbrain_6_r HSbrain_606_l HSbrain_614_l HSbrain_62_r HSbrain_620_l HSbrain_621_l HSbrain_621_r HSbrain_622_r HSbrain_624_l HSbrain_625_l HSbrain_626_r HSbrain_627_l HSbrain_627_r HSbrain_636_l HSbrain_643_l HSbrain_644_r HSbrain_647_r HSbrain_651_r HSbrain_652_l HSbrain_661_l HSbrain_662_r HSbrain_663_l HSbrain_669_r HSbrain_673_l HSbrain_673_r HSbrain_677_l HSbrain_677_r HSbrain_680_r HSbrain_684_r HSbrain_687_l HSbrain_687_r HSbrain_689_r HSbrain_690_l HSbrain_691_l HSbrain_692_l HSbrain_692_r HSbrain_695_l HSbrain_696_r HSbrain_698_r HSbrain_7_r HSbrain_703_l HSbrain_703_r HSbrain_705_l HSbrain_708_l HSbrain_716_l HSbrain_717_l HSbrain_717_r HSbrain_719_l HSbrain_72_l HSbrain_720_l HSbrain_726_l HSbrain_726_r HSbrain_728_l HSbrain_744_l HSbrain_75_l HSbrain_753_r HSbrain_754_r HSbrain_755_l HSbrain_755_r HSbrain_757_r HSbrain_764_r HSbrain_77_l HSbrain_771_l HSbrain_773_r HSbrain_776_l HSbrain_777_r HSbrain_778_l HSbrain_779_r HSbrain_780_r HSbrain_783_l HSbrain_787_l HSbrain_791_l HSbrain_792_r HSbrain_794_l HSbrain_794_r HSbrain_795_r HSbrain_796_r HSbrain_799_r HSbrain_80_l HSbrain_803_l HSbrain_809_r HSbrain_811_l HSbrain_82_r HSbrain_85_r HSbrain_91_r HSbrain_916_l HSbrain_93_r HSbrain_95_l HSbrain_970_l HSbrain_970_r Hsd_101_l Hsd_105_l Hsd_106_l Hsd_106_r Hsd_107_l Hsd_108_l Hsd_12_r Hsd_13_l Hsd_18_r Hsd_24_r Hsd_27_r Hsd_30_l Hsd_32_r Hsd_37_r Hsd_41_r Hsd_42_l Hsd_42_r Hsd_46_l Hsd_62_l Hsd_66_l Hsd_69_l Hsd_7_r Hsd_70_r Hsd_8_r Hsd_80_r Hsd_81_r Hsd_82_r Hsd_83_l Hsd_84_r Hsd_85_r Hsd_88_r Hsd_95_l Hsd_96_r Hsd_from_Mmd_107_r Hsd_from_Mmd_117_r Hsd_from_Mmd_120_r Hsd_from_Mmd_123_r Hsd_from_Mmd_136_l Hsd_from_Mmd_138_l Hsd_from_Mmd_154_l Hsd_from_Mmd_155_l Hsd_from_Mmd_157_r Hsd_from_Mmd_163_r Hsd_from_Mmd_166_l Hsd_from_Mmd_166_r Hsd_from_Mmd_167_r Hsd_from_Mmd_176_r Hsd_from_Mmd_178_l Hsd_from_Mmd_181_r Hsd_from_Mmd_189_l Hsd_from_Mmd_197_l Hsd_from_Mmd_215_r Hsd_from_Mmd_217_r Hsd_from_Mmd_222_l Hsd_from_Mmd_223_r Hsd_from_Mmd_225_l Hsd_from_Mmd_23_l Hsd_from_Mmd_237_l Hsd_from_Mmd_246_r Hsd_from_Mmd_253_l Hsd_from_Mmd_255_l Hsd_from_Mmd_261_l Hsd_from_Mmd_261_r Hsd_from_Mmd_266_r Hsd_from_Mmd_286_r Hsd_from_Mmd_302_r Hsd_from_Mmd_314_r Hsd_from_Mmd_324_l Hsd_from_Mmd_330_l Hsd_from_Mmd_346_l Hsd_from_Mmd_347_l Hsd_from_Mmd_35_r Hsd_from_Mmd_370_r Hsd_from_Mmd_371_r Hsd_from_Mmd_391_l Hsd_from_Mmd_396_l Hsd_from_Mmd_398_r Hsd_from_Mmd_405_l Hsd_from_Mmd_410_r Hsd_from_Mmd_413_r Hsd_from_Mmd_42_r Hsd_from_Mmd_422_l Hsd_from_Mmd_424_l Hsd_from_Mmd_44_r Hsd_from_Mmd_443_l Hsd_from_Mmd_452_l Hsd_from_Mmd_464_l Hsd_from_Mmd_471_r Hsd_from_Mmd_473_l Hsd_from_Mmd_478_l Hsd_from_Mmd_48_r Hsd_from_Mmd_480_l Hsd_from_Mmd_480_r Hsd_from_Mmd_485_r Hsd_from_Mmd_487_r Hsd_from_Mmd_49_l Hsd_from_Mmd_491_r Hsd_from_Mmd_500_l Hsd_from_Mmd_501_l Hsd_from_Mmd_503_l Hsd_from_Mmd_509_l Hsd_from_Mmd_511_r Hsd_from_Mmd_516_r Hsd_from_Mmd_52_r Hsd_from_Mmd_524_l Hsd_from_Mmd_527_l Hsd_from_Mmd_530_l Hsd_from_Mmd_535_r Hsd_from_Mmd_58_r Hsd_from_Mmd_70_l Hsd_from_Mmd_81_r Hsd_from_Mmd_82_r Hsd_from_Mmd_93_r Hsd_from_Mmd_94_l Hsd_from_Mmd_97_l

TABLE 5a List of small RNAs as good classifiers to distinguish colorectal control from adenoma tissue Systematic name adenoma score control score  [1,] HSbrain_377_l 0.1008 −0.3695  [2,] HS_from_PT_114_r 0.0617 −0.2261  [3,] HSbrain_377_r 0.0606 −0.2224  [4,] hsa-mir-124a-3_r −0.0447 0.164  [5,] HSbrain_411_r 0.0443 −0.1624  [6,] HS_from_MM_118_r −0.0416 0.1524  [7,] HSbrain_398_r 0.0371 −0.1359  [8,] hsa-mir-421_r 0.0368 −0.1348  [9,] HS_291_r 0.0361 −0.1322 [10,] HS_from_MM_169_r −0.0342 0.1255 [11,] hsa-mir-124a-2_r −0.0332 0.1218 [12,] HSbrain_458_r −0.033 0.121 [13,] HS_from_PT_114_l 0.0323 −0.1183 [14,] HS_from_MQbrain_594_r −0.0317 0.1161 [15,] HS_from_PT_36_l −0.0308 0.1131 [16,] hsa-mir-92-1_r 0.0306 −0.1123 [17,] HSbrain_1437_r 0.0274 −0.1005 [18,] hsa-mir-27a_r 0.027 −0.0992 [19,] hsa-mir-124a-1_r −0.0266 0.0975 [20,] HS_from_MQbrain_2700_r 0.0245 −0.0897 [21,] Hsd_from_Mmd_298_r 0.0242 −0.0887 [22,] hsa-mir-92-2_r 0.0234 −0.0858 [23,] HSbrain_52_r 0.0227 −0.0832 [24,] Hsd_from_Mmd_485_r −0.021 0.077 [25,] HSbrain_1406_l −0.0205 0.0751 [26,] Hsd_from_Mmd_452_l −0.0185 0.0679 [27,] Hsd_from_Mmd_117_r −0.0182 0.0666 [28,] HS_97_r −0.0174 0.0639 [29,] HS_from_MQbrain_79_r 0.0171 −0.0628 [30,] hsa-mir-635_l −0.0164 0.06 [31,] HSbrain_106_r 0.0147 −0.0538 [32,] HS_262_l −0.0136 0.05 [33,] HS_from_MQbrain_1311_r 0.0135 −0.0496 [34,] HS_291_r 0.0132 −0.0486 [35,] HS_from_MQbrain_1462_l 0.013 −0.0477 [36,] hsa-mir-130a_r 0.0114 −0.042 [37,] HSbrain_500_r 0.0111 −0.0408 [38,] hsa-mir-768_r 0.0109 −0.04 [39,] HS_from_MQbrain_1183_l 0.0108 −0.0396 [40,] HSbrain_224_r 0.01 −0.0365 [41,] hsa-mir-29a_r 0.0094 −0.0344 [42,] HSbrain_398_l 0.0078 −0.0285 [43,] HS_71_l −0.0073 0.0267 [44,] HS_169_l 0.0068 −0.025 [45,] hsa-mir-181c_l 0.0066 −0.0243 [46,] HSbrain_500_l 0.0038 −0.0139 [47,] HS_from_MQbrain_825_r −0.0038 0.0138 [48,] hsa-mir-146a_l 0.0036 −0.0132 [49,] hsa-mir-454_r 0.0034 −0.0124 [50,] HSbrain_1_l 0.0025 −0.0091 [51,] HS_from_MQbrain_1823_r 0.0025 −0.009 [52,] hsa-mir-145_l 0.0014 −0.0052 [53,] HS_from_MQbrain_194_l 7.00E−04 −0.0024 [54,] hsa-mir-29c_r 3.00E−04 −0.0012 [55,] HSbrain_1384_r 1.00E−04 −4.00E−04 CLASSIFICATION COLORECTAL ADENOMA VS CONTROL >pamr.listgenes(pamr_cgh.class.trained, pamr_cgh.class, threshold = threshold.chosen, genenames = FALSE)

TABLE 5b Statistical analysis prediction tumor type adenoma control Class. Error rate CLASSIFICATION COLORECTAL ADENOMA VS CONTROL >pamr.confusion(pamr_cgh.class.cv, threshold = threshold.chosen) adenoma 27 6 0.181818 control 3 6 0.333333 overall error rate 0.212 AFTER REMOVING THE 55 MIRNAS >pamr.confusion(pamr_cgh.class.cv, threshold = threshold.chosen) adenoma 24 9 0.272727 control 6 3 0.666667 overall error rate 0.349

TABLE 6a List of small RNAs as good classifiers to distinguish colorectal control from adenocarcinoma tissue CLASSIFICATION COLORECTAL ADENOCARCINOMA VS CONTROL >pamr.listgenes(pamr_cgh.class.trained, pamr_cgh.class, threshold = threshold.chosen, genenames = FALSE) carcinoma control Systematic name score score  [1,] HS_from_PT_114_r 0.1516 −0.5222  [2,] HSbrain_377_l 0.1495 −0.5149  [3,] hsa-mir-92-2_r 0.1355 −0.4668  [4,] hsa-mir-92-1_r 0.1346 −0.4635  [5,] HS_from_PT_114_l 0.118 −0.4063  [6,] HSbrain_377_r 0.099 −0.341  [7,] hsa-mir-145_l 0.0883 −0.304  [8,] hsa-mir-92b_r 0.0729 −0.2512  [9,] hsa-mir-199a-2_r 0.0619 −0.2134 [10,] hsa-mir-29a_r 0.0599 −0.2064 [11,] HSbrain_656_l −0.0536 0.1846 [12,] hsa-mir-124a-2_r −0.0507 0.1746 [13,] hsa-mir-29c_r 0.0503 −0.1734 [14,] hsa-mir-124a-1_r −0.0475 0.1635 [15,] HS_from_PT_155_l −0.0468 0.1613 [16,] HSbrain_411_r 0.0468 −0.1612 [17,] HS_from_MQbrain_991_l −0.0443 0.1525 [18,] HS_291_r 0.0435 −0.1498 [19,] hsa-mir-27a_r 0.0433 −0.1492 [20,] HS_from_MQbrain_2700_r 0.0431 −0.1485 [21,] HS_from_MQbrain_2630_l −0.0417 0.1437 [22,] hsa-mir-124a-3_r −0.0417 0.1435 [23,] hsa-mir-635_l −0.0413 0.1423 [24,] hsa-let-7f-1_l 0.0405 −0.1396 [25,] hsa-let-7a-1_l 0.04 −0.1377 [26,] hsa-mir-199a-1_r 0.0393 −0.1353 [27,] hsa-let-7a-2_l 0.0384 −0.1324 [28,] HS_from_MQbrain_1792_l −0.0384 0.1323 [29,] hsa-let-7f-2_l 0.0376 −0.1295 [30,] HS_from_MQbrain_1073_l −0.0373 0.1285 [31,] hsa-mir-564_r −0.0367 0.1263 [32,] hsa-mir-573_l 0.0355 −0.1223 [33,] HS_from_MQbrain_1320_r −0.0347 0.1197 [34,] hsa-mir-21_l 0.0328 −0.113 [35,] HS_from_MQbrain_594_r −0.0311 0.1073 [36,] hsa-mir-98_l 0.0301 −0.1037 [37,] HSbrain_638_l −0.0291 0.1001 [38,] hsa-mir-20b_l 0.0274 −0.0945 [39,] hsa-mir-768_r 0.0269 −0.0926 [40,] HSbrain_1437_r 0.0267 −0.0918 [41,] hsa-mir-181c_l 0.0265 −0.0913 [42,] HS_from_MQbrain_967_l −0.024 0.0826 [43,] HS_291_r 0.0236 −0.0813 [44,] hsa-let-7a-3_l 0.0233 −0.0803 [45,] HS_from_MQbrain_855_r −0.0231 0.0796 [46,] hsa-mir-20a_l 0.0219 −0.0755 [47,] HSbrain_99_l −0.0206 0.0711 [48,] hsa-mir-181a-1_l 0.0203 −0.07 [49,] HS_from_PT_104_l −0.0201 0.0693 [50,] HSbrain_172_l −0.0199 0.0686 [51,] HSbrain_426_r 0.0184 −0.0634 [52,] HSbrain_398_r 0.0181 −0.0623 [53,] HS_from_MQbrain_340_l −0.018 0.0619 [54,] HSbrain_500_r 0.0179 −0.0616 [55,] HSbrain_120_r −0.017 0.0584 [56,] HS_from_MQbrain_1497_l −0.0166 0.0573 [57,] U6_snRNA 0.0156 −0.0538 [58,] hsa-let-7g_l 0.0156 −0.0538 [59,] HS_from_MQbrain_1793_l −0.0156 0.0536 [60,] HS_from_MM_353_l −0.0141 0.0486 [61,] HSbrain_100_l −0.0136 0.0467 [62,] HS_from_MM_210_l −0.0132 0.0453 [63,] HSbrain_704_l −0.0131 0.045 [64,] HS_from_MQbrain_279_l −0.0124 0.0427 [65,] HS_from_MQbrain_485_l −0.0108 0.0372 [66,] Hsd_from_Mmd_328_l −0.0101 0.0348 [67,] hsa-mir-372_r −0.0037 0.0128 [68,] hsa-mir-368_l −0.0034 0.0115 [69,] hsa-mir-17_l 0.0033 −0.0114 [70,] HS_from_MQbrain_1432_l −0.003 0.0104 [71,] HS_from_MM_178_l −0.0029 0.0098 [72,] HSbrain_499_l −0.0028 0.0098 [73,] hsa-mir-126_r 0.0026 −0.0089 [74,] HS_from_PT_146_r 0.0025 −0.0086 [75,] hsa-mir-125a_l 0.0018 −0.0062 [76,] HS_from_MQbrain_827_l −0.0015 0.0053 [77,] HS_215_l −8.00E−04 0.0027 [78,] HS_from_MQbrain_755_l −5.00E−04 0.0016 [79,] HS_from_MM_47_r −3.00E−04 0.001

TABLE 6b Statistical analysis of classifier prediction Tumor type carcinoma control Class. Error rate CLASSIFICATION COLORECTAL ADENOCARCINOMA VS CONTROL >pamr.confusion(pamr_cgh.class.cv, threshold = threshold.chosen) carcinoma 25 6 0.193548 control 2 7 0.222222 overall error rate 0.198 After removing the 79 miRNAs carcinoma 24 7 0.225807 control 8 1 0.888889 overall error rate 0.365

TABLE 7a List of small RNAs as good classifiers to distinguish colorectal adenoma from adenocarcinoma tissue CLASSIFICATION OF COLORECTAL ADENOMA VS ADENOCARCINOMA >pamr.listgenes(pamr_cgh.class.trained, pamr_cgh.class, threshold = threshold.chosen, genenames = FALSE) Systematic name Ad-score Carc-score  [1,] HS_from_MQbrain_1082_l −0.0915 0.0974  [2,] HS_51_r −0.0897 0.0955  [3,] HS_from_MQbrain_1334_r −0.0794 0.0845  [4,] HS_from_MQbrain_1620_r −0.0596 0.0635  [5,] HS_from_MQbrain_1099_r −0.0574 0.0611  [6,] HS_from_MQbrain_63_r −0.0494 0.0526  [7,] HS_176_l −0.0407 0.0433  [8,] HSbrain_687_r −0.0366 0.039  [9,] hsa-mir-375_r 0.0342 −0.0364 [10,] HS_from_MQbrain_458_l −0.0301 0.0321 [11,] HS_from_MQbrain_638_l −0.03 0.032 [12,] HS_from_MM_339_l −0.0299 0.0318 [13,] HSbrain_684_r −0.0258 0.0275 [14,] HSbrain_680_r −0.0236 0.0252 [15,] HS_136_r −0.0233 0.0248 [16,] HS_from_MQbrain_1204_l −0.0196 0.0209 [17,] hsa-mir-136_l −0.0177 0.0188 [18,] HS_from_PT_36_l −0.0173 0.0184 [19,] HSbrain_390_l −0.0168 0.0179 [20,] HSbrain_570_r −0.0135 0.0143 [21,] HSbrain_669_r −0.0122 0.013 [22,] HS_from_MQbrain_824_l −0.011 0.0117 [23,] HS_from_MQbrain_825_r −0.0052 0.0056 [24,] HS_from_PT_201_l −0.0032 0.0034 [25,] HS_from_MQbrain_1985_l 0.0025 −0.0027 [26,] HS_from_MQbrain_579_l 0.0022 −0.0023

TABLE 7b Statistical analysis of classifier prediction tumor type adenoma carcinoma Class. Error rate >pamr.confusion(pamr_cgh.class.cv, threshold = threshold.chosen) CLASSIFICATION OF COLORECTAL ADENOMA VS ADENOCARCINOMA CLASSIFICATION adenoma 25 8 0.242424 carcinoma 8 23 0.258065 overall error 0.248 rate AFTER EXCLUDING THE 26 MIRNAS adenoma 23 10 0.30303 carcinoma 15 16 0.483871 overall error 0.386 rate

TABLE 8 Recovered small RNAs in faeces Systematic name signal/background¹ HS_from_MQbrain_1596_r 435.4766611 HS_from_MQbrain_610_r 397.2236261 HS_from_MQbrain_1365_r 381.7698338 HS_from_MQbrain_1686_l 381.0649897 HS_from_MQbrain_1748_l 379.1642471 HS_from_MQbrain_397_l 374.0176792 HS_from_MQbrain_1006_r 373.1830201 HS_from_PT_134_l 371.7744239 HSbrain_367_r 365.4950355 HS_from_MQbrain_1575_r 363.8207777 HS_from_MQbrain_1245_r 362.2517824 HSbrain_154_l 356.5198479 Hsd_from_Mmd_472_r 353.9520892 HSbrain_797_l 352.8430904 HS_from_MM_315_l 352.564084 Hsd_from_Mmd_167_r 352.3358142 HS_from_MQbrain_520_r 352.1386318 HS_148_r 351.4766543 HSbrain_104_l 351.1481239 HS_from_MM_347_l 350.4004069 HS_from_MQbrain_1053_r 350.2064947 HSbrain_402_l 349.5145921 HSbrain_750_l 346.8737514 HS_from_MM_73_l 346.8607343 HSbrain_783_l 345.0006901 HS_from_MQbrain_1185_r 344.3922571 HS_from_MQbrain_498_r 342.07876 HS_from_MQbrain_684_r 341.5414126 Hsd_from_Mmd_424_r 340.2003175 HS_64_l 340.1621279 HSbrain_316_l 339.4367001 HS_from_MQbrain_747_l 339.3507657 HS_from_MQbrain_301_r 337.8052813 HS_from_MQbrain_1833_r 336.9120561 HSbrain_393_r 336.1272016 HSbrain_761_r 335.820625 HSbrain_467_l 335.0856427 HSbrain_259_r 334.9867442 HS_from_MQbrain_429_r 334.982389 HSbrain_268_l 334.6908402 HSbrain_326_l 334.5936127 HSbrain_365_r 333.5124629 HS_from_MQbrain_1846_r 333.0341838 HS_from_MQbrain_1727_r 332.7123109 HSbrain_129_r 331.9994753 Hsd_from_Mmd_295_r 331.1451277 HS_98_r 330.803132 Hsd_from_Mmd_510_l 330.4724501 HS_from_MQbrain_1677_l 330.4254578 HS_38_l 330.3876378 HSbrain_273_r 329.7258072 HSbrain_431_l 329.5258621 HSbrain_668_l 328.9649666 HS_from_MQbrain_1349_l 328.4193266 HS_31_l 328.1743211 HSbrain_168_l 327.7976202 HS_from_MQbrain_115_r 327.5091884 HS_from_MM_339_r 327.2871875 HS_from_MM_355_l 326.4926227 HS_249_l 326.2091382 HS_from_MM_216_r 326.1851794 HS_from_MQbrain_341_l 325.8932327 HS_123_l 325.8368333 HS_from_MQbrain_544_r 325.7380605 HSbrain_869_r 325.529766 HS_from_MQbrain_731_l 324.8256023 HS_from_MM_240_r 324.7437047 HS_from_MQbrain_1339_l 322.8532283 HSbrain_105_l 321.4268792 HS_from_MQbrain_1711_r 320.9572229 HS_from_MQbrain_1652_r 320.4545063 HS_from_MQbrain_1470_r 320.2896415 Hsd_66_r 320.1767206 HS_39_r 320.0335858 HS_from_MQbrain_1073_r 319.8894959 HS_156_r 319.2763913 HS_from_MQbrain_1376_l 319.0687179 Hsd_39_l 318.8240319 HSbrain_490_r 318.789703 HS_from_MQbrain_753_l 318.6834937 HS_from_MQbrain_928_r 318.1021923 HS_from_MQbrain_1210_l 318.0464645 HSbrain_202_r 317.8857843 HS_from_MM_351_r 317.8521227 HSbrain_323_l 317.2801386 HS_from_PT_101_l 317.1749629 HS_from_MQbrain_559_l 316.9112294 HS_from_MQbrain_1119_l 316.6560497 HS_from_PT_185_r 316.2367142 HS_from_MQbrain_491_l 315.5363383 HSbrain_218_r 315.5273574 HS_from_MQbrain_162_r 314.656125 HSbrain_802_l 314.4005359 HS_222_r 313.9881647 HSbrain_673_l 313.971615 HS_from_MQbrain_158_r 313.8141203 HS_from_MQbrain_76_l 313.7393384 HSbrain_250_l 313.5276305 HS_from_MQbrain_33_l 313.4922139 HS_from_MQbrain_1237_l 313.2573889 HS_25_r 313.2035431 HS_from_PT_226_r 313.0722924 HS_from_MQbrain_1018_l 312.5603857 HS_from_MQbrain_1306_r 312.3615258 HSbrain_93_l 312.1999205 HSbrain_118_r 311.3195051 HSbrain_355_r 310.7457981 HSbrain_731_l 310.1586585 HS_from_MQbrain_886_r 310.0903943 HS_from_PT_231_r 310 HSbrain_1413_r 309.9504964 HS_from_MQbrain_1355_r 309.6691714 HS_279_l 309.5850497 Hsd_from_Mmd_246_r 309.4213909 Hsd_from_Mmd_344_r 309.0726717 HS_from_MQbrain_1797_r 308.3812108 HS_263_r 308.2617369 HS_from_MQbrain_495_l 307.6030143 HS_from_MQbrain_1475_l 307.3970336 HS_from_MQbrain_1890_r 307.317464 HS_from_MQbrain_1697_r 307.3045602 HS_from_MQbrain_1620_l 307.2296305 HSbrain_669_l 307.2172689 HS_from_PT_55_l 307.1963218 HS_206_l 307.0627996 Hsd_from_Mmd_237_l 306.9716516 HS_265_r 306.7532262 HS_from_MM_324_l 306.7520389 HS_from_MQbrain_1701_l 306.7083454 HSbrain_166_l 305.2218421 Hsd_from_Mmd_56_r 305.1038545 HS_55_l 304.7252967 HS_179_l 304.5575276 HS_from_MQbrain_1102_l 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Hsd_from_Mmd_524_r 14.7018346 HSbrain_602_r 14.66781038 HS_262_l 14.64955868 HS_from_MM_254_r 14.60568724 HS_from_MQbrain_1746_r 14.49926674 HS_from_MQbrain_1893_r 14.47922582 HSbrain_16_l 14.42037004 HS_from_MQbrain_1879_r 14.39648047 HSbrain_446_l 14.33402718 HSbrain_137_l 14.29565616 HS_294_r 14.28845143 HSbrain_356_l 14.19629964 HS_from_PT_155_r 14.06410331 HSbrain_24_l 14.04788368 HS_from_MQbrain_1811_l 13.90556328 HS_from_MQbrain_1799_l 13.49508607 HS_16_r 13.45833857 HS_from_PT_113_l 13.41746343 HS_from_MQbrain_1880_r 13.37337073 Hsd_9_l 13.04883428 HSbrain_732_r 12.92048191 HSbrain_432_l 12.91311938 HSbrain_454_r 12.81394683 Hsd_from_Mmd_249_r 12.73986084 HS_from_PT_195_l 12.68428891 HSbrain_256_r 12.675 HS_from_MM_72_l 12.60592101 HS_from_MQbrain_1195_l 12.59863883 HS_from_MQbrain_1188_r 12.51525581 HS_from_MQbrain_542_l 12.4589606 Hsd_from_Mmd_490_l 12.34090149 HS_202_l 12.33606455 Hsd_from_Mmd_325_l 12.27846175 HSbrain_641_l 12.19531359 HS_from_MQbrain_1805_r 12.08133366 HSbrain_222_l 12.01722409 HS_from_MQbrain_1214_l 11.99962527 HSbrain_486_r 11.92687298 HSbrain_190_l 11.90155086 HS_from_PT_282_l 11.85767781 HS_from_MQbrain_1857_l 11.81637718 HS_from_PT_253_l 11.63356298 HS_82_l 11.58743783 HS_from_MQbrain_992_l 11.55219844 HS_27_l 11.5189217 Hsd_55_l 11.47708921 HS_from_MQbrain_1217_l 11.46181019 HS_from_MQbrain_182_l 11.36963928 HS_from_PT_301_r 11.35875076 HS_from_PT_13_r 11.28505999 HS_from_PT_126_r 11.24987161 HS_from_MQbrain_1694_r 11.24856812 HSbrain_532_l 11.20284123 HS_from_PT_315_l 11.14257669 HS_from_MQbrain_656_l 11.0380573 HS_from_MQbrain_1264_r 10.9879875 HS_from_MQbrain_179_l 10.93508111 HSbrain_122_r 10.91049034 HSbrain_791_l 10.8880558 HSbrain_792_l 10.74841217 HS_from_MQbrain_8_r 10.6772637 HS_from_MQbrain_1432_l 10.63790696 Hsd_from_Mmd_523_l 10.60175496 HS_from_MQbrain_787_l 10.45276823 HSbrain_271_r 10.39774564 HS_from_PT_297_l 10.3817856 HS_from_MQbrain_389_l 10.36562841 Hsd_from_Mmd_306_r 10.35597869 HS_from_MQbrain_140_r 10.33466558 HS_130_l 10.32443146 Hsd_from_Mmd_336_r 10.26104082 Hsd_from_Mmd_243_r 10.21164464 HS_from_MQbrain_827_r 10.04636996 Hsd_from_Mmd_217_l 10.0411297 HS_from_MM_271_r 9.974500263 HSbrain_174_l 9.914419841 HS_from_MQbrain_1059_r 9.903606705 HSbrain_451_r 9.891359358 HS_from_MM_30_l 9.828879468 HSbrain_389_l 9.742590244 Hsd_from_Mmd_334_l 9.461092816 HSbrain_539_r 9.402802755 HS_from_MQbrain_172_r 9.3950049 Hsd_from_Mmd_491_r 9.356107716 HS_from_PT_321_r 9.355284488 HS_from_MM_214_r 9.312015244 HS_181_r 9.247606951 HSbrain_242_l 9.140095581 HSbrain_719_l 9.057424006 HS_from_PT_216_r 9.04533293 Hsd_106_l 9.004764262 HS_from_MQbrain_1216_l 8.977281937 HS_49_r 8.969465473 HS_from_MQbrain_521_r 8.94922503 HSbrain_76_r 8.849660075 HS_from_PT_309_l 8.806106342 HS_from_MM_275_r 8.801848936 HS_from_MQbrain_1784_r 8.765325591 HSbrain_320_l 8.739860007 HS_from_MM_169_r 8.697594288 HSbrain_414_r 8.667025277 HSbrain_468_r 8.648929144 HS_from_MQbrain_597_l 8.606774472 HS_from_MQbrain_1238_r 8.560768136 HS_from_MQbrain_1576_r 8.509211792 HSbrain_711_r 8.507528601 HS_270_l 8.500056129 HS_from_MQbrain_189_r 8.458412909 HSbrain_803_r 8.436925155 HS_from_MQbrain_354_l 8.378373604 HS_from_MQbrain_1514_r 8.3514592 Hsd_23_l 8.323337473 HS_from_MQbrain_329_r 8.298733963 HS_from_MQbrain_694_l 8.295833858 HS_from_PT_168_r 8.28827405 HS_from_MQbrain_209_l 8.267384678 HS_from_MQbrain_1124_l 8.263702597 HS_from_MQbrain_581_r 8.223408593 HS_from_MQbrain_796_r 8.179623288 Hsd_from_Mmd_464_r 8.134582867 HS_from_MQbrain_995_l 8.045505431 HSbrain_609_r 8.027284091 HS_296_l 8.020342859 HS_from_MM_164_r 8.01189659 Hsd_from_Mmd_422_r 8.004189538 HS_from_MM_34_l 7.978839103 Hsd_53_l 7.976949043 Hsd_from_Mmd_58_l 7.966323875 HS_from_MM_256_l 7.965453015 HSbrain_501_l 7.947790019 HS_from_MQbrain_817_l 7.907551804 HS_from_PT_138_r 7.906213461 HS_264_r 7.905646906 HS_from_MQbrain_1203_r 7.900397573 HSbrain_598_r 7.899656198 HS_from_MM_92_l 7.887171356 Hsd_from_Mmd_117_r 7.718924828 Hsd_54_l 7.702137509 HS_271_l 7.649964483 Hsd_from_Mmd_506_l 7.638500912 HSbrain_100_r 7.597636684 HSbrain_615_r 7.513083761 HS_from_PT_7_r 7.471471439 HSbrain_22_l 7.394968873 HSbrain_296_r 7.377471663 HS_132_l 7.348116533 HS_253_r 7.309083262 HS_269_l 7.231720764 HS_261_l 7.115946746 HS_from_MQbrain_1414_r 7.115880718 Hsd_from_Mmd_437_r 7.112646234 HS_from_MQbrain_603_r 7.108558771 HS_293_l 7.088759746 HS_from_PT_193_l 7.000684 HSbrain_345_l 6.991513121 HS_from_MQbrain_1636_l 6.953922141 HS_from_MQbrain_365_l 6.941331531 HS_from_MQbrain_367_r 6.938384447 Hsd_from_Mmd_318_r 6.911841179 HS_from_PT_35_r 6.863541091 HSbrain_519_l 6.827428395 HSbrain_83_r 6.664458888 HSbrain_99_r 6.64726838 HSbrain_397_l 6.63113271 HS_from_MQbrain_1110_r 6.60657006 HS_from_MQbrain_1428_r 6.548707334 HS_from_MQbrain_855_r 6.514975985 HS_from_MQbrain_1127_r 6.478685264 Hsd_from_Mmd_300_l 6.467880633 HS_from_MQbrain_1444_l 6.459126984 HS_from_MM_186_r 6.438164347 HSbrain_726_l 6.434813111 Hsd_from_Mmd_378_l 6.433733047 HS_from_MQbrain_1196_r 6.432257948 HS_from_MQbrain_1792_r 6.412117504 Hsd_from_Mmd_314_r 6.401270974 HS_from_MQbrain_161_r 6.387946973 HS_from_MQbrain_176_r 6.3337272 HS_from_MQbrain_728_r 6.311020118 HS_from_MQbrain_584_r 6.293457493 HS_250_l 6.287211447 HS_from_MQbrain_1726_l 6.286472819 HS_from_MQbrain_1836_l 6.267799948 HSbrain_770_l 6.241026808 Hsd_from_Mmd_75_r 6.235422423 HS_from_PT_99_l 6.209015876 HS_80_l 6.188564855 Hsd_from_Mmd_37_l 6.088255723 HS_from_MM_331_l 6.063144444 HS_from_PT_63_l 6.041521667 HS_from_MM_129_l 5.994127046 HSbrain_312_r 5.989098244 HS_from_MQbrain_1287_l 5.969747859 HS_from_PT_287_l 5.921804778 HS_from_MQbrain_1442_l 5.874225415 HS_from_MQbrain_1626_r 5.841073155 Hsd_from_Mmd_431_r 5.823283134 HSbrain_587_l 5.720693567 Hsd_from_Mmd_286_r 5.6723549 HS_from_MM_241_r 5.640741712 HSbrain_884_r 5.628250928 HS_from_MQbrain_1362_r 5.601980717 HS_from_MM_342_r 5.590510164 HS_from_MQbrain_681_r 5.585694118 HSbrain_149_r 5.583342412 HS_from_MQbrain_1325_r 5.47614768 HS_from_MM_20_l 5.47139804 HS_from_MQbrain_843_l 5.455426554 HSbrain_625_l 5.435431773 HSbrain_322_r 5.365626693 HS_from_MQbrain_1330_r 5.28181558 HS_from_PT_332_l 5.2733498 Hsd_from_Mmd_260_l 5.210287976 Hsd_from_Mmd_105_l 5.193639257 HSbrain_438_l 5.166472999 Hsd_96_r 5.165955532 Hsd_from_Mmd_54_l 5.159018659 HS_from_MQbrain_637_l 5.142521242 HSbrain_777_r 5.13504626 HS_from_MM_320_l 5.118764197 HSbrain_646_l 5.06314414 HS_from_MM_108_l 5.025117442 HSbrain_17_l 4.967438933 HS_from_MM_173_r 4.943371194 HS_from_MM_99_l 4.941226582 HS_from_MM_54_l 4.939670275 HS_from_MM_180_l 4.925462788 HS_301_l 4.918434367 HSbrain_215_r 4.813707447 HS_from_MQbrain_144_l 4.773009427 Hsd_from_Mmd_363_l 4.747442615 HS_from_MQbrain_1806_l 4.715008642 HS_from_PT_224_r 4.699668621 Hsd_from_Mmd_516_l 4.635744497 HSbrain_384_l 4.544181943 HSbrain_437_l 4.53872403 HS_from_MQbrain_1020_r 4.533028897 HSbrain_416_l 4.50890556 HS_from_MQbrain_653_l 4.501537159 Hsd_from_Mmd_48_r 4.488918042 Hsd_from_Mmd_163_r 4.482580882 HSbrain_298_l 4.466165605 HS_from_MQbrain_779_r 4.449613618 Hsd_from_Mmd_264_l 4.418448309 HS_from_MQbrain_1518_r 4.395289501 HS_from_MQbrain_1849_l 4.347274863 HSbrain_4_r 4.32906393 HS_from_PT_188_r 4.316585673 Hsd_from_Mmd_253_r 4.315801417 HS_from_MQbrain_366_r 4.292586708 HS_from_MM_50_r 4.289479841 HSbrain_579_l 4.276586895 HS_from_MM_270_r 4.214386428 HS_from_MM_263_r 4.175244885 HS_from_MQbrain_1946_l 4.165279786 HSbrain_1404_l 4.149119572 HS_from_PT_73_r 4.147610682 Hsd_from_Mmd_372_r 4.138862422 Hsd_45_r 4.133836037 HS_from_MQbrain_1550_r 4.129298294 HS_from_MQbrain_1840_l 4.101477435 HS_302_l 4.060716908 HS_210_r 4.043610319 HSbrain_695_r 4.015688972 Hsd_from_Mmd_319_r 3.975166738 HSbrain_538_r 3.973394819 HSbrain_775_r 3.957435197 HS_from_PT_172_r 3.955677596 HSbrain_714_r 3.916807584 Hsd_94_r 3.914560357 HSbrain_34_l 3.900138034 HS_from_MQbrain_1817_l 3.888478757 HS_from_MQbrain_133_l 3.872882828 Hsd_from_Mmd_316_l 3.862039898 HS_from_MM_353_l 3.859645753 HSbrain_199_r 3.848060046 HS_from_PT_177_l 3.844770953 HS_from_MM_131_l 3.843700557 HS_from_MM_283_l 3.835559931 HSbrain_327_r 3.828446699 HS_from_MQbrain_237_l 3.827625487 HS_from_MQbrain_1489_l 3.827197683 HS_from_PT_242_r 3.826482783 HS_from_MQbrain_675_l 3.821332516 HS_127_l 3.813883173 HSbrain_26_r 3.807676617 HS_from_MM_47_r 3.767205302 Hsd_from_Mmd_115_l 3.754433136 HSbrain_489_r 3.754378803 HSbrain_566_r 3.737039243 HSbrain_623_l 3.719892174 Hsd_101_l 3.714373078 HSbrain_444_l 3.697175272 HS_from_MQbrain_768_l 3.670091279 HSbrain_552_l 3.649272388 HS_from_MQbrain_236_l 3.625507462 HSbrain_779_l 3.584724644 Hsd_from_Mmd_382_l 3.519705525 HS_from_PT_206_l 3.499387091 HSbrain_395_r 3.49723377 HSbrain_28_r 3.479753348 HS_from_MQbrain_1770_l 3.46187934 HS_from_MM_41_l 3.445933309 Hsd_from_Mmd_67_l 3.440647552 Hsd_81_r 3.432967686 HSbrain_234_r 3.407293997 HSbrain_583_l 3.381538102 HS_175_r 3.357952232 HSbrain_1405_l 3.356703194 HSbrain_36_l 3.355223023 HSbrain_799_r 3.32764451 HSbrain_156_r 3.316412833 HS_292_r 3.304463889 HSbrain_270_l 3.298294118 HSbrain_120_l 3.289133711 HS_from_MQbrain_393_r 3.278433239 HSbrain_413_l 3.253659453 HS_from_MQbrain_571_l 3.230584236 HS_from_PT_36_l 3.220412941 HS_37_l 3.206393454 HS_52_r 3.202332911 Hsd_from_Mmd_137_l 3.199011474 HS_30_l 3.198916759 HS_from_MQbrain_241_r 3.185534964 HS_from_MQbrain_961_l 3.171813525 Hsd_from_Mmd_126_r 3.136748756 Hsd_from_Mmd_294_l 3.120693079 HS_from_MQbrain_1381_l 3.05930194 HS_from_MQbrain_309_r 3.055368101 HS_from_MQbrain_1453_l 2.994679273 HS_from_PT_271_l 2.99221888 HSbrain_198_r 2.990967111 Hsd_from_Mmd_293_l 2.967120325 HS_from_MQbrain_1598_r 2.953508283 HS_from_MM_48_r 2.942281873 HS_from_MM_230_l 2.933799334 Hsd_from_Mmd_321_r 2.930696257 HS_120_l 2.924334019 Hsd_75_r 2.904138309 HSbrain_179_r 2.892784879 HSbrain_766_l 2.881094354 Hsd_from_Mmd_376_l 2.856829716 Hsd_from_Mmd_154_l 2.836322667 HS_from_MQbrain_77_l 2.793426308 HS_from_MM_105_l 2.764361009 HS_from_MQbrain_600_r 2.759134838 HS_from_PT_288_l 2.734365188 HS_from_MQbrain_689_l 2.726769607 HS_241_r 2.716303039 HS_from_PT_84_l 2.714709014 HSbrain_86_r 2.701204062 HSbrain_245_r 2.699435997 Hsd_from_Mmd_373_r 2.690929354 HSbrain_377_r 2.687263122 HSbrain_20_r 2.643971939 HSbrain_755_l 2.63850582 HS_from_MQbrain_1146_r 2.637847458 HS_from_MQbrain_314_l 2.61540593 Hsd_57_r 2.605334909 HS_from_MQbrain_1343_r 2.598031533 HSbrain_87_r 2.5925368 Hsd_from_Mmd_346_l 2.586537564 Hsd_from_Mmd_396_r 2.565770876 Hsd_10_r 2.526022642 HS_from_MM_354_l 2.51152459 Hsd_from_Mmd_35_l 2.507108516 HS_14_l 2.504007921 Hsd_from_Mmd_503_r 2.500865194 HS_from_MQbrain_1042_l 2.492234297 HS_from_MQbrain_1137_l 2.48333526 HS_from_MQbrain_967_r 2.462255581 HSbrain_453_l 2.447562054 HS_from_MQbrain_1004_r 2.444952219 HSbrain_970_r 2.440271917 Hsd_from_Mmd_361_l 2.438145559 HS_from_MQbrain_1114_l 2.428090643 HS_from_MQbrain_116_r 2.413035295 HSbrain_650_r 2.37442311 HS_from_PT_201_r 2.367251208 HS_from_MM_84_l 2.359765653 HS_from_MM_35_l 2.357250026 HS_from_MM_218_l 2.349494942 HS_from_MQbrain_822_l 2.343923008 Hsd_from_Mmd_184_r 2.326116517 HS_205_r 2.316073448 HSbrain_682_l 2.31200622 HS_from_PT_118_r 2.299993921 HS_66_l 2.296381916 HS_from_MQbrain_1294_l 2.290891026 HS_from_MQbrain_384_l 2.290767433 HS_73_l 2.284341705 HSbrain_567_r 2.278153257 HS_23_r 2.270142822 Hsd_48_r 2.234838488 Hsd_41_r 2.227383669 HSbrain_644_r 2.20892511 HSbrain_308_l 2.202113484 HS_from_MM_288_r 2.194320275 HS_209_r 2.177385602 HSbrain_477_l 2.16939955 HS_from_MQbrain_1570_r 2.155106437 Hsd_from_Mmd_162_r 2.145184152 HS_from_MQbrain_748_l 2.128371426 HS_from_MM_127_r 2.123969014 Hsd_from_Mmd_302_l 2.116616569 HS_from_MQbrain_876_l 2.116156997 Hsd_from_Mmd_276_l 2.097724083 HSbrain_21_r 2.096124188 HS_from_MM_323_l 2.074777286 Hsd_from_Mmd_82_l 2.072192829 HSbrain_725_r 2.042955708 HS_237_l 2.042459608 HS_from_MM_68_l 2.035960337 HSbrain_264_r 2.028164366 ¹Cut off signal/background >2

TABLE 9a Small RNAs recovered from faeces and differentially expressed in adenoma vs control tissue: hairpin with highest expression adenoma vs control Systematic name signal/background¹ (adj p)² HS_217_l 228.449758 0.000489293 HS_169_l 153.6041594 0.000489293 HS_141_l 141.8565157 0.000489293 HS_218_r 235.8613357 0.000704567 HS_255_l 161.1405598 0.001129352 HS_232_l 120.592551 0.001129352 HS_262_l 14.64955868 0.001446314 HS_from_MM_118_r 70.86890311 0.003939952 HS_from_MM_309_r 208.0343975 0.004006907 HS_from_MM_178_r 86.39079121 0.004006907 HS_from_MM_169_r 8.697594288 0.004006907 HS_from_MM_319_l 202.6221234 0.004431894 HS_from_MM_334_l 165.3471372 0.004431894 HS_from_MM_339_r 327.2871875 0.004575487 HS_from_MQbrain_100_l 133.6513061 0.004575487 HS_from_MM_63_l 31.12592861 0.004575487 HS_from_MM_39_l 15.46864042 0.004575487 HS_from_MQbrain_1043_r 281.5762963 0.004799641 HS_from_MQbrain_1056_l 71.54390765 0.004799641 HS_from_MQbrain_1183_l 198.4935006 0.004957702 HS_from_MQbrain_1100_l 165.2906308 0.004957702 HS_from_MQbrain_1128_l 158.837926 0.004957702 HS_from_MQbrain_1297_l 270.3967365 0.006601644 HS_from_MQbrain_1292_r 121.9448163 0.006601644 HS_from_MQbrain_1393_r 223.7656716 0.00676609 HS_from_MQbrain_131_r 202.0595323 0.00676609 HS_from_MQbrain_1444_l 6.459126984 0.007781761 HS_from_MQbrain_1456_l 199.1014452 0.008573112 HS_from_MQbrain_1630_l 245.6614642 0.008946182 HS_from_MQbrain_1625_r 238.0330045 0.008946182 HS_from_MQbrain_1624_l 192.3884805 0.008946182 HS_from_MQbrain_1522_r 112.3011721 0.008946182 HS_from_MQbrain_1485_r 90.24185865 0.008946182 HS_from_MQbrain_1657_r 116.3148049 0.009734613 HS_from_MQbrain_1808_r 253.1879056 0.01044887 HS_from_MQbrain_191_l 203.1756555 0.01044887 HS_from_MQbrain_1884_r 159.9476968 0.01044887 HS_from_MQbrain_1823_r 44.43291919 0.01044887 HS_from_MQbrain_1792_r 6.412117504 0.01044887 HS_from_MQbrain_671_r 263.6821505 0.010727702 HS_from_MQbrain_71_r 252.4897985 0.010727702 HS_from_MQbrain_330_r 236.6286556 0.010727702 HS_from_MQbrain_20_r 229.8506554 0.010727702 HS_from_MQbrain_629_l 195.1102679 0.010727702 HS_from_MQbrain_350_l 189.461419 0.010727702 HS_from_MQbrain_2380_r 187.2947993 0.010727702 HS_from_MQbrain_207_l 157.9140691 0.010727702 HS_from_MQbrain_349_l 135.3020631 0.010727702 HS_from_MQbrain_619_r 122.6749499 0.010727702 HS_from_MQbrain_194_l 110.0069304 0.010727702 HS_from_MQbrain_212_r 83.02395006 0.010727702 HS_from_MQbrain_549_l 34.06783333 0.010727702 HS_from_MQbrain_441_l 32.28225695 0.010727702 HS_from_MQbrain_55_l 15.80840103 0.010727702 HS_from_MQbrain_839_r 92.94488973 0.011699489 HS_from_MQbrain_79_r 48.19976833 0.011699489 HS_from_MQbrain_917_r 280.5140354 0.012506309 HS_from_MQbrain_940_r 239.4870149 0.012506309 HS_from_MQbrain_965_l 235.4627068 0.012506309 HS_from_PT_237_r 288.8596386 0.013034759 HS_from_PT_190_r 138.4453126 0.013034759 HS_from_PT_257_r 27.728139 0.013034759 HS_from_PT_40_r 19.96645961 0.013034759 HS_from_PT_36_l 3.220412941 0.013034759 HS_from_PT_201_r 2.367251208 0.013034759 HSbrain_171_l 255.6856718 0.017198956 HSbrain_148_r 224.0526161 0.017198956 HSbrain_102_r 200.4155278 0.017198956 HSbrain_158_l 169.343928 0.017198956 HSbrain_1305_l 145.0316211 0.017198956 HSbrain_1_l 76.8373873 0.017198956 HSbrain_106_r 74.6228739 0.017198956 HSbrain_12_l 53.76557022 0.017198956 HSbrain_231_l 226.0585846 0.018600058 HSbrain_321_r 211.435012 0.018600058 HSbrain_243_l 182.2549801 0.018600058 HSbrain_224_r 81.77304743 0.018600058 HSbrain_2_l 49.67189807 0.018600058 HSbrain_426_r 262.208223 0.019454312 HSbrain_420_r 228.3614012 0.019454312 HSbrain_359_r 226.1695269 0.019454312 HSbrain_337_l 85.40127884 0.019454312 HSbrain_446_l 14.33402718 0.019454312 HSbrain_377_r 2.687263122 0.019454312 HSbrain_485_r 258.4877461 0.021088597 HSbrain_527_r 228.8704808 0.021088597 HSbrain_483_l 220.2067855 0.021088597 HSbrain_503_r 181.710235 0.021088597 HSbrain_540_r 19.28862768 0.021088597 HSbrain_583_l 3.381538102 0.021088597 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HSbrain_86_r 2.701204062 0.098921026 HS_from_MQbrain_1355_r 309.6691714 0.103393572 HS_from_MQbrain_1459_l 257.1079597 0.103393572 HSbrain_677_l 223.7296488 0.103393572 HS_from_MQbrain_609_l 213.1909341 0.103393572 HS_from_MQbrain_943_l 199.1939949 0.103393572 HSbrain_596_r 183.4234846 0.103393572 HS_from_PT_22_l 169.7548575 0.103393572 HS_from_MQbrain_1744_r 145.1169393 0.103393572 HSbrain_482_l 110.0149117 0.103393572 HSbrain_94_l 96.33702157 0.103393572 HSbrain_343_l 82.34298795 0.103393572 HS_68_l 77.85150167 0.103393572 HS_172_r 66.96978425 0.103393572 HS_from_MQbrain_906_r 47.10729944 0.103393572 HSbrain_504_r 45.47207589 0.103393572 HS_from_MQbrain_1784_r 8.765325591 0.103393572 HS_from_MQbrain_1442_l 5.874225415 0.103393572 HS_from_MQbrain_114_r 298.9587162 0.108118292 HS_from_MQbrain_546_l 288.7897335 0.108118292 HSbrain_536_r 269.1404787 0.108118292 Hsd_from_Mmd_291_r 266.1652183 0.108118292 HS_from_MQbrain_1627_l 251.4373669 0.108118292 HS_101_l 239.0332153 0.108118292 HSbrain_643_l 212.7527559 0.108118292 HS_from_MQbrain_1366_l 212.34134 0.108118292 HS_from_PT_220_l 201.2064584 0.108118292 HSbrain_280_l 188.6563025 0.108118292 HS_from_MQbrain_374_r 170.5241907 0.108118292 HS_from_MQbrain_80_l 62.18301452 0.108118292 Hsd_from_Mmd_478_l 24.52473283 0.108118292 Hsd_from_Mmd_249_r 12.73986084 0.108118292 HS_from_PT_7_r 7.471471439 0.108118292 HSbrain_384_l 4.544181943 0.108118292 HS_from_MQbrain_1840_l 4.101477435 0.108118292 HS_from_MQbrain_604_l 289.730194 0.113099484 HSbrain_328_l 280.7719926 0.113099484 HSbrain_520_l 236.1868036 0.113099484 HSbrain_227_r 226.199823 0.113099484 HSbrain_267_l 214.022333 0.113099484 HS_from_MQbrain_1478_l 192.6931886 0.113099484 HS_from_MQbrain_921_l 192.1335465 0.113099484 HSbrain_764_r 117.9645256 0.113099484 HS_from_MQbrain_1502_l 54.14110189 0.113099484 Hsd_from_Mmd_391_l 43.63503635 0.113099484 HSbrain_412_l 37.17793298 0.113099484 HSbrain_159_l 19.09259883 0.113099484 HS_from_MQbrain_105_l 16.80746034 0.113099484 HSbrain_145_l 267.9664391 0.11858389 HS_from_MQbrain_1889_l 262.029435 0.11858389 HS_from_MQbrain_999_l 259.1426385 0.11858389 Hsd_from_Mmd_518_r 238.0578899 0.11858389 HS_289_l 236.2167396 0.11858389 HSbrain_664_r 222.5408696 0.11858389 HS_from_MQbrain_1750_r 217.7023298 0.11858389 HS_from_MQbrain_1834_r 187.1781356 0.11858389 Hsd_from_Mmd_93_l 186.4505924 0.11858389 HS_from_MQbrain_592_l 181.6866459 0.11858389 HS_from_MQbrain_1590_l 163.8114142 0.11858389 HS_from_MQbrain_1487_r 119.4385433 0.11858389 HS_from_MQbrain_502_r 118.3776111 0.11858389 HS_98_r 330.803132 0.12422104 HS_25_r 313.2035431 0.12422104 Hsd_from_Mmd_237_l 306.9716516 0.12422104 Hsd_17_l 255.7570196 0.12422104 HS_from_MM_87_l 240.7726111 0.12422104 HS_from_MQbrain_789_l 239.2174834 0.12422104 HS_from_MQbrain_1184_r 208.6202764 0.12422104 HSbrain_50_l 203.7449536 0.12422104 HS_287_l 203.2812692 0.12422104 HS_from_MM_79_l 199.5386163 0.12422104 HSbrain_570_l 194.0529436 0.12422104 HS_from_MQbrain_490_r 162.3944533 0.12422104 HS_from_MQbrain_1304_r 154.625417 0.12422104 Hsd_from_Mmd_328_r 117.324613 0.12422104 HS_from_MQbrain_1109_l 62.73503843 0.12422104 HSbrain_131_l 51.07910404 0.12422104 HS_from_MQbrain_1384_r 26.20937179 0.12422104 HS_from_MQbrain_161_r 6.387946973 0.12422104 HSbrain_152_l 261.0331392 0.129399391 HS_from_MQbrain_36_r 247.5789144 0.129399391 HS_from_MQbrain_1574_l 236.4214286 0.129399391 HS_from_MQbrain_1794_r 227.1557202 0.129399391 HSbrain_204_r 217.0811451 0.129399391 HSbrain_72_l 206.0852876 0.129399391 HS_from_MQbrain_1776_l 205.2456623 0.129399391 HS_109_l 200.1919676 0.129399391 HS_from_MM_304_r 195.9761008 0.129399391 HS_from_MQbrain_1839_l 186.2075177 0.129399391 HSbrain_448_l 162.0375436 0.129399391 HS_85_l 96.48110294 0.129399391 HS_from_MQbrain_597_l 8.606774472 0.129399391 Hsd_from_Mmd_363_l 4.747442615 0.129399391 HSbrain_970_r 2.440271917 0.129399391 HS_from_MQbrain_684_r 341.5414126 0.134970683 Hsd_74_r 274.0203487 0.134970683 HS_from_MQbrain_1523_r 272.3792039 0.134970683 HS_from_MQbrain_540_l 268.4654883 0.134970683 HS_from_MQbrain_1318_l 223.6306158 0.134970683 HS_from_MQbrain_99_r 220.3197222 0.134970683 HS_from_MQbrain_234_r 205.0056018 0.134970683 Hsd_from_Mmd_101_r 177.7313602 0.134970683 HS_from_PT_250_r 169.7827673 0.134970683 HS_from_MQbrain_1692_l 158.6415708 0.134970683 HS_from_MQbrain_1097_r 128.6204149 0.134970683 HS_from_MM_185_r 68.74396066 0.134970683 HS_from_MQbrain_1081_r 20.97667628 0.134970683 HS_261_l 7.115946746 0.134970683 HS_from_MQbrain_1806_l 4.715008642 0.134970683 HSbrain_108_l 266.7753944 0.140323812 HS_219_l 254.6760586 0.140323812 HS_from_PT_178_l 242.7023061 0.140323812 HS_from_MQbrain_1855_l 238.2044165 0.140323812 HS_168_r 235.6020265 0.140323812 HSbrain_361_l 234.5281831 0.140323812 HS_121_r 231.1610876 0.140323812 Hsd_from_Mmd_123_l 230.1089517 0.140323812 HSbrain_144_r 224.6332678 0.140323812 HS_161_r 216.0695424 0.140323812 HS_from_MQbrain_467_l 209.268142 0.140323812 HS_from_MQbrain_22_r 187.1051151 0.140323812 HSbrain_716_l 180.5676912 0.140323812 HS_53_r 140.0976088 0.140323812 HS_41_r 112.6985514 0.140323812 HSbrain_737_r 53.36757802 0.140323812 Hsd_from_Mmd_523_l 10.60175496 0.140323812 HS_241_r 2.716303039 0.140323812 HS_from_MQbrain_1675_r 288.3970715 0.146822481 HS_from_MQbrain_67_l 255.5891945 0.146822481 HS_from_PT_219_l 253.1829244 0.146822481 HS_from_MQbrain_1807_l 220.9858095 0.146822481 HS_from_MQbrain_97_r 220.2493082 0.146822481 HSbrain_130_l 216.1273018 0.146822481 HS_from_MQbrain_1222_r 214.0598655 0.146822481 HS_from_MQbrain_1493_r 207.5291507 0.146822481 HS_from_MQbrain_1695_r 204.2688796 0.146822481 HS_from_MQbrain_1036_r 203.1951911 0.146822481 Hsd_77_r 200.6733718 0.146822481 HS_from_MQbrain_1030_l 164.3970563 0.146822481 HSbrain_663_r 155.8547049 0.146822481 HS_from_MQbrain_1462_r 152.9071604 0.146822481 HSbrain_705_r 113.5172383 0.146822481 HSbrain_624_l 94.53967575 0.146822481 HS_from_MQbrain_1250_r 60.18097983 0.146822481 Hsd_96_r 5.165955532 0.146822481 HS_from_PT_271_l 2.99221888 0.146822481 HS_from_PT_92_l 303.3056853 0.152858542 Hsd_38_r 285.7326061 0.152858542 HSbrain_266_l 271.4320379 0.152858542 HS_from_MQbrain_6_r 264.8578117 0.152858542 HS_from_PT_238_l 251.4029293 0.152858542 HSbrain_306_r 226.3244274 0.152858542 HS_from_MQbrain_707_l 224.9895326 0.152858542 HS_from_MQbrain_693_r 197.7309441 0.152858542 HSbrain_752_l 191.3899851 0.152858542 HS_from_MQbrain_969_r 177.1203053 0.152858542 HS_from_MQbrain_1072_r 107.9850118 0.152858542 HS_from_MQbrain_355_r 91.78580467 0.152858542 HSbrain_604_r 57.67387084 0.152858542 HS_from_MQbrain_153_l 49.32700101 0.152858542 Hsd_from_Mmd_280_l 46.29319877 0.152858542 HSbrain_22_l 7.394968873 0.152858542 HS_from_MQbrain_1127_r 6.478685264 0.152858542 HSbrain_695_r 4.015688972 0.152858542 HS_from_MQbrain_1817_l 3.888478757 0.152858542 HS_from_MQbrain_689_l 2.726769607 0.152858542 Hsd_from_Mmd_346_l 2.586537564 0.152858542 HSbrain_783_l 345.0006901 0.158799149 HSbrain_673_l 313.971615 0.158799149 HS_from_MQbrain_1018_l 312.5603857 0.158799149 HS_18_l 244.6303758 0.158799149 HS_from_MQbrain_1501_r 242.0224401 0.158799149 HS_from_PT_158_l 238.7177237 0.158799149 HSbrain_347_l 211.107069 0.158799149 HS_from_MQbrain_1204_r 209.9240502 0.158799149 HSbrain_248_l 193.8830045 0.158799149 HS_from_MQbrain_631_l 184.728 0.158799149 HS_from_PT_255_l 179.6028399 0.158799149 HS_from_MQbrain_1831_r 179.507715 0.158799149 HSbrain_121_l 163.1114217 0.158799149 HS_from_MQbrain_382_r 108.3108904 0.158799149 HS_from_MQbrain_625_l 58.16380903 0.158799149 HS_from_MQbrain_912_l 42.57025194 0.158799149 HSbrain_320_l 8.739860007 0.158799149 HS_from_MQbrain_675_l 3.821332516 0.158799149 HSbrain_413_l 3.253659453 0.158799149 HS_from_MM_35_l 2.357250026 0.158799149 HSbrain_402_l 349.5145921 0.163891418 HS_from_MQbrain_996_l 302.9472283 0.163891418 HS_from_MQbrain_824_r 298.2022039 0.163891418 HS_from_MQbrain_566_r 291.1249796 0.163891418 HSbrain_95_l 253.768018 0.163891418 HSbrain_680_l 245.548398 0.163891418 Hsd_from_Mmd_52_r 243.7569251 0.163891418 HS_from_MQbrain_1426_l 242.4325995 0.163891418 HS_from_MQbrain_1028_l 239.0895004 0.163891418 HSbrain_784_r 234.6735882 0.163891418 HS_from_MQbrain_650_r 218.5666187 0.163891418 HS_from_MQbrain_449_l 213.7795306 0.163891418 HSbrain_304_l 204.8368425 0.163891418 HS_from_MQbrain_1721_l 197.7591475 0.163891418 HS_from_MQbrain_936_r 195.7842152 0.163891418 Hsd_from_Mmd_94_l 193.7657691 0.163891418 HS_from_MQbrain_529_r 190.4031906 0.163891418 Hsd_108_r 181.7633595 0.163891418 HS_from_PT_234_l 181.4676297 0.163891418 HS_from_MQbrain_1223_l 164.5470949 0.163891418 HS_from_MQbrain_1724_l 163.9516624 0.163891418 HS_from_PT_196_r 59.89771429 0.163891418 HSbrain_598_r 7.899656198 0.163891418 HS_from_MM_218_l 2.349494942 0.163891418 HSbrain_467_l 335.0856427 0.170271053 HS_from_MQbrain_1846_r 333.0341838 0.170271053 HS_197_r 299.8398179 0.170271053 HS_212_r 293.7948013 0.170271053 HSbrain_53_l 247.0890399 0.170271053 HSbrain_701_l 245.9313661 0.170271053 HS_128_r 214.1983377 0.170271053 HSbrain_364_r 211.3556115 0.170271053 HS_from_MQbrain_281_l 197.384259 0.170271053 HS_from_MQbrain_1199_l 177.5515382 0.170271053 HSbrain_143_l 173.8367679 0.170271053 HSbrain_216_r 164.5910344 0.170271053 Hsd_from_Mmd_235_r 145.886021 0.170271053 HS_from_MQbrain_841_l 143.150258 0.170271053 Hsd_from_Mmd_367_l 120.0545039 0.170271053 HS_from_MQbrain_468_l 113.3244619 0.170271053 HS_from_MQbrain_1377_l 110.9676187 0.170271053 Hsd_from_Mmd_410_l 94.2059708 0.170271053 HS_192_r 15.41603426 0.170271053 HS_from_MQbrain_1893_r 14.47922582 0.170271053 HS_264_r 7.905646906 0.170271053 HS_from_MQbrain_603_r 7.108558771 0.170271053 HSbrain_726_l 6.434813111 0.170271053 Hsd_from_Mmd_35_l 2.507108516 0.170271053 Hsd_from_Mmd_344_r 309.0726717 0.176183859 HSbrain_626_l 275.7891397 0.176183859 HS_from_PT_27_r 221.573516 0.176183859 HSbrain_32_l 216.2330231 0.176183859 HS_186_r 203.9246728 0.176183859 HSbrain_771_l 185.5150257 0.176183859 Hsd_65_r 184.3852713 0.176183859 HS_from_MQbrain_135_l 155.6010506 0.176183859 HS_from_MQbrain_628_l 105.1976832 0.176183859 HSbrain_707_r 70.97237044 0.176183859 HS_from_MQbrain_984_l 36.17853558 0.176183859 HS_204_r 14.93137289 0.176183859 HS_130_l 10.32443146 0.176183859 HS_from_MQbrain_365_l 6.941331531 0.176183859 HS_from_MQbrain_855_r 6.514975985 0.176183859 HS_from_MQbrain_314_l 2.61540593 0.176183859 HS_from_MM_84_l 2.359765653 0.176183859 HS_from_MQbrain_1349_l 328.4193266 0.182758186 HS_from_MQbrain_162_r 314.656125 0.182758186 HS_from_MQbrain_850_l 288.5662281 0.182758186 HS_from_MQbrain_1509_r 283.4583708 0.182758186 HS_from_MQbrain_1380_r 253.5211282 0.182758186 HSbrain_388_r 213.3920423 0.182758186 HS_from_MM_6_l 190.1275732 0.182758186 HS_from_MQbrain_881_l 189.779606 0.182758186 HS_from_MM_160_l 137.0116145 0.182758186 HS_from_MM_124_r 124.074717 0.182758186 Hsd_from_Mmd_187_r 109.5214584 0.182758186 HS_from_MQbrain_361_l 108.0467095 0.182758186 HS_from_MM_149_r 75.91523091 0.182758186 Hsd_from_Mmd_68_l 61.78328125 0.182758186 HS_from_MQbrain_676_r 52.19716118 0.182758186 HS_from_MQbrain_1883_l 21.12907054 0.182758186 HSbrain_706_l 15.17246512 0.182758186 HS_from_MQbrain_1576_r 8.509211792 0.182758186 HS_132_l 7.348116533 0.182758186 HS_from_MQbrain_1137_l 2.48333526 0.182758186 HS_from_MQbrain_1596_r 435.4766611 0.188867139 HS_from_MQbrain_1073_r 319.8894959 0.188867139 HS_from_MQbrain_487_r 282.9624273 0.188867139 HSbrain_210_l 218.1425564 0.188867139 HSbrain_627_r 214.4670798 0.188867139 HS_77_l 209.1463931 0.188867139 HS_from_MM_182_r 208.0844095 0.188867139 HS_from_MQbrain_1208_l 108.8734707 0.188867139 HS_from_MM_86_l 89.48891073 0.188867139 HSbrain_553_l 69.73500772 0.188867139 HS_from_PT_328_l 64.37288073 0.188867139 HS_from_MQbrain_1734_l 57.12642239 0.188867139 HSbrain_370_r 45.65991936 0.188867139 HS_from_MM_298_l 41.95783366 0.188867139 HS_from_MQbrain_1234_l 18.99466667 0.188867139 HS_from_PT_247_l 17.14193784 0.188867139 HSbrain_242_l 9.140095581 0.188867139 Hsd_from_Mmd_314_r 6.401270974 0.188867139 HS_from_MQbrain_768_l 3.670091279 0.188867139 HSbrain_270_l 3.298294118 0.188867139 HSbrain_810_l 274.8805235 0.19639408 HS_124_l 273.022187 0.19639408 HS_198_l 239.6726 0.19639408 HSbrain_616_r 195.4635888 0.19639408 HS_from_PT_204_r 191.0832874 0.19639408 HS_from_MQbrain_406_r 189.233991 0.19639408 HS_from_MQbrain_383_l 188.3158756 0.19639408 Hsd_19_l 62.00218054 0.19639408 HSbrain_295_r 60.35523089 0.19639408 HS_from_PT_130_r 49.02454902 0.19639408 HS_from_MQbrain_389_l 10.36562841 0.19639408 ¹Cut off Signal/background >2 ²Cut off adj p < 0.2

TABLE 9b Small RNAs recovered from faeces and differentially expressed in adenoma vs control tissue: hairpin with lowest expression 2^(nd) arm adenoma vs control Systematic name signal/background¹ (adj p)² HSbrain_70_r 228.1310199 0.19639408 HS_from_MQbrain_648_l 158.7568209 0.19639408 HSbrain_658_l 129.0251642 0.19639408 HS_203_l 94.83523983 0.19639408 Hsd_from_Mmd_399_r 81.10162309 0.19639408 Hsd_from_Mmd_326_l 36.19385915 0.19639408 HSbrain_180_l 9.145529202 0.19639408 HS_from_MQbrain_84_r 9.015220167 0.19639408 HS_from_MQbrain_1883_r 6.77899065 0.19639408 HSbrain_433_r 6.513823308 0.19639408 HS_from_MQbrain_1783_r 5.660060677 0.19639408 HS_from_MQbrain_1671_l 2.718046822 0.19639408 HSbrain_403_l 130.6652289 0.188867139 HS_from_MQbrain_1760_r 68.93637025 0.188867139 Hsd_from_Mmd_120_l 6.012536709 0.188867139 HS_from_MM_331_r 5.344166534 0.188867139 Hsd_from_Mmd_325_r 2.644428741 0.188867139 HS_from_PT_271_r 2.554264498 0.188867139 HS_from_MQbrain_999_r 2.263925063 0.188867139 HS_from_PT_3_l 2.115103843 0.188867139 HS_from_PT_161_l 171.1553574 0.182758186 HS_from_MQbrain_694_r 5.319743993 0.182758186 HS_from_MQbrain_635_l 3.030934579 0.182758186 Hsd_from_Mmd_333_l 2.003374918 0.182758186 Hsd_from_Mmd_92_l 116.8521775 0.176183859 HS_from_MQbrain_1566_r 28.34610003 0.176183859 HS_from_MM_123_l 25.84005888 0.176183859 HS_from_MQbrain_1565_l 11.415781 0.176183859 Hsd_from_Mmd_123_r 3.109340734 0.176183859 Hsd_from_Mmd_328_l 2.054062827 0.176183859 HSbrain_745_l 199.5248523 0.170271053 HS_from_MM_304_l 44.91042461 0.170271053 Hsd_47_r 15.14357414 0.170271053 HS_78_r 3.599814983 0.170271053 HS_from_PT_280_l 230.7126831 0.163891418 HS_from_MQbrain_1090_r 148.6783798 0.163891418 Hsd_84_r 14.08450328 0.163891418 HS_from_MQbrain_941_r 2.300164622 0.163891418 HS_from_MM_340_r 2.08874036 0.163891418 HS_from_MQbrain_6_l 224.1267133 0.158799149 HS_from_MQbrain_414_l 178.1375421 0.158799149 HSbrain_653_l 40.34177825 0.158799149 HS_from_MQbrain_140_l 5.24618389 0.158799149 HS_from_MQbrain_68_r 3.894404987 0.158799149 Hsd_67_r 2.507940384 0.158799149 HS_from_MQbrain_340_l 2.901321612 0.152858542 HS_from_MQbrain_1759_l 210.0656412 0.146822481 HS_from_MQbrain_260_r 190.0240714 0.146822481 HS_from_PT_284_r 27.92056913 0.146822481 HS_268_l 6.398871252 0.146822481 HSbrain_126_r 185.8597074 0.140323812 HS_from_MQbrain_266_r 7.219897398 0.140323812 Hsd_from_Mmd_291_l 44.20392105 0.134970683 HS_from_MQbrain_1376_r 12.27563489 0.134970683 Hsd_from_Mmd_388_l 4.044215903 0.134970683 HSbrain_267_r 187.7274337 0.129399391 HS_from_MQbrain_466_l 173.774731 0.129399391 HS_from_MQbrain_1712_r 148.9640462 0.129399391 HS_from_MQbrain_1722_l 110.8769733 0.129399391 HS_from_MQbrain_137_r 9.243852235 0.129399391 HS_from_MQbrain_1377_r 2.685212414 0.129399391 Hsd_from_Mmd_183_r 148.0528441 0.12422104 HS_135_l 131.4469186 0.12422104 HS_from_MQbrain_485_l 8.243037088 0.12422104 HS_from_PT_237_l 3.488690264 0.12422104 HSbrain_383_l 11.26061345 0.11858389 Hsd_60_r 5.759084269 0.11858389 HS_from_MQbrain_1051_r 2.890006235 0.11858389 HS_106_r 2.537522063 0.11858389 HS_from_MM_251_r 168.6680712 0.113099484 HS_204_l 14.86560477 0.113099484 HS_from_MQbrain_824_l 2.021767126 0.113099484 HS_164_l 113.9895739 0.108118292 HSbrain_299_r 26.59238777 0.108118292 HS_from_MQbrain_594_r 2.753205678 0.108118292 HS_from_MM_124_l 2.285310959 0.108118292 Hsd_111_r 204.558847 0.103393572 HS_from_MQbrain_751_l 171.7203726 0.103393572 HSbrain_319_l 27.65786021 0.103393572 HS_from_MQbrain_1633_r 10.30485548 0.103393572 HS_from_MQbrain_1410_l 47.23710024 0.098921026 HS_from_MQbrain_1139_r 27.78815761 0.098921026 HSbrain_209_l 5.831860813 0.095394629 HS_from_MQbrain_932_l 2.123754543 0.095394629 HS_from_MQbrain_1678_r 148.7689177 0.09152926 Hsd_from_Mmd_371_r 131.2157622 0.09152926 HS_from_MQbrain_1031_l 46.34701799 0.09152926 HS_from_MQbrain_1602_l 35.32112193 0.09152926 HS_from_MQbrain_770_r 5.072552769 0.09152926 HSbrain_619_r 4.2712614 0.09152926 HSbrain_19_l 3.145160187 0.09152926 HS_from_MQbrain_1437_l 2.717424689 0.09152926 HS_from_PT_126_l 6.759793869 0.088143181 HS_11_l 6.010655386 0.088143181 HS_from_MM_202_l 65.31801875 0.083930001 HS_from_MQbrain_814_l 11.67524525 0.083930001 HS_from_MQbrain_597_r 4.765274065 0.083930001 HS_from_MQbrain_1706_l 213.0219833 0.079954597 HS_from_MQbrain_1665_r 87.0752453 0.079954597 HS_from_MQbrain_253_r 75.90944638 0.072349461 HS_81_r 55.61137135 0.072349461 HS_from_MQbrain_1748_r 19.48179132 0.072349461 HSbrain_635_l 6.819097351 0.072349461 HS_from_MQbrain_1268_l 5.668043125 0.072349461 HS_from_PT_235_l 208.8800625 0.069749265 HS_from_MM_47_l 2.919273938 0.067503134 HS_from_MQbrain_1696_l 154.0498567 0.064770288 HS_from_MQbrain_1450_r 130.7495827 0.064770288 HSbrain_776_l 114.3914887 0.064770288 HS_from_MQbrain_435_r 2.200043662 0.064770288 HS_from_MM_6_r 2.160347119 0.064770288 HS_from_PT_41_r 2.157415789 0.064770288 Hsd_from_Mmd_439_l 80.82870283 0.061046963 HS_from_PT_340_l 17.88452337 0.061046963 HS_from_MQbrain_1500_l 15.2774537 0.061046963 HS_from_MQbrain_1412_l 4.664856717 0.061046963 HS_from_PT_242_l 2.025087308 0.061046963 HS_156_l 16.10230692 0.058253679 HS_from_MQbrain_1794_l 34.34325904 0.053159859 HS_from_MQbrain_1771_l 188.7899392 0.050130838 HS_from_MQbrain_691_l 30.90923016 0.050130838 Hsd_65_l 5.317412014 0.050130838 HS_from_MQbrain_842_l 2.595893731 0.050130838 HS_from_MQbrain_1752_l 22.86665735 0.048378078 HS_from_MM_289_l 40.04595101 0.042549287 HS_177_l 39.31124871 0.042549287 HS_from_PT_91_r 11.52114628 0.042549287 HS_from_MQbrain_1087_l 8.47223421 0.038273758 Hsd_from_Mmd_410_r 2.908576361 0.036099692 Hsd_105_l 5.399875994 0.03224042 HSbrain_296_l 2.843440689 0.02997784 Hsd_from_Mmd_219_r 42.949196 0.024762366 Hsd_from_Mmd_519_l 32.14358853 0.024762366 Hsd_26_l 5.446771505 0.024762366 HSbrain_778_r 85.0377047 0.023736962 HSbrain_794_r 74.07648688 0.023736962 HSbrain_703_r 11.82131557 0.022745616 HSbrain_362_r 9.722304379 0.019454312 HSbrain_268_r 158.6132777 0.018600058 HSbrain_253_l 11.33164065 0.018600058 HS_from_MQbrain_825_r 3.634806505 0.011699489 HS_from_MQbrain_1628_r 3.67815753 0.008946182 HS_from_MQbrain_1462_l 135.9829616 0.008573112 HS_from_MQbrain_1317_r 11.20285772 0.00676609 HS_from_MQbrain_1311_r 2.389862917 0.00676609 HS_from_MQbrain_1070_r 19.32265622 0.004799641 HS_21_r 216.9668884 0.000489293 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 10a Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with highest expression carcinoma 1st arm signal/ vs control Systematic name background¹ (adj p)² HS_from_MQbrain_1393_r 223.7656716 0.016433541 HS_from_MM_334_l 165.3471372 0.016433541 Hsd_from_Mmd_473_l 15.1413037 0.019274533 HSbrain_377_r 2.687263122 0.019274533 HSbrain_617_l 59.52352443 0.022921248 HS_from_MM_178_r 86.39079121 0.030988376 HS_from_MQbrain_1056_l 71.54390765 0.031989408 HS_from_MQbrain_1823_r 44.43291919 0.0342406 HS_from_MM_39_l 15.46864042 0.0342406 Hsd_102_l 175.5645249 0.035303066 HS_from_PT_190_r 138.4453126 0.045228199 HSbrain_171_l 255.6856718 0.067337504 HS_262_l 14.64955868 0.067337504 HS_from_MQbrain_343_l 214.8585663 0.07566513 HS_from_MQbrain_1169_l 105.7095098 0.084904114 HSbrain_629_l 254.3371274 0.086503988 HSbrain_597_r 208.6310714 0.086503988 HS_from_MQbrain_350_l 189.461419 0.086503988 HSbrain_12_l 53.76557022 0.086503988 HS_from_MQbrain_2380_r 187.2947993 0.090694253 HS_255_l 161.1405598 0.090694253 HS_from_MQbrain_1128_l 158.837926 0.090694253 HS_from_MQbrain_349_l 135.3020631 0.090694253 Hsd_from_Mmd_328_r 117.324613 0.090694253 HSbrain_753_r 41.77257724 0.090694253 HS_from_MQbrain_55_l 15.80840103 0.090694253 HSbrain_177_r 132.197755 0.104922786 HSbrain_446_l 14.33402718 0.104922786 HSbrain_483_l 220.2067855 0.110995143 HS_from_MQbrain_128_r 194.6783323 0.110995143 HSbrain_709_l 274.820351 0.120015634 HS_from_MM_309_r 208.0343975 0.120015634 HS_217_l 228.449758 0.120843678 HS_from_MQbrain_930_r 167.8363796 0.120843678 HS_141_l 141.8565157 0.120843678 HS_from_MQbrain_1657_r 116.3148049 0.120843678 HS_from_MQbrain_769_r 87.406602 0.120843678 HS_from_PT_257_r 27.728139 0.120843678 HS_from_PT_201_r 2.367251208 0.120843678 HSbrain_801_r 195.7930985 0.149145996 HS_from_MQbrain_1624_l 192.3884805 0.149145996 HSbrain_158_l 169.343928 0.149145996 HSbrain_1_l 76.8373873 0.149145996 Hsd_18_l 237.5322474 0.159103307 HSbrain_261_l 83.18937251 0.159103307 HS_from_MQbrain_1459_l 257.1079597 0.166408872 HSbrain_458_l 77.3089971 0.166408872 HS_from_MM_339_r 327.2871875 0.179914563 HS_304_r 244.034349 0.179914563 HS_from_MQbrain_1513_r 128.9407151 0.19263196 Hsd_from_Mmd_298_r 48.27315482 0.19263196 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 10b Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with lowest expression carcinoma 2^(nd) arm signal/ vs control systematic name background¹ (adj p)² HS_21_r 216.9668884 0.099652833 Hsd_111_r 204.558847 0.149145996 HS_from_MQbrain_1696_l 154.0498567 0.126655157 HS_from_MM_289_l 40.04595101 0.104922786 HSbrain_299_r 26.59238777 0.159103307 HS_from_PT_340_l 17.88452337 0.090694253 HS_156_l 16.10230692 0.120015634 HS_from_MQbrain_1317_r 11.20285772 0.008895418 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 11a Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs adenoma: hairpin arm with highest expression carcinoma vs 1^(st) arm signal/ adenoma Systematic name background¹ (adj p)² HS_from_MM_118_r 70.86890311 0.012664553 HS_169_l 153.6041594 0.014416465 HS_299_l 175.2031924 0.016786613 HS_from_MQbrain_1137_l 2.48333526 0.016904198 HS_from_MQbrain_1082_l 265.0804535 0.018319912 HS_from_MQbrain_1522_r 112.3011721 0.020545593 HSbrain_306_r 226.3244274 0.023919533 HS_from_MQbrain_629_l 195.1102679 0.026776445 HS_from_MQbrain_1456_l 199.1014452 0.028202169 HS_from_MQbrain_828_l 223.2821181 0.032034428 HS_from_PT_40_r 19.96645961 0.032034428 HSbrain_384_l 4.544181943 0.034662803 HSbrain_1425_l 283.5640729 0.035941334 HS_from_MQbrain_1750_r 217.7023298 0.037874034 HS_from_MQbrain_984_l 36.17853558 0.039250091 HS_from_MQbrain_686_r 259.8101317 0.044599949 HS_141_l 141.8565157 0.044599949 HS_from_MQbrain_603_r 7.108558771 0.044599949 HS_218_r 235.8613357 0.045945376 HS_from_MM_169_r 8.697594288 0.048205391 HS_217_l 228.449758 0.050135128 HSbrain_226_r 225.405043 0.050135128 HSbrain_187_r 179.7554723 0.050135128 HSbrain_538_r 3.973394819 0.055185029 HS_from_MM_218_l 2.349494942 0.055185029 HS_from_MQbrain_1340_l 157.6981977 0.058254254 HSbrain_337_l 85.40127884 0.059897432 HSbrain_791_l 10.8880558 0.059897432 HSbrain_25_r 68.45071483 0.062381992 HS_from_MQbrain_330_r 236.6286556 0.0659723 Hsd_from_Mmd_391_l 43.63503635 0.070590475 Hsd_from_Mmd_237_l 306.9716516 0.071451516 HS_from_MQbrain_93_r 290.7380082 0.071451516 HS_from_MQbrain_1832_l 275.5897539 0.071451516 HSbrain_468_r 8.648929144 0.071451516 HSbrain_182_r 228.0472357 0.072275086 HSbrain_2_l 49.67189807 0.072275086 HS_from_MQbrain_869_l 197.9550289 0.072654718 HSbrain_1406_l 17.08291783 0.072654718 HS_from_MQbrain_74_r 225.8922409 0.074901054 HSbrain_419_l 219.8793357 0.074901054 HS_219_l 254.6760586 0.075028175 HS_from_MM_103_l 246.9217731 0.075028175 HS_from_MQbrain_1001_r 223.8116976 0.075028175 HS_from_MQbrain_470_l 131.1632076 0.075028175 Hsd_from_Mmd_189_l 180.4050764 0.07641095 Hsd_from_Mmd_527_r 126.3935973 0.07641095 HS_119_l 233.7784735 0.07715065 HSbrain_204_r 217.0811451 0.07715065 HS_118_l 214.1827525 0.07715065 HS_from_MM_275_r 8.801848936 0.07715065 HS_from_MM_342_r 5.590510164 0.07715065 HSbrain_442_r 18.08359556 0.07965977 HSbrain_361_l 234.5281831 0.080676612 HSbrain_328_l 280.7719926 0.08237725 HS_from_PT_27_r 221.573516 0.08237725 HSbrain_799_r 3.32764451 0.08237725 HS_from_MQbrain_1569_l 191.4989985 0.083833911 HS_from_MQbrain_634_r 40.90596624 0.083833911 HS_from_MQbrain_1675_r 288.3970715 0.084885584 HSbrain_95_l 253.768018 0.084885584 HSbrain_6_r 244.8860331 0.084885584 HS_from_MQbrain_1623_r 244.0389624 0.084885584 Hsd_from_Mmd_261_l 184.5887939 0.084885584 HS_from_MQbrain_1443_r 179.1434855 0.084885584 HSbrain_389_l 9.742590244 0.084885584 Hsd_106_l 9.004764262 0.084885584 HS_from_MQbrain_1294_l 2.290891026 0.084885584 HS_from_MQbrain_928_r 318.1021923 0.085697388 HS_from_MQbrain_965_l 235.4627068 0.085697388 HSbrain_764_r 117.9645256 0.085697388 Hsd_101_l 3.714373078 0.085697388 HS_49_r 8.969465473 0.088269125 HS_from_MQbrain_1355_r 309.6691714 0.089491072 HS_from_MQbrain_597_l 8.606774472 0.089491072 HS_from_MQbrain_392_l 254.8014108 0.091337111 HS_from_MQbrain_765_l 254.6466837 0.091337111 HS_from_MQbrain_1771_r 247.8706875 0.091337111 HSbrain_594_l 186.9175668 0.091337111 HS_from_MQbrain_631_l 184.728 0.091337111 HS_from_MM_219_l 47.65091531 0.091337111 HSbrain_540_r 19.28862768 0.091337111 HS_from_PT_282_l 11.85767781 0.091337111 HS_from_MQbrain_131_r 202.0595323 0.092780591 Hsd_from_Mmd_491_r 9.356107716 0.092780591 HS_from_MQbrain_191_l 203.1756555 0.094556199 Hsd_from_Mmd_330_l 200.078931 0.094556199 HSbrain_591_l 185.5052057 0.094556199 HSbrain_123_l 203.4486322 0.096132958 HS_from_MQbrain_1793_r 103.5900968 0.096132958 HSbrain_532_l 11.20284123 0.096132958 HSbrain_316_l 339.4367001 0.098301345 HS_from_MQbrain_1183_l 198.4935006 0.098301345 HS_from_MQbrain_1893_r 14.47922582 0.098301345 HS_from_MQbrain_1031_r 263.8971038 0.099488281 HSbrain_719_l 9.057424006 0.099488281 HS_from_MQbrain_1840_l 4.101477435 0.099488281 Hsd_70_l 292.1907862 0.101009439 HS_from_MQbrain_1827_l 289.495665 0.101009439 HSbrain_703_l 247.3420423 0.101009439 HSbrain_14_r 99.51998497 0.101009439 HS_from_MQbrain_1806_l 4.715008642 0.101009439 Hsd_from_Mmd_346_l 2.586537564 0.101009439 HS_from_MM_84_l 2.359765653 0.101009439 HS_from_MQbrain_628_l 105.1976832 0.102601153 HS_from_MQbrain_722_r 230.0329269 0.104515233 HS_from_MQbrain_433_l 186.8433165 0.104515233 HS_from_MQbrain_1374_l 176.8739274 0.104515233 HS_from_MQbrain_534_r 240.0925796 0.105993846 HS_from_MQbrain_22_r 187.1051151 0.105993846 HS_from_MQbrain_1127_r 6.478685264 0.105993846 HS_from_MQbrain_996_l 302.9472283 0.107794024 HS_from_MQbrain_574_l 287.7017103 0.107794024 HS_from_MQbrain_951_l 230.432556 0.107794024 HS_from_MQbrain_921_l 192.1335465 0.107794024 HS_from_MQbrain_1541_l 32.58806331 0.107794024 Hsd_from_Mmd_52_r 243.7569251 0.11066006 Hsd_from_Mmd_266_r 239.3412808 0.11066006 HSbrain_677_l 223.7296488 0.11066006 HS_from_MM_86_l 89.48891073 0.11066006 HSbrain_588_l 269.5888825 0.113095726 HSbrain_426_r 262.208223 0.113095726 HSbrain_440_l 231.4604735 0.113095726 HSbrain_50_l 203.7449536 0.113095726 HS_from_MQbrain_29_l 198.1116988 0.113095726 HS_from_MQbrain_777_r 120.2896834 0.113095726 HS_from_MQbrain_1164_r 265.941125 0.114595796 HS_from_MQbrain_56_l 221.5946492 0.114595796 HS_102_l 205.6195359 0.114595796 HS_from_MM_276_l 21.75172107 0.114595796 HS_from_MQbrain_1817_l 3.888478757 0.114595796 HS_from_MQbrain_609_l 213.1909341 0.115928328 HS_from_MQbrain_501_l 152.6321911 0.115928328 HS_from_MQbrain_1637_r 147.2561547 0.115928328 HSbrain_26_r 3.807676617 0.115928328 HS_from_MM_208_r 241.9491489 0.117828853 HS_246_l 233.9810458 0.117828853 HS_from_MM_34_l 7.978839103 0.117828853 HS_from_MQbrain_974_l 247.9593335 0.119559457 HS_from_PT_60_l 241.2340994 0.119559457 HSbrain_708_l 229.246264 0.119559457 HSbrain_606_l 181.1992813 0.119559457 HS_from_MQbrain_1632_l 234.3869839 0.121604253 HSbrain_305_r 219.5650075 0.121604253 HS_from_MQbrain_648_r 216.5701764 0.121604253 HS_from_MQbrain_161_r 6.387946973 0.121604253 HSbrain_402_l 349.5145921 0.12300785 HS_from_MQbrain_1075_l 258.9475578 0.12300785 HS_from_MQbrain_1261_r 243.9532889 0.12300785 HS_from_MQbrain_266_l 243.4504792 0.12300785 HS_from_MQbrain_340_r 243.3848161 0.12300785 HSbrain_256_r 12.675 0.12300785 Hsd_from_Mmd_314_r 6.401270974 0.12300785 HS_from_MQbrain_210_r 204.1332639 0.124263194 HS_from_MQbrain_1097_r 128.6204149 0.124263194 Hsd_from_Mmd_154_l 2.836322667 0.124263194 HSbrain_771_l 185.5150257 0.126757752 HS_from_MQbrain_314_l 2.61540593 0.126757752 HS_from_MQbrain_822_l 2.343923008 0.126757752 HSbrain_393_r 336.1272016 0.129555956 HS_from_MQbrain_1102_l 303.4601583 0.129555956 HS_from_MQbrain_1413_l 204.3272671 0.129555956 HS_from_MQbrain_453_l 57.09533664 0.129555956 HSbrain_783_l 345.0006901 0.130803986 HS_from_MQbrain_672_l 249.9938404 0.130803986 Hsd_from_Mmd_94_l 193.7657691 0.130803986 HS_from_MQbrain_216_l 182.4516418 0.130803986 HS_from_PT_313_l 113.037452 0.130803986 HSbrain_380_r 54.63237608 0.130803986 HS_from_MQbrain_868_l 260.4645119 0.132596379 HS_101_l 239.0332153 0.132596379 HS_from_MQbrain_715_l 216.9853807 0.132596379 HSbrain_691_l 201.4670994 0.132596379 HS_from_MQbrain_1100_l 165.2906308 0.132596379 HSbrain_726_l 6.434813111 0.132596379 HSbrain_484_l 270.1785451 0.134691663 Hsd_42_r 260.2142458 0.134691663 HSbrain_243_l 182.2549801 0.134691663 HS_62_l 66.38174565 0.134691663 Hsd_7_r 23.39907905 0.134691663 HS_from_PT_44_l 269.9446191 0.136637202 HSbrain_970_r 2.440271917 0.136637202 HSbrain_250_l 313.5276305 0.138217661 HS_from_MQbrain_1824_l 292.4713609 0.138217661 HS_from_MQbrain_70_l 285.3653998 0.138217661 HS_from_MQbrain_1043_r 281.5762963 0.138217661 Hsd_69_l 273.3125807 0.138217661 HS_from_MQbrain_315_l 85.77155971 0.138217661 HS_from_MQbrain_1836_l 6.267799948 0.138217661 HS_from_MQbrain_886_r 310.0903943 0.139019426 HS_from_MQbrain_1756_l 252.4873393 0.139019426 HS_from_MQbrain_399_l 238.3085443 0.139019426 HSbrain_420_r 228.3614012 0.139019426 HS_from_MQbrain_1493_r 207.5291507 0.139019426 HS_from_MQbrain_90_r 178.3364821 0.139019426 HS_277_l 168.4332786 0.139019426 Hsd_13_l 130.4556358 0.139019426 HSbrain_3_l 51.24508411 0.139019426 HS_98_r 330.803132 0.141416815 HS_39_r 320.0335858 0.141416815 HS_from_MQbrain_1331_r 233.5757256 0.141416815 HS_from_MQbrain_845_r 228.2389891 0.141416815 HS_from_MQbrain_824_r 298.2022039 0.14474535 HS_from_MQbrain_914_l 266.9248651 0.14474535 HSbrain_369_r 159.7073641 0.14474535 HSbrain_82_r 99.35128086 0.14474535 HS_from_MQbrain_1227_l 243.816199 0.145370181 HS_from_MQbrain_1810_l 218.9019542 0.145370181 HSbrain_620_l 216.6725849 0.145370181 HS_from_MQbrain_180_r 210.3209412 0.145370181 HS_from_MQbrain_1204_r 209.9240502 0.145370181 HS_54_l 185.9367326 0.145370181 HSbrain_716_l 180.5676912 0.145370181 HSbrain_117_r 100.8429431 0.145370181 HSbrain_214_l 19.36197308 0.145370181 Hsd_from_Mmd_246_r 309.4213909 0.146325218 HSbrain_307_r 231.9591602 0.146325218 HS_from_MQbrain_973_l 229.669574 0.146325218 HS_306_l 211.5536628 0.146325218 HS_133_l 183.5586928 0.146325218 HS_from_MM_199_l 170.7212373 0.146325218 HS_from_MQbrain_606_r 105.4640055 0.146325218 HS_from_MQbrain_671_r 263.6821505 0.148196723 HSbrain_627_r 214.4670798 0.148196723 HSbrain_624_l 94.53967575 0.148196723 HS_from_MQbrain_1444_l 6.459126984 0.148196723 HS_from_PT_134_l 371.7744239 0.149149579 HS_139_l 299.5699263 0.149149579 HS_58_l 238.3731335 0.149149579 HS_from_MQbrain_1088_l 194.3140687 0.149149579 HS_from_MQbrain_1773_l 173.1308074 0.149149579 HS_from_MQbrain_1419_r 158.7663804 0.149149579 HSbrain_177_r 132.197755 0.149149579 HS_from_MQbrain_817_l 7.907551804 0.149149579 Hsd_81_r 3.432967686 0.149149579 HS_111_r 266.2298017 0.152177614 HSbrain_717_l 241.5872727 0.152177614 HSbrain_41_l 239.6624516 0.152177614 HSbrain_304_l 204.8368425 0.152177614 HS_from_PT_20_r 188.3393313 0.152177614 Hsd_from_Mmd_509_l 115.5595143 0.152177614 HS_204_r 14.93137289 0.152177614 HSbrain_625_l 5.435431773 0.152177614 HS_from_MQbrain_1433_r 204.5305106 0.155479351 HSbrain_578_r 203.0612339 0.155479351 HS_from_MQbrain_1128_l 158.837926 0.155479351 HS_from_MQbrain_536_r 150.565992 0.155479351 HSbrain_431_l 329.5258621 0.15865589 HSbrain_673_l 313.971615 0.15865589 HS_from_MQbrain_1601_r 288.3631003 0.15865589 HSbrain_652_l 240.7492888 0.15865589 HSbrain_202_r 317.8857843 0.159708794 HS_from_MQbrain_604_l 289.730194 0.159708794 Hsd_from_Mmd_480_r 278.0451339 0.159708794 HS_167_r 253.7791765 0.159708794 HS_from_MQbrain_529_r 190.4031906 0.159708794 HS_from_PT_254_r 38.90953686 0.159708794 HS_from_MQbrain_1882_r 15.42159484 0.159708794 HS_from_MQbrain_1753_r 15.00695265 0.159708794 HS_292_r 3.304463889 0.159708794 HSbrain_644_r 2.20892511 0.159708794 HS_from_MQbrain_1877_r 232.7961089 0.161647438 HSbrain_72_l 206.0852876 0.161647438 HS_from_MQbrain_1839_l 186.2075177 0.161647438 HS_288_l 171.5705836 0.161647438 HSbrain_16_l 14.42037004 0.161647438 HSbrain_220_l 226.9273128 0.16463875 HS_208_r 211.3635201 0.16463875 HS_from_PT_41_l 209.4264654 0.16463875 HS_from_MM_319_l 202.6221234 0.16463875 HS_from_MQbrain_1229_r 179.8888306 0.16463875 Hsd_from_Mmd_223_r 19.94197059 0.16463875 HSbrain_111_l 19.09214846 0.16463875 HS_130_l 10.32443146 0.16463875 HSbrain_168_l 327.7976202 0.167313007 HS_from_MQbrain_1876_r 294.6889637 0.167313007 HSbrain_513_r 225.3093848 0.167313007 HS_from_MQbrain_699_r 210.3435386 0.167313007 HS_from_MQbrain_1372_l 173.5611463 0.167313007 HS_from_MQbrain_2670_r 88.75898562 0.167313007 HS_from_MQbrain_496_r 276.9628577 0.170255758 HS_from_MQbrain_1855_l 238.2044165 0.170255758 HS_114_l 214.0153294 0.170255758 HSbrain_113_r 100.6056081 0.170255758 HSbrain_614_l 255.7168248 0.173467438 HS_29_l 201.5999875 0.173467438 HS_from_MQbrain_57_l 186.5917929 0.173467438 HSbrain_336_l 103.7156038 0.173467438 HSbrain_777_r 5.13504626 0.173467438 HS_from_MQbrain_734_l 272.5872546 0.175200251 HS_from_MQbrain_1777_l 271.5768067 0.175200251 HS_from_MQbrain_1463_l 269.5851659 0.175200251 HSbrain_687_l 261.7764626 0.175200251 HS_from_PT_34_r 259.0811135 0.175200251 HSbrain_643_l 212.7527559 0.175200251 HS_from_MQbrain_1091_l 169.2750909 0.175200251 HS_from_MQbrain_1708_l 154.1529962 0.175200251 Hsd_from_Mmd_167_r 352.3358142 0.177405071 HS_from_MQbrain_1470_r 320.2896415 0.177405071 HSbrain_692_r 285.9738106 0.177405071 Hsd_from_Mmd_42_r 266.6423152 0.177405071 HSbrain_794_l 265.9452768 0.177405071 HS_from_MQbrain_386_r 231.6815526 0.177405071 HSbrain_690_l 231.2618802 0.177405071 HSbrain_347_l 211.107069 0.177405071 HSbrain_1305_l 145.0316211 0.177405071 HS_from_MQbrain_1485_r 90.24185865 0.177405071 HS_from_MQbrain_1442_l 5.874225415 0.177405071 HS_from_MQbrain_550_l 253.7757692 0.180260145 HS_285_r 233.586665 0.180260145 HS_from_MQbrain_1631_r 227.5696524 0.180260145 HSbrain_593_r 222.0517315 0.180260145 HSbrain_263_r 108.4481826 0.180260145 HS_from_MQbrain_991_r 72.5119085 0.180260145 HS_from_MQbrain_1110_r 6.60657006 0.180260145 Hsd_from_Mmd_286_r 5.6723549 0.180260145 HSbrain_778_l 276.1268612 0.184337179 Hsd_from_Mmd_120_r 256.1765933 0.184337179 HSbrain_621_l 240.1453763 0.184337179 HS_243_l 211.6547669 0.184337179 HS_138_l 198.1359437 0.184337179 HS_from_MM_131_l 3.843700557 0.184337179 HSbrain_166_l 305.2218421 0.185815478 HS_from_MQbrain_1394_l 277.0531964 0.185815478 HSbrain_1364_l 251.9113433 0.185815478 HS_142_l 223.5805612 0.185815478 HS_from_MQbrain_272_l 218.2733075 0.185815478 HSbrain_32_l 216.2330231 0.185815478 HS_from_MQbrain_17_r 210.8657734 0.185815478 HS_77_l 209.1463931 0.185815478 HS_303_r 198.3144581 0.185815478 HSbrain_662_r 47.55963248 0.185815478 HS_from_MQbrain_1778_r 16.56308131 0.185815478 Hsd_from_Mmd_48_r 4.488918042 0.185815478 HSbrain_141_r 277.8002235 0.188706417 HS_50_l 272.9010802 0.188706417 HS_from_MQbrain_745_r 271.8779897 0.188706417 HS_from_MQbrain_36_r 247.5789144 0.188706417 HS_from_MQbrain_940_r 239.4870149 0.188706417 HS_from_MQbrain_691_r 205.3284172 0.188706417 HSbrain_570_l 194.0529436 0.188706417 HS_189_l 117.9592496 0.188706417 HSbrain_497_l 22.40769173 0.188706417 Hsd_96_r 5.165955532 0.188706417 HS_241_r 2.716303039 0.188706417 HS_from_MQbrain_397_l 374.0176792 0.190550803 HS_from_PT_238_l 251.4029293 0.190550803 HS_105_l 249.0808996 0.190550803 HS_from_MM_80_l 221.3749747 0.190550803 HS_166_l 221.2754845 0.190550803 HS_from_MQbrain_97_r 220.2493082 0.190550803 HS_from_MQbrain_626_r 217.3494318 0.190550803 HS_from_MQbrain_968_r 212.4682002 0.190550803 Hsd_62_l 208.0883252 0.190550803 HSbrain_809_r 156.7134677 0.190550803 Hsd_from_Mmd_117_r 7.718924828 0.190550803 HS_from_MQbrain_653_l 4.501537159 0.190550803 Hsd_from_Mmd_163_r 4.482580882 0.190550803 HS_from_MQbrain_675_l 3.821332516 0.190550803 HSbrain_259_r 334.9867442 0.194339793 HS_from_MQbrain_1272_l 282.8549789 0.194339793 HS_from_MQbrain_1421_l 270.6118637 0.194339793 Hsd_from_Mmd_298_r 48.27315482 0.194339793 HSbrain_755_l 2.63850582 0.194339793 HS_from_MQbrain_1159_l 267.9987738 0.197457594 HS_from_MQbrain_635_r 239.4679434 0.197457594 HSbrain_479_l 219.1097463 0.197457594 HSbrain_210_l 218.1425564 0.197457594 HS_from_MQbrain_467_l 209.268142 0.197457594 HS_from_MQbrain_1514_r 8.3514592 0.197457594 HS_from_MQbrain_1210_l 318.0464645 0.199721903 HS_from_MQbrain_1357_l 252.6330054 0.199721903 HSbrain_388_r 213.3920423 0.199721903 HSbrain_651_r 190.7821606 0.199721903 HSbrain_482_l 110.0149117 0.199721903 HS_from_MM_63_l 31.12592861 0.199721903 HS_from_MQbrain_1405_l 28.83096971 0.199721903 Hsd_from_Mmd_478_l 24.52473283 0.199721903 HSbrain_22_l 7.394968873 0.199721903 Hsd_41_r 2.227383669 0.199721903 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 11b Small RNAs recovered from faeces and differentially expressed in adenocarcinoma vs adenoma: hairpin arm with lowest expression carcinoma 2^(nd) arm signal/ vs adenoma Systematic name background¹ (adj p)² HS_from_MQbrain_1100_r 120.6214414 0.199721903 HS_from_MQbrain_1747_l 16.76994109 0.199721903 HS_from_MQbrain_229_l 4.081069893 0.199721903 HS_from_MQbrain_1517_r 2.83503588 0.199721903 HSbrain_289_r 4.948455623 0.197457594 HSbrain_190_r 4.058257011 0.197457594 HS_from_MQbrain_819_r 5.824652829 0.190550803 HS_from_MQbrain_1437_l 2.717424689 0.190550803 Hsd_from_Mmd_471_r 16.97699294 0.188706417 HS_from_PT_126_l 6.759793869 0.188706417 HS_from_MM_256_r 3.393653412 0.185815478 HS_177_l 39.31124871 0.184337179 Hsd_84_r 14.08450328 0.184337179 HSbrain_180_l 9.145529202 0.180260145 HS_from_MQbrain_85_l 156.4403527 0.175200251 HS_from_MQbrain_1752_l 22.86665735 0.175200251 HS_231_l 2.714286111 0.175200251 HSbrain_429_l 2.118433497 0.175200251 HS_from_MM_6_r 2.160347119 0.173467438 HS_from_MQbrain_1376_r 12.27563489 0.167313007 HS_from_MQbrain_42_l 10.06865266 0.167313007 HS_from_MQbrain_1268_l 5.668043125 0.167313007 HS_from_MQbrain_808_l 18.66016883 0.16463875 HS_from_MQbrain_1722_l 110.8769733 0.161647438 HS_from_MQbrain_2441_r 18.63671222 0.161647438 HS_from_MQbrain_635_l 3.030934579 0.161647438 HS_from_MM_124_l 2.285310959 0.161647438 HS_from_PT_91_r 11.52114628 0.159708794 HS_from_MQbrain_1168_l 20.50912815 0.15865589 Hsd_from_Mmd_58_r 3.243424426 0.15865589 Hsd_66_l 18.13978635 0.152177614 HS_from_MQbrain_666_l 92.89661383 0.149149579 HS_from_MQbrain_535_r 186.6969315 0.145370181 HS_from_MQbrain_64_l 11.00783751 0.145370181 HSbrain_381_l 4.039805518 0.145370181 HS_from_MQbrain_770_r 5.072552769 0.14474535 Hsd_from_Mmd_123_r 3.109340734 0.14474535 HS_from_MQbrain_809_l 18.13661315 0.139019426 HSbrain_174_r 4.177116441 0.136637202 HSbrain_776_l 114.3914887 0.130803986 Hsd_from_Mmd_219_r 42.949196 0.130803986 HS_from_MQbrain_800_l 20.11153179 0.129555956 HS_from_MQbrain_140_l 5.24618389 0.129555956 HS_from_MQbrain_814_l 11.67524525 0.124263194 HS_from_MQbrain_1633_r 10.30485548 0.124263194 HS_from_MQbrain_268_r 3.108624251 0.124263194 HS_from_MQbrain_1412_l 4.664856717 0.12300785 HS_from_MM_180_r 2.63242039 0.119559457 HS_from_MM_331_r 5.344166534 0.115928328 HS_from_MQbrain_842_l 2.595893731 0.114595796 HS_from_MQbrain_1339_r 21.84300167 0.11066006 HS_21_r 216.9668884 0.107794024 HS_from_MQbrain_1783_r 5.660060677 0.105993846 HS_from_MQbrain_1116_r 48.72741718 0.104515233 HS_from_MQbrain_1748_r 19.48179132 0.101009439 HS_from_MQbrain_1771_l 188.7899392 0.098301345 HSbrain_553_r 7.093626312 0.098301345 HS_from_MQbrain_1481_l 32.02173709 0.089491072 HS_from_MQbrain_597_r 4.765274065 0.084885584 HS_from_MQbrain_824_l 2.021767126 0.084885584 HS_from_MQbrain_1087_l 8.47223421 0.083833911 HSbrain_319_l 27.65786021 0.07965977 HS_from_MQbrain_1462_l 135.9829616 0.07715065 HSbrain_253_l 11.33164065 0.07715065 Hsd_105_l 5.399875994 0.07715065 HS_from_MQbrain_881_r 3.552631725 0.07715065 Hsd_from_Mmd_410_r 2.908576361 0.07641095 Hsd_from_Mmd_464_l 2.017405172 0.07641095 HS_from_MQbrain_266_r 7.219897398 0.075028175 HS_from_MQbrain_435_r 2.200043662 0.072654718 HSbrain_93_r 4.274468514 0.072275086 HS_from_MQbrain_932_l 2.123754543 0.068270026 Hsd_from_Mmd_371_r 131.2157622 0.058218978 HS_from_MQbrain_1070_r 19.32265622 0.058218978 HS_from_MQbrain_1628_r 3.67815753 0.051819249 HS_from_MQbrain_1565_l 11.415781 0.050135128 HSbrain_703_r 11.82131557 0.047341086 HS_from_MM_251_r 168.6680712 0.039250091 Hsd_85_r 3.438673873 0.034662803 HS_from_MQbrain_1500_l 15.2774537 0.023919533 HS_from_MQbrain_941_r 2.300164622 0.016904198 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

Presence of Classifying Small RNAs in Faeces

TABLE 12a Classification of control vs adenoma The following 21 out of 55 classifying small RNAs can be detected in blood HSbrain_377_r Hsd_from_Mmd_452_l HSbrain_224_r HS_from_MM_118_r Hsd_from_Mmd_117_r HS_169_l HS_from_MM_169_r HS_from_MQbrain_79_r HS_from_MQbrain_825_r HS_from_MQbrain_594_r HSbrain_106_r HSbrain_1_l HS_from_PT_36_l HS_262_l HS_from_MQbrain_1823_r Hsd_from_Mmd_298_r HS_from_MQbrain_1311_r HS_from_MQbrain_194_l Hsd_from_Mmd_485_r HS_from_MQbrain_1462_l HSbrain_1406_l HS_from_MQbrain_1183_l

TABLE 12b Classification of control vs adenocarcinoma The following 16 out of 79 classifying small RNAs can be detected in blood HS_from_MQbrain_1320_r HS_from_MQbrain_594_r HS_from_MQbrain_855_r HSbrain_426_r HS_from_MQbrain_340_l HS_from_MM_353_l HS_from_MM_210_l HSbrain_704_l HS_from_MQbrain_485_l Hsd_from_Mmd_328_l HS_from_MQbrain_1432_l HS_from_MM_178_l HSbrain_499_l HS_from_MQbrain_827_l HS_from_MM_47_r

TABLE 12c Classification of adenoma vs adenocarcinoma The following 4 out of 26 classifying small RNAs can be detected in blood HS_from_MQbrain_1082_l HS_from_PT_36_l HS_from_MQbrain_824_l HS_from_MQbrain_825_r

TABLE 13 Recovered small RNAs in blood 1st arm Systematic name signal/backgr¹ HSbrain_685_l 4143.44 Hsd_12_l 3822.46 HS_from_MQbrain_1364_l 3810.98 HS_from_MQbrain_1412_r 3753.01 HS_from_MM_111_r 3707.66 Hsd_34_l 3535.17 HSbrain_550_r 3519.10 HSbrain_188_r 3508.56 HS_from_MQbrain_1804_l 3483.45 HSbrain_221_l 3453.74 HS_199_r 3400.22 Hsd_from_Mmd_535_l 3397.88 HS_from_MQbrain_1426_l 3397.58 HS_from_MQbrain_1777_l 3386.15 HS_72_r 3347.62 HS_from_MQbrain_1683_l 3345.13 HSbrain_10_l 3325.13 HSbrain_328_l 3271.08 HS_from_MQbrain_533_l 3263.08 HS_from_MQbrain_1741_l 3259.71 HS_from_MQbrain_1863_l 3259.56 HSbrain_160_l 3253.62 HSbrain_172_r 3241.21 Hsd_from_Mmd_185_l 3235.16 HS_from_MQbrain_655_r 3221.03 HS_from_MQbrain_1219_l 3215.41 HSbrain_664_r 3210.45 HS_from_MQbrain_1306_r 3210.23 HSbrain_731_l 3209.06 HSbrain_769_r 3201.06 HS_from_MQbrain_487_r 3196.14 HS_from_MQbrain_108_l 3190.76 HS_from_MQbrain_1652_r 3171.46 HSbrain_55_r 3168.27 HS_from_MQbrain_1727_r 3152.31 HSbrain_679_l 3143.27 HS_from_MQbrain_115_r 3142.08 Hsd_from_Mmd_448_r 3129.79 HSbrain_299_l 3118.98 HS_from_MQbrain_1709_r 3100.66 HSbrain_611_l 3099.01 HS_48_l 3088.27 HS_from_MQbrain_330_r 3085.23 HS_from_MQbrain_265_r 3084.01 HS_from_MQbrain_111_r 3079.60 HS_173_r 3074.67 HS_from_MQbrain_229_r 3071.27 HS_78_l 3066.99 HSbrain_191_l 3066.36 HS_32_l 3064.10 HSbrain_244_r 3058.16 Hsd_from_Mmd_472_r 3055.30 HS_from_MQbrain_428_r 3049.36 HS_from_MQbrain_459_l 3044.63 HSbrain_1377_r 3044.23 HS_from_MQbrain_1632_l 3014.17 Hsd_from_Mmd_487_l 3011.40 HSbrain_676_l 3009.99 HS_19_l 3008.92 HS_from_PT_64_r 3003.40 HS_284_l 2997.74 HSbrain_306_r 2986.89 HS_from_MM_103_l 2974.49 HS_from_MQbrain_734_l 2968.08 HS_from_MQbrain_1575_r 2955.83 HS_from_MQbrain_1848_l 2953.59 HS_from_MQbrain_1241_l 2950.15 HS_from_MQbrain_688_l 2949.66 HS_from_PT_305_l 2949.38 HSbrain_279_r 2940.84 HSbrain_210_l 2938.20 HS_from_MQbrain_1380_r 2936.43 HS_from_MQbrain_1599_l 2929.74 HS_from_MQbrain_1084_r 2928.75 HS_from_MQbrain_1803_l 2927.91 HS_from_MQbrain_311_l 2926.98 HSbrain_152_l 2922.92 HSbrain_1407_l 2916.25 HSbrain_334_l 2905.21 HSbrain_114_l 2900.41 HS_from_MQbrain_1697_r 2900.13 HS_from_MQbrain_1134_l 2892.26 HSbrain_425_r 2881.36 Hsd_from_Mmd_405_r 2881.01 HS_from_MQbrain_1399_l 2880.82 HS_from_PT_134_l 2880.24 HS_163_l 2877.66 Hsd_21_l 2876.65 HS_from_MQbrain_715_l 2873.52 HSbrain_783_l 2871.64 HS_from_MQbrain_1509_r 2861.75 HS_from_MQbrain_1686_l 2850.33 HSbrain_326_l 2841.30 HSbrain_404_r 2841.00 HS_from_PT_18_l 2829.14 HSbrain_440_l 2827.75 HSbrain_141_r 2820.17 HS_from_MQbrain_810_l 2819.61 HS_from_MM_5_r 2818.77 HSbrain_283_l 2809.33 HS_from_MQbrain_1236_l 2808.42 HS_135_r 2806.71 HS_from_MQbrain_324_r 2803.91 HS_from_MQbrain_184_r 2802.82 HSbrain_1298_l 2802.59 HS_from_PT_226_r 2799.23 HSbrain_313_r 2798.16 HS_198_l 2797.81 Hsd_50_l 2796.99 HS_from_MQbrain_1365_r 2796.98 HS_from_MQbrain_863_r 2785.40 HS_from_MQbrain_610_r 2783.73 HS_from_MQbrain_877_l 2776.99 HS_from_MQbrain_33_l 2774.13 HS_from_PT_102_l 2772.91 HS_75_l 2768.60 HS_from_MQbrain_1581_l 2763.55 HS_from_MQbrain_387_l 2762.99 HSbrain_250_l 2758.18 HSbrain_1236_r 2749.95 HSbrain_45_r 2746.16 HS_from_MQbrain_301_r 2746.14 HSbrain_367_r 2743.94 HS_from_MQbrain_129_l 2741.16 HS_from_PT_92_l 2739.09 HSbrain_240_l 2736.22 HS_from_MQbrain_345_r 2731.68 HS_from_MQbrain_1523_r 2731.64 HSbrain_365_r 2731.35 HS_from_MQbrain_996_l 2730.34 HS_9_l 2720.49 HSbrain_688_l 2718.05 HS_197_r 2713.25 HSbrain_745_r 2713.11 HS_from_MQbrain_1331_r 2711.38 HS_from_MQbrain_1864_r 2711.06 HS_from_MQbrain_1631_r 2710.28 HS_113_r 2700.28 HSbrain_192_l 2698.44 HS_133_l 2696.57 HS_from_MQbrain_765_l 2695.54 HSbrain_109_l 2695.37 HS_from_MQbrain_935_r 2688.96 HS_from_MQbrain_900_l 2685.43 HS_from_MM_346_l 2685.36 HS_171_l 2683.04 HS_from_MQbrain_1812_l 2682.09 HSbrain_680_l 2680.84 HSbrain_761_r 2676.91 HS_from_MM_45_l 2671.67 Hsd_46_r 2671.21 HS_from_PT_158_l 2670.87 HS_from_MQbrain_142_l 2670.59 HS_from_PT_115_l 2669.44 HS_from_MQbrain_48_l 2663.41 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HS_from_MQbrain_1673_r 313.25 HS_from_MQbrain_981_l 311.17 HS_from_MQbrain_413_l 306.41 HS_from_MQbrain_801_l 305.81 HSbrain_582_r 304.05 HS_from_MQbrain_862_l 303.62 HS_from_MQbrain_284_r 302.38 HS_from_MQbrain_178_l 300.55 HS_from_MQbrain_1393_l 298.80 HS_87_r 297.76 HS_from_MQbrain_1831_r 297.75 HS_from_MQbrain_18_l 297.60 HS_from_MQbrain_84_l 297.02 HSbrain_353_r 294.70 HSbrain_121_l 293.17 HS_4_r 293.08 HS_from_MQbrain_1875_l 292.51 HS_from_MQbrain_706_l 291.66 HS_from_MQbrain_149_l 291.54 HS_303_r 290.92 Hsd_1_l 290.92 Hsd_from_Mmd_488_l 288.56 HS_from_MQbrain_1303_r 288.49 HS_from_MQbrain_1565_r 286.84 HS_from_PT_325_r 286.73 HS_from_MM_179_l 286.55 HSbrain_300_r 286.46 HSbrain_51_r 284.78 HSbrain_383_l 283.64 HSbrain_698_l 283.24 HS_from_MQbrain_1719_l 282.17 HSbrain_136_l 282.00 HSbrain_301_r 281.80 HSbrain_288_l 280.92 HS_268_r 279.89 HS_from_MQbrain_659_l 278.81 HS_from_MQbrain_1784_r 278.43 HSbrain_723_l 277.73 HS_from_MQbrain_913_r 276.93 HSbrain_176_l 276.55 HS_from_MQbrain_191_l 276.03 HSbrain_364_l 275.31 HS_152_l 271.53 HSbrain_421_r 271.48 HS_from_MQbrain_490_r 269.59 HS_from_MQbrain_1051_l 269.40 HSbrain_1437_l 266.70 HS_from_MQbrain_28_r 265.68 HSbrain_564_r 265.22 HSbrain_41_l 264.89 HS_from_MQbrain_1551_r 262.98 HSbrain_61_r 261.35 HSbrain_534_l 261.28 HSbrain_616_r 260.24 HS_from_MQbrain_661_l 259.94 HSbrain_248_l 258.90 Hsd_65_r 258.71 HS_from_MQbrain_1708_l 257.81 HS_from_MQbrain_1664_r 257.46 HSbrain_762_r 257.10 HSbrain_590_r 254.85 Hsd_64_r 254.29 HSbrain_403_r 254.03 HS_from_MQbrain_388_r 253.35 HS_from_MQbrain_868_l 251.95 HS_from_MQbrain_2633_l 251.66 HS_from_MQbrain_1456_l 251.46 HS_from_MQbrain_1010_l 250.06 HS_from_MQbrain_315_l 248.59 HS_from_MQbrain_1340_l 248.35 Hsd_from_Mmd_530_r 248.30 Hsd_77_r 247.78 HS_247_l 247.65 HS_from_PT_300_l 245.35 HSbrain_183_r 245.06 HSbrain_74_l 244.28 HS_from_MM_299_r 243.94 HS_from_MQbrain_965_l 243.53 HSbrain_793_r 243.17 HS_from_MQbrain_1374_l 242.85 HS_186_r 242.25 HSbrain_49_r 241.32 HS_from_MQbrain_1561_l 240.38 HS_from_MQbrain_1288_l 238.85 HS_from_MQbrain_1279_r 238.31 HS_from_MQbrain_629_l 237.88 HSbrain_1305_l 237.71 HS_from_MQbrain_1745_r 237.34 HS_146_l 235.71 HS_from_MQbrain_1315_l 234.79 HSbrain_776_r 233.87 Hsd_from_Mmd_189_l 233.41 HS_from_MQbrain_1433_r 232.94 HSbrain_608_r 232.74 HSbrain_751_l 232.40 HS_from_PT_211_l 230.31 HS_from_MQbrain_41_r 229.85 HSbrain_768_r 229.66 HSbrain_613_l 229.34 HS_from_MQbrain_504_l 229.11 HSbrain_155_l 228.39 HS_from_MQbrain_1227_l 228.29 HS_from_PT_207_r 227.55 HSbrain_784_r 227.25 HS_from_MQbrain_343_l 224.21 HS_from_MQbrain_405_l 224.19 HS_124_l 223.23 Hsd_52_l 223.10 HS_from_MQbrain_1175_r 221.91 HS_164_l 221.00 HS_22_l 220.60 HSbrain_303_l 220.32 HS_from_MQbrain_1212_r 220.09 Hsd_from_Mmd_483_l 219.16 Hsd_from_Mmd_20_l 216.97 HS_from_MQbrain_951_l 216.15 HS_from_MQbrain_1555_l 215.81 HSbrain_1414_l 214.70 HS_from_MQbrain_349_l 214.68 HS_from_MQbrain_1055_r 214.02 HS_from_MQbrain_414_l 212.24 HSbrain_65_r 211.29 HS_from_MQbrain_492_l 210.90 HS_from_MQbrain_948_r 210.86 Hsd_from_Mmd_145_l 209.51 HSbrain_126_l 208.87 HSbrain_359_r 207.52 HS_from_MQbrain_128_r 205.98 Hsd_from_Mmd_353_l 205.36 HS_from_PT_256_l 203.51 HS_from_MQbrain_1535_l 203.26 HS_86_l 202.01 HS_from_MQbrain_806_l 201.32 HS_from_MQbrain_1395_r 200.62 HSbrain_142_l 200.51 HS_from_PT_146_l 200.34 HS_from_MQbrain_1608_l 200.30 HS_from_MQbrain_1744_r 199.26 HS_from_MQbrain_154_l 198.44 Hsd_19_l 198.35 HS_283_r 197.92 HSbrain_369_r 197.24 HS_from_MQbrain_650_r 195.56 HS_from_MQbrain_630_l 195.03 HSbrain_124_l 194.72 HS_91_r 193.84 HS_258_l 193.39 HS_from_MQbrain_922_r 192.40 HS_112_l 192.23 HS_from_MQbrain_251_r 190.83 HSbrain_362_l 190.33 HSbrain_637_l 190.08 HS_from_MQbrain_1590_l 189.53 HSbrain_441_l 189.11 HS_from_MQbrain_350_l 188.59 HS_from_MQbrain_1718_l 188.57 HS_from_MQbrain_1573_l 188.47 HSbrain_1210_r 188.45 HS_from_PT_291_l 188.08 HS_from_MM_44_l 187.87 HS_from_MQbrain_472_r 187.77 HS_143_l 185.71 HS_from_MQbrain_165_l 185.39 Hsd_from_Mmd_246_r 185.28 HSbrain_1421_r 185.02 HSbrain_35_r 185.02 HS_34_r 182.83 HS_from_MQbrain_467_l 182.78 Hsd_from_Mmd_93_l 182.17 HSbrain_785_r 181.62 HSbrain_117_r 181.24 HS_88_l 181.19 HS_from_MQbrain_1346_l 180.35 Hsd_from_Mmd_91_r 178.23 Hsd_87_r 177.68 HS_from_MQbrain_38_l 177.46 HS_from_MQbrain_919_r 177.21 HS_from_MQbrain_1061_l 172.98 HS_178_r 172.77 HS_from_MQbrain_1808_r 172.48 HS_from_MQbrain_1569_l 171.53 Hsd_108_r 171.48 Hsd_74_r 170.76 HS_from_MQbrain_403_l 169.68 HS_from_MM_251_l 168.81 HS_from_MQbrain_658_r 167.88 HS_from_MQbrain_404_l 165.99 HS_33_r 164.78 HSbrain_1066_l 164.40 HS_from_MQbrain_1028_l 164.03 HS_156_r 163.86 HSbrain_459_l 163.49 HS_from_MQbrain_1088_l 162.85 HS_from_MQbrain_1558_r 162.47 HSbrain_620_l 161.99 HSbrain_37_l 161.83 HS_from_MQbrain_1260_l 161.33 HS_from_MQbrain_1795_l 161.31 HS_from_MQbrain_458_r 160.80 HSbrain_648_r 160.66 HS_from_MQbrain_1869_l 160.25 HS_from_MQbrain_123_r 158.71 HS_from_MQbrain_931_r 158.29 HSbrain_484_l 158.28 Hsd_100_l 157.67 Hsd_99_r 157.49 HS_from_MQbrain_867_r 157.00 Hsd_from_Mmd_141_l 156.62 Hsd_from_Mmd_371_l 155.83 HS_from_MQbrain_1459_l 154.95 HS_from_MQbrain_889_r 154.79 HS_from_MM_289_r 153.91 HS_from_MQbrain_562_l 153.24 HS_from_MM_293_r 153.22 HS_from_MQbrain_785_l 152.69 HS_from_MQbrain_1108_r 152.69 HS_from_MQbrain_936_r 152.19 HS_from_MQbrain_464_l 151.75 HSbrain_524_r 151.72 HS_from_MQbrain_1300_l 151.72 HS_from_MQbrain_494_l 151.57 HS_from_MQbrain_327_r 151.54 HS_from_MM_219_l 151.42 HSbrain_596_r 151.36 Hsd_from_Mmd_468_r 151.35 HSbrain_290_l 150.85 HS_from_MQbrain_1841_r 150.14 HS_from_MM_163_r 149.79 HSbrain_495_l 149.74 Hsd_from_Mmd_344_r 149.50 Hsd_from_Mmd_266_r 148.01 HS_from_MM_175_l 147.90 HS_from_MM_150_l 147.44 HS_from_MQbrain_1589_r 147.20 Hsd_92_l 146.01 HSbrain_573_l 145.75 Hsd_from_Mmd_52_r 145.37 HSbrain_1409_r 144.95 HS_from_PT_121_r 144.82 HS_255_l 144.06 HSbrain_178_l 143.88 HS_from_MQbrain_482_r 143.47 HS_from_MQbrain_221_l 143.40 HS_261_r 142.25 HS_from_MQbrain_558_r 141.63 Hsd_from_Mmd_439_l 141.63 HS_from_MQbrain_427_l 140.97 HS_from_MQbrain_612_r 140.83 HS_from_MQbrain_973_l 140.65 HS_169_l 138.82 HSbrain_658_r 138.37 HSbrain_165_l 137.58 HS_from_MQbrain_360_r 137.28 HS_from_MM_136_r 137.03 HS_from_MQbrain_470_l 136.89 HS_from_MQbrain_1463_l 136.60 HS_from_MQbrain_741_r 136.21 HS_from_MQbrain_1790_r 135.71 HSbrain_203_l 134.99 HSbrain_360_r 134.83 HSbrain_27_r 132.91 HS_from_MQbrain_9_r 130.51 HS_from_MQbrain_1656_l 130.22 HS_from_PT_31_r 130.08 HS_from_MQbrain_369_r 129.29 HS_from_MQbrain_666_r 129.05 HS_from_MQbrain_606_l 128.88 HS_from_MM_202_l 128.65 Hsd_101_l 127.99 HS_from_MQbrain_183_l 126.73 HS_from_MQbrain_2689_l 125.98 HS_138_l 125.63 HS_from_MQbrain_56_l 125.18 HS_from_MQbrain_1822_r 125.05 Hsd_from_Mmd_501_r 125.01 HS_2_l 123.48 HS_from_MQbrain_486_l 123.37 Hsd_97_l 123.35 HSbrain_387_r 123.32 HS_from_MQbrain_1722_l 121.03 HSbrain_181_r 120.88 HS_from_MQbrain_383_l 120.82 HS_from_MQbrain_621_r 120.69 HS_from_MQbrain_1542_r 119.21 Hsd_from_Mmd_112_l 119.21 HSbrain_578_r 119.12 HS_from_MQbrain_52_r 118.77 HS_from_MQbrain_1205_r 118.18 HSbrain_38_r 118.09 HSbrain_733_l 117.71 HSbrain_592_r 117.60 HSbrain_69_r 117.41 HS_from_MQbrain_663_r 117.29 HSbrain_502_l 117.21 Hsd_79_l 115.62 HS_from_PT_303_l 115.42 HSbrain_68_r 115.20 HSbrain_807_r 114.06 Hsd_11_l 114.03 HS_from_MM_109_r 113.69 HSbrain_490_r 113.20 Hsd_from_Mmd_284_r 112.69 HS_from_MQbrain_1183_l 112.54 HS_from_MQbrain_1070_l 112.16 HS_from_MQbrain_1781_r 111.29 HS_from_MQbrain_287_r 110.79 HS_from_MQbrain_591_l 110.25 Hsd_from_Mmd_245_r 110.10 HSbrain_729_l 109.77 HS_232_l 109.73 Hsd_61_l 109.69 HS_from_PT_234_l 109.50 HS_from_MQbrain_304_r 109.46 HS_from_MQbrain_261_r 108.55 Hsd_83_r 107.53 Hsd_from_Mmd_136_r 107.29 HS_from_MM_319_l 107.03 Hsd_78_l 106.73 HS_from_MQbrain_1854_r 106.61 HSbrain_346_l 106.26 HSbrain_617_l 106.18 HS_from_MM_33_r 106.17 HS_from_MQbrain_1743_r 106.15 HS_141_l 105.74 HSbrain_640_r 105.57 HS_267_r 105.00 HS_from_MQbrain_1818_r 104.59 HS_from_MQbrain_1030_l 104.18 HS_189_l 103.99 HSbrain_772_l 103.44 HS_from_MQbrain_1610_r 102.62 HS_110_l 102.30 HS_from_MQbrain_841_l 101.61 HSbrain_1168_l 101.59 HS_from_MQbrain_1775_r 101.49 HSbrain_129_r 101.04 Hsd_from_Mmd_193_l 100.90 HS_from_MQbrain_1766_r 100.48 HS_from_MQbrain_2380_r 100.43 HSbrain_310_l 100.30 HS_from_MM_273_l 99.76 Hsd_from_Mmd_270_l 99.75 HSbrain_436_l 99.64 HS_from_MM_153_l 99.43 HS_from_MM_176_r 98.96 HSbrain_98_l 98.56 HS_from_MQbrain_1830_r 97.76 HS_from_MQbrain_1797_r 97.58 Hsd_109_l 96.85 HS_from_MQbrain_618_r 96.31 HSbrain_342_l 96.28 Hsd_from_Mmd_519_r 95.12 HS_from_MQbrain_557_l 94.76 HSbrain_194_r 94.74 HS_from_MQbrain_1649_l 94.72 HS_from_MQbrain_1816_r 94.61 HS_from_MQbrain_57_l 94.28 HS_from_MM_321_r 92.98 Hsd_111_r 92.66 Hsd_from_Mmd_235_r 92.57 HSbrain_778_l 91.71 Hsd_from_Mmd_526_r 89.64 HS_from_MQbrain_1749_r 89.49 Hsd_from_Mmd_482_r 88.64 HS_from_MM_182_r 88.50 HS_from_MQbrain_346_r 88.45 HS_from_MM_161_l 88.26 HS_from_MQbrain_249_l 88.26 Hsd_82_l 88.10 HS_from_PT_136_l 88.09 HS_from_MQbrain_1871_r 86.87 HSbrain_756_l 86.23 HS_from_MQbrain_1730_r 86.13 HS_from_MQbrain_1751_r 85.80 HS_from_MQbrain_1566_l 85.25 Hsd_from_Mmd_412_l 84.96 Hsd_from_Mmd_515_l 84.90 HSbrain_2_l 84.89 HS_from_MM_155_r 84.60 HS_from_MQbrain_155_r 84.50 HS_from_MQbrain_1304_r 84.49 HS_from_MQbrain_81_r 84.46 HS_from_MQbrain_622_r 83.61 HS_from_MQbrain_1131_l 83.55 Hsd_56_l 83.20 Hsd_8_l 83.04 HS_212_r 82.75 HSbrain_212_l 82.21 HS_from_MQbrain_398_r 82.13 HS_from_MQbrain_1779_l 81.98 HS_from_MQbrain_1852_r 81.57 HSbrain_801_r 81.51 Hsd_from_Mmd_466_l 80.93 HS_from_MM_199_l 79.91 HS_from_MQbrain_1209_r 79.23 HSbrain_526_r 78.78 HS_from_MQbrain_151_r 78.11 HS_from_PT_103_l 77.68 HSbrain_113_r 77.28 Hsd_from_Mmd_271_r 77.04 Hsd_from_Mmd_172_l 76.79 HS_from_PT_180_l 75.89 HSbrain_697_l 75.83 Hsd_from_Mmd_438_r 75.54 HS_from_MQbrain_517_r 75.18 HS_from_MQbrain_1182_l 75.16 HS_from_MQbrain_160_l 74.92 HS_from_MQbrain_674_r 74.90 HS_282_l 74.89 HS_from_MQbrain_1002_l 74.73 HS_from_MQbrain_1740_l 74.72 HS_from_PT_340_l 74.70 HS_from_MQbrain_58_r 74.41 HS_from_MQbrain_1638_l 74.01 HS_174_l 73.96 Hsd_from_Mmd_228_r 73.75 HS_from_MQbrain_1325_r 73.72 Hsd_from_Mmd_186_l 73.39 HS_from_MQbrain_1788_r 73.00 HS_from_MM_12_l 72.97 HS_from_MQbrain_525_r 72.69 HS_from_MQbrain_1145_r 72.63 HS_from_MM_334_l 71.92 HS_from_MQbrain_1417_r 71.89 HS_from_MQbrain_370_r 71.88 HS_from_MQbrain_1692_l 71.86 HS_from_MQbrain_1363_r 71.66 Hsd_from_Mmd_96_l 71.59 HS_from_MQbrain_500_l 71.53 HS_from_MQbrain_949_l 71.15 HS_from_MQbrain_1297_l 70.63 Hsd_from_Mmd_461_l 70.50 HS_from_PT_248_l 70.46 HSbrain_585_l 70.01 HSbrain_435_r 69.54 HS_from_MM_316_r 69.22 HS_from_MQbrain_15_l 69.02 HS_from_PT_74_r 68.99 HS_from_MQbrain_1027_r 68.90 Hsd_from_Mmd_190_l 68.83 HS_from_MQbrain_1685_l 68.54 HSbrain_148_r 68.52 HS_from_MQbrain_714_l 68.40 HS_from_MQbrain_1886_r 68.24 HSbrain_71_l 67.99 HSbrain_351_l 67.80 HS_184_l 67.16 HS_from_MQbrain_1445_l 67.15 HSbrain_434_l 67.13 HSbrain_253_l 67.08 HS_68_l 66.74 HSbrain_631_r 66.51 HS_203_r 66.49 HS_from_MQbrain_1422_r 66.39 HS_from_MQbrain_1207_l 66.20 Hsd_from_Mmd_430_r 65.51 HSbrain_705_r 64.83 Hsd_from_Mmd_176_l 64.49 HS_from_MQbrain_1478_l 63.78 HS_216_r 63.62 HS_from_MQbrain_1640_r 63.45 HSbrain_289_l 63.38 HS_from_MQbrain_1835_r 63.36 HS_from_MM_301_l 63.22 HS_from_MM_40_l 63.15 HS_from_MQbrain_575_r 63.09 Hsd_from_Mmd_161_l 62.81 HS_from_MQbrain_113_l 62.81 HS_from_MM_336_r 62.68 HSbrain_77_r 62.61 HSbrain_1436_l 62.57 HS_from_MQbrain_100_l 62.37 HS_from_MQbrain_979_r 62.19 HS_from_MQbrain_31_r 61.82 HSbrain_116_l 61.35 HSbrain_557_r 60.82 HSbrain_157_l 60.78 HS_from_MQbrain_740_l 60.73 HSbrain_760_l 60.42 HSbrain_304_l 60.38 HS_from_PT_176_r 60.13 HS_from_MM_96_l 59.61 HS_from_MQbrain_69_r 59.60 HSbrain_376_r 59.58 HSbrain_630_l 59.49 HSbrain_282_l 59.48 HS_from_MQbrain_372_l 59.38 Hsd_from_Mmd_169_r 59.27 Hsd_59_r 59.20 HS_from_PT_206_l 58.76 HS_from_MQbrain_1_l 58.07 HS_180_r 57.76 HSbrain_375_r 57.73 HS_20_r 56.85 HSbrain_505_l 56.76 HSbrain_245_r 56.71 HS_from_MQbrain_132_l 55.92 HS_from_MQbrain_222_l 55.76 HSbrain_916_l 55.74 HS_106_l 55.68 HSbrain_739_l 55.15 HSbrain_223_r 55.06 HS_from_MM_38_l 55.05 HS_from_MQbrain_710_l 55.00 HSbrain_589_r 54.91 HS_from_MQbrain_484_r 54.66 HS_from_MQbrain_977_r 54.29 HS_from_MQbrain_802_l 54.04 HS_from_MQbrain_391_r 53.80 HS_from_MQbrain_240_l 53.57 HSbrain_106_r 53.44 HS_from_MQbrain_255_l 53.09 HS_from_MQbrain_1517_l 52.95 HS_179_l 52.66 HS_from_MQbrain_118_l 52.25 Hsd_from_Mmd_204_l 52.22 HS_215_l 51.87 HSbrain_195_l 51.67 HSbrain_424_l 51.64 HSbrain_448_l 51.31 HS_from_MM_126_l 51.22 Hsd_102_l 51.20 HSbrain_341_r 50.96 HS_from_MQbrain_235_l 50.81 HS_from_MQbrain_619_r 50.44 HS_from_MM_335_r 50.36 HSbrain_197_l 49.79 HS_from_MQbrain_869_l 49.56 HS_from_MQbrain_433_l 49.52 HS_10_l 49.43 HS_from_MQbrain_1520_r 49.34 HS_from_MQbrain_20_r 49.05 HS_from_MQbrain_1400_l 48.14 HSbrain_236_r 48.09 HS_from_MQbrain_713_r 47.95 HS_from_MQbrain_1654_l 47.95 HSbrain_14_r 47.92 HS_from_MQbrain_1765_r 47.70 HS_from_MQbrain_1672_r 47.58 HSbrain_206_l 46.96 HSbrain_209_r 46.69 HS_257_r 46.69 Hsd_from_Mmd_34_r 46.61 HS_286_l 46.37 HS_from_MQbrain_1769_r 46.33 Hsd_68_l 45.49 HSbrain_262_l 45.22 HS_from_MQbrain_535_r 45.21 HS_from_MQbrain_468_l 45.02 HS_from_MM_159_l 44.47 Hsd_from_Mmd_507_l 44.29 HS_from_MQbrain_1527_l 44.13 HS_from_MQbrain_256_l 44.09 HS_from_PT_338_r 44.05 HS_from_MQbrain_894_l 43.92 HSbrain_158_l 43.60 HS_192_r 43.57 HS_from_MQbrain_1739_r 43.35 HSbrain_42_r 43.31 HS_from_MQbrain_466_r 43.22 HS_from_MQbrain_45_r 42.99 HS_from_MQbrain_890_r 42.96 HS_from_MQbrain_997_l 42.80 HS_from_MQbrain_135_l 42.75 Hsd_from_Mmd_81_l 42.55 HS_from_MQbrain_832_l 42.51 HSbrain_764_r 42.39 HS_from_PT_108_l 42.07 Hsd_from_Mmd_324_r 41.99 HS_from_MQbrain_632_l 41.42 HS_from_MQbrain_110_r 41.30 Hsd_from_Mmd_478_l 40.92 HS_from_MQbrain_1757_l 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HS_from_MQbrain_787_r 5.40 Hsd_from_Mmd_74_r 5.38 HS_270_l 5.38 HS_from_MQbrain_1056_l 5.37 HS_296_r 5.37 Hsd_from_Mmd_476_l 5.36 HSbrain_498_l 5.35 Hsd_40_r 5.34 HSbrain_232_l 5.33 HSbrain_119_l 5.32 HS_from_MQbrain_1474_l 5.32 HSbrain_1434_r 5.32 HS_from_MQbrain_1034_r 5.31 HS_from_MQbrain_817_l 5.30 HS_from_MM_124_r 5.30 HSbrain_1423_r 5.23 Hsd_from_Mmd_533_l 5.22 HS_from_MQbrain_1503_r 5.21 HS_from_MM_54_l 5.20 HS_from_MQbrain_1836_l 5.19 Hsd_from_Mmd_263_r 5.17 HSbrain_314_l 5.16 HS_from_PT_157_l 5.16 HS_from_MQbrain_777_r 5.15 HS_from_MQbrain_1606_r 5.15 HSbrain_466_l 5.14 HS_from_MM_194_r 5.14 HS_from_MQbrain_915_l 5.12 HSbrain_571_l 5.09 HS_from_MQbrain_1181_r 5.09 Hsd_from_Mmd_249_r 5.05 HSbrain_111_l 5.04 HSbrain_238_l 5.04 HSbrain_214_l 5.03 HS_293_r 5.01 Hsd_from_Mmd_343_l 4.99 HS_273_l 4.98 HS_from_MM_236_l 4.96 HSbrain_394_l 4.95 HS_from_MQbrain_1793_r 4.95 HS_from_MQbrain_812_r 4.94 HSbrain_339_l 4.92 HS_14_l 4.90 HS_252_l 4.87 HSbrain_1392_l 4.86 HS_103_r 4.86 HS_from_PT_1_r 4.86 HS_251_l 4.82 HSbrain_294_l 4.82 HS_from_MQbrain_907_r 4.81 HS_from_MM_359_r 4.80 HS_from_MQbrain_521_r 4.77 HSbrain_1388_l 4.75 Hsd_from_Mmd_436_r 4.74 HS_60_r 4.73 HSbrain_25_r 4.72 HSbrain_261_l 4.72 HS_from_PT_155_r 4.70 Hsd_from_Mmd_490_l 4.66 HS_from_MM_63_l 4.64 HSbrain_795_l 4.64 HSbrain_447_r 4.64 Hsd_from_Mmd_280_l 4.61 HSbrain_678_l 4.61 HSbrain_170_r 4.60 HSbrain_1391_l 4.58 HSbrain_1387_l 4.56 HS_from_MQbrain_43_r 4.54 Hsd_from_Mmd_437_r 4.54 HS_from_MQbrain_1762_l 4.53 HS_from_PT_221_r 4.52 HS_from_PT_288_l 4.46 HS_from_MQbrain_1377_l 4.44 HS_from_MM_149_r 4.41 HSbrain_674_l 4.40 Hsd_from_Mmd_286_r 4.40 HSbrain_46_r 4.40 Hsd_from_Mmd_262_l 4.39 HS_181_r 4.32 HSbrain_689_l 4.31 HSbrain_322_r 4.31 HSbrain_533_r 4.30 HSbrain_468_l 4.28 HS_from_MQbrain_1234_l 4.28 HS_from_MQbrain_1518_r 4.26 Hsd_from_Mmd_506_l 4.24 HSbrain_94_l 4.24 HSbrain_681_l 4.24 HS_from_MQbrain_1058_l 4.22 HS_from_MM_147_l 4.22 HS_from_MM_114_r 4.22 Hsd_from_Mmd_524_r 4.21 HS_from_MQbrain_1301_l 4.17 HSbrain_449_r 4.16 HS_from_MQbrain_1391_l 4.14 HS_from_MM_160_l 4.14 HSbrain_336_l 4.14 HS_from_MQbrain_168_l 4.14 HS_from_MQbrain_904_r 4.09 HSbrain_805_l 4.08 HSbrain_706_l 4.08 HSbrain_666_l 4.08 Hsd_from_Mmd_333_r 4.01 HSbrain_683_l 4.00 HS_from_MQbrain_542_l 3.97 HSbrain_1390_l 3.97 HSbrain_302_l 3.96 HS_132_l 3.95 HS_from_MM_178_r 3.95 HSbrain_377_r 3.94 HS_from_PT_35_r 3.93 HS_from_MQbrain_91_l 3.92 Hsd_from_Mmd_274_l 3.91 HS_from_MQbrain_361_l 3.90 HS_162_l 3.89 HSbrain_773_l 3.88 HS_from_MQbrain_835_r 3.86 HSbrain_81_l 3.85 HS_from_MQbrain_453_r 3.84 HS_from_MQbrain_1525_l 3.83 HS_from_MQbrain_1723_l 3.83 HS_from_MQbrain_1461_l 3.83 Hsd_from_Mmd_137_r 3.80 HSbrain_384_l 3.79 HS_from_MQbrain_790_r 3.78 HS_from_MQbrain_329_l 3.77 HS_from_MQbrain_719_l 3.75 HSbrain_754_l 3.73 HSbrain_190_l 3.72 HSbrain_340_r 3.71 Hsd_from_Mmd_149_l 3.70 HS_from_MQbrain_1895_l 3.68 HS_from_PT_269_l 3.67 Hsd_from_Mmd_170_r 3.65 HS_from_MQbrain_637_l 3.64 HSbrain_20_r 3.64 HS_from_MQbrain_972_l 3.63 HSbrain_473_r 3.62 HSbrain_225_l 3.62 HS_from_MQbrain_769_r 3.62 HS_from_MM_50_r 3.61 Hsd_104_r 3.60 HSbrain_1386_l 3.60 HS_from_MQbrain_1197_r 3.59 Hsd_3_r 3.58 HS_from_MM_201_l 3.56 HSbrain_163_r 3.56 HSbrain_667_l 3.54 HSbrain_523_r 3.48 HS_37_r 3.47 HS_from_MM_86_l 3.47 Hsd_from_Mmd_187_r 3.46 HS_from_MQbrain_1791_l 3.45 HS_from_MQbrain_587_l 3.45 HS_from_MM_314_l 3.44 HS_from_MQbrain_1815_r 3.43 HSbrain_672_l 3.43 HS_from_MQbrain_1792_r 3.43 HSbrain_237_r 3.41 Hsd_from_Mmd_486_r 3.41 HSbrain_3_r 3.37 HS_from_MQbrain_279_l 3.36 Hsd_88_l 3.35 HSbrain_205_r 3.35 HS_from_MQbrain_791_l 3.34 HSbrain_1389_l 3.34 HS_264_l 3.32 HS_from_MM_9_r 3.31 HSbrain_604_r 3.30 HS_from_MM_268_l 3.29 HS_from_MQbrain_193_r 3.28 Hsd_53_l 3.27 HS_from_MQbrain_314_l 3.26 Hsd_from_Mmd_328_r 3.25 Hsd_from_Mmd_426_l 3.24 HS_from_MQbrain_855_r 3.24 HS_from_MQbrain_814_r 3.24 HSbrain_354_r 3.23 HS_from_MQbrain_732_l 3.21 HS_from_MM_105_l 3.20 HSbrain_655_r 3.20 Hsd_from_Mmd_293_l 3.20 HS_from_MQbrain_827_r 3.20 HS_from_MQbrain_910_l 3.19 HS_from_MQbrain_1256_l 3.19 HS_from_PT_284_r 3.19 HS_from_MQbrain_829_l 3.17 HS_from_MQbrain_367_r 3.17 HSbrain_544_l 3.17 HS_302_l 3.16 HS_from_MM_185_r 3.15 HS_from_PT_130_r 3.15 Hsd_from_Mmd_391_l 3.15 HS_from_MQbrain_1820_r 3.15 HS_from_MQbrain_1137_r 3.15 HSbrain_1405_l 3.14 HS_from_MQbrain_608_r 3.12 HS_from_MQbrain_1408_l 3.11 HS_175_l 3.10 HSbrain_122_r 3.07 HS_from_PT_104_r 3.06 Hsd_from_Mmd_272_r 3.06 HS_from_MQbrain_593_r 3.02 HS_from_MQbrain_393_l 2.99 HS_from_MQbrain_854_l 2.97 HS_from_PT_32_l 2.96 HSbrain_742_r 2.95 Hsd_from_Mmd_459_r 2.93 HS_from_MM_180_l 2.93 HS_from_MQbrain_1514_r 2.92 HS_from_PT_257_r 2.92 HS_301_l 2.91 Hsd_from_Mmd_509_l 2.90 HS_from_MQbrain_797_l 2.90 HS_from_MQbrain_1269_l 2.89 HS_from_MM_146_l 2.89 HS_from_PT_154_r 2.88 HSbrain_247_l 2.87 HSbrain_423_l 2.86 Hsd_54_l 2.85 HS_from_PT_149_r 2.84 HSbrain_494_l 2.84 HS_from_MQbrain_906_r 2.83 HSbrain_755_l 2.82 HSbrain_541_l 2.81 HS_from_PT_203_r 2.80 HS_214_l 2.79 Hsd_from_Mmd_505_r 2.79 HS_from_MM_93_l 2.78 HSbrain_641_r 2.78 HS_from_MQbrain_140_r 2.77 HS_from_MQbrain_772_r 2.77 HS_from_MQbrain_438_r 2.76 HS_from_MQbrain_389_l 2.75 HS_205_r 2.74 HS_from_MQbrain_1428_r 2.73 HSbrain_1404_l 2.73 Hsd_85_l 2.73 HS_from_MM_132_r 2.73 HS_237_l 2.70 Hsd_from_Mmd_184_r 2.70 HSbrain_700_r 2.69 HSbrain_295_l 2.68 Hsd_from_Mmd_378_l 2.68 HS_from_MQbrain_1849_l 2.67 HS_from_MQbrain_283_l 2.66 HS_from_MQbrain_55_l 2.66 Hsd_22_l 2.62 HS_from_MQbrain_1694_l 2.61 HS_from_MQbrain_1250_r 2.61 HS_from_MQbrain_1598_l 2.61 HS_235_l 2.61 HSbrain_540_r 2.58 HS_from_MQbrain_681_l 2.58 HS_from_MQbrain_1195_r 2.58 HS_from_MQbrain_1296_l 2.58 HS_61_r 2.57 HS_229_l 2.57 HS_from_MQbrain_1257_l 2.57 Hsd_33_r 2.56 HSbrain_671_r 2.56 Hsd_from_Mmd_525_r 2.56 Hsd_from_Mmd_51_l 2.55 HSbrain_545_l 2.54 HS_from_MQbrain_1778_r 2.54 Hsd_16_l 2.53 HS_from_MM_168_l 2.53 HSbrain_781_l 2.52 HSbrain_382_l 2.52 HS_from_MQbrain_1103_r 2.51 Hsd_from_Mmd_26_r 2.50 HSbrain_1338_l 2.50 Hsd_from_Mmd_410_l 2.50 HSbrain_405_r 2.49 HSbrain_574_r 2.49 HSbrain_619_l 2.49 HS_13_r 2.45 HSbrain_1417_r 2.44 HSbrain_543_r 2.44 HS_from_MQbrain_1114_r 2.43 HS_127_l 2.43 HS_from_MQbrain_462_r 2.41 HS_from_MQbrain_1238_r 2.40 HS_from_MQbrain_195_l 2.39 HSbrain_246_r 2.36 HSbrain_662_r 2.36 HS_from_PT_271_r 2.36 HS_from_MQbrain_689_r 2.35 Hsd_from_Mmd_388_r 2.35 HSbrain_580_l 2.35 HSbrain_281_l 2.34 Hsd_from_Mmd_59_l 2.33 HS_from_MQbrain_1636_l 2.33 HS_from_MQbrain_62_l 2.30 Hsd_from_Mmd_154_r 2.30 HSbrain_546_r 2.27 Hsd_30_r 2.27 HS_from_MM_285_r 2.25 HS_from_MQbrain_141_l 2.24 HSbrain_414_r 2.22 HSbrain_76_l 2.22 HS_from_MQbrain_176_r 2.22 HS_223_l 2.21 Hsd_from_Mmd_159_l 2.21 HS_from_MM_47_r 2.21 Hsd_from_Mmd_298_r 2.19 HS_from_MQbrain_816_l 2.17 HS_from_MQbrain_1469_r 2.17 HS_220_l 2.15 HS_27_l 2.15 HSbrain_358_l 2.14 HS_from_MQbrain_144_l 2.14 HSbrain_1422_l 2.12 HS_204_r 2.11 HS_from_PT_128_r 2.11 HS_from_MM_101_l 2.10 HS_69_l 2.10 HS_120_r 2.10 HS_from_MQbrain_451_l 2.09 HS_104_l 2.08 HS_from_MM_116_r 2.08 HS_from_PT_126_r 2.08 HS_from_MQbrain_209_l 2.06 HS_from_MQbrain_1946_l 2.06 HS_from_MQbrain_1308_r 2.05 HS_from_MQbrain_334_l 2.04 HS_from_MQbrain_1444_l 2.03 HS_from_MQbrain_594_l 2.01 HS_from_MM_1_r 2.00 HS_from_MM_181_r 2.00 ¹Signal/background cut off > 2

TABLE 14a Small RNAs recovered from blood and differentially expressed in adenoma vs normal tissue: hairpin arm with highest expression 1^(st) arm adenoma vs control Systematic name signal/background¹ (adj p)² HS_169_l 138.82 0.000489293 HS_141_l 105.74 0.000489293 HS_217_l 34.38 0.000489293 HS_218_r 2191.38 0.000704567 HS_255_l 144.06 0.001129352 HS_232_l 109.73 0.001129352 HS_71_l 28.7 0.003939952 HS_from_MM_309_r 39.96 0.004006907 HS_from_MM_178_r 3.95 0.004006907 HS_from_MM_334_l 71.92 0.004431894 HS_from_MM_319_l 107.03 0.004431894 HS_from_MM_339_r 2501.25 0.004575487 HS_from_MM_63_l 4.64 0.004575487 HS_from_MQbrain_100_l 62.37 0.004575487 HS_from_MQbrain_1043_r 1537.86 0.004799641 HS_from_MQbrain_1056_l 5.37 0.004799641 HS_from_MQbrain_1128_l 33.94 0.004957702 HS_from_MQbrain_1183_l 112.54 0.004957702 HS_from_MQbrain_1100_l 37.05 0.004957702 HS_from_MQbrain_1297_l 70.63 0.006601644 HS_from_MQbrain_1292_r 11.08 0.006601644 HS_from_MQbrain_131_r 447.53 0.00676609 HS_from_MQbrain_1444_l 2.03 0.007781761 HS_from_MQbrain_1456_l 251.46 0.008573112 HS_from_MQbrain_1462_l 33.63 0.008573112 HS_from_MQbrain_1522_r 7.73 0.008946182 HS_from_MQbrain_1485_r 5.89 0.008946182 HS_from_MQbrain_1624_l 1452.35 0.008946182 HS_from_MQbrain_1625_r 907.04 0.008946182 HS_from_MQbrain_1630_l 1834.56 0.008946182 HS_from_MQbrain_1657_r 10.62 0.009734613 HS_from_MQbrain_191_l 276.03 0.01044887 HS_from_MQbrain_1792_r 3.43 0.01044887 HS_from_MQbrain_1823_r 6.11 0.01044887 HS_from_MQbrain_1884_r 7.89 0.01044887 HS_from_MQbrain_1808_r 172.48 0.01044887 HS_from_MQbrain_629_l 237.88 0.010727702 HS_from_MQbrain_330_r 3085.23 0.010727702 HS_from_MQbrain_349_l 214.68 0.010727702 HS_from_MQbrain_55_l 2.66 0.010727702 HS_from_MQbrain_207_l 1356.12 0.010727702 HS_from_MQbrain_20_r 49.05 0.010727702 HS_from_MQbrain_549_l 5.98 0.010727702 HS_from_MQbrain_671_r 1023.79 0.010727702 HS_from_MQbrain_350_l 188.59 0.010727702 HS_from_MQbrain_2380_r 100.43 0.010727702 HS_from_MQbrain_212_r 7.74 0.010727702 HS_from_MQbrain_71_r 790.88 0.010727702 HS_from_MQbrain_619_r 50.44 0.010727702 HS_from_MQbrain_194_l 16.83 0.010727702 HS_from_MQbrain_79_r 29.36 0.011699489 HS_from_MQbrain_839_r 10.92 0.011699489 HS_from_MQbrain_965_l 243.53 0.012506309 HS_from_MQbrain_940_r 317.39 0.012506309 HS_from_MQbrain_917_r 1391.24 0.012506309 HS_from_PT_237_r 1800.67 0.013034759 HS_from_PT_190_r 545.93 0.013034759 HS_from_PT_257_r 2.92 0.013034759 HSbrain_12_l 6.74 0.017198956 HSbrain_171_l 2560.96 0.017198956 HSbrain_1_l 471.82 0.017198956 HSbrain_106_r 53.44 0.017198956 HSbrain_158_l 43.6 0.017198956 HSbrain_1305_l 237.71 0.017198956 HSbrain_148_r 68.52 0.017198956 HSbrain_102_r 653.85 0.017198956 HSbrain_2_l 84.89 0.018600058 HSbrain_253_l 67.08 0.018600058 HSbrain_243_l 593.95 0.018600058 HSbrain_321_r 587.71 0.018600058 HSbrain_224_r 25.38 0.018600058 HSbrain_231_l 1709.15 0.018600058 HSbrain_337_l 18.24 0.019454312 HSbrain_377_r 3.94 0.019454312 HSbrain_426_r 1715.96 0.019454312 HSbrain_420_r 1374.92 0.019454312 HSbrain_359_r 207.52 0.019454312 HSbrain_540_r 2.58 0.021088597 HSbrain_52_r 24.74 0.021088597 HSbrain_503_r 388.85 0.021088597 HSbrain_483_l 33.11 0.021088597 HSbrain_485_r 2284.67 0.021088597 HSbrain_527_r 1052.64 0.021088597 HSbrain_6_r 2079.02 0.022745616 HSbrain_617_l 106.18 0.022745616 HSbrain_597_r 342.91 0.022745616 HSbrain_629_l 1754.85 0.022745616 HSbrain_709_l 1509.68 0.022745616 HSbrain_636_l 1264.65 0.022745616 HSbrain_727_l 22.41 0.023736962 HSbrain_723_l 277.73 0.023736962 Hsd_18_l 551.25 0.023736962 HSbrain_801_r 81.51 0.023736962 HSbrain_8_r 2366.39 0.023736962 HSbrain_75_l 940.56 0.023736962 HSbrain_811_r 5.93 0.023736962 HSbrain_916_l 55.74 0.023736962 HSbrain_722_l 554.56 0.023736962 Hsd_70_l 685 0.024762366 Hsd_from_Mmd_298_r 2.19 0.024762366 Hsd_from_Mmd_527_r 11.56 0.024762366 Hsd_49_r 2232.71 0.024762366 Hsd_from_Mmd_92_r 34.05 0.024762366 Hsd_from_Mmd_533_l 5.22 0.024762366 Hsd_26_l 6.89 0.024762366 HS_from_MQbrain_734_l 2968.08 0.026800941 HS_from_MQbrain_1684_l 714.03 0.026800941 HS_from_MQbrain_509_r 8.85 0.026800941 HS_from_MQbrain_74_r 1469.53 0.028655448 HSbrain_318_l 2130.43 0.028655448 HS_from_PT_139_l 28.77 0.028655448 HS_from_MQbrain_391_r 53.8 0.028655448 HS_from_MQbrain_1832_l 2323.53 0.02997784 HS_from_MQbrain_1169_l 27.22 0.02997784 HSbrain_259_r 1597.52 0.02997784 HS_from_PT_299_l 1425.1 0.02997784 HS_106_l 55.68 0.02997784 HSbrain_546_r 2.27 0.02997784 HSbrain_713_l 2635.96 0.02997784 HS_from_MQbrain_918_l 604.37 0.02997784 HS_from_MQbrain_1443_r 361.33 0.03224042 HS_118_l 634.82 0.03224042 HS_from_MQbrain_1469_r 2.17 0.03224042 HS_from_MQbrain_1392_r 1984.76 0.03224042 HS_from_PT_103_l 77.68 0.03224042 HS_from_MQbrain_1445_l 67.15 0.03224042 HS_from_MQbrain_1863_l 3259.56 0.03224042 HSbrain_316_l 1216.28 0.03374871 HSbrain_41_l 264.89 0.03374871 HS_231_r 34.84 0.03374871 HSbrain_165_l 137.58 0.03374871 HSbrain_458_l 14.44 0.03374871 HS_from_MQbrain_435_l 14.03 0.03374871 Hsd_from_Mmd_81_l 42.55 0.03374871 HS_from_MQbrain_1690_l 10.98 0.03374871 HSbrain_760_l 60.42 0.03374871 HS_from_MQbrain_1340_l 248.35 0.036099692 Hsd_102_l 51.2 0.036099692 HS_from_MQbrain_1513_r 11.02 0.036099692 HSbrain_261_l 4.72 0.038273758 HS_from_MQbrain_498_r 2610.14 0.038273758 HSbrain_543_r 2.44 0.038273758 HS_from_MQbrain_282_l 762.12 0.038273758 HS_from_MQbrain_1315_l 234.79 0.038273758 HSbrain_700_r 2.69 0.038273758 HS_from_MQbrain_470_l 136.89 0.040151024 HS_from_MQbrain_951_l 216.15 0.040151024 HS_from_MQbrain_1080_l 6.04 0.040151024 HS_189_l 103.99 0.040151024 HS_56_r 793.43 0.040151024 HSbrain_92_l 1202.44 0.040151024 HS_from_PT_43_l 1108.55 0.040151024 HSbrain_109_l 2695.37 0.040151024 Hsd_from_Mmd_436_r 4.74 0.040151024 HS_from_MQbrain_1747_r 1297.11 0.040151024 HS_261_r 142.25 0.042549287 Hsd_from_Mmd_261_l 2305.13 0.042549287 HS_from_MQbrain_1227_l 228.29 0.042549287 Hsd_42_r 755.65 0.042549287 HSbrain_1410_l 22.68 0.042549287 HS_from_MQbrain_782_r 761.75 0.042549287 HS_15_l 316.41 0.042549287 HS_from_MQbrain_1388_l 1165.24 0.042549287 HS_from_MQbrain_1844_r 1717.31 0.042549287 HS_266_r 5.54 0.045725655 HSbrain_284_l 2165.84 0.045725655 Hsd_63_r 1446.53 0.045725655 HS_from_PT_70_r 1095.93 0.045725655 Hsd_from_Mmd_34_r 46.61 0.045725655 HSbrain_25_r 4.72 0.048378078 HS_from_MQbrain_1075_l 2494.05 0.048378078 HSbrain_703_l 1943.04 0.048378078 HS_114_l 715.1 0.048378078 HSbrain_1362_l 962.43 0.048378078 HS_from_MQbrain_92_l 462.65 0.048378078 HS_from_MQbrain_1773_l 479.94 0.048378078 HS_from_MM_1_r 2 0.048378078 HS_from_MQbrain_539_r 1889.5 0.048378078 HS_from_MQbrain_472_r 187.77 0.048378078 HS_from_MQbrain_343_l 224.21 0.050130838 HS_from_MQbrain_315_l 248.59 0.050130838 HSbrain_652_l 1052.64 0.050130838 HS_from_MQbrain_572_l 7.03 0.050130838 HS_from_MQbrain_1610_r 102.62 0.050130838 HSbrain_84_l 13.53 0.050130838 HS_from_PT_136_l 88.09 0.050130838 HS_from_MQbrain_1686_l 2850.33 0.050130838 HSbrain_585_l 70.01 0.050130838 HS_from_MQbrain_774_r 383.95 0.050130838 HS_from_MQbrain_901_l 2410.6 0.050130838 HS_215_l 51.87 0.050130838 HS_from_MQbrain_1283_l 692.85 0.050130838 HS_from_MQbrain_1334_r 10.69 0.053159859 HSbrain_442_r 5.68 0.053159859 HS_from_MQbrain_1395_r 200.62 0.053159859 Hsd_37_l 37.1 0.053159859 HS_from_MQbrain_1239_l 588.81 0.053159859 HS_from_MQbrain_873_r 599.55 0.053159859 HS_131_r 546.58 0.053159859 HS_from_MQbrain_1484_l 1417.92 0.053159859 HSbrain_419_l 1039 0.05566524 HS_from_MQbrain_56_l 125.18 0.05566524 HS_62_l 8.32 0.05566524 HS_from_MQbrain_1620_l 1575.67 0.05566524 HS_from_MM_49_l 28.19 0.05566524 HS_from_MQbrain_664_l 35.08 0.05566524 HS_from_MM_115_l 2053.1 0.05566524 HS_59_l 19.16 0.05566524 HSbrain_239_l 22.71 0.05566524 HS_from_MQbrain_1674_l 6.8 0.05566524 HSbrain_85_l 443.76 0.05566524 HSbrain_671_r 2.56 0.05566524 HS_from_MQbrain_974_l 1938.97 0.058253679 HSbrain_123_l 2450.67 0.058253679 HS_from_MQbrain_1374_l 242.85 0.058253679 Hsd_7_r 7.55 0.058253679 HS_from_MQbrain_883_r 626.09 0.058253679 HS_from_MQbrain_1119_l 2299.12 0.058253679 HS_from_PT_121_r 144.82 0.058253679 HS_190_l 2565.53 0.058253679 HS_from_MQbrain_1300_l 151.72 0.058253679 HSbrain_35_r 185.02 0.058253679 HS_from_MQbrain_810_l 2819.61 0.058253679 HS_from_PT_340_l 74.7 0.061046963 HSbrain_214_l 5.03 0.061046963 HS_from_MQbrain_128_r 205.98 0.061046963 HS_from_MQbrain_70_l 2632.56 0.061046963 HS_304_r 442.22 0.061046963 HSbrain_409_r 1021.91 0.061046963 Hsd_from_Mmd_439_l 141.63 0.061046963 HS_36_l 35.1 0.061046963 HS_from_MQbrain_1354_l 14.56 0.061046963 HS_150_l 1178.4 0.061046963 HSbrain_157_l 60.78 0.064770288 HSbrain_755_l 2.82 0.064770288 HSbrain_506_l 9.24 0.064770288 HS_from_MQbrain_750_r 348.17 0.064770288 HS_180_r 57.76 0.064770288 HSbrain_116_l 61.35 0.064770288 Hsd_62_l 733.75 0.067503134 HS_from_MQbrain_239_r 1469.78 0.067503134 HSbrain_330_l 636.49 0.067503134 Hsd_from_Mmd_524_r 4.21 0.067503134 HS_from_MQbrain_745_r 2408.79 0.067503134 HS_203_r 66.49 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2713.25 0.170271053 HS_212_r 82.75 0.170271053 HSbrain_467_l 2150.69 0.170271053 HS_from_MQbrain_281_l 1617.63 0.170271053 HS_from_MQbrain_1846_r 1712.53 0.170271053 Hsd_from_Mmd_410_l 2.5 0.170271053 HS_from_MQbrain_468_l 45.02 0.170271053 HS_from_MQbrain_1377_l 4.44 0.170271053 HS_128_r 595.8 0.170271053 HSbrain_216_r 2537.24 0.170271053 HSbrain_143_l 2228.78 0.170271053 HSbrain_53_l 2212.76 0.170271053 HS_from_MQbrain_1199_l 2060.7 0.170271053 HSbrain_701_l 1684.34 0.170271053 HS_from_MQbrain_841_l 101.61 0.170271053 Hsd_from_Mmd_235_r 92.57 0.170271053 HS_192_r 43.57 0.170271053 Hsd_from_Mmd_367_l 13.74 0.170271053 Hsd_from_Mmd_35_l 7.49 0.170271053 HS_from_MQbrain_984_l 6.6 0.176183859 HS_from_PT_27_r 1359.52 0.176183859 HS_from_MQbrain_628_l 20.61 0.176183859 HS_from_MQbrain_314_l 3.26 0.176183859 HSbrain_771_l 1417.26 0.176183859 HS_204_r 2.11 0.176183859 HS_220_l 2.15 0.176183859 HSbrain_32_l 1943.03 0.176183859 HS_from_MQbrain_855_r 3.24 0.176183859 Hsd_65_r 258.71 0.176183859 HSbrain_626_l 1507.69 0.176183859 Hsd_from_Mmd_344_r 149.5 0.176183859 HS_186_r 242.25 0.176183859 HS_from_MQbrain_135_l 42.75 0.176183859 HSbrain_707_r 9.72 0.176183859 HS_from_MM_123_l 7.67 0.176183859 HS_from_MQbrain_361_l 3.9 0.182758186 HSbrain_388_r 1236.45 0.182758186 HS_132_l 3.95 0.182758186 HS_from_MM_6_l 372.25 0.182758186 HS_from_MQbrain_881_l 29.79 0.182758186 HS_from_MM_124_r 5.3 0.182758186 HS_from_MQbrain_1380_r 2936.43 0.182758186 HS_from_MQbrain_1509_r 2861.75 0.182758186 HS_from_MQbrain_1349_l 2206.2 0.182758186 HS_from_MQbrain_162_r 1795.5 0.182758186 HS_from_MQbrain_850_l 1651.86 0.182758186 HS_from_MQbrain_676_r 14.81 0.182758186 HS_from_MM_149_r 4.41 0.182758186 HS_from_MM_160_l 4.14 0.182758186 HSbrain_706_l 4.08 0.182758186 Hsd_from_Mmd_187_r 3.46 0.182758186 HS_from_MM_86_l 3.47 0.188867139 HSbrain_198_l 7.92 0.188867139 HSbrain_571_l 5.09 0.188867139 HSbrain_627_r 27.61 0.188867139 HS_77_l 1287.06 0.188867139 HSbrain_210_l 2938.2 0.188867139 HSbrain_553_l 12.16 0.188867139 HS_from_PT_271_r 2.36 0.188867139 HS_from_MQbrain_487_r 3196.14 0.188867139 HS_from_MQbrain_1073_r 2353.25 0.188867139 HS_from_MQbrain_1596_r 2252.81 0.188867139 HS_from_PT_328_l 317.19 0.188867139 HS_from_MM_182_r 88.5 0.188867139 HS_from_MQbrain_1734_l 26.58 0.188867139 HS_from_MQbrain_1208_l 19.05 0.188867139 HSbrain_370_r 9.51 0.188867139 HS_from_MQbrain_1760_r 9.4 0.188867139 HS_from_MQbrain_1234_l 4.28 0.188867139 HS_from_MQbrain_1424_r 11.94 0.19639408 Hsd_from_Mmd_326_l 9.49 0.19639408 HS_from_PT_130_r 3.15 0.19639408 HS_124_l 223.23 0.19639408 Hsd_19_l 198.35 0.19639408 HS_from_MQbrain_648_l 898.68 0.19639408 HS_198_l 2797.81 0.19639408 HS_from_PT_204_r 2648.95 0.19639408 HSbrain_810_l 2281.81 0.19639408 HSbrain_70_r 1587.77 0.19639408 HS_from_MQbrain_406_r 1158.97 0.19639408 HSbrain_616_r 260.24 0.19639408 HS_from_MQbrain_383_l 120.82 0.19639408 HS_from_MQbrain_1883_r 6.04 0.19639408 HS_from_MQbrain_389_l 2.75 0.19639408 ¹Cut off Signal/background>2 ²Cut off adj p < 0.2

TABLE 14b Small RNAs recovered from blood and differentially expressed in adenoma vs normal tissue: hairpin arm with lowest expression 2^(nd) arm adenoma vs control Systematic name signal/background¹ (adj p)² HS_21_r 99.11 0.000489293 HS_215_r 6.03 0.000489293 HS_291_r 4.17 0.001647426 HS_9_r 15.33 0.003939952 HS_from_MQbrain_1103_l 2.46 0.004957702 HS_from_MQbrain_1393_r 240.51 0.00676609 HS_from_MQbrain_2700_r 3.75 0.010727702 HS_from_MQbrain_825_r 5.01 0.011699489 HS_from_PT_26_r 5.11 0.013034759 HSbrain_1437_r 4.06 0.017198956 HSbrain_268_r 27.49 0.018600058 HSbrain_362_r 41.61 0.019454312 HSbrain_472_l 2.61 0.019454312 HSbrain_458_r 2.23 0.019454312 HSbrain_713_r 3.19 0.022745616 HSbrain_703_r 2.01 0.022745616 HSbrain_794_r 128.92 0.023736962 HSbrain_778_r 5.4 0.023736962 Hsd_107_l 3.8 0.023736962 Hsd_from_Mmd_219_r 5.96 0.024762366 Hsd_from_Mmd_519_l 3.96 0.024762366 Hsd_from_Mmd_155_l 2.23 0.024762366 HS_from_MQbrain_800_r 17.09 0.03374871 HS_from_PT_295_r 2.59 0.036099692 HS_from_MQbrain_1561_r 7.06 0.040151024 HSbrain_752_r 43.13 0.042549287 HS_from_MM_289_l 5.4 0.042549287 HS_from_MQbrain_1143_r 47.51 0.045725655 HSbrain_48_r 18.16 0.048378078 HS_from_MQbrain_1752_l 3.64 0.048378078 HS_from_MQbrain_1006_l 3.57 0.048378078 HS_from_MQbrain_1771_l 115.56 0.050130838 HS_from_MQbrain_691_l 50.85 0.050130838 HS_from_MQbrain_1642_l 2.65 0.050130838 Hsd_65_l 2.04 0.050130838 HS_from_MQbrain_1794_l 7.63 0.053159859 HSbrain_374_r 4.56 0.053159859 Hsd_76_r 4.51 0.053159859 Hsd_18_r 2.34 0.053159859 HSbrain_916_r 3.45 0.05566524 HSbrain_300_l 16.46 0.058253679 HS_156_l 7.17 0.058253679 HSbrain_304_r 6.39 0.058253679 HS_from_MQbrain_1404_r 6.61 0.061046963 HSbrain_776_l 156.06 0.064770288 HS_from_MQbrain_1696_l 43.62 0.064770288 HS_from_MQbrain_1450_r 35.38 0.064770288 HS_from_PT_41_r 32.51 0.064770288 Hsd_42_l 3.47 0.067503134 HS_from_PT_235_l 23.13 0.069749265 HS_from_MQbrain_37_r 13.27 0.069749265 HS_98_l 38.97 0.072349461 HS_81_r 30.21 0.072349461 HSbrain_301_l 16.09 0.072349461 HSbrain_635_l 6.83 0.072349461 HS_from_MQbrain_253_r 5.37 0.072349461 HSbrain_788_l 19.27 0.076797167 HS_166_r 4.11 0.076797167 HS_from_MQbrain_1665_r 6.67 0.079954597 HSbrain_172_l 3.38 0.079954597 HSbrain_661_l 2.82 0.079954597 HS_from_MQbrain_48_r 16.99 0.083930001 HS_from_MQbrain_113_r 7.1 0.083930001 HS_from_MM_229_r 74.93 0.088143181 HSbrain_122_l 3.01 0.088143181 HS_from_MQbrain_1031_l 34.93 0.09152926 HS_from_MQbrain_1678_r 18.12 0.09152926 HS_from_MQbrain_1602_l 17.41 0.09152926 HS_from_MQbrain_487_l 9.22 0.09152926 HSbrain_19_l 6.76 0.09152926 HS_from_MQbrain_1726_l 4.39 0.09152926 HS_from_MQbrain_1037_r 2.65 0.09152926 Hsd_from_Mmd_371_r 2.09 0.09152926 HS_173_l 40.18 0.095394629 HS_from_MQbrain_932_l 13.46 0.095394629 HS_from_MQbrain_755_l 8.96 0.095394629 HS_from_MQbrain_1201_r 5.23 0.095394629 HS_38_r 10.14 0.098921026 HSbrain_680_r 8.65 0.098921026 HS_from_MQbrain_1139_r 2.47 0.098921026 HS_from_MQbrain_751_l 41.92 0.103393572 Hsd_63_l 41.23 0.103393572 HS_from_MQbrain_1633_r 9.89 0.103393572 HSbrain_673_r 9.27 0.103393572 HSbrain_684_r 8.86 0.103393572 HSbrain_319_l 6.7 0.103393572 HSbrain_299_r 32.14 0.108118292 HS_from_PT_95_l 8.24 0.108118292 HS_from_MQbrain_824_l 17.99 0.113099484 HSbrain_47_r 9.58 0.113099484 HSbrain_216_l 5.87 0.113099484 HSbrain_390_l 3.48 0.113099484 HS_from_MQbrain_241_l 3.41 0.113099484 Hsd_60_r 11.8 0.11858389 HS_from_MQbrain_560_r 9.17 0.11858389 HS_from_MQbrain_301_l 4.97 0.11858389 HS_from_PT_237_l 42.41 0.12422104 HS_from_MQbrain_485_l 23.03 0.12422104 HS_135_l 15.42 0.12422104 HS_from_MQbrain_406_l 7.81 0.12422104 HS_from_PT_283_r 7.34 0.12422104 HS_from_MQbrain_1712_r 154.76 0.129399391 HSbrain_267_r 33.77 0.129399391 HS_from_MQbrain_466_l 11.16 0.129399391 HSbrain_347_r 8.32 0.129399391 HS_from_MQbrain_129_r 6.71 0.129399391 HS_from_PT_207_l 4.65 0.129399391 HS_from_MQbrain_967_l 2.73 0.129399391 HS_from_MQbrain_382_l 2.37 0.129399391 HS_from_MQbrain_684_r 403 0.134970683 Hsd_from_Mmd_291_l 96.8 0.134970683 HSbrain_687_r 7.98 0.134970683 HS_from_MQbrain_1640_l 5.27 0.134970683 HS_from_MQbrain_968_l 4.35 0.134970683 HS_51_r 2.98 0.134970683 HSbrain_126_r 43.17 0.140323812 HS_from_MQbrain_56_r 4.85 0.140323812 HS_157_r 3.41 0.140323812 HS_from_MQbrain_1759_l 748.44 0.146822481 HSbrain_107_r 10.31 0.146822481 HS_from_MQbrain_1462_r 5.15 0.146822481 HSbrain_139_r 3.45 0.146822481 HS_from_MQbrain_6_r 318.83 0.152858542 HSbrain_32_r 19.15 0.152858542 HS_from_MQbrain_340_l 7.36 0.152858542 HSbrain_1325_r 5.49 0.152858542 HS_from_MQbrain_154_r 3.24 0.152858542 HS_176_l 2.96 0.152858542 HSbrain_653_l 76.21 0.158799149 HS_from_MQbrain_281_r 11.13 0.158799149 HSbrain_669_r 8.92 0.158799149 HS_128_l 8.45 0.158799149 HS_from_MQbrain_1090_r 156.7 0.163891418 HS_from_PT_280_l 18.01 0.163891418 HS_from_MQbrain_1520_l 9.18 0.163891418 HS_from_MQbrain_1535_r 8.09 0.163891418 Hsd_84_r 4.61 0.163891418 HS_from_MQbrain_629_r 4.6 0.163891418 HSbrain_578_l 3.13 0.163891418 HS_from_PT_155_l 2.23 0.163891418 HSbrain_745_l 1921.15 0.170271053 HSbrain_364_r 156.81 0.170271053 HS_from_MM_304_l 93.08 0.170271053 HSbrain_724_l 18.81 0.170271053 HSbrain_41_r 8.29 0.170271053 HS_from_MM_163_l 5.4 0.170271053 HSbrain_177_l 3.34 0.170271053 HSbrain_755_r 2.58 0.170271053 Hsd_47_r 2.41 0.170271053 HS_264_r 2.41 0.170271053 Hsd_from_Mmd_92_l 25.04 0.176183859 HS_from_MQbrain_1832_r 7.61 0.176183859 Hsd_from_Mmd_212_r 6.76 0.176183859 HS_from_MQbrain_520_l 5.39 0.176183859 HS_from_MQbrain_1565_l 4.63 0.176183859 Hsd_from_Mmd_412_r 3.21 0.176183859 HSbrain_491_l 3.17 0.176183859 HSbrain_151_r 2.12 0.176183859 Hsd_27_r 2.1 0.176183859 HS_from_MQbrain_1497_l 2.09 0.176183859 HS_from_PT_161_l 23.16 0.182758186 HS_from_MQbrain_1219_r 20.97 0.182758186 HS_from_MQbrain_635_l 20.97 0.182758186 HS_from_MQbrain_736_r 15.8 0.182758186 HS_from_MQbrain_559_r 10.46 0.182758186 HSbrain_456_r 4.65 0.182758186 HS_from_MQbrain_1883_l 3.79 0.182758186 HS_from_MQbrain_1137_l 2.89 0.182758186 Hsd_from_Mmd_68_l 2.5 0.182758186 HS_from_MQbrain_999_r 84.53 0.188867139 HSbrain_403_l 20.91 0.188867139 HS_from_MQbrain_524_l 8.94 0.188867139 HSbrain_153_r 8.32 0.188867139 HS_from_MQbrain_178_r 8.01 0.188867139 HS_from_MQbrain_1353_l 5.24 0.188867139 Hsd_from_Mmd_120_l 3.25 0.188867139 HS_from_MM_331_r 2.57 0.188867139 HS_from_MQbrain_436_r 2.14 0.188867139 HS_203_l 52.23 0.19639408 HSbrain_658_l 17.81 0.19639408 Hsd_from_Mmd_399_r 11.23 0.19639408 HS_from_MQbrain_1402_r 9.06 0.19639408 HSbrain_690_r 5.57 0.19639408 HS_from_MQbrain_1671_l 2.75 0.19639408 HSbrain_295_r 2.25 0.19639408 HSbrain_143_r 2.01 0.19639408 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 15a Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with highest expression 1^(st) arm carcinoma vs Systematic name signal/background¹ control (adj p)² HS_from_MM_334_l 71.92 0.016433541 HSbrain_377_r 3.94 0.019274533 HSbrain_617_l 106.18 0.022921248 HS_from_MM_178_r 3.95 0.030988376 HS_from_MQbrain_1056_l 5.37 0.031989408 HS_from_MQbrain_1823_r 6.11 0.0342406 Hsd_102_l 51.2 0.035303066 HS_from_PT_190_r 545.93 0.045228199 HSbrain_171_l 2560.96 0.067337504 HS_from_MQbrain_343_l 224.21 0.07566513 HS_from_MQbrain_1169_l 27.22 0.084904114 HSbrain_12_l 6.74 0.086503988 HS_from_MQbrain_350_l 188.59 0.086503988 HSbrain_597_r 342.91 0.086503988 HSbrain_629_l 1754.85 0.086503988 HS_255_l 144.06 0.090694253 HS_from_MQbrain_1128_l 33.94 0.090694253 HS_from_MQbrain_349_l 214.68 0.090694253 HS_from_MQbrain_55_l 2.66 0.090694253 HS_from_MQbrain_2380_r 100.43 0.090694253 Hsd_from_Mmd_328_r 3.25 0.090694253 HS_from_PT_340_l 74.7 0.090694253 HSbrain_494_l 2.84 0.104922786 HSbrain_177_r 9.75 0.104922786 HSbrain_483_l 33.11 0.110995143 HS_from_MQbrain_128_r 205.98 0.110995143 HS_from_MM_309_r 39.96 0.120015634 HSbrain_709_l 1509.68 0.120015634 HS_141_l 105.74 0.120843678 HS_217_l 34.38 0.120843678 HS_from_MQbrain_1657_r 10.62 0.120843678 HS_from_PT_257_r 2.92 0.120843678 HS_from_MQbrain_930_r 8.71 0.120843678 HS_from_MQbrain_769_r 3.62 0.120843678 HS_from_MQbrain_572_l 7.03 0.126655157 HS_from_MQbrain_1624_l 1452.35 0.149145996 HSbrain_1_l 471.82 0.149145996 HSbrain_158_l 43.6 0.149145996 HSbrain_801_r 81.51 0.149145996 Hsd_111_r 92.66 0.149145996 Hsd_18_l 551.25 0.159103307 HSbrain_261_l 4.72 0.159103307 HSbrain_458_l 14.44 0.166408872 HS_from_MQbrain_1459_l 154.95 0.166408872 HS_from_MM_339_r 2501.25 0.179914563 HS_304_r 442.22 0.179914563 Hsd_from_Mmd_298_r 2.19 0.19263196 HS_from_MQbrain_1513_r 11.02 0.19263196 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 15b Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs normal tissue: hairpin arm with lowest expression 2^(nd) arm carcinoma vs Systematic name signal/background¹ control (adj p)² HS_from_MQbrain_1393_r 240.51 0.016433541 HS_215_r 6.03 0.016433541 HS_291_r 4.17 0.035303066 HS_21_r 99.11 0.099652833 HS_from_MQbrain_1103_l 2.46 0.099652833 HS_from_MM_289_l 5.4 0.104922786 HS_from_PT_26_r 5.11 0.110995143 HS_156_l 7.17 0.120015634 HS_from_MQbrain_1696_l 43.62 0.126655157 HSbrain_299_r 32.14 0.159103307 ¹ Cut off Signal/background > 2 ² Cut off adj p < 0.2

TABLE 16a Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs adenoma: hairpin arm with highest expression 1^(st) arm carcinoma vs Systematic name (signal/background)¹ adenoma (adj p)² HS_from_MQbrain_1391_l 4.14 0.012664553 HS_169_l 138.82 0.014416465 HS_from_MQbrain_1334_r 10.69 0.015599346 HS_299_l 29.47 0.016786613 HS_from_MQbrain_1082_l 744.36 0.018319912 HS_from_MQbrain_1522_r 7.73 0.020545593 HSbrain_306_r 2986.89 0.023919533 HS_from_MQbrain_629_l 237.88 0.026776445 HS_from_MQbrain_1456_l 251.46 0.028202169 HS_from_MQbrain_828_l 1227.9 0.032034428 HSbrain_384_l 3.79 0.034662803 HSbrain_1425_l 1793.99 0.035941334 HS_from_MQbrain_1750_r 2658.65 0.037874034 HS_from_MQbrain_984_l 6.6 0.039250091 HS_from_MQbrain_43_r 4.54 0.039250091 HS_141_l 105.74 0.044599949 HS_from_MQbrain_686_r 2145.46 0.044599949 HS_218_r 2191.38 0.045945376 HS_217_l 34.38 0.050135128 HSbrain_226_r 1502.51 0.050135128 HSbrain_494_l 2.84 0.053747925 HS_from_MQbrain_1340_l 248.35 0.058254254 HSbrain_337_l 18.24 0.059897432 HSbrain_25_r 4.72 0.062381992 HS_from_MQbrain_330_r 3085.23 0.0659723 HS_261_r 142.25 0.068590471 Hsd_from_Mmd_391_l 3.15 0.070590475 HS_from_MQbrain_1832_l 2323.53 0.071451516 Hsd_from_Mmd_237_l 2452.36 0.071451516 HS_from_MQbrain_93_r 1882.36 0.071451516 HSbrain_2_l 84.89 0.072275086 HSbrain_52_r 24.74 0.072275086 HSbrain_182_r 2216.91 0.072275086 HS_from_MQbrain_869_l 49.56 0.072654718 HS_from_MQbrain_74_r 1469.53 0.074901054 HSbrain_419_l 1039 0.074901054 HS_from_MQbrain_470_l 136.89 0.075028175 HS_from_MM_103_l 2974.49 0.075028175 HS_219_l 2255.05 0.075028175 HS_from_MQbrain_1001_r 1683.09 0.075028175 Hsd_from_Mmd_527_r 11.56 0.07641095 Hsd_from_Mmd_189_l 233.41 0.07641095 HS_from_MQbrain_1462_l 33.63 0.07715065 HSbrain_253_l 67.08 0.07715065 HS_118_l 634.82 0.07715065 HS_119_l 2088.91 0.07715065 HSbrain_204_r 1075.46 0.07715065 HSbrain_442_r 5.68 0.07965977 HSbrain_361_l 2360.92 0.080676612 HSbrain_328_l 3271.08 0.08237725 HS_from_PT_27_r 1359.52 0.08237725 HS_from_MQbrain_1569_l 171.53 0.083833911 HSbrain_6_r 2079.02 0.084885584 HS_from_MQbrain_1443_r 361.33 0.084885584 Hsd_from_Mmd_261_l 2305.13 0.084885584 HSbrain_389_l 15.54 0.084885584 HS_from_MQbrain_1675_r 791.8 0.084885584 HSbrain_95_l 464.25 0.084885584 HS_from_MQbrain_1623_r 992.29 0.084885584 HS_from_MQbrain_1494_r 8.2 0.084885584 HS_from_MQbrain_965_l 243.53 0.085697388 Hsd_101_l 127.99 0.085697388 HSbrain_764_r 42.39 0.085697388 HS_from_MQbrain_928_r 1544.69 0.085697388 HS_from_MQbrain_1355_r 2362.21 0.089491072 HSbrain_695_l 10.34 0.089491072 HSbrain_540_r 2.58 0.091337111 HS_from_MM_219_l 151.42 0.091337111 HS_from_MQbrain_1771_r 1664.95 0.091337111 HS_from_MQbrain_631_l 1729.43 0.091337111 HS_from_MQbrain_765_l 2695.54 0.091337111 HS_from_MQbrain_392_l 1903.25 0.091337111 HSbrain_594_l 1061.87 0.091337111 HS_from_MQbrain_131_r 447.53 0.092780591 HS_from_MQbrain_634_l 7.38 0.092780591 HS_from_MQbrain_191_l 276.03 0.094556199 Hsd_from_Mmd_330_l 1411.51 0.094556199 HSbrain_591_l 1813.41 0.094556199 HSbrain_123_l 2450.67 0.096132958 HS_from_MQbrain_1793_r 4.95 0.096132958 HS_from_MQbrain_1183_l 112.54 0.098301345 HSbrain_316_l 1216.28 0.098301345 HS_from_MQbrain_1031_r 987.03 0.099488281 Hsd_70_l 685 0.101009439 HSbrain_703_l 1943.04 0.101009439 HSbrain_14_r 47.92 0.101009439 HS_from_MQbrain_1827_l 2658.72 0.101009439 HS_from_MQbrain_628_l 20.61 0.102601153 HS_from_MQbrain_1374_l 242.85 0.104515233 HS_from_MQbrain_433_l 49.52 0.104515233 HS_from_MQbrain_722_r 36.55 0.104515233 HS_from_MQbrain_62_l 2.3 0.104515233 HS_from_MQbrain_22_r 1898.63 0.105993846 HS_from_MQbrain_534_r 1775.11 0.105993846 HS_from_MQbrain_951_l 216.15 0.107794024 HS_from_MQbrain_574_l 439.75 0.107794024 HS_from_MQbrain_921_l 1527.75 0.107794024 HS_from_MQbrain_996_l 2730.34 0.107794024 HSbrain_677_l 2284.34 0.11066006 Hsd_from_Mmd_52_r 145.37 0.11066006 HS_from_MM_86_l 3.47 0.11066006 Hsd_from_Mmd_266_r 148.01 0.11066006 HSbrain_426_r 1715.96 0.113095726 HSbrain_50_l 1128.11 0.113095726 HSbrain_588_l 2412.89 0.113095726 HSbrain_440_l 2827.75 0.113095726 HS_from_MQbrain_777_r 5.15 0.113095726 HS_from_MQbrain_29_l 1136.64 0.113095726 HS_from_MQbrain_56_l 125.18 0.114595796 HS_102_l 2248.72 0.114595796 HS_from_MQbrain_1164_r 1604.05 0.114595796 HS_71_l 28.7 0.115928328 HS_from_MQbrain_1637_r 961.67 0.115928328 HS_from_MQbrain_609_l 1532.45 0.115928328 HS_from_MQbrain_501_l 1907.55 0.115928328 HS_from_MQbrain_354_r 14.17 0.117828853 HS_246_l 518 0.117828853 HS_from_MM_208_r 1993.74 0.117828853 HS_from_MQbrain_974_l 1938.97 0.119559457 HSbrain_708_l 2404.97 0.119559457 HS_from_PT_60_l 2122.55 0.119559457 HSbrain_606_l 993.78 0.119559457 HSbrain_305_r 2302.79 0.121604253 HS_from_MQbrain_1632_l 3014.17 0.121604253 HS_from_MQbrain_1075_l 2494.05 0.12300785 HSbrain_402_l 2283.48 0.12300785 HS_from_MQbrain_266_l 878.84 0.12300785 HS_from_MQbrain_1261_r 2483.06 0.12300785 HS_from_MQbrain_340_r 387 0.12300785 HS_from_MQbrain_1097_r 22.37 0.124263194 HS_from_MQbrain_210_r 1848.78 0.124263194 HS_from_MQbrain_681_l 2.58 0.124263194 HS_from_MQbrain_314_l 3.26 0.126757752 HSbrain_771_l 1417.26 0.126757752 HS_from_MQbrain_1102_l 2428.54 0.129555956 HSbrain_393_r 1557.67 0.129555956 HS_from_MQbrain_1413_l 2113.32 0.129555956 HS_from_MQbrain_800_l 28.04 0.129555956 HSbrain_783_l 2871.64 0.130803986 Hsd_from_Mmd_94_l 10 0.130803986 HS_from_PT_313_l 19.26 0.130803986 HS_from_MQbrain_672_l 2227.7 0.130803986 HS_from_MQbrain_216_l 1590.82 0.130803986 HSbrain_380_r 28.02 0.130803986 HS_from_MQbrain_1100_l 37.05 0.132596379 HS_from_MQbrain_715_l 2873.52 0.132596379 HS_from_MQbrain_868_l 251.95 0.132596379 HSbrain_691_l 1101.52 0.132596379 HS_101_l 2303.1 0.132596379 HSbrain_243_l 593.95 0.134691663 HS_62_l 8.32 0.134691663 Hsd_42_r 755.65 0.134691663 Hsd_7_r 7.55 0.134691663 HSbrain_484_l 158.28 0.134691663 HS_from_PT_44_l 2616.23 0.136637202 HS_from_MQbrain_1043_r 1537.86 0.138217661 HS_from_MQbrain_315_l 248.59 0.138217661 HS_from_MQbrain_70_l 2632.56 0.138217661 HS_from_MQbrain_1836_l 5.19 0.138217661 HS_from_MQbrain_1824_l 2661.19 0.138217661 HSbrain_250_l 2758.18 0.138217661 Hsd_69_l 1207.06 0.138217661 HSbrain_420_r 1374.92 0.139019426 HS_from_MQbrain_1493_r 472.59 0.139019426 Hsd_13_l 16.95 0.139019426 HS_from_MQbrain_1756_l 1749.72 0.139019426 HS_277_l 776.25 0.139019426 HS_from_MQbrain_809_l 21.62 0.139019426 HS_from_MQbrain_886_r 1484.58 0.139019426 HS_from_MQbrain_90_r 1911.93 0.139019426 HS_from_MQbrain_399_l 1395.01 0.139019426 HS_98_r 2382.13 0.141416815 HS_from_MQbrain_845_r 365.11 0.141416815 HS_from_MQbrain_1331_r 2711.38 0.141416815 HS_39_r 1944.78 0.141416815 HS_from_MQbrain_824_r 1660.01 0.14474535 HSbrain_369_r 197.24 0.14474535 HS_from_MQbrain_914_l 2107.69 0.14474535 HS_from_MQbrain_1143_l 566.08 0.14474535 HSbrain_82_r 10.7 0.14474535 HS_from_MQbrain_1227_l 228.29 0.145370181 HSbrain_214_l 5.03 0.145370181 HS_175_l 3.1 0.145370181 HSbrain_716_l 1552.16 0.145370181 HS_from_MQbrain_1204_r 2072.07 0.145370181 HS_54_l 705.25 0.145370181 HS_from_MQbrain_1810_l 923.33 0.145370181 HSbrain_117_r 181.24 0.145370181 HS_from_MQbrain_535_r 45.21 0.145370181 HSbrain_620_l 161.99 0.145370181 HS_from_MQbrain_180_r 1754.02 0.145370181 HS_from_MM_199_l 79.91 0.146325218 HS_133_l 2696.57 0.146325218 Hsd_from_Mmd_246_r 185.28 0.146325218 HS_306_l 22.09 0.146325218 HSbrain_307_r 2494.19 0.146325218 HS_from_MQbrain_973_l 140.65 0.146325218 HS_from_MQbrain_1444_l 2.03 0.148196723 HS_from_MQbrain_671_r 1023.79 0.148196723 HS_from_MM_118_l 5.89 0.148196723 HSbrain_624_l 1034.54 0.148196723 HSbrain_627_r 27.61 0.148196723 HSbrain_647_r 16.58 0.148196723 HSbrain_177_r 9.75 0.149149579 HS_from_MQbrain_1773_l 479.94 0.149149579 HSbrain_198_l 7.92 0.149149579 HS_from_PT_134_l 2880.24 0.149149579 HS_from_MQbrain_1088_l 162.85 0.149149579 HS_139_l 2103.33 0.149149579 HS_from_MQbrain_817_l 5.3 0.149149579 HS_from_MQbrain_1419_r 1654.34 0.149149579 HS_58_l 1112.12 0.149149579 HSbrain_41_l 264.89 0.152177614 HSbrain_717_l 2399.92 0.152177614 HS_from_PT_20_r 1411.59 0.152177614 HS_204_r 2.11 0.152177614 HSbrain_304_l 60.38 0.152177614 HS_111_r 2642.45 0.152177614 Hsd_from_Mmd_509_l 2.9 0.152177614 HS_from_MQbrain_1128_l 33.94 0.155479351 HS_from_MQbrain_536_r 1796.18 0.155479351 HS_from_MQbrain_1433_r 232.94 0.155479351 HSbrain_578_r 119.12 0.155479351 HSbrain_652_l 1052.64 0.15865589 HSbrain_673_l 2432.23 0.15865589 HS_220_l 2.15 0.15865589 HSbrain_431_l 2250.77 0.15865589 HS_from_MQbrain_1168_l 25.63 0.15865589 HS_from_PT_254_r 11.89 0.159708794 Hsd_from_Mmd_480_r 1038.29 0.159708794 HS_from_MQbrain_604_l 2116.19 0.159708794 HSbrain_571_l 5.09 0.159708794 HS_from_MQbrain_529_r 1669.81 0.159708794 HS_167_r 2325.07 0.159708794 HSbrain_202_r 646.85 0.159708794 HS_288_l 1661.49 0.161647438 HSbrain_72_l 1994.62 0.161647438 HS_from_MQbrain_1839_l 2242.94 0.161647438 HS_from_MQbrain_1722_l 121.03 0.161647438 HS_from_MQbrain_587_l 3.45 0.161647438 HS_from_MQbrain_1877_r 1438.74 0.161647438 HSbrain_16_l 6.68 0.161647438 HS_from_MM_319_l 107.03 0.16463875 HS_208_r 514.2 0.16463875 HS_from_PT_41_l 688.41 0.16463875 HS_from_MQbrain_808_l 23 0.16463875 HS_from_MQbrain_1229_r 1561.04 0.16463875 HSbrain_220_l 1272.15 0.16463875 HSbrain_111_l 5.04 0.16463875 HS_from_MQbrain_1268_l 6.35 0.167313007 HS_from_MQbrain_2670_r 19.49 0.167313007 HSbrain_168_l 636.93 0.167313007 HS_from_MQbrain_699_r 2022.54 0.167313007 HS_from_MQbrain_1372_l 983.18 0.167313007 HSbrain_513_r 778.63 0.167313007 HS_from_MQbrain_1876_r 2589.02 0.167313007 HS_114_l 715.1 0.170255758 HSbrain_113_r 77.28 0.170255758 HS_from_MQbrain_1855_l 1224.15 0.170255758 HS_61_r 2.57 0.170255758 HS_from_MQbrain_496_r 2625.7 0.170255758 HSbrain_157_l 60.78 0.173467438 HSbrain_336_l 4.14 0.173467438 HSbrain_614_l 2539.17 0.173467438 HS_29_l 950.02 0.173467438 HS_from_MQbrain_57_l 94.28 0.173467438 HS_from_MQbrain_734_l 2968.08 0.175200251 HS_from_MQbrain_1777_l 3386.15 0.175200251 HS_from_MQbrain_437_l 15.23 0.175200251 HSbrain_643_l 1935.82 0.175200251 HS_from_PT_34_r 2623.29 0.175200251 HSbrain_687_l 1178.66 0.175200251 HS_from_MQbrain_1091_l 2553.31 0.175200251 HS_from_MQbrain_1708_l 257.81 0.175200251 HS_from_MQbrain_1463_l 136.6 0.175200251 HS_from_MQbrain_1485_r 5.89 0.177405071 HSbrain_1305_l 237.71 0.177405071 HSbrain_347_l 1854.13 0.177405071 HSbrain_794_l 1200.68 0.177405071 HS_from_MQbrain_1470_r 2318.58 0.177405071 Hsd_from_Mmd_167_r 2610.41 0.177405071 HSbrain_692_r 2311.79 0.177405071 HSbrain_690_l 1719.12 0.177405071 Hsd_from_Mmd_42_r 30.99 0.177405071 HS_266_r 5.54 0.180260145 HS_from_MQbrain_550_l 2602.74 0.180260145 HS_from_MQbrain_1631_r 2710.28 0.180260145 HSbrain_593_r 1548.5 0.180260145 HS_285_r 925.13 0.180260145 HSbrain_263_r 37.25 0.180260145 Hsd_from_Mmd_286_r 4.4 0.180260145 Hsd_from_Mmd_120_r 1906.46 0.184337179 HSbrain_621_l 2344.81 0.184337179 HSbrain_778_l 91.71 0.184337179 HS_243_l 1837.67 0.184337179 HS_138_l 125.63 0.184337179 HSbrain_1364_l 1439.39 0.185815478 HSbrain_32_l 1943.03 0.185815478 HS_77_l 1287.06 0.185815478 HS_from_MQbrain_1778_r 2.54 0.185815478 HS_303_r 290.92 0.185815478 HS_from_MQbrain_272_l 1172.26 0.185815478 HS_from_MQbrain_453_r 3.84 0.185815478 HSbrain_166_l 2487.26 0.185815478 HS_142_l 1918.3 0.185815478 HS_from_MQbrain_17_r 39.73 0.185815478 HSbrain_662_r 2.36 0.185815478 HS_from_MQbrain_940_r 317.39 0.188706417 HS_189_l 103.99 0.188706417 HS_from_MQbrain_745_r 2408.79 0.188706417 HS_from_MQbrain_36_r 1728.75 0.188706417 HSbrain_570_l 1042.7 0.188706417 HSbrain_497_l 5.9 0.188706417 HSbrain_141_r 2820.17 0.188706417 HS_from_MQbrain_691_r 1239.61 0.188706417 HS_50_l 1776.71 0.188706417 Hsd_62_l 733.75 0.190550803 HS_from_MQbrain_397_l 2241.37 0.190550803 HS_from_PT_238_l 2054.08 0.190550803 HS_from_MQbrain_97_r 346.64 0.190550803 HS_166_l 2194.77 0.190550803 HS_from_MQbrain_626_r 2474.16 0.190550803 HS_from_MQbrain_968_r 1722.97 0.190550803 HS_105_l 2468.12 0.190550803 HS_from_MM_80_l 2105.14 0.190550803 HSbrain_809_r 1761.33 0.190550803 Hsd_from_Mmd_298_r 2.19 0.194339793 HSbrain_259_r 1597.52 0.194339793 HSbrain_755_l 2.82 0.194339793 HS_from_MQbrain_1272_l 1771.43 0.194339793 HS_from_MQbrain_1421_l 2558.01 0.194339793 HS_from_PT_149_r 2.84 0.194339793 HS_from_MQbrain_467_l 182.78 0.197457594 HSbrain_210_l 2938.2 0.197457594 HS_from_MQbrain_635_r 1594.99 0.197457594 HS_from_MQbrain_1159_l 2053.58 0.197457594 HSbrain_479_l 10.28 0.197457594 HS_from_MQbrain_1514_r 2.92 0.197457594 HS_from_MM_63_l 4.64 0.199721903 HSbrain_482_l 36.52 0.199721903 Hsd_from_Mmd_478_l 40.92 0.199721903 HSbrain_388_r 1236.45 0.199721903 HSbrain_651_r 2230.86 0.199721903 HS_from_MQbrain_1357_l 1967.07 0.199721903 HS_from_MQbrain_1210_l 1544.01 0.199721903 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 16a Small RNAs recovered from blood and differentially expressed in adenocarcinoma vs adenoma: hairpin arm with lowest expression 2^(nd) arm carcinoma vs Systematic name (signal/background)¹ adenoma (adj p)² HS_from_MQbrain_638_l 2.57 0.00750624 HSbrain_390_l 3.48 0.012664553 HS_8_r 4.22 0.014224152 HS_176_l 2.96 0.014416465 HSbrain_293_l 2.65 0.015226536 HS_from_MQbrain_63_r 2.96 0.015599346 HS_from_MQbrain_1137_l 2.89 0.016904198 HS_291_r 4.17 0.020545593 HS_157_r 3.41 0.020545593 HSbrain_217_r 2.23 0.020545593 HS_51_r 2.98 0.024910624 HSbrain_680_r 8.65 0.031432755 HSbrain_687_r 7.98 0.034662803 Hsd_70_r 2.28 0.035037528 HSbrain_351_r 3.85 0.039250091 Hsd_18_r 2.34 0.039250091 HSbrain_1325_r 5.49 0.040852758 HSbrain_669_r 8.92 0.044599949 HSbrain_703_r 2.01 0.047341086 HSbrain_304_r 6.39 0.04754573 HSbrain_177_l 3.34 0.048205391 HSbrain_122_l 3.01 0.049767746 HSbrain_187_r 7.95 0.050135128 HS_from_MQbrain_1565_l 4.63 0.050135128 HSbrain_673_r 9.27 0.052756328 HSbrain_684_r 8.86 0.052756328 HS_17_l 4.22 0.053747925 Hsd_from_Mmd_371_r 2.09 0.058218978 HSbrain_374_r 4.56 0.058254254 HS_from_MQbrain_346_l 2.9 0.059897432 Hsd_from_Mmd_413_r 2.19 0.06455063 HS_from_MQbrain_932_l 13.46 0.068270026 HS_from_MQbrain_108_r 6.38 0.068590471 HS_from_MQbrain_736_r 15.8 0.071451516 HSbrain_93_r 9.48 0.072275086 HS_from_MQbrain_1006_l 3.57 0.072275086 HS_200_r 6.42 0.072654718 HS_from_MQbrain_301_l 4.97 0.072654718 HSbrain_47_r 9.58 0.075028175 HS_from_MQbrain_154_r 3.24 0.07715065 HSbrain_319_l 6.7 0.07965977 Hsd_42_l 3.47 0.083833911 HS_from_MQbrain_634_r 2.4 0.083833911 HS_from_MQbrain_824_l 17.99 0.084885584 HS_54_r 2.68 0.084885584 HS_from_MQbrain_534_l 4.92 0.085697388 HSbrain_512_l 4.96 0.089491072 Hsd_27_r 2.1 0.089491072 HS_from_MQbrain_1264_l 4.83 0.092780591 HS_14_r 2.37 0.092780591 HS_from_MQbrain_1771_l 115.56 0.098301345 HSbrain_553_r 3.4 0.098301345 HS_from_MQbrain_129_r 6.71 0.102601153 HSbrain_661_l 2.82 0.102601153 HS_from_MQbrain_1116_r 14.63 0.104515233 Hsd_from_Mmd_405_l 2.88 0.104515233 HS_21_r 99.11 0.107794024 HS_from_MQbrain_1339_r 2.71 0.11066006 Hsd_12_r 4.6 0.113095726 HSbrain_677_r 11.53 0.114595796 HS_38_r 10.14 0.114595796 HSbrain_621_r 2.02 0.114595796 HSbrain_795_r 2.01 0.114595796 HS_from_MM_331_r 2.57 0.115928328 HS_from_MM_260_l 2.24 0.117828853 HSbrain_441_r 4.99 0.119559457 HSbrain_1437_r 4.06 0.119559457 HS_from_MQbrain_648_r 84.85 0.121604253 HS_154_r 2.89 0.121604253 HS_from_MQbrain_760_l 13.31 0.12300785 HS_from_MQbrain_1633_r 9.89 0.124263194 HSbrain_393_l 6.32 0.124263194 HS_from_MQbrain_268_r 2.07 0.124263194 HS_from_MQbrain_1675_l 2.27 0.126757752 HS_from_MQbrain_453_l 3.29 0.129555956 HSbrain_776_l 156.06 0.130803986 HS_from_MQbrain_37_r 13.27 0.130803986 Hsd_from_Mmd_219_r 5.96 0.130803986 HS_from_MQbrain_1520_l 9.18 0.132596379 HS_from_MQbrain_382_l 2.37 0.132596379 HS_from_MQbrain_1549_l 2.35 0.134691663 HS_from_MQbrain_281_r 11.13 0.136637202 HS_from_PT_95_l 8.24 0.136637202 HS_from_MQbrain_178_r 8.01 0.139019426 HSbrain_1416_r 5.33 0.139019426 HS_from_MQbrain_332_l 5.24 0.141416815 HS_from_PT_283_r 7.34 0.145370181 HSbrain_139_r 3.45 0.145370181 HS_from_MQbrain_64_l 2.57 0.145370181 HS_from_MQbrain_606_r 51.46 0.146325218 HS_from_MQbrain_666_l 37.07 0.149149579 HS_from_MQbrain_629_r 4.6 0.155479351 HS_from_MQbrain_1601_r 343.75 0.15865589 HS_from_MQbrain_936_l 3.59 0.15865589 HSbrain_218_l 33.26 0.161647438 HS_from_MQbrain_635_l 20.97 0.161647438 HS_from_PT_338_l 2.54 0.167313007 HS_from_MQbrain_401_l 2.38 0.167313007 HS_from_MQbrain_1627_r 19.73 0.170255758 HSbrain_626_r 13.91 0.170255758 HS_from_MQbrain_560_r 9.17 0.173467438 HS_from_MQbrain_85_l 89.3 0.175200251 HS_from_MQbrain_1752_l 3.64 0.175200251 HS_from_MQbrain_386_r 337.53 0.177405071 HSbrain_1414_r 2.58 0.177405071 Hsd_84_r 4.61 0.184337179 HS_182_r 2.36 0.184337179 HS_from_MQbrain_1394_l 617.11 0.185815478 HS_from_MQbrain_2700_r 3.75 0.185815478 HS_from_MQbrain_500_r 7.18 0.197457594 HS_from_MQbrain_968_l 4.35 0.197457594 HSbrain_190_r 3.15 0.197457594 HSbrain_755_r 2.58 0.197457594 HS_from_MQbrain_1100_r 10.88 0.199721903 HS_from_MQbrain_1415_r 4.64 0.199721903 HS_from_MQbrain_1747_l 3.37 0.199721903 ¹Cut off Signal/background > 2 ²Cut off adj p < 0.2

TABLE 17 Summary of small RNAs detectable in faeces and blood and differentially expressed in the different tissue categories Analysis Sample Reference Result Universal miRNAs Carcinoma Control 59 miRNA recovered from Table 10 Faeces faeces and differentially expressed in adenocarcinoma vs control Universal miRNAs Adenoma Control 857 miRNA recovered from Table 9 Faeces faeces and differentially expressed in adenoma vs control Universal miRNAs Carcinoma Adenoma 461 miRNA recovered from Table 11 Faeces faeces and differentially expressed in adenocarcinoma vs adenoma Universal miRNAs Carcinoma Control 58 miRNA recovered from Table 15 Blood blood and differentially expressed in adenocarcinoma vs control Universal miRNAs Adenoma Control 842 miRNA recovered from Table14 Blood blood and differentially expressed in adenoma vs control Universal miRNAs Carcinoma Adenoma 461 miRNA recovered from Table 16 Blood blood and differentially expressed in adenocarcinoma vs adenoma

Presence of Classifying Small RNAs in Blood

Lengthy table referenced here US20130190379A1-20130725-T00001 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00002 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00003 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00004 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00005 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00006 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00007 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00008 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00009 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00010 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00011 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00012 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00013 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00014 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00015 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00016 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00017 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00018 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00019 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00020 Please refer to the end of the specification for access instructions.

Lengthy table referenced here US20130190379A1-20130725-T00021 Please refer to the end of the specification for access instructions.

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Lengthy table referenced here US20130190379A1-20130725-T00026 Please refer to the end of the specification for access instructions.

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LENGTHY TABLES The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20130190379A1). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3). 

1. A collection of probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and/or 6a.
 2. A collection of probes or primers according to claim 1, comprising probes or primers for detecting each of the nucleic acid molecules of table 25a and table 6a.
 3. A collection of probes or primers according to claim 2, comprising probes or primers for detecting each of the nucleic acid molecules of table 25a, table 5a and table 6a.
 4. A collection of probes or primers for detecting each of the nucleic acid molecules of according to claim 1-3 for use in discriminating between normal colorectal tissue, colorectal adenoma and colorectal adenocarcinoma.
 5. A collection of probes or primers for detecting each of the nucleic acid molecules of table 23 and/or table
 24. 6. A method for selecting probes that discriminate between at least two types of samples comprising nucleic acid from cells said method comprising hybridizing nucleic acid from a representative number of samples of said at least two types of samples to a collection of probes according to any one of claims 1-5, quantifying hybridization of said probes with nucleic acid in said samples, and selecting a subset of probes from said collection of probes, that discriminates between said at least two types of samples.
 7. A method according to claim 6, wherein said cells are human cells.
 8. A method according to claim 6 or claim 7, wherein at least one of said at least two types of samples comprises nucleic acid from tumor cells.
 9. A method according to claim 8, wherein said tumor cells are colon tumor cells.
 10. A method according to any one of claims 6-9, wherein at least one of said at least two types of samples comprises nucleic acid from faeces or blood.
 11. A method according to any one of claims 6-10, wherein at least one of said at least two types of samples is a sample of normal cells, preferably normal colon epithelial cells.
 12. A subset of probes or primers from a collection of probes or primers according to any one of claims 1-5, obtainable by a method according to any one of claims 6-11.
 13. A subset of probes or primers according to claim 12, comprising probes or primers for at least 10 of the nucleic acid identified in table 23 or table
 24. 14. A subset of probes or primers according to claim 12, comprising probes or primers for each of the nucleic acids identified in table 2a, table 3a, table 4a, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table
 35. 15. A subset of probes or primers from the collection of probes or primers according to any one of claims 1-5, comprising probes or primers for each of the nucleic acids identified in table 8 or table
 13. 16. A method for determining whether a sample comprises nucleic acid from a particular type of cells, said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 1, table 2a, table 3a, table 4a, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference.
 17. A method for determining whether a sample comprises nucleic acid of a particular type of cells, said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 1, table 2a, table 3a, table 4a, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20 table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference.
 18. A method according to claim 16 or claim 17, wherein said cells are tumor cells or suspected of being tumor cells.
 19. A method according to any one of claims 16-18, wherein said cells are colon cells.
 20. A method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 1 in said sample, and comparing the result of said quantification with a reference.
 21. A method for determining whether a sample comprises nucleic acid from colorectal cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 1, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference.
 22. A method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 2a, table 4a, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d table 20, table 25a, table 26, table 27, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference.
 23. A method for determining whether a sample comprises nucleic acid from adenoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 2a, table 4a, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20 table 21, table 25a, table 26, table 27, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference.
 24. A method according to claim 22 or claim 23, wherein said reference is a quantification of a hybridization of a sample comprising nucleic acid from adenocarcinoma cells or from normal cells, with said collection of probes.
 25. A method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising detecting and quantifying the level of the nucleic acid molecules identified in table 3a, table 4a, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35 in said sample, and comparing the result of said quantification with a reference.
 26. A method for determining whether a sample comprises nucleic acid from adenocarcinoma cells said method comprising hybridising nucleic acid from said sample to a collection of probes as identified in table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 20, table 21, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, quantifying hybridization of said probes with nucleic acid in said sample, and comparing the result of said quantification with a reference.
 27. A method according to claim 25 or claim 26, wherein said reference is a quantification of a hybridization of a sample comprising nucleic acid from adenoma cells or from normal cells, with said collection of probes.
 28. A method according to claim 24 or claim 27, wherein said normal cells are brush cells from normal colon.
 29. Use of a collection of probes or primers for small RNAs, preferably miRNAs and/or precursors thereof for classifying a sample as derived from a cell that contains a chromosomal aberration.
 30. Use according to claim 29, wherein said cells are tumor cells, preferably colon tumor cells.
 31. Use according to claim 29 or claim 30, wherein said collection of probes or primers is a collection of probes or primers according to any one of claims 1-5, 12-15.
 32. Use according to any one of claims 29-31, for detecting gain or loss of a chromosome arm or a substantial part thereof.
 33. Use according to claim 32, for detecting loss of chromosome 8p or 17p.
 34. A collection of probes comprising the nucleic acid sequences identified in table
 21. 35. A subset of probes according to claim 34, comprising at least 10 of the probes identified in table
 21. 36. A subset of probes according to claim 35, comprising the probes for the nucleic acids as identified in table 1, table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table
 35. 37. A subset of probes from the collection of probes according to claim 34, comprising the probes for the nucleic acids as identified in table 8 or table
 13. 38. A method for detecting cells in a sample of blood or a fractionated part thereof, comprising detecting small RNA in said sample.
 39. A method according to claim 38, wherein said cells are colon cells.
 40. A method according to claim 38 or claim 39, comprising detecting the level of nucleic acid molecules identified in table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, or table 18c, table 23, table 24 and/or table
 35. 41. A method for detecting cells in a faeces sample comprising detecting small RNA in said sample.
 42. A method according to claim 41, wherein said cells are colon cells.
 43. A method according to claim 41 or claim 42, comprising detecting the level of nucleic acid molecules identified in table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 23, table 24 and/or table
 34. 44. A method for the treatment and/or prevention of a disease in an individual comprising administering to said individual at least one nucleic acid molecule of table 23 or table 24, at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, or a functional equivalent of said at least one nucleic acid molecule.
 45. A method according to claim 44, wherein said individual is suffering from colon cancer or is at risk of suffering therefrom.
 46. A method according to claim 44 or claim 45, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 2a, table 3a, table 4a, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, or a functional equivalent thereof.
 47. A method according to any one of claims 44-46, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 2a, table 2b, table 2c, table 2d, table 3a, table 3b, table 3c, table 3d, table 4a, table 4b, table 4c, table 4d, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 19c, table 19d, table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table 35, or a functional equivalent thereof.
 48. A method according to any one of claims 44-47, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 20, table 26 or table
 27. 49. A method according to any one of claims 44-48, for the treatment of disease, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 3a, table 4a, table 6a, table 7a, table 10a, table 10b, table 11a, table 11b, table 12b, table 12c, table 15a, table 15b, table 16a, table 16b, table 18b, table 18c, table 19c, table 19d, table 20, table 25a, table 26, table 27 or table 33, or a functional equivalent thereof.
 50. A method according to any one of claims 44-49, for the treatment of disease, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 5a, table 6a, table 7a or table 25a, or a functional equivalent thereof.
 51. A method according to any one of claims 44-48, for the prevention of disease, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, is a nucleic acid molecule of table 2a, table 4a, table 5a, table 7a, table 9a, table 9b, table 11a, table 11b, table 12a, table 12c, table 14a, table 14b, table 16a, table 16b, table 18a, table 18c, table 19c, table 19d, table 20, table 25a, table 26 or table 27, or a functional equivalent thereof.
 52. A method according to any one of claims 44-48, 51, for the prevention of disease, wherein said at least one nucleic acid molecule of table 23 or table 24 or the reverse complement thereof, comprises a nucleic acid molecule of table 5a, table 7a or table 25a, or a functional equivalent thereof.
 53. A method according to any one of claims 44-52, wherein said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2d, table 3d, table 4d, table 19c, table 19d, table 26, table 27 or table
 33. 54. A method according to claim 53, wherein said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 5a, table 7a, or table 25a or a functional equivalent thereof.
 55. A method according to any one of claims 44-53, wherein said at least one nucleic acid molecule comprising the reverse complementary sequence of a nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 2c, table 3c, table 4c or table 19c or table 19d.
 56. A method according to claim 55, wherein said at least one nucleic acid molecule of table 23 or table 24, comprises a nucleic acid molecule of table 5a, table 7a, or table 25a or a functional equivalent thereof.
 57. Use of a nucleic acid molecule of table 23 or table 24, as a drug target.
 58. Use according to claim 58, wherein said nucleic acid molecule is a nucleic acid molecule as identified in table 20, table 26 or table
 27. 59. Use of a nucleic acid molecule of table 23 or table 24, for identifying a molecular process in a cell that is contributing to a disease or a disease state.
 60. Use according to claim 59, wherein said nucleic acid molecule is a nucleic acid molecule as identified in table 20, table 26 or table
 27. 61. A collection of nucleic acid molecules comprising the nucleic acid molecules of table 23 or table
 24. 62. A subset nucleic acid molecules of a collection of nucleic acids according to claim 61, comprising at least 10 of the nucleic acids identified in table 23 or table
 24. 63. A subset of nucleic acid molecules according to claim 62, comprising the nucleic acid molecules identified in table 1, table 2a, table 3a, table 4a, table 5a, table 6a, table 7a, table 9a, table 9b, table 10a, table 10b, table 11a, table 11b, table 12a, table 12b, table 12c, table 14a, table 14b, table 15a, table 15b, table 16a, table 16b, table 18a, table 18b, table 18c, table 19c, table 19d table 20, table 25a, table 26, table 27, table 28a, table 28b, table 29a, table 29b, table 30, table 31a, table 31b, table 32a, table 32b, table 33, table 34 and/or table
 35. 64. A subset of nucleic acid molecules according to claim 62, comprising the nucleic acid molecules identified in table 8 or table
 13. 65. A method for determining whether a colon cell comprises a deletion of less than 3 megabases in chromosomal region 1p32.2, 1q21.1, 1q22, 6p22.2, 7p15.2, 11p15.5, 16q12.2 or 17p13.1 comprising determining whether said cell comprises a deletion of DNA coding for a small RNA as identified in table 28a, or a precursor thereof.
 66. A method according to claim 65, wherein nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof.
 67. A method according to claim 65 or claim 66, wherein said small RNA is a small RNA as identified in table 28b.
 68. A method according to any one of claims 65-67, further comprising typing said cell as a colon carcinoma cell.
 69. A method according to any one of claims 65-68, wherein said small RNA is a small RNA as identified in table
 30. 70. A method according to claim 69, further comprising typing said cell as a microsatellite stable colon carcinoma cell.
 71. A method according to any one of claims 65-68, wherein said small RNA is a small RNA as identified in table 32a or table 32b.
 72. A method according to claim 70, wherein said small RNA is a small RNA as identified in table 32b.
 73. A method according to claim 70 or claim 71, further comprising typing said cell as a microsatellite instable colon carcinoma cell.
 74. A method for determining whether a colon cell comprises an additional chromosomal copy of less than 3 megabases of chromosomal region 5q31.3, 8p21.3, 9p21.3, 10p15.1 or 16q13 comprising determining whether said cell comprises an additional copy of DNA coding for a small RNA as identified in table 29a, or a precursor thereof.
 75. A method according to claim 74, wherein nucleic acid of said cell is contacted with a primer or a probe specific for said small RNA, a precursor thereof, a DNA encoding said small RNA and/or a precursor thereof.
 76. A method according to claim 74 or claim 75, wherein said small RNA is a small RNA as identified in table 29b.
 77. A method according to any one of claims 74-76, further comprising typing said cell as a colon carcinoma cell.
 78. A method according to any one of claims 74-77, wherein said small RNA is a small RNA as identified in table 31a or table 31b.
 79. A method according to claim 78, wherein said small RNA is a small RNA as identified in table 31b.
 80. A method according to claim 78 or claim 79, further comprising typing said cell as a microsatellite stable colon carcinoma cell.
 81. A method for the treatment of an individual suffering from a colon tumor comprising administering to said individual a nucleic acid comprising a nucleic acid as identified in table 28a, table 28b, table 30, table 32a, table 32b or 33 or a functional equivalent thereof.
 82. A method according to claim 81, wherein said nucleic acid is a nucleic acid as identified in table 28b, table 32b or table
 33. 83. A method according to claim 81 or claim 82, wherein the nucleic acid is provided as a nucleic acid encoding a precursor for the nucleic acid. 